Browsing by Author "Özerdem, A"
Now showing 1 - 5 of 5
Results Per Page
Sort Options
Item Assessment of quality of life with the WHOQOL-BREF in a group of Turkish psychiatric patients compared with diabetic and healthy subjectsAkvardar, Y; Akdede, BB; Özerdem, A; Eser, E; Topkaya, S; Alptekin, KDecreased quality of life is often an important cause or consequence of psychiatric illness, and needs to be included in a comprehensive treatment plan. The authors aimed to identify how psychiatric patients characterize the quality of their lives compared to others who are suffering from a chronic physical illness (diabetes) and healthy individuals. A total of 100 psychiatric patients were recruited from Dokuz Eylul University Psychiatry Department outpatient clinic. Of these, 34 had 4th edition Diagnostic and Statistical Manual diagnosis of alcohol dependence, 38 had schizophrenia, and 28 had bipolar disorder. A total of 35 patients with diabetes and 49 healthy individuals were also included in the study. The World Health Organization's Quality of Life Questionnaire was used to measure the quality of life. Patients with alcohol dependence, bipolar disorder, and schizophrenia scored lower than healthy subjects on the physical aspects of quality of life. Patients with schizophrenia had lower scores in the psychological domain compared to patients with bipolar disorder, patients with diabetes, and healthy subjects. In the social relationship domain, patients with schizophrenia and alcohol dependence scored lower compared to healthy subjects. Patients with schizophrenia were worse with respect to social relationships than bipolar patients and diabetics. World Health Organization's Quality of Life Questionnaire is useful for evaluating the needs and targets for interventions in psychiatric patients.Item Can serum BDNF levels be identified as a candidate endophenotype in bipolar disorder?Ceylan, D; Özerdem, A; Yalçin, SNG; Hidiroglu, C; Aslan, YÇ; Bagci, B; Bayin, M; Aydemir, Ö; Cengisiz, C; Resmi, H; Tunca, ZItem Executive dysfunction and cognitive subgroups in a large sample of euthymic patients with bipolar disorderBora, E; Hidiroglu, C; Özerdem, A; Kaçar, ÖF; Sarisoy, G; Arslan, FC; Aydemir, Ö; Tas, ZC; Vahip, S; Atalay, A; Atasoy, N; Atesci, F; Tümkaya, SBipolar disorder (BP), at the group level, is associated with significant but modest cognitive deficits, including executive dysfunction. Among executive functions, response inhibition deficits have been suggested to be particularly relevant to BR However, BP is associated with significant heterogeneity in neurocognitive performance and level of functioning. Very few studies have investigated neurocognitive subgroups in BP with data-driven methods rather than arbitrarily defined criteria. Other than having relatively small sample sizes, previous studies have not taken into consideration the neurocognitive variability in healthy subjects. Five hundred-fifty-six euthymic patients with BP and 416 healthy controls were assessed using a battery of cognitive tests and clinical measures. Neurocognitive subgroups were investigated using latent class analysis, based on executive functions. Four neurocognitive subgroups, including a good performance cluster, two moderately low-performance groups, which differ in response inhibition and reasoning abilities, and a severe impairment cluster were found. In comparison to healthy controls, BP patients were overrepresented in severe impairment cluster (27% vs 5.3%) and underrepresented in good performance cluster. BP patients with lower educational attainment and older age were significantly more likely to be members of cognitively impaired subgroups. Antipsychotic use was less common in good performance cluster. These results suggest that there is a considerable overlap of cognitive functions between BP and healthy controls. Neurocognitive differences between BP and healthy controls are driven by a subgroup of patients who have severe and global, rather than selective, cognitive deficits. (C) 2016 Elsevier B.V. and ECNP. All rights reserved.Item Development of a questionnaire to assess inter-episode functioning in bipolar disorder: Bipolar disorder functioning questionnaireAydemir, Ö; Eren, I; Savas, H; Oguzhanoglu, NK; Koçal, N; Özgüven, HD; Akkaya, C; Basterzi, AD; Karlidag, R; Yenilmez, Ç; Özerdem, A; Kora, K; Tamam, L; Gülseren, S; Oral, T; Vahip, SObjective: Even though quality of life and functioning are topics that are point of interest, they are not assessed adequately in mood disorders. In this study, it is aimed to develop a functioning assessment scale in bipolar disorder. Method: Bipolar Disorder Functioning Questionnaire (BDFQ) is developed by the Scientific Section for Mood Disorders of the Psychiatric Association of Turkey. The questionnaire contains 58 items, and consists of eleven subscales: emotional functioning, intellectual functioning, sexual functioning, feelings of stigmatization, social withdrawal household relations, relations with friends, participation to social activities, daily activities and hobbies, taking initiative and self sufficiency, and occupation. Results: In this study, 252 remitted bipolar patients from 15 centers were included. In addition, thirty subjects without any lifetime psychiatric, neurological or physical disease were recruited. The mean age of the patients was 38.6 +/- 12.1 and 56% (n=141) were female. The mean duration of the bipolar disorder was 11.9 +/- 9.2 years, and 91.3% of the patients were diagnosed to have bipolar I disorder. In the reliability analyses, after the exclusion of six items with low reliability coefficients, The Cronbach alpha coefficient was calculated to be 0.91. The item-total scale correlations were between 0.22-0.86. In test-retest reliability, the correlation between the two ratings was high (r=0.82, p<0.0001). In validity analyses, 13 factors were obtained representing 65.1% of the total variance in exploratory factor analysis. In confirmatory factor analysis, 11 domains fit the model with a RMSEA of 0.061. BDFQ significantly correlated with GAF (r=0.428, p<.0001). BDFQ also showed significantly negative correlation with HAM-D (r=-0.541, p<0.0001) and YMRS (r=-0.365, p<0.0001). It discriminated the patients (mean score=111.8 +/- 15.2) from the healthy subjects (mean score=121.4 +/- 10.4) well (t=-2.300, p=0.038). Conclusion: With the six items excluded, it is suggested that the 52-item BDFQ is a reliable and valid instrument in the assessment of functioning in bipolar disorder.Item Can clinical features determine long term monotherapy lithium response?Özerdem, A; Aydemir, Ö; Akkaya, C; Kesebir, S; Altinbas, K; Yenilmez, Ç; Ersoy, Z; Basterzi, AD; Yildiz, I; Tunca, Z