Browsing by Author "Çiftdogan, DY"
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Item The Factor V G1691A, Factor V H1299R, prothrombin G20210A polymorphisms in children with family history of premature coronary artery diseaseÇiftdogan, DY; Coskun, S; Ulman, C; Tikiz, HAtherosclerosis, the major cause of coronary artery disease (CAD), has a very long asymptomatic development phase, which begins in childhood. In this study, we describe the Factor V G1691A, Factor V H1299R and prothrombin G20210A gene polymorphisms in children with a family history of premature CAD. Evidence of these polymorphisms in these children may predict the probability of having atherosclerosis in the future. Our study included a total of 140 children, 72 males and 68 females between the ages of 4.9 and 15.7 years. Among these children, 73 had a parental history of premature CAD and the remaining 67 belonged to our control group. The participants were screened for the mutations Factor V G1691 A, Factor V H1299R and prothrombin G20210A by polymerase chain reaction amplified DNA products with specific oligonucleotide probes. Our results suggested that frequencies of the mutated allele of Factor V G1691A and prothrombin G20210A are higher in children with a parental history of premature CAD. In conclusion, Factor V G1691A and prothrombin G20210A polymorphisms which were detected in higher frequencies in children with a parental history of premature CAD may indicate a risk for developing atherosclerosis and might be useful in screening for CAD in children; however, large population-based research is necessary to investigate further genetic risk assessment for CAD. Coron Artery Dis 20:435-439 (C) 2009 Wolters Kluwar Health vertical bar Lippincott Williams & Wilkins.Item The association of apolipoprotein E polymorphism and Lipid levels in children with a family history of premature coronary artery diseaseÇiftdogan, DY; Coskun, S; Ulman, C; Tikiz, HBACKGROUND: Polymorphisms in the apolipoprotein E (apoE) gene may modulate lipoprotein metabolism and influence plasma lipid levels. Thus, they have been associated with relative risk of coronary artery disease (CAD). OBJECTIVE: To evaluate the association of apolipoprotein E polymorphism and lipid levels in children with family history of premature coronary artery disease. METHODS: The apoE genotypes, allele frequencie,s and plasma lipid levels were analyzed in 137 children. Among these children, 70 (study group) had and 67 (control group) did not have a parental history of premature CAD RESULTS: Total cholesterol (TO levels were greater in the study group (P = .04). The frequencies of epsilon 3 epsilon 4 genotype and epsilon 4 allele were significantly greater in the study group (P = 005 for both), The epsilon 2 allele correlated negatively with Tc and low-density lipoprotein cholesterol levels, and e4 had a positive correlation with Tc and low-density lipoprotein cholesterol levels. CONCLUSIONS: Tc levels are influenced by apoE genotypes in childhood. Also, the frequency of the epsilon 4 allele is greater in children with family history of premature CAD. The e4 allele may be associated with an increased risk for development of atherosclerosis by elevated levels of Tc in children with family history of CAD. The evaluation of apoE gene polymorhisms may contribute to the assessment of cardiovascular risk in children with a family history of CAD. (C) 2012 National Lipid Association. All rights reserved.Item Evaluation of sleep quality in mothers of children with bronchiolitis obliteransYüksel, H; Çiftdogan, DY; Yilmaz, Ö; Sögüt, AAim: The aim of this study was to evaluate the quality of sleep in mothers of children with bronchiolitis obliterans. Material and Method: The study group consisted of 36 mothers with a child who had