Browsing by Author "Öztürkcan S."

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    Pedunculated lipofibroma
    (Japanese Dermatological Association, 2000) Öztürkcan S.; Terzioǧlu A.; Akyol M.; Altinor S.; Yildiz E.
    Pedunculated lipofibroma is a relatively rare form of nevus lipomatosus superficialis. The lesions are large, slow growing, pedunculated tumors. Histologically, groups and strands of fat cells are found embedded among the collagen bundles of the dermis. We presented a woman diagnosed with a pedunculated lipofibroma clinically and histopathologically.
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    Blue naevus with satellitosis mimicking malignant melanoma
    (2001) Sahin M.T.; Demir M.A.; Yoleri L.; Can M.; Öztürkcan S.
    Blue naevus is an acquired benign melanocytic naevus. It is a firm, sharply defined dark blue to grey-black papule or nodule, which is likely to arise from the arrested dermal melanocytes in the dermis. In the last few years, blue naevus has attracted much attention due to the recognition of new entities and to its confusion with malignant melanoma. We report a 69-year-old man who developed a blue-black nodular lesion with satellitosis on his scalp. Although clinically it was thought to be a malignant melanoma, histopathological investigation and conservative methods such as dermatoscopy and power Doppler ultrasonography did not confirm this diagnosis. Histopathological examination excluded malignant melanoma, as there were no cellular atypia and mitotic activity in either the nodular lesion or the satellitosis. Doppler ultrasonography confirmed the benign nature of the lesion. Dermatoscopic examination showed homogeneous steel-blue pigmentation with individual blue globules, dots and some brown veils, and confirmed the histopathological diagnosis. To the best of our knowledge, our case is the third reported case of a blue naevus with satellitosis mimicking malignant melanoma.
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    Wolf's isotopic response: A case of zosteriform lichen planus
    (Japanese Dermatological Association, 2002) Türel A.; Öztürkcan S.; Sahin M.T.; Türkdogan P.
    Lichen planus is a lichenoid disorder characterized by shiny, flat papules. In addition to the classical appearance, there are several variants. Zonal or zosteriform lesions have been described. A 25-year-old male with a complaint of increasing numbers of erythematous swellings on his left groin for twenty days was admitted to our out-patient clinic. He had a history of herpes zoster in the same localization which had been treated with topical acyclovir two weeks prior to his admission. Dermatological examination revealed multiple, shiny, erythematous, umblicated papules localized to the left inguinal region in a linear pattern. A biopsy was taken from the lesions. According to the clinical and pathological findings the diagnosis was zosteriform lichen planus. Zosteriform lichen planus is a rare variant of lichen planus; its differentiation from zona zoster and other linear dermatoses is difficult. We presented our case because of its rarity as a variant of lichen planus and its appearance in the area of healed herpes zoster as an isotopic response.
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    Linear porokeratosis. A case report
    (Dermatologia Pediatrica, 2002) Sahin M.T.; Öztürkcan S.; Türel A.; Kandiloglu A.R.
    Linear porokeratosis (LP) is a rare variant of porokeratosis of Mibelli. It is a disorder of keratinization, which consists of atrophic lesions with a raised horny margin. The cause is quite unknown. No definite inheritance pattern has been established. Among the five clinical forms of porokeratosis of Mibelli (PM), LP represents the segmental form, in which porokeratotic lesions are arranged in a linear fashion, usually corresponding to a dermatome or Blaschko's lines. The condition is strictly unilateral and onset is usually in infancy and childhood. There is slight risk of malignant transformation. We report a 16-year-old girl with a 14-year history of typical lesions in a linear arrangement on the dorsal aspect of her right leg, which were diagnosed as linear porokeratosis based on the clinical and histopathological features.
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    Malignant eccrine poroma in an unusual location
    (2002) Sahlin M.T.; Türel A.; Gündüz K.; Kandiloglu A.R.; Öztürkcan S.
