MCBÜ Açıkerişim Sistemi :: Browsing by Author "Öztürk F."

Browsing by Author "Öztürk F."

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Evaluation of intraocular pressure and cataract formation following the long-term use of nasal corticosteroids
(Medquest Communications LLC, 1998) Öztürk F.; Yücetürk A.V.; Kurt E.; Ünlü H.H.; Ilker S.S.
It is possible that corticosteroids administered via nasal spray might reach ocular structures in levels sufficient to provoke an ocular hypertensive response and cause posterior subcapsular cataracts (PSCs) in susceptible individuals. In the present study, 26 patients who had undergone endoscopic sinus surgery were evaluated prospectively with respect to intraocular pressure and PSC formation following the use of nasal steroids for at least three months. Eighteen patients (69%) self-administered 200 μg/day of budesonide nasal spray twice daily, and eight patients (31%) self- administered 200 μg/day of beclomethasone dipropionate nasal spray twice daily, for a period of three to 19 months (mean 8.8 ± 3.6 months). Ophthalmologic examination, tonometry, visual field testing and biomicroscopic studies revealed no evidence of ocular hypertension or PSCs during postoperative follow-up. We conclude that intranasal corticosteroids can be used safely for prolonged periods without increasing the risk of ocular hypertension or PSCs.
The effect of long-term use and inflammation on the ocular penetration of topical ofloxacin
(Swets en Zeitlinger B.V., 1999) Öztürk F.; Kortunay S.; Kurt E.; Inan Ü.Ü.; Ilker S.S.; Basci N.; Bozkurt A.
Purpose. To study the penetration of ofloxacin into the aqueous and vitreous humors after long-term topical administration and to investigate the effects of inflammation on drug penetration in rabbits. Methods. A standardized model of intraocular infection after penetrating injury was achieved in the right eyes of 16 rabbits. The animals were randomly and equally divided into two groups. The intact left eyes of the groups were maintained as the control. Ofloxacin eyedrops (0.3) were instilled into all eyes at a frequency of 2 drops every hour for 7 hours in the first group and for 14 hours in the second group. Half an hour after the last drop, samples of the aqueous and vitreous humors were taken and ofloxacin concentrations were measured by using HPLC. Results. The mean aqueous humor concentrations of ofloxacin in control eyes after 7 and 14 hours of instillation were: 1.45 ± 0.93 μg/ml and 2.48 ± 0.33 μg/ml, respectively; those in infected eyes 2.35 ± 1.84 μg/ml and 3.49 ± 1.47 μg/ml, respectively. However the differences among the groups were not significant (p > 0.05). The vitreous ofloxacin concentrations in the control eyes were similar after 7 and 14 hours of instillation (0.23 ± 0.14 μg/ml, 0.27 ± 0.10 μg/ml, respectively). In infected eyes, the mean vitreous ofloxacin concentration after 14 hour of instillation was significantly higher than that in control eyes (p < 0.05; 0.4 ± 0.09 μg/ml, 0.29 ± 0.11 μg/ml, respectively). The mean vitreous ofloxacin concentration in infected eyes after 14 hours instillation was not significantly higher than that after 7 hours instillation. Conclusions. Topical ofloxacin instillation for 7 or 14 hours yields aqueous concentrations above the MIC90 for common ocular pathogens. Prolonged application and the presence of inflammation increased the penetration of ofloxacin into the vitreous humor.
Axial length measurement and asteroid hyalosis
(1999) Erkin E.F.; Tarhan S.; Öztürk F.
