Browsing by Author "Öztürk, F"
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Item Hyperbaric oxygen therapy for the management of chronic woundsÖztürk, F; Ermertcan, AT; Inanir, IWound healing is actually a complex, precisely coordinated interaction between inflammatory cells and mediators, establishing significant overlap between the phases of wound healing. Chronic wounds are defined as wounds that do not follow the well-defined stepwise process of physiologic healing. The true incidence and economic impact of chronic wounds are difficult to assess because of the wide range of causative diseases and available treatment options. Despite multiple simultaneous and sequential therapeutic approaches, chronic wounds are highly resistant to treatment and are often indolent or even slowly progressive. Hyperbaric oxygen therapy (HBOT) has been explored as a treatment modality for chronic wounds because of its potential to promote healing and reduce bioburden in the wound bed. Multiple potential beneficial effects for wound healing have been demonstrated in various laboratory studies and experimental animal models. In this manuscript, HBOT, its mechanism of action, adverse effects and usage in diabetic and nondiabetic chronic wounds have been reviewed.Item Giant eccrine porocarcinoma in an unusual locationErmertcan, AT; Evrenos, MK; Öztürk, F; Temiz, PItem Relationship of retinopathy and hearing loss in type 2 diabetes mellitusKurt, E; Öztürk, F; Günen, A; Sadikoglu, Y; Sari, RA; Yoldas, TK; Avsar, A; Inan, ÜÜThis study investigated whether the degree of diabetic retinopathy correlates with degree of sensorineural hearing loss. Seventy-five diabetic patients and 45 sex- and age-matched healthy controls were evaluated audiologically. Patients were classified into groups by severity of retinopathy. group 1 (n=28), no retinopathy, group 2 (n= 4), background retinopathy, and group 3 (n=23), proliferative, or end-stage retinopathy. Diabetics had a statistically significant difference at all frequencies of hearing loss, as compared with controls.Item Effect of propolis on endotoxin-induced uveitis in rabbitsÖztürk, F; Kurt, E; Inan, ÜÜ; Emiroglu, L; Ilker, SS; Sobaci, GPurpose: To test the anti-inflammatory effect of propolis, a natural bee-produced compound, and compare it with corticosteroids fur the: treatment of endotoxin-induced uveitis (EIU). Methods: EIU was produced in all rabbits by unilateral intravitreal injection of 2,000 ng Salmonella typhimurium endotoxin. The animals were then divided randomly into three groups as follows: group A received no treatment (control), group B received methylprednisolone (5 mg/0.1 mL) (positive control); and group C received propolis (5 mg/0.16 mL) by anterior sub-Tenon injection at the time of uveitis induction and at 4 and 8 hours after induction. Inflammation was evaluated by clinical manifestations and by measuring the protein concentration and inflammatory cell content of the aqueous humor. Results: The clinical grade, cell count: and protein levels in the aqueous humor were: control group (6.0 +/- 0.8, 2,519 +/- 470 cells/mu L. 32.9 +/- 2.4 mg/mL); methylprednisolone group (1.8 +/- 0.7, 572 +/- 137 cells/mu L. 15.2 +/- 1.8 mg/mL); and propolis group (2.3 +/- 0.5, 503 +/- 124 cells/mu L, 13.8 +/- 1.5 mg/mL). Statistically significant differences were recorded in the treatment groups when compared to the control group (P < .001). The effects of methylprednisolone and propolIs on EIU were similar (P > .05). Conclusions: Propolis showed significant anti-inflammatory effects on EIU iii rabbits. The mechanism of its action warrants further investigation. Jpn J Ophthalmol 1999;43:285-289. (C) 1999 Japanese Ophthalmological Society.Item Urticarial Vasculitis Successfully Treated With OmalizumabErmertcan, AT; Aktas, A; Öztürk, F; Temiz, PItem Relationship between serum lipoprotein (a) levels and retinopathy in patients with type 2 diabetesKurt, E; Öztürk, F; Ari, Z; Yigitoglu, MR; Sari, RA; Ilker, SSWe studied whether there was an association between development of background or proliferative retinopathy and changes in plasma lipid, lipoprotein, and lipoprotein (a) levels in 111 patients with type 2 diabetes mellitus and in 57 controls. Serum lipoprotein (a) levels were higher in patients with retinopathy than in individuals without retinopathy. Increased serum lipoprotein (a) levels correlated with higher degrees of retinopathy. Thus, lipoprotein (a) may play a role in the development of diabetic retinopathy.Item Penetration of topical and oral ofloxacin into the aqueous and vitreous humor of inflamed rabbit eyesÖztürk, F; Kurt, E; Inan, ÜÜ; Kortunay, S; Ilker, SS; Basci, NE; Bozkurt, APurpose: This study aimed to investigate