Browsing by Author "Özhan B."
Now showing 1 - 9 of 9
Results Per Page
Sort Options
Item The effect of obesity on testicular function by insulin-like factor 3, inhibin B, and leptin concentrations in obese adolescents according to pubertal stages(2010) Taneli F.; Ersoy B.; Özhan B.; Çalkan M.; Yilmaz Ö.; Dinç G.; Genç A.; Taneli C.Objectives: The aim of the present study is to investigate the effect of obesity on testicular function by evaluating reproductive hormones, inhibinB, insulin-like 3(INSL3), and leptin, in obese and non-obese adolescents according to pubertal Tanner stages. Design and methods: Eighty adolescent boys were grouped (n=20) as; Group1: obese-Tanner2, Group2: non-obese-Tanner2, Group3: obese-Tanner4, Group4: non-obese-Tanner4. Serum INSL3, luteinizing hormone, follicle-stimulating hormone, total testosterone, free testosterone, estradiol, sex hormone binding globulin, inhibin B and leptin levels were assessed in all groups. Results: INSL3 levels were significantly lower in obese adolescents compared to non-obese boys (p=0.003, Tanner2) and (p=0.031, Tanner4). There was a negative correlation between INSL3 and leptin (r=-0.468, p=0.001). The negative correlation between INSL3 and BMISDS indicates that pubertal obesity leads to Leydig cell impairment. Conclusions: This study demonstrated for the first time in the literature that obesity effects testicular Leydig cell function starting from Tanner stage 2. © 2010.Item The frequency and associated factors of diabetic ketoacidosis at diagnosis in children with type 1 diabetes; [Tip 1 diyabetli çocuklarda tanıda diyabetik ketoasidoz sıklıǧı ve i̇liflkili faktörler](Galenos Yayincilik,, 2010) Demir K.; Büyükinan M.; Dizdarer C.; Şimşek D.G.; Özen S.; Asar G.; Can Ş.; Altincik A.; Özhan B.; Ersoy B.; Böber E.; Darcan Ş.Introduction: In this study, it was aimed to assess the frequency and associated factors of diabetic ketoacidosis (DKA) at diagnosis in patients with newly diagnosed type 1 diabetes who were admitted to pediatric endocrinology clinics in tertiary referral hospitals in Izmir and Manisa provinces. Materials and Method: The files of the patients were evaluated retrospectively. Data regarding sex, date of birth, family history for diabetes, and health insurances of the patients were recorded and compared with respect to the form of clinical presentation. Results: It was noted that 139 patients (M/F:74/65, mean age 8.7±3.9 years) were diagnosed in 2008. At the time of diagnosis, the clinical picture of the majority of the patients were ketosis (n=58, 41.7%) or DKA (n=57, 41%). Mortality or severe morbidity developed in none of the patients. It was detected that lack of family history for type 1 diabetes and being less than 5 years of age were associated with DKA at the time of diagnosis. When logistic regression analysis was used to perform risk analysis, only being less than 5 years of age was found to be a risk factor for DKA (p=0.008, Odds Ratio 3.3, 95% confidential interval 1.4-8.1). Conclusion: These results led us consider that large-scale campaigns/studies are needed to be performed to reduce the ratio of DKA at the time of diagnosis by making the society conscious of diabetes in childhood. © The Journal of Current Pediatrics, published by Galenos Publishing.Item Inflammatory marker levels in obese adolescents with glucose intolerance: Increased chitotriosidase activity(2012) Kabaroǧlu C.; Onur E.; Barutçuoǧlu B.; Özhan B.; Erdinç S.; Var A.; Bayindir O.; Ersoy B.Objectives: Existance of low grade persistent inflammation in obese children may increase the risk of metabolic and cardiovascular events. The aim was to determine whether glucose intolerance has an influence on inflammatory markers in obese adolescents. Designs and methods: 45 obese adolescents (mean BMI: 30.34±5.42kg/m 2) were grouped as normal or impaired glucose tolerance. IL-6 and CRP levels were analyzed by commercially available kits. Chitotriosidase activity was measured by a fluorescence method and neopterin levels were determined by ELISA. Data were expressed as mean±SD. Results: IL-6 and CRP levels