Purpose: To evaluate the effect of asteroid hyalosis on automated and manual A-scan axial length measurements. Setting: Celal Bayar University School of Medicine, Manisa, Turkey. Methods: A case-control study comprised 15 patients with unilateral asteroid hyalosis. The uninvolved eyes were used as controls. Axial length measurements by manual and automated A-scan biometry were performed in both eyes. The main outcome measures were comparisons between manual and automated measurements in asteroid hyalosis eyes with those in control eyes and the assessment of density of asteroid bodies on B-scan photographs. Results: Statistical analysis revealed no significant differences between axial lengths of asteroid hyalosis eyes and those in control eyes with automated (P = .524) or manual (P = .163) methods. Using automated biometry, 1 patient (7%) had a false (6.23 mm) short axial length measurement in the eye with asteroid hyalosis. There were no significant correlations between manual versus automated measurement differences and the density of the asteroid bodies. Conclusion: The axial length of the eye without asteroid hyalosis can be used to calculate intraocular lens power if the patient has no history of clinical anisometropia.
Effects of trauma and infection on ciprofloxacin levels in the vitreous cavity
(Lippincott Williams and Wilkins, 1999) Öztürk F.; Kortunay S.; Kurt E.; Ilker S.S.; Inan U.U.; Basci N.E.; Bozkurt A.; Kayaalp S.O.
Objective: This study was designed to determine the effects of trauma and infection on vitreous ciprofloxacin levels after intravitreal injection of ciprofloxacin in rabbits. Methods: A penetrating injury was made in the right eyes of 24 rabbits. In the eyes of half of the traumatized animals, a standardized intraocular infection was induced by intravitreal injection of a suspension of Staphylococcus aureus. The intact left eyes of the traumatized group were maintained as controls. Ciprofloxacin (200 μg/0.1 mL) was injected into the midvitreous cavity of both eyes in all animals and samples were obtained at 2, 8, 24, and 48 hours after injection. Drug concentrations were measured using high-pressure liquid chromatography analysis. Results: At the second hour, the mean vitreous concentration of ciprofloxacin in the traumatized eyes was lower than that in control eyes (P < 0.05). The mean ciprofloxacin concentrations were significantly higher (P < 0.05) in the traumatized-infected eyes than were those in control or traumatized eyes at 24 and 48 hours. The elimination half-life of ciprofloxacin in control and traumatized eyes was 6.02 hours and 5.02 hours, respectively, and infection prolonged the half-life to 15.06 hours. Vitreous levels of ciprofloxacin were above the minimum inhibitory concentration (MIC90) for most of the common microorganisms causing endophthalmitis in all groups at 2 and 8 hours, but also at 24 and 48 hours in traumatized-infected eyes. Conclusion: Infection appears to decrease the clearance of ciprofloxacin. Therapeutic drug levels in traumatized-infected eyes were maintained up to 48 hours. Assuming that the animal model used may have a predictive value for the drug elimination in traumatized-infected human eyes, we suggest that local administration of ciprofloxacin every 2 days may be relevant from the therapeutic perspective.
The effects of acetylcholine and propolis extract on corneal epithelial wound healing in rats
(Lippincott Williams and Wilkins, 1999) Öztürk F.; Kurt E.; Inan U.U.; Emiroǧlu L.; Ilker S.S.
Purpose. To investigate the effects of topical acetylcholine and topical administration of propolis, a natural beehive product, on corneal epithelial wound healing. Methods. The whole corneal epithelium was debrided in 42 eyes of 21 rats by mechanical scraping with a dulled scalpel blade. Animals were divided into three groups. Group 1 received topical 1% water extract of propolis (WEP), group 2 received topical acetylcholine (ACh), and group 3 (control group) received topical phosphate-buffered saline, 6 times a day for 3 days, starting immediately after debridement. The area of the corneal epithelial defect was stained with fluorescein, photographed, and then measured every 12 h. The mean epithelial defect area and the mean percentage of epithelial defect remaining at each follow-up were compared between the groups. Results. The mean epithelial defect area and the mean percentage of epithelial defect remaining at each time were significantly smaller (p < 0.001, p < 0.05, respectively) in the ACh and propolis groups as compared with control groups. There was no statistically significant difference between the propolis or ACh groups at any time (p > 0.05). At 72 h, the mean percentage of defect remaining was 2.58% in the ACh group, 1.3% in the propolis-treated group, and 8.68% in the control group. Conclusions. This study demonstrated that ACh and propolis facilitated corneal epithelial wound healing of rats. Although the mechanisms of the effect of propolis on wound healing and its clinical use still remain to be determined, ACh may have a place in the treatment of corneal epithelial injuries.