    Malignant eccrine poroma is a rare skin appendage tumour, originating from the intraepidermal and upper dermal eccrine ducts. The tumour either arises spontaneously or develops in a long-standing eccrine poroma, generally in elderly people over 60. Clinically, it tends to be a localized lesion, which manifests itself as a nodule or ulcerated tumour, favouring extremities. We report an 83-year-old female with an enlarging and bleeding tumour on her lumbosacral region. This lesion first appeared as a small pigmented papule and progressed to an erythematous patch with central papular portion and some peripheral pigmentation, Histopathology revealed malignant eccrine poroma. Also, immunohistochemically, diffuse and intense p53 staining was observed. Regular pigment pattern, brown globules and black dots were seen in dermoscopic examination. After performing a wide excision, 20 months of follow-up revealed no recurrence or metastasis of the tumour. This case represents an unusually located malignant eccrine poroma with some pigmentation.
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    Case report. Tinea pedis and onychomycosis in primary school children in Turkey
    (2002) Inanir I.; Şahin M.T.; Gündüz K.; Dinç G.; Türel A.; Arisoy A.; Öztürkcan S.
    A cross-sectional study was performed in two primary schools with different socioeconomic status in the suburban and central areas of Manisa, Turkey, in order to determine the prevalence of tinea pedis and onychomycosis. A full dermatological examination and a questionnaire on socioeconomic conditions were performed in a group of 785 randomly selected children aged 6-14. Of 9 clinically suspected tinea pedis and 4 onychomycoses cases, KOH examination (direct microscopy) and/or mycological cultures were positive in six boys, in whom Candida glabrata and C. tropicalis grew. Older age and higher number of siblings were found to be significant factors for fungal infection.
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    The effects of colchicine on neutrophil function in subjects with recurrent aphthous stomatitis [1]
    (2003) Altinor S.; Öztürkcan S.; Hah M.M.
    [No abstract available]
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    Inguinal keratotic basal cell carcinoma mimicking giant solitary trichoepithelioma
    (Japanese Dermatological Association, 2003) Şahin M.T.; Demir M.A.; Kaya Y.; Can M.; Inanir I.; Öztürkcan S.
    Keratotic basal cell carcinoma may not only clinically but also histologically share more or less the same features with giant solitary trichoepithelioma. It can be difficult to distinguish these two entities from each other, even for an experienced dermatopathologist. We present an unusual case of inguinal keratotic basal cell carcinoma mimicking giant solitary trichoepithelioma in a 56-year-old woman with a finger-like tumor of 20 years duration. The patient presented with an asymptomatic, skin colored, firm, nonulcerative, nodular lesion. Scanty mitotic activity and apoptotic cells were the histopathologic findings against basal cell carcinoma, whereas absence of papillary mesenchymal bodies, presence of peritumoral lacunae detected only around the solid areas, and accumulation of amyloid-like hyalinized material were the findings in favor of basal cell carcinoma. This case illustrates that keratotic basal cell carcinoma must be taken into account in the differential diagnosis of inguinally located solitary, polypoid masses, especially giant solitary trichoepithelioma.
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    Acrodermatitis continua of Hallopeau: Was it an outcome of a surgical trauma or initially misdiagnosed as onychomycosis? [8]
    (2003) Şahin M.T.; Öztürkcan S.; Türel A.; Kandiloǧlu A.R.
    [No abstract available]
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    A rare side-effect of systemic isotretinoin treatment: Pyogenic granuloma [6]
    (2003) Türel A.; Öztürkcan S.; Şahin M.T.; Türkdoǧan P.
    [No abstract available]
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    Coexistence of basalioma, Bowen's disease and porokeratosis of Mibelli; [Ayni olguda bazalyoma, Bowen hastaliǧi ve porokeratozis Mibelli birlikteliǧi]
    (2003) Şahin M.T.; Türkdoǧan P.; Öztürkcan S.; Türel A.
