Browsing by Author "Çinar, S"
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Item ANTIMICROBIAL AND SOD-LIKE ACTIVITIES OF N,N'-BIS(FERROCENYLMETHYLENE)ETHYLENEDIAMINE SCHIFF BASE AND IT'S METAL COMPLEXESÖzbek, HA; Çinar, S; Oskay, M; Aydemir, T; Demirhan, FThe synthesized N,N'-bis(ferrocenylmethylene)ethylenediamine Schiff base and it's metal complexes were screened in vitro for antimicrobial activity against two Gram-positive (Staphylococcus aureus ATCC 25923, Bacillus cereus ATCC 7064), four Gram-negative (Escherichia coli ATCC 25922, Citrobacter koseri DBCC 01, Entorebacter aeruginosa ATCC 13048, Salmonella typhimurium DBCC 02) and antifungal activity against a Candida albicans. MIC values of the compounds ranged from 27 to 533 mu g/mL. Compound (5) showed very strong activity against S. aureus with the best MIC (27 mu g/mL). The lowest MIC for C. albicans was obtained 107 mu g/mL. The superoxide dismutase activity of Schiff base and it's metal complexes has been measured and discussed. SOD-like activities of bis ferrocenyl Schiff base ligand metal complexes were investigated using NBT. While only the Cu (II) complex showed SOD-like (40 mu m IC50) activity, the SOD-like activity value was not determined in the other complex and ligand.Item SLEEP QUALITY, OBSTRUCTIVE SLEEP APNEA SYNDROME, AND SYMPTOMS IN PATIENTS WITH VARICOSE VEIN: THE EFFECT OF REGULAR PRESSURED VARICOSE VEIN STOCKING USAGEAtik, D; Erdogan, Z; Karatepe, H; Atik, C; Çinar, SIntroduction: Lower extremity varicosity is an important health problem frequently seen in society that decreases the quality of life and can cause serious complications under certain circumstances. This study was aimed to determine the effect of pressured varicose vein stockings on sleep quality, obstructive sleep apnea syndrome symptoms, and symptoms of patients with varicose veins who were suggested for conservative treatment. Materials and methods: The study was designed according to a pretest posttest single study group pattern from experimental research methods. In gathering data for the study, a questionnaire on sociodemographic and clinical characteristics, The Berlin Sleep Questionnaire, and the Sleep Quality Scale were used. Results: One month of varicose vein stocking use was seen to decrease Obstructive Sleep Apnea Syndrome (OSAS) risk (p<0.05). When the sleep quality of patients for the last month was evaluated using the The Pittsburgh Sleep Quality Scale (PSQS), a statistically significant difference between the mean scores of the first inventory application and the last inventory application was found (p<0.01), and statistically meaningful decreases in pain, cramps, edema, itching, weight feeling and leg fatigue perceptions were seen in patients (p<0.05). Conclusion: Regular varicose vein stocking use was found to increase sleep quality and improve OSAS symptoms. In addition, regular varicose vein stocking use was found to decrease symptoms of patients with varicose veins.Item The Effect of a Training Program on Oral Health and Behavior Change in Asthma PatientsYilmaz, FT; Çinar, S; Yilmaz, A; Kumsar, AKBackground: Asthma is a chronic disease which is prevalent throughout the world. Physical problems such as deterioration in oral health, which may occur due to the triggering factors of asthma as well as the ineffective use of asthma medicine, seem to affect the daily lives of asthma patients. Therefore, it is important to protect oral health and promote positive behavior changes in asthma patients in order to achieve effective treatment and asthma control. Aims: The present study aimed to determine the effects of a training program provided for asthma patients on oral health, inhaler use skills, and behavior change. Study Design: Controlled experimental study. Methods: A total of 124 asthma patients were included in the study. Of the patients, 62 were assigned to the experimental group and the other 62 were assigned to the control group. Data were collected using the patient identification form, the oral assessment guide, the inhaler use skill form, and the evaluation form for behavior change over time. The experimental group received training provided by the researchers on the first meeting and one month later. Written and visual training material were used. Both groups were subject to a final evaluation which was conducted 4 months after their first meeting. Results: It was determined that the oral assessment guide scores (p<0.01) and inhaler use skills of the experimental group improved significantly after the training compared to the control group (p<0.01). In addition, it was observed that the number of patients in the experimental group who quit