were similar in the two groups. Serum neopterin levels were not different between the groups. The chitotriosidase activity was significantly higher in the IGT group than NGT (124.33 ± 51.97 μmol/L/h vs 84.50 ± 53.99μmol/L/h, p=0.04). Conclusion: Serum chitotriosidase activity is increased in obese adolescents with impaired glucose tolerance. © 2011 The Canadian Society of Clinical Chemists.Item Elevated glucose level at 30 minutes during an oral glucose tolerance test in obese adolescents: A new disorder of glucose tolerance(2013) Kabaroǧlu C.; Ersoy B.; Onur E.; Özhan B.; Erdin S.; Var A.; Bayindir O.; Dinç G.We observed glucose levels >140 mg/dL measured at 30 minutes (min) during an oral glucose tolerance test (OGTT) in some obese patients. We aimed to investigate the significance of this finding by comparing lipid profiles, insulin resistance indices, and systemic inflammatory mediators between obese adolescents with normal glucose tolerance (NGT), impaired glucose tolerance (IGT), and elevated glucose levels at 30 min. The study involved 80 obese (body mass index >95th percentile for age and sex) adolescents (48 female, 32 male) between 11 and 16 years of age. Depending on OGTT results, patients were divided into NGT and IGT groups. The third group was recruited from the NGT group as having glucose levels > 140 mg/dL at 30 minutes. Lipid profiles, [interleukin-6 (IL-6)], neopterin, and lipoprotein associated phospholipase A2 (Lp-PLA2)] were assessed. Neopterin and Lp-PLA2 levels were significantly higher in obese adolescents with elevated glucose levels at 30 min. compared with those in both NGT and IGT groups (p=0.013, and 0.004, respectively). In these adolescents, IL-6 levels were significantly higher only than the NGT group (p=0.01). In logistic regression analysis, IL-6, neopterin and Lp-PLA2 levels were detected to be related to high blood glucose levels at 30 min (OR 1.11, p = 0.01; OR 9.03, p=0.013; OR 1.01, p=0.004 respectively). Obese adolescents with elevated glucose levels at 30 min. demonstrated higher inflammatory mediators levels, which were atherosclerotic indicators, than obese adolescents with NGT and IGT. These results suggest that glucose levels >140 mg/dL measured at 30 min during an OGTT may be a new disorder of glucose tolerance in obesity. ©The Japan Endocrine Society.Item Primary hypothyroidism: an unusual manifestation of Wolcott–Rallison syndrome(Springer Verlag, 2014) Ersoy B.; Özhan B.; Kiremitçi S.; Rubio-Cabezas O.; Ellard S.Wolcott–Rallison syndrome has been reported to be associated with early-onset diabetes, epiphyseal dysplasia, hepatic and renal dysfunction, mental retardation, severe growth retardation, neutropenia, exocrine pancreatic dysfunction, and central hypothyroidism. We report on primary hypothyroidism, which has not been previously described, of a patient with Wolcott–Rallison syndrome due to novel mutation (W521X), who showed improved growth after thyroid hormone treatment. © 2013, Springer-Verlag Berlin Heidelberg.Item Turner syndrome and associated problems in turkish children: A multicenter study(Galenos Yayincilik,, 2015) Yeşilkaya E.; Bereket A.; Darendeliler F.; Baş F.; Poyrazoğlu Ş.; Aydın B.K.; Darcan Ş.; Dündar B.; Büyükinan M.; Kara C.; Sarı E.; Adal E.; Akıncı A.; Atabek M.E.; Demirel F.; Çelik N.; Özkan B.; Özhan B.; Orbak Z.; Ersoy B.; Doğan M.; Ataş A.; Turan S.; Gökşen D.; Tarım Ö.; Yüksel B.; Ercan O.; Hatun Ş.; Şimşek E.; Ökten A.; Abacı A.; Döneray H.; Özbek M.N.; Keskin M.; Önal H.; Akyürek N.; Bulan K.; Tepe D.; Emeksiz H.C.; Demir K.; Kızılay D.; Topaloğlu A.K.; Eren E.; Özen S.; Abalı S.; Akın L.; Eklioğlu B.S.; Kaba S.; Anık A.; Baş S.; Ünüvar T.; Sağlam H.; Bolu S.; Özgen T.; Doğan D.; Çakır E.D.; Şen Y.; Andıran N.; Çizmecioğlu F.; Evliyaoğlu O.; Karagüzel G.; Pirgon Ö.; Çatlı G.; Can H.D.; Gürbüz F.; Binay Ç.; Baş V.N.; Fidancı K.; Polat A.; Gül D.; Açıkel C.; Demirbilek H.; Cinaz P.; Bondy C.Objective: Turner syndrome (TS) is a chromosomal disorder caused by complete or partial X chromosome monosomy that manifests various clinical features depending on the karyotype