    Basal cell carcinomas (BCCs) usually appear as solitary lesions, with or without having definite causes such as long term solar exposure, overtreatment with X-ray irradiation, skin types 1 or 2, and burn or wound eschars. Bowen's disease (BD), which usually appears as a permanent, progressive, flat, erythematous and squamous plaque, is a squamous carcinoma in situ. Solar exposure is the most important etiologic agent. The development of lesions, involving other than sun-exposed areas is favoured by chronic arsenic intake related to occupation or treatment. Porokeratosis of Mibelli (PM) is a rare disorder of keratinization, which developes in a long period of time, starting in childhood. There is risk of the development of squamous cell carcinoma (SCC) and/or BCC on the atrophic lesions of PM. We report a 64-year-old farmer who has developed coexisting BCC, BD and PM. In this article, we discussed etiologic, clinical and histopathologic aspects of these premalignant and malignant dermatoses, together with the importance of prevention from the harmful effects of the solar radiation.
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    Efficiency of benzoyl peroxide-erythromycin gel in comparison with metronidazole gel in the treatment of acne rosacea
    (Japanese Dermatological Association, 2004) Öztürkcan S.; Ermertcan A.T.; Şahin M.T.; Afşar F.Ş.
    Oral wide-spectrum antibiotics are the linchpin of rosacea treatment. Oral and topical metronidazole, topical tretinoin, and topical benzoyl peroxide may also be used in the treatment of rosacea. We aimed to show that benzoyl peroxide-erythromycin gel is efficient in the treatment of acne rosacea. Fifty-six patients with acne rosacea were enrolled in our study. We administered benzoyl peroxide-erythromycin gel to 27 patients and metronidazole gel to 29 patients. In all the patients, the intensities of erythema, telangiectasia, papules/pustules, and nodules were evaluated before, during and after the treatment. The positivity of Demodex folliculorum from skin scratches was compared between the two groups at each visit. At the end of the therapy on the third examination, in the benzoyl peroxide-erythromycin group, 91.7% of the patients showed marked clinical improvement, and 8.3% of them showed complete remission. In the metronidazole group, 73.3% showed marked clinical improvement, and 26.7% of them showed complete remission. Clinical improvement in the papular component was 65.2% for the benzoyl peroxide-erythromycin group, and 81.5% for metronidazole group. In the first examination, the clinical results of the agents were similar. Although both of the drugs were found to be effective in the second and third examinations, metronidazole gel was more effective than benzoyl peroxide-erythromycin. Both of the drugs were found to be significantly effective especially in treating the papular component of rosacea. Demodex folliculorum was found to be positive in 74.1% of the benzoyl peroxide-erythromycin group and in 62.1% of the metronidazole group at the beginning. In the benzoyl peroxide-erythromycin group, 40.7% of Demodex folliculorum positive patients, became negative by the first examination. This was 17.2% for the metronidazole group. In the benzoyl peroxide-erythromycin group, among the patients who were positive for Demodex folliculorum in the first examination, 37.5% of them became negative. This was 36.7% for the metronidazole group. Benzoyl peroxide-erythromycin gel was superior to metronidazole gel in decreasing Demodex folliculorum by the first examination, but the effect of the two drugs on Demodex folliculorum was similar by the second examination. As a result, topically applied combined benzoyl peroxide-erythromycin gel may be an alternative choice of treatment for acne rosacea.
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    Bullous pemphigoid associated with prostate adenocarcinoma
    (2004) Öztürkcan S.; Ermertcan A.T.; Şahin M.T.; Türkdoǧan P.; Inanir I.; Lekili M.
