Browsing by Author "Ölmezoğlu A."

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    Evaluation of volumetric and morphological changes of vestibular schwannomas following CyberKnife therapy
    (Istanbul University Press, 2019) Yardımcı E.U.; Apaydın M.; Gelal F.; Dağ F.; Ölmezoğlu A.; Sarp A.F.
    Objectives: This study aims to evaluate volumetric and morphological changes following CyberKnife radiotherapy of vestibular schwannomas. Patients and Methods: Between March 2011 and December 2013, a total of 39 patients (15 males, 24 females; mean age 52 years; range, 19 to 86 years) who underwent CyberKnife hypofractionated radiotherapy were retrospectively analyzed. Tumor volume calculations were done by manual segmentation. Tumor morphology was classified by arbitrary cystic scaling. Local tumor control, tumor progression, transient swelling rates, and changes in tumor morphology were evaluated. Results: Local tumor control and transient swelling rates were 87% and 46%, respectively. Cystic tumors responded better than solid tumors to treatment as evidenced by volume reduction rates (87% vs. 58%), although local control rates were not significantly different (93% vs. 83%). Transient swelling rates were significantly higher in cystic tumors than in solid tumors (67% vs. 29%). Post-treatment volume changes were not correlated with gender, age group, or pre-procedural tumor volume. Conclusion: CyberKnife radiotherapy is an effective way of achieving local tumor control in patients with vestibular schwannomas. Although higher rates of volumetric regression would be expected in more cystic tumors than more solid tumors, local control rates are similar. © 2019, Istanbul University Press. All rights reserved.
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    The effect of human recombinant epidermal growth factor on capsule contraction in an irradiated rat model
    (Springer Science and Business Media Deutschland GmbH, 2023) Tuluy Y.; Evrenos M.K.; Yoleri L.; Temiz P.; Ölmezoğlu A.
    Background: Breast implants are commonly used in plastic surgery for aesthetic and reconstructive purposes. One of the most important complications of this surgery is capsule contraction. Methods: In this study, it is aimed to evaluate the effect of recombinant human epidermal growth factor (rh-EGF) on capsule contraction in the model of capsule contraction provided by radiation therapy after silicone block placement in rats. The results were evaluated by histopathologic examination. Twenty-four rats were divided into 4 groups. In the group A, rats were followed for 63 days without radiation therapy and rh-EGF. In the groups B, C, and D, a total of 19.56 Gy radiation therapy was administrated in two fractions with an interval of 1 week. Forty-two days after the last radiation therapy, 3 doses of rh-EGF were given to the group C and 6 doses of rh-EGF to the group D with an interval of 1 day. Rats were sacrificed on the 63rd day of the study. Results: In the study, no statistically significant difference was observed between the groups in chronic inflammation, eosinophil, and inflammatory cell amount. Neutrophil levels, collagen amount, vascular proliferation, and capsule thicknesses were examined, and it was observed that they were significantly increased in the experimental groups compared to the control group. However, there was no significant difference between the experimental groups. Conclusions: Different rh-EGF doses were used in the study, and no significant effect was observed on capsule contraction. Different doses and durations may be considered to evaluate the effectiveness. Level of evidence: Not gradable © 2023, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.