Browsing by Author "Özkan, Y"

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    Mental health of both child and parents plays a larger role in the health-related quality of life of obese and overweight children
    Kizilay, DÖ; Sapmaz, SY; Sen, S; Özkan, Y; Özyurt, BC; Ersoy, B
    Aims: A decrease in health-related quality of life (HRQOL) measures among obese (OB) and overweight (OW) children has been shown in several studies, but knowledge about the variables affecting HRQOL impairments is missing. The aim of this study was to evaluate the relationship between HRQOL and sociodemographic characteristics, anthropometric measurements, metabolic parameters, mental symptoms and parental attitudes in a sample of OB/OW children. Methods: Eighty-six OB/OW children, aged between 9 and 17 years, participated in the study. We performed sociodemographic questioning, anthropometric examinations and laboratory evaluations of the participants. HRQOL was assessed using the Pediatric Quality-of-Life Inventory (PedsQL), and levels of anxiety and depressive symptoms were measured using the Screen for Child Anxiety-Related Disorders (SCARED) questionnaire and the Children's Depression Inventory (CDI), respectively. Parental attitudes were assessed with the Parental Attitude Research Instrument (PARI) questionnaire. Results: A statistically significant relationship was found between total scores of CDI and SCARED answered by children and the total and subscale scores of PedsQL. Scores of total quality of life subscale, physical functionality and emotional functionality subscales were significantly lower in children with a family history of mental illness. No relationship was found between PedsQL subscales, anthropometric and metabolic parameters. Conclusions: Emotional problems and parental psychological distress are important factors in models of HRQOL in the OB/OW pediatric population.
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    TGF-β1, neopterin, tetrahydrobiopterin, and nitric oxide levels in pediatric obsessive-compulsive disorder
    Özkan, Y; Kandemir, H; Sapmaz, SY; Taneli, F
    The biological mechanisms underlying obsessive-compulsive disorder (OCD) are not sufficiently elucidated. Chronic inflammation and oxidative stress were shown to increase neopterin and decrease tetrahydrobiopterin (BH4) levels by activating the neopterin-BH4 pathway. This study compared serum TGF-beta 1, TNF-alpha, IL-1 beta, IL-2, IL-6, IL-10, IL-17, neopterin, BH4, and nitric oxide (NO) levels between child and adolescent patients diagnosed with OCD and a healthy control group. The study included 29 patients diagnosed with OCD (comorbidity free, drug free) and 28 healthy children as an aged and sex matched control group. Serum samples were analyzed for TGF-beta 1, TNF-alpha, IL-1 beta, IL-2, IL-6, IL-10, IL-17, neopterin, and BH4 by using enzyme-linked immunosorbent assay method, and NO concentrations were assessed by colorimetric method based on Griess reaction. All cytokine levels were found to be low, but this decrease was statistically significant only for TGF-beta 1. The neopterin and NO levels were significantly higher and BH4 significantly lower in children with OCD compared to the healthy control group. Also, a statistically significant correlation was found between NO, neopterin, and BH4 levels. The results of our study show that the levels of TGF-beta 1 and NO and the activation of the neopterin-BH4 pathway may be implicated in the pathophysiology of OCD.
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    Thiol/Disulfide Homeostasis: A Potential New Peripheral Biomarker in Adolescent Depression
    Öztürk, M; Özkan, Y; Sapmaz, SY; Erdal, S; Taneli, F; Kandemir, H
    Background: Thiol-disulfide homeostasis (TDH), one of the most important antioxidants, is involved in the non -enzymatic removal of reactive oxygen molecules in the body and is one of the many methods to measure the level of oxidative stress (OS). In the present study, TDH is investigated in adolescent depression, and its relationship to clinical variables is examined. Methods: Thirty-two (50.0%) patients diagnosed with major depressive disorder (MDD) and without psychotropic drug use and 32 (50.0%) healthy controls were included in the present study. The subjects MDD and control groups were between 13 and 18 years old. Participants completed the DSM-5 Level -2 scales for depression and irritability. A colorimetric method proposed by Erel and Neselioglu was used to analyze the TDH parameters of serum samples. Results: Biochemical analyses of samples from the MDD and control groups showed significant differences between the groups in native thiol (SH) levels ( P = .002), disulfide (SS) levels ( P = .021), disulfide/total thiol (SS/ToSH) ( P = .009), and disulfide/native thiol (SS/SH) ( P = .003) levels. Analysis of receiver operating characteristic showed that the area under the curve values with acceptable discrimination potential for the TDH parameters were significantly able to discriminate individuals with MDD from healthy controls. Conclusion: Thiol-disulfide homeostasis, one of the OS parameters, was found to be impaired in adolescents with depression. Our results suggest that TDH may contribute to the etiopathogenesis of adolescent MDD and that TDH may be a novel approach to assess OS in adolescent depression.