and on the genetic background of affected girls. This study aimed to systematically investigate the key clinical features of TS in relationship to karyotype in a large pediatric Turkish patient population. Methods: Our retrospective study included 842 karyotype-proven TS patients aged 0-18 years who were evaluated in 35 different centers in Turkey in the years 2013-2014. Results: The most common karyotype was 45,X (50.7%), followed by 45,X/46,XX (10.8%), 46,X,i(Xq) (10.1%) and 45,X/46,X,i(Xq) (9.5%). Mean age at diagnosis was 10.2±4.4 years. The most common presenting complaints were short stature and delayed puberty. Among patients diagnosed before age one year, the ratio of karyotype 45,X was significantly higher than that of other karyotype groups. Cardiac defects (bicuspid aortic valve, coarctation of the aorta and aortic stenosi) were the most common congenital anomalies, occurring in 25% of the TS cases. This was followed by urinary system anomalies (horseshoe kidney, double collector duct system and renal rotation) detected in 16.3%. Hashimoto’s thyroiditis was found in 11.1% of patients, gastrointestinal abnormalities in 8.9%, ear nose and throat problems in 22.6%, dermatologic problems in 21.8% and osteoporosis in 15.3%. Learning difficulties and/or psychosocial problems were encountered in 39.1%. Insulin resistance and impaired fasting glucose were detected in 3.4% and 2.2%, respectively. Dyslipidemia prevalence was 11.4%. Conclusion: This comprehensive study systematically evaluated the largest group of karyotype-proven TS girls to date. The karyotype distribution, congenital anomaly and comorbidity profile closely parallel that from other countries and support the need for close medical surveillance of these complex patients throughout their lifespan. © Journal of Clinical Research in Pediatric Endocrinology.Item Growth curves for Turkish girls with turner syndrome: Results of the Turkish turner syndrome study group(Galenos Yayincilik,, 2015) Darendeliler F.; Yeşilkaya E.; Bereket A.; Baş F.; Bundak R.; Sarı E.; Aydın B.K.; Darcan Ş.; Dündar B.; Büyükinan M.; Kara C.; Mazıcıoğlu M.M.; Adal E.; Akıncı A.; Atabek M.E.; Demirel F.; Çelik N.; Özkan B.; Özhan B.; Orbak Z.; Ersoy B.; Doğan M.; Ataş A.; Turan S.; Gökşen D.; Tarım Ö.; Yüksel B.; Ercan O.; Hatun Ş.; Şimşek E.; Ökten A.; Abacı A.; Döneray H.; Özbek M.N.; Keskin M.; Önal H.; Akyürek N.; Bulan K.; Tepe D.; Emeksiz H.C.; Demir K.; Kızılay D.; Topaloğlu A.K.; Eren E.; Özen S.; Demirbilek H.; Abalı S.; Akın L.; Eklioğlu B.S.; Kaba S.; Anık A.; Baş S.; Ünüvar T.; Sağlam H.; Bolu S.; Özgen T.; Doğan D.; Çakır E.D.; Şen Y.; Andıran N.; Çizmecioğlu F.; Evliyaoğlu O.; Karagüzel G.; Pirgon Ö.; Çatlı G.; Can H.D.; Gürbüz F.; Binay Ç.; Baş V.N.; Sağlam C.; Gül D.; Polat A.; Açıke C.; Cinaz P.Objective: Children with Turner syndrome (TS) have a specific growth pattern that is quite different from that of healthy children. Many countries have population-specific growth charts for TS. Considering national and ethnic differences, we undertook this multicenter collaborative study to construct growth charts and reference values for height, weight and body mass index (BMI) from 3 years of age to adulthood for spontaneous growth of Turkish girls with TS. Methods: Cross-sectional height and weight data of 842 patients with TS, younger than 18 years of age and before starting any therapy, were evaluated. Results: The data were processed to calculate the 3rd, 10th, 25th, 50th, 75th, 90th and 97th percentile values for defined ages and to construct growth curves for height-for-age, weight-for-age and BMI-for-age of girls with TS. The growth pattern of TS girls in this series resembled the growth pattern of TS girls in other reports, but there were differences in height between our series and the others. Conclusion: This study provides disease-specific growth charts for Turkish girls with TS. These disease-specific national growth charts will serve to improve the evaluation of growth and its management with growth-promoting therapeutic agents in TS patients. © Journal of Clinical Research in Pediatric