    Bullous pemphigoid is a common autoimmune skin disease characterized by the presence of subepidermal blisters. It has been associated with underlying neoplasia in isolated reports. A 78-year-old man with generalized blisters was diagnosed as bullous pemphigoid on clinical, histopathological and direct immunofluorescence grounds. His free and total prostate specific antigen (PSA) levels were high and histopathological examination of a prostate specimen revealed prostate adenocarcinoma. We present this rare case to discuss the possible association between bullous pemphigoid and prostate adenocarcinoma.
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    Inappropriate treatments at beauty centers: A case report of burns caused by hot wax stripping [2]
    (Japanese Dermatological Association, 2004) Türel-Ermertcan A.; Şahin M.T.; Yurtman D.; Kapulu N.; Öztürkcan S.
    [No abstract available]
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    A comparison of dermoscopic features among lentigo senilis/initial seborrheic keratosis, seborrheic keratosis, lentigo maligna and lentigo maligna melanoma on the face
    (Japanese Dermatological Association, 2004) Şahin M.T.; Öztürkcan S.; Ermertcan A.T.; Güneş A.T.
    Clinical differentiation of facial lentigo senilis/initial seborrheic keratosis (LS/ISK), seborrheic keratosis (SK), lentigo maligna (LM), and lentigo maligna melanoma (LMM) can be difficult. Dermoscopy improves the diagnoses in pigmented skin lesions (PSLs), but it is not helpful for the sun-exposed face because of the flat rete ridges without network-derived features. Therefore, development of new diagnostic criteria for this particular localization is a current issue of dermatology. In this retrospective study, dermoscopic slides of facial pigmented skin lesions of 66 patients referred to two clinics in Turkey were evaluated. Our aim was to determine the reliability of dermoscopy in the differentiation of these entities. The facial PSLs of 66 patients (34 males and 32 females) (median age: 58.2) were photographed with a Dermaphot (Heine, Hersching, Germany) over a five year period from November of 1995 to May of 2000. All of the dermoscopic slides were analysed according to 27 dermoscopic criteria developed by Schiffner et al. This data set contained 22 histologically proven malignant (14 LM, 8 early LMM) and 44 benign (18 SK, 26 LS/ISK) PSLs. In general, asymmetric pigmented follicular openings, dark streaks, slate-gray streaks, dark globules, slate-gray globules, dark dots, dark rhomboidal structures, light brown rhomboidal structures, dark homogeneous areas and dark pseudonetworks were statistically significant for malignant growth. On the other hand, milia-like cysts, pseudo-follicular openings, cerebriform structures, light brown globules, light brown dots, light brown homogeneous areas, yellow opaque homogeneous areas, and light brown pseudonetworks were statistically significant for benign growth. This research emphasizes that dermoscopic features on the face differ from criteria used in other locations of the body. Analysis of the data suggests that dermoscopy can be used in the differentiation of LS/ISK, SK, LM and LMM from each other.
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    Ectodermal dysplasia showing clinical overlap between AEC, Rapp-Hodgkin and CHAND syndromes
    (2004) Sahin M.T.; Türel-Ermertcan A.; Chan I.; McGrath J.A.; Öztürkcan S.
    The ectodermal dysplasias represent a complex collection of congenital abnormalities of skin, hair, teeth, nail, and sweat gland development, many of which have overlapping clinical features. In this report, we describe a 7-year-old girl, born to clinically normal parents, with ankyloblepharon, cleft lip/palate and hair abnormalities, features resembling the autosomal dominant disorder, ankyloblepharon-ectodermal dysplasia-clefting (AEC) syndrome, which results from mutations in the sterile-alpha motif domain of the gene encoding the transcription factor, p63. However, direct sequencing of the p63 gene in this individual did not reveal any pathogenic sequence variants. Moreover, two of her paternal cousins were discovered to have similar congenital ectodermal anomalies, raising the alternative possibility of an autosomal recessive pattern of inheritance. Furthermore, all affected individuals lacked a history of erosive scalp dermatitis that is usually characteristic of AEC syndrome. Instead, the scalp hair was coarse and wiry. In addition, another atypical feature, hypohidrosis, was present. Collectively, the clinical features also resembled Rapp-Hodgkin syndrome, Bowen-Armstrong syndrome and CHAND syndrome, but did not appear to fit neatly with any one particular disorder. This case highlights the difficulties in trying to classify the ectodermal dysplasia syndromes on clinical features alone.
