Browsing by Author "Özturk, F"

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    Efficacy of topical lodoxamide vs sodium cromoglycate and dexamethasone in rabbits with passive allergic conjunctivitis
    Özturk, F; Güler, M; Ilker, SS; Sobaci, G
    A comparative study was conducted to evaluate the efficacy of lodoxamide tromethamine vs sodium cromoglycate and dexamethasone sodium phosphate in experimental allergic conjunctivitis in 45 rabbit eyes. The animals were randomly divided into 3 groups and treated with lodoxamide, cromoglycate, or dexamethasone. Blood-conjunctival permeability index and the weight of the conjunctiva were used to quantify the ocular inflammatory reaction. Lodoxamide was more effective than sodium cromoglycate but not dexamethasone in the treatment of acute allergic conjunctivitis.
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    The effects of acetylcholine and propolis extract on corneal epithelial wound healing in rats
    Özturk, F; Kurt, E; Inan, ÜÜ; Emiroglu, L; Ilker, SS
    Purpose. To investigate the effects of topical acetylcholine and topical administration of propolis, a natural beehive product, on corneal epithelial wound healing. Methods. The whole corneal epithelium was debrided in 42 eyes of 21 rats by mechanical scraping with a dulled scalpel blade. Animals were divided into three groups. Group 1 received topical 1% water extract of propolis (WEP), group 2 received topical acetylcholine (ACh), and group 3 (control group) received topical phosphate-buffered saline, 6 times a day for 3 days, starting immediately after debridemenl. The area of the corneal epithelial defect was stained with fluorescein, photographed, and then measured every 12 h. The mean epithelial defect area and the mean percentage of epithelial defect remaining at each follow-up were compared between the groups. Results. The mean epithelial defect area and the mean percentage of epithelial defect remaining at each time were significantly smaller (p < 0.001, p < 0.05, respectively) in the ACh and propoIis groups as compared with control groups. There was no statistically significant difference between the propolis or ACh groups at any lime (p > 0.05), At 72 h, the mean percentage of defect remaining was 2.58%, in the ACh group, 1.3% in the propolis-treated group, and 8.68% in the control group. Conclusions. This study demonstrated that ACh and propolis facilitated corneal epithelial wound healing of rats. Although the mechanisms of the effect of propolis on wound healing and its clinical use still remain to be determined, ACh may have a place in the treatment of corneal epithelial injuries.
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    Prevention of posterior capsule opacification by intraoperative single-dose pharmacologic agents
    Inan, ÜÜ; Özturk, F; Kaynak, S; Kurt, E; Emiroglu, L; Özer, E; Ilker, SS; Güler, C
    Purpose. To determine whether an intraoperative single dose of dexamethasone, diclofenac, ethylenediaminetetraacetic acid (EDTA), a combination of EDTA and RGD peptide (arginine-glycin-aspartic acid sequence), or mitomycin-C (MMC) is a pharmacological means of preventing or reducing the development of posterior capsule opacification (PCO). Setting. Department of Ophthalmology, Celal Bayar University, School of Medicine, Manisa, and Department of Pathology, Dokur Eylul University, School of Medicine, izmir, Turkey. Methods: Fifty-four rabbits were randomly divided into 6 groups. Dexamethasone (4 mg/cc), diclofenac (2.5 mg/cc), EDTA (8 mg/cc), a combination of EDTA and RGD peptide (2.5 mg/cc), or MMC (0.04 mg/cc) was given, 0.1 cc by hydrodissection and 0.9 cc into the capsular bag after phacoemulsification. The sixth group served as a control group. After 3 months, the PCO was graded clinically and the proliferation of lens epithelial cells (LECs) was evaluated histologically. Results: The drugs were significantly effective in preventing PCO compared with the control (P < .005). Dexamethasone had a weaker effect than the other drugs. In histological analysis, although monolayer LECs in the dexamethasone and diclofenac groups were observed, there was no proliferative activity on the posterior capsules in the EDTA, EDTA+RGD, and MMC groups in contrast to the multilayer cells in the control. Conclusions: Intraoperative single-dose application of EDTA, EDTA+RGD peptide combination, and MMC significantly prevented the development of PCO in rabbit eyes. Diclofenac was less effective but also reduced PCO. Although dexamethasone did not prevent the proliferation of LECs, it decreased PCO clinically. (C) 2001 ASCRS and ESCRS.