Ofloxacin levels after intravitreal injection. Effects of trauma and inflammation
(1999) Öztürk F.; Kortunay S.; Kurt E.; Inan Ü.Ü.; Ilker S.S.; Basci N.E.; Bozkurt A.; Kayaalp S.O.
Purpose: This study was carried out to get an insight into the ofloxacin elimination after intravitreal injection in rabbits. We also studied the effects of trauma and inflammation on the vitreous ofloxacin levels after intravitreal injection of ofloxacin. Methods: A penetrating eye injury in the right eye was inflicted on 24 rabbits and another 12 animals were used as control. A standardized intraocular inflammation was induced by intravitreal injection of a suspension of Staphylococcus aureus in half of the traumatized eyes. Ofloxacin (200 μg/0.1 ml) was injected into the midvitreous cavity of both traumatized and control right eyes, and samples were obtained at 2, 8, 24 and 48 h after injection. Drug concentrations were measured using high-pressure liquid chromatography analysis. Results: Vitreous levels of ofloxacin were above the MIC90 at 2 and 8 h in all groups for most of the common microorganisms causing endophthalmitis and also at 24 h in traumatized-infected eyes. At the second hour, the mean vitreous concentrations of ofloxacin both in traumatized and traumatized-infected eyes were lower than that in the control eyes (p < 0.05). At 8 h, the mean vitreous concentrations of ofloxacin in the traumatized and in the traumatized-infected eyes were higher than that in the control eyes (p < 0.05). At 24 h, the mean ofloxacin concentration was higher in the traumatized-infected eyes than that in control (p < 0.01) and traumatized eyes (p < 0.05), and also higher in the traumatized eyes than that in the control eyes (p < 0.05). The mean ofloxacin concentrations in the traumatized and traumatized-infected eyes were significantly higher (p < 0.01) than those in the controls at 48 h. The elimination half-life of ofloxacin in the control eyes was 5.65 h and trauma and inflammation prolonged the half-life to 9.47 and 9.72 h, respectively. Conclusion: Clearance of ofloxacin is fast and appears to be reduced by trauma and inflammation. Therapeutic drug levels in traumatized-infected eyes were maintained up to 24 h. This may be an important pharmacokinetic advantage in treating endophthalmitis unless the dose used has local toxicity and allows a longer dose interval when the dose is repeated.
Ophthalmic findings in GAPO syndrome
(1999) Ilker S.S.; Öztürk F.; Kurt E.; Temel M.; Gül D.; Sayli B.S.
Background: The main manifestations of GAPO syndrome are growth retardation (G), alopecia (A), pseudoanodontia (P), and optic atrophy (O). Cases: This syndrome has been described in 21 patients from 16 different families. Four cases are from Turkey and have been presented by Sayli and Gul. The purpose of our study is to document the cases from Turkey and discuss the ophthalmological and neuro-ophthalmolgical findings of these and other reported GAPO cases. Observations: All patients in the literature and our 4 cases have severe growth retardation with delayed bone age in infancy, characteristic facial appearance (high and bossed forehead, midface hypoplasia), alopecia or severe hypotrichosis, and pseudoanodontia. Optic atrophy was present in 1 of our cases and in 5 previous cases. Glaucoma was present in 5 cases, including 2 of ours. Buphthalmia and keratopathy secondary to glaucoma were also observed. White eyelashes, seen only in our cases, may be a sign of 'early senility.' Conclusions: Optic atrophy is not a constant finding in GAPO syndrome. Glaucoma may accompany the ocular findings. This syndrome has been attributed to either ectodermal dysplasia or the accumulation of extracellular connective tissue matrix, due to an enzyme deficiency involved in its metabolism. Current studies show that an elastin defect and secondary changes in collagen may be important in the pathogenesis of the disease.