Endocrinology, Published by Galenos Publishing.Item Anthropometric findings from birth to adulthood and their relation with karyotpye distribution in Turkish girls with Turner syndrome(Wiley-Liss Inc., 2016) Sari E.; Bereket A.; Yeşilkaya E.; Baş F.; Bundak R.; Aydin B.K.; Darcan S.; Dündar B.; Büyukinan M.; Kara C.; Adal E.; Akinci A.; Atabek M.E.; Demirel F.; Çelik N.; Özkan B.; Özhan B.; Orbak Z.; Ersoy B.; Doğan M.; Ataş A.; Turan S.; Gökşen D.; Tarim O.; Yüksel B.; Ercan O.; Hatun S.; Şimşek E.; Ökten A.; Abaci A.; Döneray H.; Özbek M.N.; Keskin M.; Önal H.; Akyürek N.; Bulan K.; Tepe D.; Emeksiz H.C.; Demir K.; Kizilay D.; Topaloğlu A.K.; Eren E.; Özen S.; Demirbilek H.; Abali S.; Akin L.; Eklioğlu B.S.; Kaba S.; Anik A.; Baş S.; Unuvar T.; Sağlam H.; Bolu S.; Özgen T.; Doğan D.; Çakir E.D.; Şen Y.; Andiran N.; Çizmecioğlu F.; Evliyaoğlu O.; Karagüzel G.; Pirgon O.; Çatli G.; Can H.D.; Gürbüz F.; Binay C.; Baş V.N.; Fidanci K.; Gül D.; Polat A.; Acikel C.; Cinaz P.; Darendeliler F.To evaluate the anthropometric features of girls with Turner syndrome (TS) at birth and presentation and the effect of karyotype on these parameters. Data were collected from 842 patients with TS from 35 different centers, who were followed-up between 1984 and 2014 and whose diagnosis age ranged from birth to 18 years. Of the 842 patients, 122 girls who received growth hormone, estrogen or oxandrolone were excluded, and 720 girls were included in the study. In this cohort, the frequency of small for gestational age (SGA) birth was 33%. The frequency of SGA birth was 4.2% (2/48) in preterm and 36% (174/483) in term neonates (P<0.001). The mean birth length was 1.3cm shorter and mean birth weight was 0.36kg lower than that of the normal population. The mean age at diagnosis was 10.1±4.4 years. Mean height, weight and body mass index standard deviation scores at presentation were -3.1±1.7, -1.4±1.5, and 0.4±1.7, respectively. Patients with isochromosome Xq were significantly heavier than those with other karyotype groups (P=0.007). Age at presentation was negatively correlated and mid-parental height was positively correlated with height at presentation. Mid-parental height and age at presentation were the only parameters that were associated with height of children with TS. The frequency of SGA birth was found higher in preterm than term neonates but the mechanism could not be clarified. We found no effect of karyotype on height of girls with TS, whereas weight was greater in 46,X,i(Xq) and 45,X/46,X,i(Xq) karyotype groups. © 2016 Wiley Periodicals, Inc.Item Waist to height ratio: A simple screening tool for nonalcoholifatty liver disease in obese children(Turkish Journal of Pediatrics, 2016) Özhan B.; Ersoy B.; Özkol M.; Kiremitci S.; Ergin A.Simple predictors are needed for the screening of nonalcoholic fatty liver disease (NAFLD) in obese children. We aimed to assess the role of anthropometric parameters in the prediction of NAFLD. Three hundred and thirty two obese children (152 male, 180 female) aged 4.6-17.0 years were included in this study. Weight, height, waist (WC), and hip circumference were measured. Body mass index (BMI), waist-hip-ratio (WHR), and waist-height-ratio (WHtR) were calculated. Obesity was defined as BMI for age and sex ≥ 95th percentile. NAFLD was diagnosed using ultrasonography (US). NAFLD was present in 60.8% of obese children. Fatty liver prevalence differed significantly by gender and puberty (55.0% of girls vs 67.7% of boys, and 28.7% in prepubertal vs 71.3% in pubertal children; p<0.05). Significantly higher BMI, BMI standard deviation score (SDS), WC, and WHtR were found in obese children with NAFLD compared to obese children without NAFLD (p<0.05). Only WHtR was found to be an independent predictor for NAFLD in a logistic regression analysis (p<0.001, B:1.096, 95% CI 1.047–1.148). Fatty liver is common among obese children, particularly in obese boys. WHtR is a simple and easy index for predicting of NAFLD in obese children and can be used for mass screening in public health. © 2017, Turkish Journal of Pediatrics. All rights reserved.