bronchiolitis obliterans and 62 mothers with healthy children. All mothers enrolled in the study filled in the Pittsburgh Sleep Quality Index (PSQI). Results: The mean ages of the children of the mothers enrolled in the study were statistically similar (3.57 +/- 2.58 vs 3.85 +/- 1.46 years, p>0.05). Total Pittsburgh Sleep Quality Index scores and subjective sleep quality scores in the mothers of children with bronchiolitis obliterans were significantly higher than those in the mothers of healthy children (both p=0.015). Conclusions: In this study, it was found that mothers of children with bronchiolitis obliterans have poor sleep quality. Therefore, assessment may be needed for the requirement of support regarding sleep quality in them. (Turk Arch Ped 2009; 44: 99-102)Item Common viral etiologies of community acquired lower respiratory tract infections in young children and their relationship with long term complicationsYüksel, H; Yilmaz, Ö; Akçali, S; Sögüt, A; Çiftdogan, DY; Urk, V; Ertan, P; Sanlidag, TViral lower respiratory tract infections (LRTIs) and their late complications are important causes of morbidity and mortality in childhood. The aims of this study were the detection of viral agents that cause community-acquired LRTIs in young children and investigation of the relationship between viral etiology and bronchiolitis obliterans (130) which is one of the late complications of LRTIs. A total of 151 children (86 male, 65 female; mean age: 2.9 +/- 1.9 years) who were diagnosed to have LRTIs between the period of 2002-2004, at Pediatric Allergy and Pulmonology Department of a University Hospital in Manisa (located in the Aegean region of Turkey) were included to the study. The presence of respiratory viruses [respiratory syncytial virus (RSV), influenza virus type A and B, parainfluenza virus types 1, 2 and 3, adenovirus] in the nasopharyngeal aspirate specimens collected from children have been searched by direct fluorescence antibody test (Biotrin, Ireland). Respiratory viruses were detected in 25.2% (38/151) of the patients with LRTIs, while this rate was 46.8% (22147) for 2002 period, 13.3% (8/60) for 2003 period and 18.2% (8/44) for 2004 period. RSV and adenoviruses both detected with a frequency of 31.5% (n = 12/38); were the most common agents encountered, and followed by parainfluenza (110/38, 26.3%) and influenza (9/38, 23.6%) viruses. Postinfectious BO have been diagnosed in 7.3% (11/151) of the patients; seven in 2002, one in 2003 and three in 2004 periods. Viral etiology were present in all of the patients who developed BO in 2002, while viral infection was detected in one of the patients who developed BO in 2003-2004 periods. Adenoviruses were the most frequently detected agents (n = 5) in BO cases with viral etology (n = 8). Viral agents were found positive in 72.7% (8/11) and 21.4% (30/140) of the patients with and without BO development, respectively, and this difference was found statistically significant (p = 0.02). Besides, BO development was detected in 21.1% (8/38) and 2.6% (3/113) of LRTI patients with and without viral etiology, respectively, and this difference was also significant (p<0.05). In conclusion, the long term follow-up is important in young children with viral LRTIs for the early diagnosis of complications. Thus the identification of viruses might aid in estimation of prognosis.Item Evaluation of Attitudes and Knowledge of Influenza Diagnosis, Treatment and Vaccination Among Pediatric ResidentsGaripçin, P; Keles, YE; Öncel, EK; Kiymet, E; Böncüoglu, E; Özlü, CO; Asrak, HK; Özenen, GG; Ümit, Z; Kara, SS; Sen, S; Aksay, AK; Bal, ZS; Devrim, I; Belet, N; Çiftdogan, DYObjective: Influenza virus is common in children, especially in winter, causing hospitalization, admission to the intensive care unit, or even