Penetration of topical and oral ciprofloxacin into the aqueous and vitreous humor in inflamed eyes
(Lippincott Williams and Wilkins, 1999) Öztürk F.; Kortunay S.; Kurt E.; Ilker S.S.; Basci N.E.; Bozkurt A.
Purpose: To assess the aqueous and vitreous penetration of ciprofloxacin after topical and combined topical and oral administration and investigate the effects of inflammation on drug penetration. Methods: A standardized penetrating injury was made in the right eyes of 16 rabbits. Intraocular inflammation was induced by intravitreal injection of a suspension of Staphylococcus aureus in these eyes. The animals were divided into two groups according to treatment methodology: topical and topical-oral. The intact left eyes of the animals were maintained as controls. In the topical treatment group, two drops of ciprofloxacin 0.3% were instilled to both eyes every 30 minutes for 4 hours. In the topical-oral treatment group, animals were given two oral 40 mg/kg doses of ciprofloxacin at 12-hour intervals. After the last oral dose, the protocol of the topical group was applied to these eyes. Half an hour after the last drop, 100-μL samples were taken from aqueous and vitreous humor of all eyes. Drug concentrations were measured using high- pressure liquid chromatography. Results: Mean aqueous levels of ciprofloxacin in control eyes were 2.31 μg/mL (range, 1.02-6.27 μg/mL) in the topical group and 5.88 μg/mL (1.52-17.81) in the topical-oral group. Mean aqueous levels in inflamed eyes were 7.36 μg/mL (2.34-17.15) in the topical group and 14.43 μg/mL (2.18-18.66) in the topical-oral group. Mean vitreous levels in control eyes were 0.77 μg/mL (0.09-1.93) in the topical group and 1.01 μg/mL (0.49-1.57) in the topical-oral group. Mean vitreous levels in inflamed eyes were 0.95 μg/mL (0.18-1.27) in the topical group and 1.98 μg/mL (0.51-3.34) in the topical-oral group. There was no significant difference among the groups (P > 0.05). Mean aqueous levels in all eyes and mean vitreous levels in the combined topical and oral group of inflamed eyes were above the 90% minimum inhibitory concentration for most of the common microorganisms causing endophthalmitis. Conclusion: There is an increase in both aqueous and vitreous humor concentrations with inflammation and with oral and topical administrations, as opposed to topical only, of ciprofloxacin. Using oral as well as topical treatment may be a beneficial method of antibiotic prophylaxis in ocular trauma once a patient has received intravenous or intravitreal therapy.
Effect of propolis on endotoxin-induced uveitis in rabbits
(1999) Öztürk F.; Kurt E.; I.nan U.U.; Emiroǧlu L.; I.lker S.S.; Sobaci G.
Purpose: To test the anti-inflammatory effect of propolis, a natural bee-produced compound, and compare it with corticosteroids for the treatment of endotoxin-induced uveitis (EIU).Methods: EIU was produced in all rabbits by unilateral intravitreal injection of 2,000 ng Salmonella typhimurium endotoxin. The animals were then divided randomly into three groups as follows: group A received no treatment (control); group B received methylprednisolone (5 mg/0.1 mL) (positive control); and group C received propolis (5 mg/0.16 mL) by anterior sub-Tenon injection at the time of uveitis induction and at 4 and 8 hours after induction. Inflammation was evaluated by clinical manifestations and by measuring the protein concentration and inflammatory cell content of the aqueous humor.Results: The clinical grade, cell count, and protein levels in the aqueous humor were: control group (6.0 ± 0.8, 2,519 ± 470 cells/μL, 32.9 ± 2.4 mg/mL); methylprednisolone group (1.8 ± 0.7, 572 ± 137 cells/μL, 15.2 ± 1.8 mg/mL); and propolis group (2.3 ± 0.5, 503 ± 124 cells/μL, 13.8 ± 1.5 mg/mL). Statistically significant differences were recorded in the treatment groups when compared to the control group (P < .001). The effects of methylprednisolone and propolis on EIU were similar (P > .05).Conclusions: Propolis showed significant anti-inflammatory effects on EIU in rabbits. The mechanism of its action warrants further investigation. Copyright (C) 1999 Japanese Ophthalmological Society.