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    Reliability And Validity Study For Quick Assessment Scale Of Lymphoedem Management Information
    Özkan, Y; Okyay, P; Cerrahoglu, L; Turan, Y; Sönmez, A; Öztürk, S
    Objective: A scale to evaluate knowledge about lymphedema has not been found in the Turkish literature before. With this study, it was aimed to develop a scale that enables the evaluation of the level of knowledge of healthcare personnel on lymphedema management. Materials and Methods: The permission for this methodological study was obtained from the Ethics Committee of University Faculty of Medicine with protocol 31 number 1453. Application permission was obtained from University Rectorate Practice and Research Hospital Chief Physician. With literature review, the item pool of the Lymphedema Management Knowledge Scale, consisting of 35 45 items including the headings of etiology, diagnosis, treatment, and lifestyle, was organized. For 36 the evaluation of the scale, opinions of 16 faculty members who are experts in the field of Physical Therapy and Rehabilitation were consulted. Results:In our study, lymphedema management was gathered under four main headings and a conceptual framework was created, and it was seen that it was appropriate to evaluate all the questions in one dimension after the construct and reliability validity analyses. The scale is suitable for real life and easy to apply in terms of the questions it contains. Conclusion: With this Lymphedema Management Information Rapid Assessment Scale, which was developed by reviewing the literature and taking expert opinions, the quality of counselling services provided to lymphedema patients will be raised, and the rise in protective measures will increase the quality of life of the patients
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    Insulin Resistance as Related to Psychiatric Disorders in Obese Children
    Kizilay, DÖ; Sapmaz, SY; Sen, S; Özkan, Y; Ersoy, B
    Objective: The current study aimed to investigate psychiatric consequences of obesity and the relationship between componenets of the metabolic syndrome and psychiatric disorders in children. Our second aim was to elucidate which of the anthropometric parameters or metabolic components were most strongly associated with psychiatric disorders. Methods: The study included 88 obese and overweight children with a body mass index (BMI) greater than 85th percentile. The patients were evaluated for psychiatric disorders by a single child and adolescent psychiatrist. Forty patients diagnosed with psychiatric disorders and 48 patients with normal psychiatric evaluation were compared in terms of anthropometric and metabolic parameters. BMI, BMI-standard deviation score and BMI percentile, waist circumference, waist to hip ratio, blood pressure and pubertal stage of all patients were recorded. Fasting serum glucose, insulin, lipid profile and homeostatic model assessments of insulin resistance (HOMA-IR) were measured to evaluate the metabolic parameters. Serum and 24 hour urine cortisol levels were measured. Results: HOMA-IR in the group with psychiatric disorders was found to be significantly higher than in the group without psychiatric disorders (6.59 +/- 3.36 vs 5.21 +/- 2.67; p = 0.035). Other anthropometric measurements and metabolic parameters were not significantly different between the two groups. Conclusion: An understanding of the relationships between obesity related medical comorbidities and psychiatric pathologies is important to encourage patients and their families to make successful healthy lifestyle changes and for weight management in terms of appropriate treatment.