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    Transient eruptive seborrhoeic keratoses associated with erythrodermic pityriasis rubra pilaris [8]
    (2004) Sahin M.T.; Öztürkcan S.; Ermertcan A.T.; Saçar T.; Türkdogan P.
    [No abstract available]
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    A case of traumatic ulceration mimicking spinocellular carcinoma; [Spinosellüler karsinomu taklit eden skalp yerleşimli bir travmatik ülser]
    (Turkiye Klinikleri, 2005) Şahin M.T.; Türel Ermertcan A.; Öztürkcan S.; Türkdoǧan P.
    In this article, it was aimed to show that ulcerations can develop not only following circulatory insufficiency, localized pressure, granulomatous degeneration, malignant tumors and local injections, but following exogenous traumas to skin as well. We present a 65-year-old male with a history of ulcer development on his nape following a cranial trauma 6 weeks before. A biopsy was taken to differentiate it from squamous cell carcinoma. Histopathologic examination revealed no tumor cell areas. Bacteriologic culture from ulcer floor revealed enterobacter. By enacting a combined systemic therapy with ciprofloxacin and gentamycin in addition to topical antiseptic therapy, the ulcer underwent complete remission in 15 days. This case is presented not only to draw attention to the possible clinical similarities between traumatic ulceration and squamous cell carcinoma, but also to emphasize the importance of differential diagnosis in the proper treatment of ulcers. Copyright © 2005 by Türkiye Klinikleri.
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    Sunscreen use and sun protection practices in students and personnel of Celal Bayar University
    (2005) Ermertcan A.T.; Öztürkcan S.; Dinç G.; Yurtman D.; Pala T.; Şahin M.T.
    Background/Purpose: The steady increase in the incidence of melanoma, non-melanoma cutaneous neoplasia and preneoplastic disorders has contributed to the demand for more effective protection from the sun. In this study, we aimed to determine the prevalence of sunscreen use and other sun protection behaviors in a large sample of students and personnel of Celal Bayar University, Manisa, Turkey. Methods: The study group included 1018 participants of whom 607 work in the Celal Bayar University Hospital and 411 are students from the Medical Faculty and School for Health Professionals. All participants completed a questionnaire composed of 45 items about sun protection and other health behaviors, such as sports activity, use of cigarettes, alcohol and seat-belts. Sun protection factor (SPF) of sunscreen, avoiding sun exposure during peak hours, wearing clothing, a hat and sunglasses were studied. Results: Of the 1018, 403 participants were male and 615 were female. While avoiding sun exposure during peak hours was the most popular preventive behavior for men (42.5%), wearing sunglasses was the most popular one for women (50.7%). Avoiding exposure was the second preventive behavior for women (42.1%). Use of sunscreen with SPF 15+ was the second popular protective measure for men (19.4%) and the third one for women (39.2%). There were no significant relationships between sun protection behaviors and obesity, use of cigarettes and alcohol. We also investigated behavioral changes with sunburn experience in the participants who had sunburn history. Among these behavioral changes, increased use of sunscreen and decreased sun exposure during peak hours with sunburn experience were significant. Conclusion: Our study demonstrated that the risk of sun exposure is largely unrecognized in Manisa, Turkey, and we have very incomplete information about protective measures. An efficient policy of education on the effective use of sun protection methods should be developed to prevent skin cancer. Copyright © Blackwell Munksgaard 2005.
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    Pilomatricoma: A late onset case in the neck
    (2005) Türel A.; Öztürkcan S.; Şahin M.T.; Güçlü G.; Türkdoǧan P.
    [No abstract available]