Chiasmal decussation in tilted disc syndrome PVER in tilted disc
(Swets en Zeitlinger B.V., 1999) Öztürk F.; Kurt E.; Yoldaş T.; Ilker S.S.; Inan Ü.Ü.
The tilted disc syndrome is a benign congenital abnormality of the optic nerve head. Since it can be confused with papilledema and chiasmal lesions, differential diagnosis is important. The tilting anomaly may be associated with other abnormalities along the optic nerve. Visual field defects may be similar to those in chiasmal lesions. In order to determine whether the normal crossover of nerve fibers at the chiasm is altered, the crossed and the uncrossed fibers were investigated using the pattern visual evoked responses (PVER) test. Thirty-four eyes of 17 patients diagnosed with tilted disc syndrome were evaluated for refraction, keratometry, color vision with Ishihara, visual field, and PVER. The presence of abnormal nerve fiber decussation was determined by recording PVER from the electrodes mounted on the scalp of both hemispheres. The amplitude and latency differences between the 'crossed' and 'uncrossed' fibers were not statistically significant (p>0.05). As a result, the tilting abnormality of papilla was found to be without chiasmal abnormal decussation.
The efficacy of 2.5% phenylephrine and flurbiprofen combined in inducing and maintaining pupillary dilatation during cataract surgery
(Wichtig Editore s.r.l., 2000) Öztürk F.; Kurt E.; Inan Ü.Ü.; Ilker S.S.
PURPOSE. To evaluate the effectiveness of phenylephrine 2.5% and flurbiprofen 0.03% combined in inducing and maintaining mydriasis during extracapsular cataract extraction (ECCE). METHODS. One hundred patients undergoing ECCE + intraocular lens (IOL) implantation were randomly divided into four groups. The first group was given phenylphrine 10%, the second group phenylephrine 10% + flurbiprofen, the third group phenylephrine 2.5% and fourth group phenylephrine 2.5% + flurbiprofen. Cyclopentolate 1% was used in all patients. Phenylephrine and cyclopentolate were instilled preoperatively four times during 1 hour and flurbiprofen was given four times the day before surgery and twice with an hour's interval before operation. Pre-operative and post-cortex aspiration horizontal pupil diameters were measured with callipers viewed through the operating microscope. RESULTS. Pupil diameters in pre-operative and post-cortex aspiration were no different in the 2.5% and 10% phenylephrine groups (p>0.05). Both diameters were larger and pupillary constriction was smaller in the flurbiprofen groups (p<0.05). CONCLUSIONS. 2.5% phenylephrine was as effective as 10% phenylephrine, with and without flurbiprofen, in inducing and maintaining pupil dilatation during ECCE surgery.
The effect of propolis extract in experimental chemical corneal injury
(S. Karger AG, 2000) Öztürk F.; Kurt E.; Çerçi M.; Emiroǧlu L.; Inan U.; Türker M.; Ilker S.
Purpose: To investigate the effect of propolis, a natural resin produced by honeybees, in the treatment of alkali-injured rabbit eyes. Method: A corneal alkali burn was induced by applying filter paper immersed in 1 N NaOH on the central axis of the right corneas of 24 rabbits for 30 s. The animals were divided into three treatment groups: group 1 (control) was given 0.3% tobramycin and phosphate-buffered solution; group 2 was treated with antibiotic coverage and topical 1% ethanolic extract of propolis; group 3 received antibiotic coverage and topical 1% dexamethasone. The dexamethasone-treated group was maintained as the positive control. Drugs were instilled 4 times a day for 7 days. The corneal inflammation was evaluated by calculating the average inflammatory index obtained from clinical observation of the ciliary hyperemia, central and peripheral corneal edema at 24 h, 48 h, on day 5 and day 7, before sacrificing the animals. Then, the corneas underwent routine histological examination. Results: The effects of dexamethasone and propolis on healing of injured corneas were similar (p > 0.05) and significantly better than controls at 24 h (p < 0.01, p < 0.05, respectively), and on day 7 (p < 0.05) with respect to the inflammatory index. On histological observation, inflammatory cell infiltration was lower as compared to control in both the dexamethasone and propolis groups (p < 0.001) and similar with each other (p > 0.05). Conclusions: Our study shows that propolis has an anti-inflammatory effect comparable to dexamethasone in chemical corneal injury. Copyright (C) 2000 S. Karger AG, Basel.