death. There are few studies on the attitudes or knowledge of influenza diagnosis, treatment, and vaccination among pediatricians. This study was planned to determine pediatric residents' attitudes and behaviors about recognizing the influenza virus, making treatment decisions, prophylaxis, and immunization. Material and Methods: This descriptive cross-sectional study was performed from 31 July-1 December 2019 among pediatric residents working in six different hospitals in the Aegean Region by an online survey. Twenty-seven questions were asked regarding articipant's demographic characteristics, recognition of the influenza symptoms, treatment, prophylaxis, and immunization. Results: Two hundred and four (58.5%) of 349 pediatric residents were included in the study, who answered the questionnaire. Among the participants, 72.5% were females, and their mean age was 27.9 +/- 2.1 years, and 59.3% worked as a pediatric residents for less than two years. When the symptoms of influenza were evaluated, the most known symptoms were fever (94.1%), myalgia (81.9%), tiredness (77.0%), headache (70.1%), and cough (68.6%). When oseltamivir treatment indications were questioned, most pediatric residents (82.2%) answered the questions. It was observed that 21.1% of the pediatric residents had the flu vaccine in the current season. According to the state of having chronic diseases, the rate of vaccination in participants was not statistically significant (p= 0.136). Conclusion: In this study, it was determined that pediatric residents' knowledge about influenza awareness, treatment, and immunization was insufficient. It may be beneficial to train pediatric residents about the influenza virus and vaccine before each influenza season.Item Antibiotic associated diarrhea in outpatient pediatric antibiotic therapyBasaranoglu, ST; Karaaslan, A; Sali, E; Çiftçi, E; Aydin, ZGG; Kocabas, BA; Kaya, C; Bayturan, SS; Kara, SS; Çiftdogan, DY; Çay, Ü; Aktürk, HG; Çelik, M; Ozdemir, H; Somer, A; Diri, T; Yazar, AS; Sütçü, M; Tezer, H; Oncel, EK; Kara, M; Çelebi, S; Parlakay, AÖ; Karakaslilar, S; Arisoy, ES; Tanir, G; Kara, TT; Devrim, I; Erat, T; Aykaç, K; Kaba, Ö; Güven, S; Yesil, E; Yilmaz, AT; Durmus, SY; Çaglar, I; Günay, F; Özen, M; Dinleyici, EÇ; Kara, ABackgroundAntibiotic-associated diarrhea is one of the most frequent side effects of antimicrobial therapy. We assessed the epidemiological data of antibiotic-associated diarrhea in pediatric patients in our region.MethodsThe prospective multi-center study included pediatric patients who were initiated an oral antibiotic course in outpatient clinics and followed in a well-established surveillance system. This follow-up system constituded inclusion of patient by the primary physician, supply of family follow-up charts to the family, passing the demographics and clinical information of patient to the Primary Investigator Centre, and a close telephone follow-up of patients for a period of eight weeks by the Primary Investigator Centre.ResultsA result of 758 cases were recruited in the analysis which had a frequency of 10.4% antibiotic-associated diarrhea. Among the cases treated with amoxicillin-clavulanate 10.4%, and cephalosporins 14.4% presented with antibiotic-associated diarrhea. In the analysis of antibiotic-associated diarrhea occurrence according to different geographical regions of Turkey, antibiotic-associated diarrhea episodes differed significantly (p = 0.014), particularly higher in The Eastern Anatolia and Southeastern Anatolia. Though most commonly encountered with cephalosporin use, antibiotic-associated diarrhea is not a frequent side effect.ConclusionThis study on pediatric antibiotic-associated diarrhea displayed epidemiological data and the differences geographically in our region.Item Education of Healthcare