Browsing by Author "Çinar S."

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    Partial purification and some properties of polyphenol oxidase from Laurus nobilis L.
    (Industrie Grafiche V. Lischi e Figli, 2006) Aydemir T.; Çinar S.
    Polyphenol oxidase from laurel leaves tissue (Laurus nobilis L.) was isolated by (NH4)2SO4 precipitation and dialysis. Stable and highly active PPO extracts were obtained using 1.5% (w/v) Triton X-100 and 1.0% (w/v) polyethylene glycol (PEG) in 0.05 M potassium phosphate buffer pH 7.0. The optimum pH values were found to be 7.0 for catechol, DL-dopa and L-dopa, 6.5 for 4-methylcatechol, 6.0 for pyrogallol and 5.0 for gallic acid. Laurus nobilis PPO is more stable at basic pH than acidic pH values. The optimum temperature was found to be 40°C for catechol, 35°C for 4-methylcatechol, 30°C for pyrogallol and gallic acid, 25°C for DL-dopa and L-dopa. Half lives of PPO activity were 28 min. at 60°C and 7 min. at 70°C with catechol. Ea value was calculated from the Arhenius equation 16.628 kj/mol for catechol as substrate. Polyphenol oxidase showed activity toward catechol, 4-methylcatechol, gallic acid, pyrogallol, L-dopa and DL-dopa (KM and Vmax values were 8.3 mM and 15538 U/ml for catechol. 14.8 mM and 11300 U/ml for 4-methylcatechol, 15.6 mM and 9153 U/ml for gallic acid, 28.0 mM and 8835 U/ml for pyrogallol, 66.7 mM and 7142 U/ml for L-dopa, 70.9 mM and 5000 U/ml for DL-dopa). L-tyrosine was also tested but was not oxidized by Laurus nobilis PPO. The I50 value was found to be 7.60×10-6 M for dithiothreitol, 1.60×10-5 M for β-mercaptoethanol, 2.40×10-5 M for glutathione, 3.00×10-5 M for sodium thiosulphate, 0.76×10-4 M for sodium azide, 0.80×10-4 M for thiourea, 0.84×10-4 M for sodium metabisulfite, 1.45×10 -4 M for L-csyteine, 5.00 ×10-4 for ascorbic acid, 6,00×10-4 M for oxalic acid, 1.11×10-2 M for citric acid and 4.40×10-2 M for EDTA. Various amino acids such as L-csyteine, L-glycine, L-arginine, L-phenyl alanin, L-glutamic acid and L-aspartic acid have been investigated and the results showed that L-cysteine was the most effective inhibitors. NaCl, CoCl2, CaCl2, were poor inhibitors of enzyme at 1 mM. Fe++, Mg++, Mn++, Zn++ ions did not show away significant effect on partially purified enzyme activity.
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    Human capabilities and economic growth: A comparative human capability index
    (Econjournals, 2015) Yilmazer M.; Çinar S.
    The purpose of this paper is to contribute to research probing the underlying role human capital plays on economic growth in 1985-2011 for 17 developed and developing countries. Firstly, we examined the determinants of human capabilities and formulated a new human capital index (comparative human capability index). Secondly, we analyzed the relationship between human capital and economic growth using the endogenous growth model. Results of the panel cointegration tests support a long-run positive relationship between human capital and economic growth in both developed and developing countries, however, our results show that human capital is more effective in developed countries than in developing countries. © 2015 Econjournals. All rights reserved.
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    Effect of educational on symptom control and quality of life on asthmatic patients; [Astimli hastalarda eğitimin semptom kontrolüne ve yaşam kalitesine etkisi]
    (Anatolian Journal of Clinical Investigation, 2015) Taşkin Yilmaz F.; Çinar S.
    The aim of this study was to determine the effects of education on symptom control, exacerbation frequency and quality of life in asthma patients. The study which was randomize experiment and control was conducted 1 March – 31 December 2011 with 124 asthma patients (62 intervention group and 62 control group), who applied to a training and research hospital’s chest diseases polyclinic in the city of Istanbul. The data was collected using the patient information form, Asthma Control Test, exacerbation frequency questioning form and Asthma Quality of Life Questionnaire. The intervention group received education from the nurse researcher at the first meeting and one month later. Both of the groups were evaluated four months after their first meeting. After the education, the intervention group showed improvements in the pulmonary function test parameters, asthma-related symptoms, asthma exacerbation frequency and in all the sub-dimensions of quality of life. Patient education is recommended along with the treatment based on the research results for regularly and effective medication use with symptom control, prevent exacerbations, reduce the exacerbation frequency and for a better quality of life. © 2015, Anatolian Journal of Clinical Investigation. All rights reserved.
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    Sleep quality, obstructive sleep apnea syndrome, and symptoms in patients with varicose vein: The effect of regular pressured varicose vein stocking usage
    (A. CARBONE Editore, 2016) Atik D.; Erdoğan Z.; Karatepe H.; Cematik; Çinar S.
    Introduction: Lower extremity varicosity is an important health problem frequently seen in society that decreases the quality of life and can cause serious complications under certain circumstances. This study was aimed to determine the effect of pressured varicose vein stockings on sleep quality, obstructive sleep apnea syndrome symptoms, and symptoms of patients with varicose veins who were suggested for conservative treatment. Materials and methods: The study was designed according to a pretest posttest single study group pattern from experimental research methods. In gathering data for the study, a questionnaire on sociodemographic and clinical characteristics, The Berlin Sleep Questionnaire, and the Sleep Quality Scale were used. Results: One month of varicose vein stocking use was seen to decrease Obstructive Sleep Apnea Syndrome (OSAS) risk (p < 0.05). When the sleep quality of patients for the last month was evaluated using the The Pittsburgh Sleep Quality Scale (PSQS), a statistically significant difference between the mean scores of the first inventory application and the last inventory application was found (p < 0.01), and statistically meaningful decreases in pain, cramps, edema, itching, weight feeling and leg fatigue perceptions were seen in patients (p < 0.05). Conclusion: Regular varicose vein stocking use was found to increase sleep quality and improve OSAS symptoms. In addition, regular varicose vein stocking use was found to decrease symptoms of patients with varicose veins.
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    Nexus between energy consumption and economic growth: The comparison of non-renewable natural resource poor and rich countries
    (Inderscience Enterprises Ltd., 2016) Acikgoz B.; Yilmazer M.; Çinar S.
    The aim of this study is to determine the effects of renewable and non-renewable energy resources on economic growth in non-renewable natural resource poor and rich countries. For this purpose, a Cobb-Douglas production function is used by adding the energy source as an element of production from 1990 to 2012. In the models, the cointegration between resources and economic growth is tested by a panel cointegration technique. For long-Term coefficient estimation, the panel autoregressive distributed lag (ARDL) test that is based on Pesaran et al. (1999) is used. According to the results of the pooled mean group (PMG), long-Term and short-Term results are consistent. Renewable resources have a relatively higher positive effect on economic growth in non-renewable natural resource rich countries. Moreover, these positive effects are higher in lower and upper middle-income countries (LMIC and UMIC) than in high-income countries (HIC). Our findings suggest LMIC and UMIC countries-especially in the group of non-renewable natural resource rich countries-value and consider the use of renewable energy resources for energy production decisions in their economic growth policies. © Copyright 2016 Inderscience Enterprises Ltd.