The effects of prolonged acute use and inflammation on the ocular penetration of topical ciprofloxacin
(2000) Öztürk F.; Kurt E.; Inan Ü.Ü.; Kortunay S.; Ilker S.S.; Başci N.E.; Bozkurt A.
Purpose: To study the aqueous and vitreous penetration of ciprofloxacin after prolonged acute topical administration and to investigate the effects of inflammation on drug penetration. Methods: A standardized model of intraocular infection after penetrating injury was made in the right eyes of eight rabbits. The intact left eyes were maintained as the control. Two drops of ciprofloxacin 0.3% eyedrops were instilled topically every 1 h for 7 h to all eyes of the rabbits. Aqueous and vitreous samples (100 μl) were obtained half an hour after the last drop. Instillation was continued for 7 h more and samples were obtained as before. Drug concentrations were measured using HPLC. Results: The mean aqueous humor levels of ciprofloxacin were: in control eyes 1.31 ± 0.78 μg/ml after 7 h and 1.85 ± 1.69 μg/ml after 14 h of instillation; in inflamed eyes 2.18 ± 1.02 μg/ml after 7 h and 2.91 ± 2.12 μg/ml after 14 h. The mean vitreous humor levels were: in control eyes 0.65 ± 0.44 μg/ml after 7 h and 0.72 ± 0.8 μg/ml after 14 h of instillation; in inflamed eyes 0.67 ± 0.77 μg/ml after 7 h and 1.01 ± 0.43 μg/ml after 14 h. However, the differences among the groups were not significant (P > 0.05). Conclusions: Ciprofloxacin penetration into aqueous humor was higher in 14-h topical application than that for 7 h. Inflammation increased the penetration of topical ciprofloxacin into aqueous while administered for 7 h and into both aqueous and vitreous humor while administered for 14 h. (C) 2000 Elsevier Science B.V.
Endoscopic dacryocystorhinostomy without stents
(2000) Ünlü H.H.; Öztürk F.; Mutlu C.; Ilker S.S.; Tarhan S.
Objective: The aim of this study is to present our endoscopic DCR operation method without the use of silicone tubing and our results on the patients suffering from chronic epiphora with postsaccal stenosis. Methods: Endoscopic dacryocystorhinostomy operations were performed to 21 sides of 18 patients who had chronic epiphora. No silicone tubing was used in any of the cases. In the postoperative healing period, the rhinostomy opening was maintained with frequent removal of nasal debris and using eyedrops. The patients were evaluated by fluoresceine test and endoscopic controls. Results: Symptomatic improvement was achieved in 19 out of 21 sides of the patients (90.5%) and the results were confirmed by the fluoresceine test under endoscopic control. Conclusion: Our results of 21 sides of 18 cases underwent primary DCR without stents are as successful as those reported in the literature and the technique seems to be promising. Copyright (C) 2000 Elsevier Science Ireland Ltd.
Penetration of topical and oral ofloxacin into the aqueous and vitreous humor of inflamed rabbit eyes
(2000) Öztürk F.; Kurt E.; Inan Ü.Ü.; Kortunay S.; Ilker S.S.; Başci N.E.; Bozkurt A.