smoking (p<0.05), used their medicine (p<0.01) and brushed their teeth on a regular basis (p<0.01), and washed their mouth after inhaler use significantly increased in the experimental group after training compared to the control group (p<0.01). Conclusion: The study demonstrated that the training provided for asthma patients improved oral health and promoted inhaler use skills and was partially effective in promoting positive asthma-related behavior change.Item Pulsed Deposited Manganese and Vanadium Oxide Film Modified with Carbon Nanotube and Gold Nanoparticle: Chitosan and Ionic Liquid-based BiosensorAkogullari, S; Çinar, S; Özdokur, KV; Aydemir, T; Ertas, FN; Koçak, SPresent study describes the synthesis of mixed oxide films of manganese and vanadium by electrochemical pulsed deposition technique on a glassy carbon electrode (GCE) modified with multiwall carbon nanotubes (MWCNT). The film was further decorated with gold nanoparticles to enhance the reduction signal of dissolved oxygen in pH 5.17 acetate buffer solution. All of the electrochemical synthesized modified electrodes have been characterized with Scanning electron microscopy(SEM), High-resolution transmission electron microscopy (HRTEM), X-Ray photoelectron spectroscopy (XPS), X-Ray diffraction (XRD) techniques. The electrode obtained (AuNPs/MnOx-VOx/CNT/GCE) was utilized as a platform for glucose biosensor where the glucose oxidase enzyme was immobilized on the composite film with the aid of chitosan and an ionic liquid. The electrochemical performance of the biosensor was investigated by cyclic voltammetry and the relative parameters have been optimized by amperometric measurements in pH 5.17 acetate buffer solution. The developed biosensor exhibited a linear range for glucose between 0.1-1.0 mM and the limit of detection was calculated as 0.02 mM.Item Assessment of the relationship between peer support and academic success among students of vocational school of healthcare servicesÇirpan, FK; Çinar, SObjectives: This study was conducted to assess the relationship between peer support and academic success as descriptive and correlation. Methods: Sample of the study consisted of 258 senior students available and enrolled to Marmara University Vocational School of Healthcare Services in academic year 2010-2011 and who accepted to participate in the research. Data was collected using Peer Support Scale and Student Identification Form containing students' socio-demographical characteristics and academic grade points. Variance Analysis, Student t- test, Correlation Analysis and Oneway ANOVA were used for analysis of data. Results: Upon comparison of sub-dimensions of Peer Support Scale, it was observed that physical assistance point was higher than emotional assistance point and academic assistance point was higher than emotional assistance point. There was no relationship between academic grade points and sub-dimensions and total points of Peer Support Scale. It was found that Peer Support Scale total points of Students of Medical Imaging department was higher than students of First Aid and Emergency Service Department and academic grade points of female students were higher than male students. Conclusion: We can recommend that providing of appropriade environment to work together to the students and supporting of male students in order to increase their academic grade points.Item Follow-up of patients with type 2 diabetes via cell phone: randomized controlled trialSezgin, H; Çinar, SObjective: To evaluate whether diabetes education and nurse follow up via phone call-SMS have an impact on metabolic parameter and social factors of type 2 diabetic patients. Method: 120 diabetic patients were randomly selected and formed control, education and short message service (SMS) follow up groups that each contains 40 patients. After giving education to phone call- SMS group, in an attempt to get HbA1c level closer to normal value (<%7), it was planned to give social and cognitive support for 12 weeks. Results: At the end of 12 weeks, glycosylated hemoglobin (HbA1c) dropped (1.8%) in intervention, (0.58%) education and (0.59%) in control group. Fasting blood glucose dropped 38 mg/dl in the phone call-SMS group, 36mg/dl in the control group, post prandial glucose dropped in only phone call SMSgroup (52 mg/dl); sistolic pressure dropped both phone call-SMS and education groups. While scores of severity and self efficiency increased in every three groups, scores of support increased only in control group, outcome expectation scores increased both phone call-SMS and education groups. 