the penetration of topical and oral ofloxacin into aqueous humor and vitreous humor in post-traumatic endophthalmitis model in rabbits. Methods: A standardized intraocular infection after penetrating injury was made in the right eyes of 16 rabbits. Intraocular infection was induced by intravitreal injection of a suspension of Staphylococcus aureus. The intact left eyes were maintained as controls. The animals were divided randomly into two groups. (1) In the topical group, two drops of offloxacin 0.3% eyedrops were instilled to both eyes every 30 min for 4 h. (2) In the topical-oral group, two doses of 25 mg/kg of ofloxacin at 12-h intervals were given orally, then the protocol of the first group was applied. Aqueous and vitreous humor samples were taken 30 min after the last drop. Ofloxacin concentrations were measured by using HPLC. Results: Mean aqueous levels of ofloxacin in control eyes were: 3.25 +/- 2.55 mu g/ml in topical group, 4.58 +/- 5.39 mu g/ml in topical-oral group. Mean aqueous levels in inflamed eyes were: 5.21 +/- 4.55 mu g/ml in topical group, 10.34 +/- 8.88 mu g/ml in topical-oral group. Mean vitreous levels of ofloxacin in control eyes were: 0.17 +/- 0.07 mu g/ml in topical group, 1.30 +/- 1.23 mu g/ml in topical-oral group. Mean vitreous levels in inflamed eyes were: 0.35 +/- 0.22 mu g/ml in topical group, 3.48 +/- 2.69 mu g/ml in topical-oral group. There was no significant difference among the groups (P > 0.05), however. Conclusions: The result of this study suggests that oral supplementation of ofloxacin to topical instillation increased the ocular levels of ofloxacin in the post-traumatic endophthalmitis model. Mean drug concentrations in aqueous and vitreous humors were above the 90% minimum inhibitory concentrations (MIC90) for most of the common microorganisms causing endophthalmitis in all eyes, except in the vitreous humors of the intact eyes instilled topically. (C) 2000 Elsevier Science B.V. All rights reserved.Item Penetration of topical and oral ciprofloxacin into the aqueous and vitreous humor in inflamed eyesÖztürk, F; Kortunay, S; Kurt, E; Ilker, SS; Basci, NE; Bozkurt, APurpose:To assess the aqueous and vitreous penetration of ciprofloxacin after topical and combined topical and oral administration and investigate the effects of inflammation on drug penetration. Methods: A standardized penetrating injury was made in the right eyes of 16 rabbits. Intraocular inflammation was induced by intravitreal injection of a suspension of Staphylococcus aureus in these eyes. The animals were divided into two groups according to treatment methodology: topical and topical-oral. The intact left eyes of the animals were maintained as controls. In the topical treatment group, two drops of ciprofloxacin 0.3% were instilled to both eyes every 30 minutes for 4 hours. In the topical-oral treatment group, animals were given two oral 40 mg/kg doses of ciprofloxacin at 12-hour intervals. After the last oral dose, the protocol of the topical group was applied to these eyes. Half an hour after the last drop, 100-muL samples were taken from aqueous and vitreous humor of ail eyes. Drug concentrations were measured using high-pressure liquid chromatography. Results: Mean aqueous levels of ciprofloxacin in control eyes were 2.31 mug/mL (range, 1.02-6.27 mug/ml) in the topical group and 5.88 mug/mL (1.52-17.81) in the topical-oral group. Mean aqueous levels in inflamed eyes were 7.36 mug/mL (2.34-17.15) in the topical group and 14.43 mug/mL (2.18-18.66) in the topical-oral group. Mean vitreous levels in control eyes were 0.77 mug/mL (0.09-1.93) in the topical group and 1.01 mug/mL(0.49-1.57) in the topical-oral group. Mean vitreous levels in inflamed eyes were 0.95 mug/mL (0.18-1.27) in the topical group and 1.98 mug/mL (0.51-3.34) in the topical-oral group. There was no significant difference among the groups (P > 0.05). Mean aqueous levels in all eyes and mean vitreous levels in the combined topical and oral group of inflamed eyes were above the 90% minimum inhibitory concentration for most of the common microorganisms causing endophthalmitis. Conclusion: There is an increase in both aqueous and Vitreous humor concentrations with inflammation and with oral and topical administrations, as opposed to topical only, of ciprofloxacin, Using oral as well as topical treatment may be a beneficial method of antibiotic prophylaxis in ocular trauma once a patient has received intravenous or intravitreal therapy.Item Ofloxacin levels after intravitreal injection -: Effects of trauma and inflammationÖztürk, F; Kortunay, S; Kurt, E; Inan, ÜÜ; Ilker, SS; Basci, NE; Bozkurt, A; Kayaalp, SOPurpose: This study was carried out to get an insight into the ofloxacin elimination