Purpose: This study aimed to investigate the penetration of topical and oral ofloxacin into aqueous humor and vitreous humor in post-traumatic endophthalmitis model in rabbits. Methods: A standardized intraocular infection after penetrating injury was made in the right eyes of 16 rabbits. Intraocular infection was induced by intravitreal injection of a suspension of Staphylococcus aureus. The intact left eyes were maintained as controls. The animals were divided randomly into two groups. (1) In the topical group, two drops of ofloxacin 0.3% eyedrops were instilled to both eyes every 30 min for 4 h. (2) In the topical-oral group, two doses of 25 mg/kg of ofloxacin at 12-h intervals were given orally, then the protocol of the first group was applied. Aqueous and vitreous humor samples were taken 30 min after the last drop. Ofloxacin concentrations were measured by using HPLC. Results: Mean aqueous levels of ofloxacin in control eyes were: 3.25 ± 2.55 μg/ml in topical group, 4.58 ± 5.39 μg/ml in topical-oral group. Mean aqueous levels in inflamed eyes were: 5.21 ± 4.55 μg/ml in topical group, 10.34 ± 8.88 μg/ml in topical-oral group. Mean vitreous levels of ofloxacin in control eyes were: 0.17 ± 0.07 μg/ml in topical group, 1.30 ± 1.23 μg/ml in topical-oral group. Mean vitreous levels in inflamed eyes were: 0.35 ± 0.22 μg/ml in topical group, 3.48 ± 2.69 μg/ml in topical-oral group. There was no significant difference among the groups (P > 0.05), however. Conclusions: The result of this study suggests that oral supplementation of ofloxacin to topical instillation increased the ocular levels of ofloxacin in the post-traumatic endophthalmitis model. Mean drug concentrations in aqueous and vitreous humors were above the 90% minimum inhibitory concentrations (MIC90) for most of the common microorganisms causing endophthalmitis in all eyes, except in the vitreous humors of the intact eyes instilled topically. (C) 2000 Elsevier Science B.V.
Antineovascular effect of α-interferon on corneal neovascularization in rats
(2001) Öztürk F.; Sobaci G.; Sami Ilker S.; Can C.
Clinical and histologic effects of topical recombinant α-interferon (IFN), systemic IFN, topical dexamethasone, and dexamethasone plus topical IFN on corneal neovascularization in response to silver nitrate cauterization were investigated in 110 eyes of 60 Wistar rats. The eyes were evaluated according to the burn stimulus, neovascularization, and histologic inflammation grades 5 days after cauterization. Antineovascular effects of topical and systemic IFN were significantly greater than a placebo but less than dexamethasone alone or in combination with IFN.
Prevention of posterior capsule opacification by intraoperative single-dose pharmacologic agents
(Elsevier Inc., 2001) Inan Ü.Ü.; Öztürk F.; Kaynak S.; Kurt E.; Emiroǧlu L.; Özer E.; Ilker S.S.; Güler C.
Purpose: To determine whether an intraoperative single dose of dexamethasone, diclofenac, ethylenediaminetetraacetic acid (EDTA), a combination of EDTA and RGD peptide (arginine-glycin-aspartic acid sequence), or mitomycin-C (MMC) is a pharmacological means of preventing or reducing the development of posterior capsule opacification (PCO). Setting: Department of Ophthalmology, Celal Bayar University, School of Medicine, Manisa, and Department of Pathology, Dokur Eylül University, School of Medicine, izmir, Turkey. Methods: Fifty-four rabbits were randomly divided into 6 groups. Dexamethasone (4 mg/cc), diclofenac (2.5 mg/cc), EDTA (8 mg/cc), a combination of EDTA and RGD peptide (2.5 mg/cc), or MMC (0.04 mg/cc) was given, 0.1 cc by hydrodissection and 0.9 cc into the capsular bag after phacoemulsification. The sixth group served as a control group. After 3 months, the PCO was graded clinically and the proliferation of lens epithelial cells (LECs) was evaluated histologically. Results: The drugs were significantly effective in preventing PCO compared with the control (P < .005). Dexamethasone had a weaker effect than the other drugs. In histological analysis, although monolayer LECs in the dexamethasone and diclofenac groups were observed, there was no proliferative activity on the posterior capsules in the EDTA, EDTA+RGD, and MMC groups in contrast to the multilayer cells in the control. Conclusions: Intraoperative single-dose application of EDTA, EDTA+ RGD peptide combination, and MMC significantly prevented the development of PCO in rabbit eyes. Diclofenac was less effective but also reduced PCO. Although dexamethasone did not prevent the proliferation of LECs, it decreased PCO clinically. © 2001 ASCRS and ESCRS.