12 weeks. Scores of positive misguided reinforcing behavior dropped only in phone call-SMS group. A positive relationship was found between severity -support and self efficiacy-outcome expectation scores of the groups. Conclusion: Follow up and management of diabetic patients by nurse via SMS and mobile phone have given successful result on providing social compliance and optimal glycemic control.Item Analysis of the Relationships among Financial Development, Economic Growth, Energy Use, and Carbon Emissions by Co-Integration with Multiple Structural BreaksGeyikci, UB; Çinar, S; Sancak, FMIn this study, the effects of financial and economic development on energy consumption and CO2 emissions are analyzed using multiple structural breaks, second-generation panel unit root tests, the Westerlund Cointegration Test, and PMG and MG estimators. Unlike classical studies, financial development is included, in the analysis, as an indicator of the accumulated capital as a result of industrial production that has been realized for many years. We conducted a panel data analysis on 13 developing countries for which we could obtain uninterrupted data in the Morgan Stanley Developing Countries index. We found significant relationships between economic growth, energy usage, and CO2 emissions. Financial development and carbon emissions are cointegrated in the long-term, and financial development is found to accelerate environmental pollution. Therefore, energy economists should consider the effect of financial development on energy use and carbon emissions in future studies. Policy-makers in emerging markets are also advised to take necessary actions to reduce carbon emissions while increasing financial development. It is important that the same results were obtained in medium- and small-scale countries, as well as in large economies (e.g., China) under the scope of this review.Item Nexus between energy consumption and economic growth: the comparison of non-renewable natural resource poor and rich countriesAcikgoz, B; Yilmazer, M; Çinar, SThe aim of this study is to determine the effects of renewable and non-renewable energy resources on economic growth in non-renewable natural resource poor and rich countries. For this purpose, a Cobb-Douglas production function is used by adding the energy source as an element of production from 1990 to 2012. In the models, the cointegration between resources and economic growth is tested by a panel cointegration technique. For long-term coefficient estimation, the panel autoregressive distributed lag (ARDL) test that is based on Pesaran et al. (1999) is used. According to the results of the pooled mean group (PMG), long-term and short-term results are consistent. Renewable resources have a relatively higher positive effect on economic growth in non-renewable natural resource rich countries. Moreover, these positive effects are higher in lower and upper middle-income countries (LMIC and UMIC) than in high-income countries (HIC). Our findings suggest LMIC and UMIC countries - especially in the group of non-renewable natural resource rich countries - value and consider the use of renewable energy resources for energy production decisions in their economic growth policies.Item Modelling and Optimization of Uranium (VI) Ions Adsorption Onto Nano-ZnO/Chitosan Bio-composite Beads with Response Surface Methodology (RSM)Kaynar, ÜH; Çinar, S; Kaynar, SÇ; Ayvacikli, M; Aydemir, TNano-ZnO-chitosan bio-composite beads were prepared for the sorption of from aqueous media. The resulting nano-ZnO/CTS bio-composite beads were characterized by TEM, XRD etc. The sorption of by bio-composite beads was optimized using RSM. The correlation between four variables was modelled and studied. According to RSM data, correlation coefficients (R-2 = 0.99) and probability F-values (F = 2.24 x 10(- 10)) show that the model fits the experimental data well. Adsorption capacity for nano-ZnO/CTS bio-composite beads was obtained at 148.7 mg/g under optimum conditions. The results indicate that nano-ZnO/CTS bio-composite beads are appropriate for the adsorption of ions from aqueous media. Also, the suitability of adsorption values to adsorption isotherms was researched and thermodynamic data were calculated.Item Application of crosslinked chitosan-nanoclay composite beads for efficient removal of Ponceau S azo dye from aqueous mediumÇinar, S; Dinçer, A; Eser, A; Aydemir, TIn this study, chitosan-nanoclay composite beads (CS/NC composite beads) were used to remove Ponceau S from aqueous solutions. CS/NC composites characterization was performed with FTIR, SEM-EDX, TGA, BET and XRD analyzes. The adsorption procedure was optimized by changing various parameters in batch experiments such as pH, dye concentration, contact time