Personnel Working with Pediatric Patients During COVID-19 Pandemic within the Framework of Infection ControlOygar, PD; Büyükçam, A; Bal, ZS; Dalgiç, N; Bozdemir, SE; Karbuz, A; Çetin, BS; Kara, Y; Çetin, C; Hatipoglu, N; Uygun, H; Aygün, FD; Törün, SH; Okur, DS; Çiftdogan, DY; Kara, TT; Yahsi, A; Özer, A; Demir, SÖ; Akkoç, G; Turan, C; Sali, E; Sen, S; Erdeniz, EH; Kara, SS; Emiroglu, M; Erat, T; Aktürk, H; Gürlevik, SL; Sütçü, M; Aydin, ZGG; Atikan, BY; Yesil, E; Güner, G; Çelebi, E; Efe, K; Isançli, DK; Durmus, HS; Tekeli, S; Karaarslan, A; Bülbül, L; Almis, H; Kaba, Ö; Keles, YE; Yazicioglu, B; Oguz, SB; Ovali, HF; Dogan, HH; Çelebi, S; Çakir, D; Karasulu, B; Alkan, G; Yenidogan, I; Gül, D; Küçükalioglu, BP; Avcu, G; Kukul, MG; Bilen, M; Yasar, B; Üstün, T; Kiliç, Ö; Akin, Y; Cebeci, SO; Turgut, M; Yanartas, MS; Sahin, A; Arslanoglu, S; Elevli, M; Öz, SKT; Hatipoglu, H; Erkum, IT; Demirbuga, A; Özçelik, T; Sari, EE; Akkus, G; Hatipoglu, SS; Dinleyici, EÇ; Hacimustafaoglu, M; Özkinay, F; Kurugöl, Z; Cengiz, AB; Somer, A; Tezer, H; Kara, AObjective: In the early stages of any epidemic caused by new emerging pathogens healthcare personnel is subject to a great risk. Pandemic caused by SARS-CoV-2, proved to be no exception. Many healthcare workers died in the early stages of pandemic due to inadequate precautions and insufficient protection. It is essential to protect and maintain the safety of healthcare personnel for the confinement of pandemic as well as continuity of qualified healthcare services which is already under strain. Educating healthcare personnel on appropiate use of personal protective equipment (PPE) is as essential as procuring them. Material and Methods: A survey is conducted on 4927 healthcare personnel working solely with pediatric patients from 32 different centers. Education given on PPE usage were questioned and analyzed depending on age, sex, occupation and region. Results: Among four thousand nine hundred twelve healthcare personnel from 32 different centers 91% (n=4457) received education on PPE usage. Of those who received education only 36% was given both theoretical and applied education. Although there was no differences among different occupation groups, receiving education depended on regions. Conclusion: It is essential to educate healthcare personnel appropiately nationwidely for the continuity of qualified healthcare services during the pandemic.Item Antifungal consumption, indications and selection of antifungal drugs in paediatric tertiary hospitals in Turkey: Results from the first national point prevalence surveyÇaglar, I; Devrim, I; Özdemir, H; Sahbudak, Z; Sönmez, G; Buyukcam, A; Gulhan, B; Kara, A; Aygun, DF; Bayram, N; Celebi, S; Çetin, B; Nepesov, MI; Yilmaz, AT; Kepenekli, E; Çiftdogan, DY; Acar, MK; Yayla, BC; Okumus, C; Ecevit, Z; Hatipoglu, N; Kuyucu, N; Kosker, M; Sen, S; Karbuz, A; Sutcu, M; Duramaz, BB; Özen, M; Çiftçi, E; Alabaz, D; Kurugol, Z; Kara, A; Kanik, S; Kilic, O; Oncel, S; Somer, A; Tapisiz, A; Belet, N; Akcan, ÖM; Türel, Ö; Ozkaya, A; Tezer, H; Cengiz, AB; Ince, E; Camcioglu, Y; Kocabas, E; Arisoy, ES; Salman, NObjectives: The aim of this point prevalence survey was to evaluate the consumption, indications and strategies of antifungal therapy in the paediatric population in Turkey. Methods: A point prevalence study was performed at 25 hospitals. In addition to general data on paediatric units of the institutes, the generic name and indication of antifungal drugs, the presence of fungal isolation and susceptibility patterns, and the presence of galactomannan test and high-resolution computed tomography (HRCT) results were reviewed. Results: A total of 3338 hospitalised patients were evaluated. The number of antifungal drugs prescribed was 314 in 301 patients (9.0%). Antifungal