after intravitreal injection in rabbits. We also studied the effects of trauma and inflammation on the vitreous ofloxacin levels after intravitreal injection of ofloxacin. Methods: A penetrating eye injury in the right eye was inflicted on 24 rabbits and another 12 animals were used as control. A standardized intraocular inflammation was induced by intravit-real injection of a suspension of Staphylococcus aureus in half of the traumatized eyes. Ofloxacin (200 mu g/0.1 ml) was injected into the midvitreous cavity of both traumatized and control right eyes, and samples were obtained at 2, 8, 24 and 48 h after injection. Drug concentrations were measured using high-pressure liquid chromatography analysis. Results: Vitreous levels of ofloxacin were above the MIC90 at 2 and 8 h in all groups for most of the common microorganisms causing endophthalmitis and also at 24 h in traumatized-infected eyes. At the second hour, the mean vitreous concentrations of ofloxacin both in traumatized and traumatized infected eyes were lower than that in the control eyes (p < 0.05). At 8 h, the mean vitreous concentrations of ofloxacin in the traumatized and in the traumatized-infected eyes were higher than that in the control eyes (p < 0.05). At 24 h, the mean ofloxacin concentration was higher in the traumatized-infected eyes than that in control (p < 0.01) and traumatized eyes (p < 0.05), and also higher in the traumatized eyes than that in the control eyes (p < 0.05). The mean ofloxacin concentrations in the traumatized and traumatized-infected eyes were significantly higher (p < 0.01) than those in the controls at 48 h. The elimination half-life of ofloxacin in the control eyes was 5.65 h and trauma and inflammation prolonged the half-life to 9.47 and 9.72 h, respectively. Conclusion: Clearance of ofloxacin is fast and appears to be reduced by trauma and inflammation. Therapeutic drug levels in traumatized-infected eyes were maintained up to 24 h. This may be an important pharmacokinetic advantage in treating endophthalmitis unless the dose used has local toxicity and allows a longer dose interval when the dose is repeated.Item Propolis Prevents the Effects of Chronic Alcohol Intake on Ocular TissuesEmre, S; Yilmaz, Z; Öztürk, F; Emre, MHAim: This study is designed to investigate the protective effects of propolis in ocular tissues against chronic alcohol exposure. Material and Method: Wistar albino rats were used in this study. Rats were divided into 4 groups, and each group was fed a special liquid diet which contained an equal amount of calories. The control group was fed the liquid special diet without alcohol and propolis. We added propolis (150 mg/kg) to the diet of the second group. The diet of the third group contained alcohol, the concentration of which was increased progressively. The fourth group was fed a diet including propolis and alcohol. To counterbalance caloric intake, we decreased the amount of glucose in the special liquid diet for groups 3 and 4. At the end of 30 days, the animals were sacrificed and samples were kept at -80 degrees C until evaluation. Specimens were investigated by light microscopy for morphology and morphometry. Results: In the histological investigation of ocular tissues, alcohol caused an increase in thickness of the cornea and corneal epithelium compared to the control group (p < 0.05). This incremental tendency was significantly reduced by propolis, and values were very close to those of the control group (p > 0.05). Alcohol did not cause any significant alteration of rat retinal thickness. Conclusion: This study showed that propolis is highly effective against corneal edema secondary to chronic alcohol intake. Copyright (C) 2009 S. Karger AG, BaselItem The effect of long-term use and inflammation on the ocular penetration of topical ofloxacinÖztürk, F; Kortunay, S; Kurt, E; Inan, ÜÜ; Ilker, SS; Basci, N; Bozkurt, APurpose. To study the,penetration of ofloxacin into the aqueous and vitreous humors after long-term topical administration and to investigate the effects of inflammation on drug penetration in rabbits. Methods. A standardized model of intraocular infection after penetrating injury was achieved in the right eyes of 16 rabbits. The animals were randomly and equally-divided into two groups. The intact left eyes of the groups were maintained as the control. Ofloxacin eyedrops (0.3%) were instilled into all eyes at a frequency of 2 drops every hour for 7 hours in the first group and for 14 hours in the second group. Half an hour after the last drop, samples of the aqueous and vitreous humors were taken and ofloxacin concentrations were measured by using HPLC. Results. The mean aqueous humor concentrations of ofloxacin in control