and temperature. Ponceau S adsorption took place at a higher rate in the acidic region, and the highest adsorption was observed at pH 2.0. The amount of adsorbed dye increased as the temperature increased at low dye concentrations and the time required to reach equilibrium was shorter than at higher dye concentrations. Linear and non-linear forms of Langmuir, Freundlich and Temkin adsorption models were applied. The adsorption behavior of Ponceau S is compatible with the linear Langmuir model, and the maximum adsorption capacity was found to be 140.85 mg g-1. Linear and nonlinear forms of adsorption kinetics and thermodynamic parameters were investigated for dye concentrations of 150-400 mg/L. The adsorption kinetics fit the linear pseudo-second-order kinetic model and the Ponceau S adsorption on CS/NC composites was spontaneous and endothermic. The results show that the CS/NC composites can be used as an effective adsorbent in industrial wastewater treatment.Item An efficient removal of RB5 from aqueous solution by adsorption onto nano-ZnO/Chitosan composite beadsÇinar, S; Kaynar, UH; Aydemir, T; Kaynar, SC; Ayvacikli, MIn this study, the removal of Reactive Black 5 (RB-5) by nano-ZnO/Chitosan composite beads (nano-ZnO/CT-CB) from aqueous solution was investigated. ZnO nanoparticles were prepared by the via the microwave-assisted combustion technique. And then nano-ZnO/Chitosan composite beads were prepared by polymerization in the presence of nano-ZnO and chitosan. Characterization of composite beads were conducted using SEM, TEM, FTIR, TGA and XRD. Several important parameters influencing the removal of RB 5 such as contact time, pH and temperature were investigated systematically by batch experiments. At optimum conditions of pH 4 and adsorbent concentration of 0.2 g, dye removal efficiency was found 76%. Langmuir, Freundlich and Temkin adsorption models were used to describe adsorption isotherms and constants. The maximum adsorption capacity (q(m)) by Langmuir isotherm has been found to be 189.44 mg/g. Isotherms have also been used to obtain the thermodynamic parameters such as free energy, enthalpy and entropy of adsorption. The positive value of the enthalpy change (32.7 kJ/mol) indicated that the adsorption is an endothermic process. The obtained results showed that the tested adsorbents are efficient and alternate low-cost adsorbent for removal of dyes from aqueous media. (C) 2016 Elsevier B.V. All rights reserved.Item Partial purification and some properties of polyphenol oxidase from Laurus nobilis L.Aydemir, T; Çinar, SPolyphenol oxidase from laurel leaves tissue (Laurus nobilis L.) was isolated by (NH4)(2)SO4 precipitation and dialysis. Stable and highly active PPO extracts were obtained using 1.5% (w/v) Triton X-100 and 1.0% (w/v) polyethylene glycol (PEG) in 0.05 M potassium phosphate buffer pH 7.0. The optimum pH values were found to be 7.0 for catechol, DL-dopa and L-dopa, 6.5 for 4-methylcatechol, 6.0 for pyrogallol and 5.0 for gallic acid. Laurus nobilis PPO is more stable at basic pH than acidic pH values. The optimum temperature was found to be 40 degrees C for catechol, 35 degrees C for 4-methylcatechol, 30 degrees C for pyrogallol and gallic acid, 25 degrees C for DL-dopa and L-dopa. Half lives of PPO activity were 28 min. at 60 degrees C and 7 min. at 70 degrees C with catechol. Ea value was calculated from the Arhenius equation 16.628 kj/mol for catechol as Substrate. Polyphenol oxidase showed activity toward catechol, 4-methylcatechol, gallic acid, pyrogallol, L-dopa and DL-dopa (K,, and V,, values were 8.3 mM and 15538 U/ml for catechol. 14.8 mM and 11300 U/ml for 4-methylcatechol, 15.6 mM and 9153 U/ml for gallic acid, 28.0 mM and 8835 U/mI for pyrogallol, 66.7 mM and 7142 U/ml for L-dopa, 70.9 mM and 5000 U/mI for DL-dopa). L-tyrosine was also tested but was not oxidized by Laurus nobilis PPO. The 1511 Value was found to be 7.60x 10(-6) M for dithiothreitol, 1.60 x 10(-5) M for beta-mercaptoethanol. 2.40 x 10(-5) M for glutathione, 3.00 x 10(-5) M for sodium thiosulphate, 0.76x10(-4) M for sodium azide, 0.80x10(-4) M for thiourea, 0.84x10(-4) M for sodium metabisulfite, 1.45x10(-4) M for L-csyteine, 5.00 x 10(-4) for ascorbic acid, 6,00x10(-4) M for oxalic acid, 1.1 x 10(-2) M for citric acid and 4.40x 10(-2) M for EDTA. Various amino acids such as L-csyteme, L-glycine, L-arginine, L-phenyl alanin, L-glutamic acid and L-aspartic acid have been investigated and the results showed that L-cysteine was the most effective inhibitors. NaCl, CoCl2, CaCl2, were poor inhibitors of enzyme at 1 mM. Fe++, Mg++, Mn++, Zn++ ions did not show away significant effect on partially purified enzyme activity.