drugs were mostly prescribed in paediatric haematology and oncology (PHO) units (35.2%), followed by neonatal ICUs (NICUs) (19.6%), paediatric services (18.3%), paediatric ICUs (PICUs) (14.6%) and haematopoietic stem cell transplantation (HSCT) units (7.3%). Antifungals were used for prophylaxis in 147 patients (48.8%) and for treatment in 154 patients (50.0%). The antifungal treatment strategy in 154 patients was empirical in 77 (50.0%), diagnostic-driven in 29 (18.8%) and targeted in 48 (31.2%). At the point of decision-making for diagnostic-driven antifungal therapy in 29 patients, HRCT had not been performed in 1 patient (3.4%) and galactomannan test results were not available in 12 patients (41.4%). Thirteen patients (8.4%) were receiving eight different antifungal combination therapies. Conclusion: The majority of antifungal drugs for treatment and prophylaxis were prescribed in PHO and HSCT units (42.5%), followed by ICUs. Thus, antifungal stewardship programmes should mainly focus on these patients within the availability of diagnostic tests of each hospital. (C) 2018 International Society for Chemotherapy of Infection and Cancer. Published by Elsevier Ltd. All rights reserved.Item SARS-CoV-2 seropositivity among pediatric health care personnel after the first peak of the pandemic: nationwide surveillance in TurkeyOygar, PD; Büyükçam, A; Bal, ZS; Dalgiç, N; Bozdemir, SE; Karbuz, A; Çetin, BS; Kara, Y; Çetin, C; Hatipoglu, N; Uygun, H; Aygün, FD; Törün, SH; Okur, DS; Çiftdogan, DY; Kara, TT; Yahsi, A; Özer, A; Demir, SÖ; Akkoç, G; Turan, C; Sali, E; Sen, S; Erdeniz, EH; Kara, SS; Emiroglu, M; Erat, T; Aktürk, H; Gürlevik, SL; Sütçü, M; Aydin, ZGG; Atikan, BY; Yesil, E; Güner, G; Çelebi, E; Efe, K; Isançli, DK; Durmus, HS; Tekeli, S; Karaaslan, A; Bülbül, L; Almis, H; Kaba, Ö; Keles, YE; Yazicioglu, B; Oguz, SB; Ovali, HF; Dogan, HH; Çelebi, S; Çakir, D; Karasulu, B; Alkan, G; Yenidogan, I; Gül, D; Küçükalioglu, BP; Avcu, G; Kukul, MG; Bilen, M; Yasar, B; Üstün, T; Kiliç, Ö; Akin, Y; Cebeci, SO; Bucak, IH; Yanartas, MS; Sahin, A; Arslanoglu, S; Elevli, M; Çoban, R; Öz, SKT; Hatipoglu, H; Erkum, IT; Turgut, M; Demirbuga, A; Özçelik, T; Çiftçi, D; Sari, EE; Akkus, G; Hatipoglu, SS; Dinleyici, EÇ; Hacimustafaoglu, M; Özkinay, F; Kurugöl, Z; Cengiz, AB; Somer, A; Tezer, H; Kara, ABackground: Understanding SARS-CoV-2 seroprevalence among health care personnel is important to ex-plore risk factors for transmission, develop elimination strategies and form a view on the necessity and frequency of surveillance in the future. Methods: We enrolled 4927 health care personnel working in pediatric units at 32 hospitals from 7 different regions of Turkey in a study to determine SARS Co-V-2 seroprevalence after the first peak of the COVID-19 pandemic. A point of care serologic lateral flow rapid test kit for immunoglobulin (Ig)M/IgG was used. Seroprevalence and its association with demographic characteristics and possible risk factors were analyzed. Results: SARS-CoV-2 seropositivity prevalence in health care personnel tested was 6.1%. Seropositivity was more common among those who did not universally wear protective masks (10.6% vs 6.1%). Having a COVID-19-positive co-worker increased the likelihood of infection. The least and the most experienced personnel were more likely to be infected. Most of the seropositive health care personnel (68.0%) did not suspect that they had previously had COVID-19. Conclusions: Health surveillance for health care personnel involving routine point-of-care nucleic acid testing and monitoring personal protective equipment adherence are suggested as important strategies to protect health care personnel from COVID-19 and reduce nosocomial SARS-CoV-2 transmission. (C) 2021 The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.