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    I mmigration-related mental health disorders in refugees 5-18 years old living in Turkey
    Sapmaz, SY; Tanriverdi, BU; Öztürk, M; Gözaçanlar, O; Ülker, GY; Özkan, Y
    Purpose: This study assessed early-onset psychiatric disorders and factors related to these disorders in a group of refugee children after immigration due to war. Materials and methods: This study was conducted between January 2016 and June 2016. Clinical interviews were conducted with 89 children and their families, and were performed by native speakers of Arabic and Persian who had been primarily educated in these languages and were living in Turkey. A strengths and difficulties questionnaire (SDQ) that had Arabic and Persian validity and reliability was applied to both children and their families. Independent variables for cases with and without a psychiatric disorder were analyzed using the chi(2) test for categorical variables, Student's t-test for those that were normally distributed, and Mann-Whitney U-test for data that were not normally distributed. Data that showed significant differences between groups who had a psychiatric disorder and on common effects in emerging psychiatric disorders were analyzed through binary logistic regression analysis. Results: A total of 89 children and adolescents were interviewed within the scope of the study. The mean age of cases was 9.96 +/- 3.98 years, and 56.2% (n=50) were girls, while 43.8% (n=39) were boys. Among these children, 47 (52.8%) had come from Syria, 27 (30.3%) from Iraq, 14 (15.7%) from Afghanistan, and 1 (1.1%) from Iran. A psychiatric disorder was found in 44 (49.4%) of the children. A total of 26 children were diagnosed with anxiety disorders, 12 with depressive disorders, 8 with trauma and related disorders, 5 with elimination disorders, 4 with attention deficit/hyperactivity disorder, and 3 with intellectual disabilities. It was determined that seeing a dead or injured person during war/emigration and the father's unemployment increased the risk of psychopathology. The OR was 7.077 (95% CI 1.722-29.087) for having seen a dead or injured individual and 4.51 (95% GA 1.668-12.199) for father's employment status. Conclusion: Within the context of war and emigration, these children try to cope with the negative circumstances they experience prior to migration, as well as the despair they see their parents experience.
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    Paliperidone Metabolic Effects in Children and Adolescents: A Case Report
    Kefal, MI; Kandemir, H; Sapmaz, SY; Öztürk, M; Özkan, Y; Özkan, ÖG
    The use of atypical antipsychotics in children and adolescents has increased in recent years. A 16-year-old male patient reported that he had used paliperidone for 3 years and had gained weight during this period. Various laboratory tests were performed when the patient started treatment in our clinic. It is evident from the test result that 3-year use of paliperidone dramatically increased fasting blood sugar, total cholesterol, low-density lipoprotein, triglycerides and prolactin levels in the patient. The metabolic parameters of the patient decreased into the normal range once the medication was stopped. Thus, paliperidone should be used carefully based on the side effects for patients under 18 years of age.
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    Evaluation of the physical and emotional effects of the COVID-19 pandemic on patients with fibromyalgia and chronic low back pain: A multicenter cross-sectional controlled study
    Bagcier, F; Kibar, S; Evcik, D; Ketenci, A; Sindel, D; Tur, BS; Ünlü, Z; Tikiz, C; Keskin, D; Alp, A; Ay, S; Yanik, B; Külcü, DG; Karakas, M; Nazlikul, FGU; Oktay, KNK; Aksoy, MK; Findikoglu, G; Eser, F; Atici, A; Yurdakul, OV; Koçak, FA; Kurt, EE; Özkan, Y; Dogan, SK; Sultanoglu, TE; Ordahan, B; Umay, EK; Demirhan, E; Yagci, HC; Balbaloglu, Ö; Tezel, N; Satis, S; Atar, S; Akaltun, MS
    Objectives: This study aimed to investigate the physical and emotional effects of the coronavirus disease 2019 pandemic in patients with fibromyalgia syndrome (FMS) and chronic low back pain (CLBP) patients. Patients and methods: The cross-sectional controlled study was performed with 1,360 participants (332 males, 1,028 females; mean age: 42.3 +/- 12.5 years; range, 18 to 65 years) between September 2020 and February 2021. The participants were evaluated in three groups: the FMS group (n=465), the CLBP group (n=455), and the healthy control group (n=440). Physical activity, pain levels, and general health status before and during the pandemic were evaluated in all participants. Stress levels were analyzed with the perceived stress scale (PSS) in all groups, and disease activity was analyzed with the fibromyalgia impact questionnaire (FIQ) in patients with FMS. Results: Patients with FMS had worsened general health status and pain levels during the pandemic compared to the other groups (p<0.01). The FMS group showed significantly higher PSS scores than those in other groups (p<0.01). There was a weak-positive correlation between FIQ and PSS parameters in patients with FMS (p<0.05, r= 0.385). Conclusion: The general health status, pain, and stress levels of the patients with FMS and CLBP tended to worsen during the pandemic. This high-stress level appeared to affect disease activity in patients with FMS.