eyes after 7:and 14 hours of instillation were: 1.45 +/- 0.93 mu g/ml and 2.48 +/- 0.33 mu g/ml, respectively; those in infected eyes 2.35 +/- 1.84 mu g/ml and 3.49 +/- 1.47 mu g/ml, respectively. However the differences among the groups were not significant (p > 0.05). The vitreous ofloxacin concentrations in the control eyes were similar after 7 and 14 hours of instillation (0.23 +/- 0.14 mu g/ml, 0.27 +/- 0.10 mu g/ml, respectively). In infected eyes, the mean vitreous ofloxacin concentration after 14 hour of instillation was significantly higher than that in control eyes (p < 0.05; 0.4 +/- 0.09 mu g/ml, 0.29 +/- 0.11 mu g/ml, respectively). The mean vitreous ofloxacin concentration in infected eyes after 14 hours instillation was not significantly higher than that after 7 hours instillation. Conclusions. Topical ofloxacin instillation for 7 or 14 hours yields aqueous concentrations above the MIC90 for common ocular pathogens. Prolonged application and the presence of inflammation increased the penetration of ofloxacin into the vitreous humor.Item Effects of trauma and infection on ciprofloxacin levels in the vitreous cavityÖztürk, F; Kortunay, S; Kurt, E; Ilker, SS; Inan, ÜÜ; Basci, NE; Bozkurt, A; Kayaalp, SOObjective: This study was designed to determine the effects of trauma and infection on vitreous ciprofloxacin levels after intravitreal injection of ciprofloxacin in rabbits. Methods: A penetrating injury was made in the right eyes of 24 rabbits, in the eyes of half of the traumatized animals, a standardized intraocular infection was induced by intravitreal injection of a suspension of Staphylococcus aureus. The intact left eyes of the traumatized group were maintained as controls. Ciprofloxacin (200 mug/0.1 mL) was injected into the midvitreous cavity of both eyes in all animals and samples were obtained at 2, 8, 24, and 48 hours after injection. Drug concentrations were measured using high-pressure liquid chromatography analysis. Results: At the second hour, the mean Vitreous concentration of ciprofloxacin in the traumatized eyes was lower than that in control eyes (P < 0.05). The mean ciprofloxacin concentrations were significantly higher (P < 0.05) in the traumatized-infected eyes than were those in control or traumatized eyes at 24 and 48 hours. The elimination half-life of ciprofloxacin in control and traumatized eyes was 6.02 hours and 5.02 hours, respectively, and infection prolonged the half-life to 15.06 hours. Vitreous levels of ciprofloxacin were above the minimum inhibitory concentration (MIC90) for most of the common microorganisms causing endophthalmitis in all groups at 2 and 8 hours, but also at 24 and 48 hours in traumatized-infected eyes. Conclusion: Infection appears to decrease the clearance of ciprofloxacin. Therapeutic drug levels in traumatized-infected eyes were maintained up to 48 hours. Assuming that the animal model used may have a predictive Value for the drug elimination in traumatized-infected human eyes, we suggest that local administration of ciprofloxacin every 2 days may be relevant from the therapeutic perspective.Item Multiple benign symmetric lipomatosis without chronic alcohol consumptionÖztürkean, S; Bilaç, C; Öztürk, F; Sahin, MTItem Terra firma-forme dermatosisÖztürk, F; Kocabas, E; Ertan, P; Ermertcan, ATTerra firma-forme dermatosis (TFFD) is an uncommon disorder of keratinization with an unknown etiology in which patients present with dirt-like lesions that are resistant to washing. A 6-year old girl presented with the complaint of an asymptomatic brownish black dirt-like eruption on her body. Her parents reported no response to washing with soap and water. Dermatologic examination revealed brown hyperpigmented patches on the trunk and abdominal region. TFFD was suspected, and isopropyl alcohol was applied to the patient's lesions. All lesions completely disappeared after rubbing with alcohol. Terra firma-forme dermatosis is a relatively recently described entity that is much more common than might be expected when surveying the medical literature. With the very few reports found in the literature about TFFD, we believe that an increased awareness of this entity among primary care physicians would help decrease unnecessary worries or medical procedures, since TFFD lesions simply resolve by rubbing with isopropyl alcohol.Item Psoriatic uveitis responding to adalimumab therapyErmertcan, AT; Emre, S; Öztürk, F; Gençoglan, G; Gündüz, KItem Pott's disease with scrofuloderma and psoas abscess misdiagnosed and treated as hidradenitis suppurativaErmertcan, AT; Öztürk, F; Gençoglan, G; Inanir, I; Özkütük, N; Temiz, PA 29-year-old man with painless ulcers on the lumbar and inguinal regions associated with purulent