Prevention of posterior capsule opacification by retinoic acid and mitomycin
(2001) Inan U.U.; Öztürk F.; Kaynak S.; Ilker S.S.; Özer E.; Güler C.
Background: Our aim was to evaluate the effect of an intraoperative single dose of retinoic acid (RA) or mitomycin C (MMC) in preventing posterior capsule opacification (PCO). Methods: Twenty-seven rabbits were divided randomly into three groups. RA (250 μg/ml) and MMC (0.04 mg/ml) were given 0.1 ml by hydrosection and 0.9 ml into the capsular bag after phacoemulsification. The third group served as a control group. Three months after intervention PCO was graded clinically. Furthermore, proliferation of lens epithelial cells was evaluated histologically. Results: Two eyes developed corneal edema in the MMC group. On clinical assessment, RA and MMC were significantly effective in preventing PCO compared with controls (P<0.005). On histological analysis, there was significantly reduced proliferative activity on posterior capsules in the treatment groups, in contrast to multi-layer cells in the control group. Conclusion: Intraoperative single-dose administration of RA and MMC significantly prevented the development of PCO in rabbit eyes. The optimal biocompatible dosage must be carefully determined by further investigation.
Familial pathologic myopia, corneal dystrophy, and deafness: A new syndrome
(2001) Kurt E.; Günen A.; Sadkolu Y.; Öztürk F.; Tarhan S.; Sar R.A.; Fstk T.; Ar Z.
Background: Numerous syndromes with myopia and hearing loss have been described up to now. We present a family with pathologic myopia, corneal dystrophy, and deafness distinct from these syndromes. Cases: Ten patients in the same Turkish family were evaluated by ophthalmologic, audiologic, physical, radiologic, genetic, serologic, and biochemical examinations. Observations: Ophthalmic examination indicated that all the cases had myopia, 7 of them had pathologic myopia, 1 had intermediate, and 2 had mild. Four of the patients with pathologic myopia had corneal dystrophy that was bilaterally manifest as white opacities in the posterior stroma near Descemet's membrane in an axial distribution; 1 of these 4 patients also had a tilted disc. Otolaryngologic examination revealed conductive hearing loss in 3 cases, mixed hearing loss in 2, and sensorineural hearing loss in 1. The results of karyotypic analyses of all cases were normal. The pedigree analysis showed the disease was inherited through successive generations as an autosomal dominant trait. The results of biochemical, serologic, and radiologic investigations were normal. The same pathophysiologic process in all cases seemed to account for the myopia, the corneal dystrophy and the deafness. Conclusions: To our knowledge, this type of case has not been reported in the literature. Therefore, we named this syndrome "familial pathologic myopia, corneal dystrophy and deafness." © 2001 Japanese Ophthalmological Society.
Relationship of retinopathy and hearing loss in type 2 diabetes mellitus
(2002) Kurt E.; Öztürk F.; Günen A.; Sadikoglu Y.; Sari R.A.; Yoldas T.K.; Avsar A.; Inan Ü.Ü.
This study investigated whether the degree of diabetic retinopathy correlates with degree of sensorineural hearing loss. Seventy-five diabetic patients and 45 sex- and age-matched healthy controls were evaluated audiologically. Patients were classified into groups by severity of retinopathy: group 1 (n=28), no retinopathy, group 2 (n=4), background retinopathy; and group 3 (n=23), proliferative or end-stage retinopathy. Diabetics had a statistically significant difference at all frequencies of hearing loss, as compared with controls.

Browsing by Author "Öztürk F."

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