discharge of 1.5 years' duration presented to our outpatient clinic. Dermatological examination revealed palpable nodules, discharging sinuses and scars on the left lumbar, gluteal and inguinal regions. According to the clinical, histopathological, scintigraphy, and magnetic resonance imaging findings as well as mycobacteriological examinations, the patient was diagnosed with Pott's disease with scrofuloderma and psoas abscess. Herein, we present an interesting case of Pott's disease with scrofuloderma and psoas abscess mistreated as hidradenitis suppurativa for a long time.Item A Case Report of Postpubertal Eruptive Syringoma Triggered With Antiepileptic DrugsÖztürk, F; Ermertcan, AT; Bilaç, C; Temiz, PEruptive syringoma is a rare variant of syringoma, which typically occurs in large numbers as multiple yellow-brown colored papules. It usually presents before or during puberty. The pathogenesis of eruptive syringoma is unclear. It could represent a hyperplastic response of the eccrine ducts to an inflammatory reaction caused by an unknown trigger. The association between drugs and eruptive syringoma has not been reported in the literature until now. A 34-year-old woman with multiple asymptomatic papular eruptions of nine years' duration visited the authors' outpatient clinic. She had been using antiepileptic drugs for epilepsy for 10 years. Dermatological examination revealed multiple skin-colored to brownish papules, 1-3 mm in diameter, on the trunk and neck. Skin biopsy was performed from a lesion on the neck. According to clinical and histopathological findings, the patient was diagnosed as having eruptive syringoma. This case is very interesting, because the patient had been using antiepileptic drugs for a long time and the onset of her lesions was in postpubertal period. The authors' hypothesize that her lesions occured due to antiepileptics which may be a trigger of syringomatous proliferation. The authors conclude that drugs, especially antiepileptics, should be kept in mind in reference to the etiology of eruptive syringomas.Item Antineovascular effect of α-interferon on corneal neovascularization in ratsÖztürk, F; Sobaci, G; Ilker, SS; Can, CClinical and histologic effects of topical recombinant a-interferon (IFN) systemic IFN topical dexamethasone, and dexamethasone plus topical IFN on corneal neovascularization in response to silver nitrate cauterization were investigated in 110 eyes of 60 Wistar rats. The eyes were evaluated according to tire burn stimulus, neovascularization, and histologic inflammation grades 5 days after cauterization. Antineovascular effects of topical and systemic IFN were significantly greater than a placebo but less than dexamethasone alone or in combination with IFN.Item Chiasmal decussation in tilted disc syndrome PVER in tilted discÖztürk, F; Kurt, E; Yoldas, T; Ilker, SS; Inan, ÜÜThe tilted disc syndrome is a benign congenital abnormality of the optic nerve head. Since it can be confused with papilledema and chiasmal lesions, differential diagnosis is important. The tilting anomaly may be associated with other abnormalities along the optic nerve. Visual field defects may be similar to those in chiasmal lesions. In order to determine whether the normal crossover of nerve fibers at the chiasm is altered, the crossed and the uncrossed fibers were investigated using the pattern visual evoked responses (PVER) test. Thirty-four eyes of 17 patients diagnosed with tilted disc syndrome were evaluated for refraction, keratometry, color vision with Ishihara, visual field, and PVER. The presence of abnormal nerve fiber decussation was determined by recording PVER from the electrodes mounted on the scalp of both hemispheres. The amplitude and latency differences between the 'crossed' and 'uncrossed' fibers were not statistically significant (p>0.05). As a result, the tilting abnormality of papilla was found to be without chiasmal abnormal decussation.Item Toll-like receptors and skinErmertcan, AT; Öztürk, F; Gündüz, KToll-like receptors are important pattern recognition receptors which have key roles in both innate and adaptive immune responses. They are strongly associated with the pathogenesis of inflammatory and autoimmune diseases. Furthermore, Toll-like receptors have also been implicated in the pathogenesis of several skin diseases such as skin infections, psoriasis, acne vulgaris, lichen planus, Behcet's disease, leprosy, syphilis, Lyme disease, atopic dermatitis and allergic contact dermatitis, mycosis fungoides, non-melanoma skin cancers and melanoma. In this manuscript, the structure and functions of Toll-like receptors in immune responses, their impact on skin diseases and recent advances on therapeutic usage have been reviewed.