Browsing by Author "Özyurt, B"
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Item Evaluation of the effect of surgical treatment on quality of life with the Dermatology Life Quality Index in patients with facial nonmelanoma skin cancerÇetinarslan, T; Evrenos, MK; Bilaç, C; Özyurt, B; Ermertcan, ATSkin cancers are the most common type of cancer. Nonmelanoma skin cancers (NMSCs) are more common than melanoma. Although the mortality rate is low, cancer word can be frightening for patients. Surgery is the main treatment. As skin cancers are most commonly located on the face, undesirable cosmetic results can occur as a result of treatments or due to primary disease. Therefore, the quality of life of patients could be affected. To determine the effect of surgical treatment on quality of life of the patients with facial NMSC using the Dermatology Life Quality Index (DLQI) at baseline and 3 months after surgery. We aimed to see if there was any improvement in quality of life scores after surgery, and to identify factors affecting quality of life. A total of 255 patients; 174 basal cell carcinoma (BCC) (68.2%) and 81 squamous cell carcinoma (SCC) (31.8%) were included in our study. All participants completed DLQI at baseline and 3 months after surgery. The mean total DLQI scores were 6.37 +/- 6.28 in patients with BCC, and 6.35 +/- 6.16 in patients with SCC. The mean total DLQI scores were 3.96 +/- 5.14 in patients with BCC (P < .001), and 4.49 +/- 5.24 in patients with SCC (P < .001) 3 months after surgery. In patients with primary skin cancer, all subscale scores and total DLQI scores were worse than the recurrent skin cancer group in both BCC and SCC at baseline. According to the treatment modalities, total DLQI scores and all subscales were worse in the graft group in BCC and SCC patients at baseline. Interestingly, the sex and the type of skin cancer did not affect quality of life, but tumor localization ([auricula OR: 6.45 [95% CI: 1.28-37.47] and eyelid OR:0.20 [95% CI: 0.04-0.96]) treatment procedure ([flap procedure OR: 7.90 [95% CI: 2.64-23.62] and graft procedure OR: 5.47 [95% CI: 1.60-18.71]) and, primary tumor OR:3.86 (95% CI: 1.01-14.78) were significant. The quality of life of skin cancer patients was affected by tumor localization, treatment procedure, primary, or recurrent tumor. The quality of life showed a significant improvement in patients with facial NMSC after surgical treatment. However, the type of NMSC seems to have no effect on the quality of life.Item Carotid intima-media thickness in postmenopausal women is associated with an endometrial thickness greater than 5 mmEskicioglu, F; Eskicioglu, MS; Özdemir, AT; Özyurt, BAim: The aim of this study was to investigate the relationship between ultrasonographic carotid intima-media thickness (C-IMT) and visceral fat thickness (VFT) and an endometrial thickness (ET) of more than 5 mm in postmenopausal women. Methods: C-IMT, VFT, and ET measurements were performed in 63 postmenopausal women using ultrasonography. The relationships between ultrasonographic data and demographic data, anthropometric measurements, such as waist circumference, metabolic syndrome parameters, and insulin resistance were examined. Moreover, the role of VFT and C-IMT in predicting an ET of more than 5mm was investigated. Results: Only the C-IMT was higher in the ultrasonographic measurements of women with an ET >5 mm (p = 0.03). Insulin resistance was also significantly higher in these women (p = 0.03). ET showed a positive correlation with VFT and body mass index (BMI) (r = 0.286, p = 0.02 and r = 0.249, p = 0.04), and C-IMT showed a positive correlation with age, pregnancy, parity, and time since menopause (p<0.05). Multivariate analysis showed that high-C-IMT levels were associated with an ET >5 mm (p = 0.04). Conclusions: There was a positive correlation between the ultrasonographic measures of VFT and ET, and high-C-IMT levels were independently associated with an ET>5 mm. Thus, C-IMT may be a predictor of pathologic ET in the postmenopausal period.Item Correlation Between Intestinal Colony Numbers and Inflammation Markers (TNF-Alpha, IL-6, High-Sensitive CRP) Following the Use of Sevelamer in Rats with Kidney FailureKürsat, S; Çolak, H; Yilmaz, O; Kolatan, E; Ulman, C; Kurutepe, S; Özyurt, BObjective: Our aim was to investigate anti-inflammatory effect of sevelamer in experimentally induced renal failure (RF) and whether this effect was related to a decrease in Escherichia coli colony counts in feces. Material and Methods: Eighteen female Wistar albino rats weighted 200-250 g were divided into three groups. RF was induced by 5/6 nephrectomy. Group 1 was the control group. Group 2 rats were those with induced RF receiving a high phosphate diet. Group 3 contained rats with induced RF receiving a high phosphate diet + sevelamer. E.coli count in feces, plasma creatinine, high-sensitive C-reactive protein (hsCRP), interleukin 6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) concentrations were determined at the beginning and at the end of 1st, 3rd and 6th weeks in all rats. Results: In Group 2 and 3, creatinine concentrations were found to be increased (p=0.03, p=0.02) in the 1st week. In Group 2, there was an increase in number of E. coli colony count in the 3rd week (p=0.05). In group 3, E. coli colony count and levels of inflammatory markers (IL-6, CRP, TNF-alfa) significantly were increased in comparison to the basal :+alues (p=0.042, p=0.021, p=0.042, respectively) in the 1st week. In group 3, in the sixth week, E. coli colony count (p=0.02) and levels of inflammatory markers (IL-6, hsCRP, TNFalpha) (p<0.05) were found to be significantly decreased in comparison to the 1st week levels. Conclusion: Anti-inflammatory effects of sevelamer might be explained by its effects on the bacterial colonization in colon.Item Socioeconomic Status and Age at Menarche in TurkiyeErsoy, B; Hanedan, N; Özyurt, BObjectives: The trend in declining age at menarche (AAM) largely continues while body size increases globally. The aim was to investigate trends in AAM, menstrual characteristics, and post-menarcheal anthropometric parameters in adolescents living in an urban area in T & uuml;rkiye between 1999 and 2018. Methods: Female adolescent high school students in the Manisa region were asked about menarche and socioeconomic status (SES). There were 1017 girls in the first study (1999-2001) and 1304 (2016-2018) in the second study. Height and weight were measured. Body mass index (BMI) was calculated. Adolescent girls were grouped into three socioeconomic status (SES) groups based on parental education and occupation, and all parameters were evaluated using SES. Results: The mean +/- standard deviation for AAM in the first period was 12.82 +/- 1.07 years and 12.83 +/- 0.9 years in the second. AAM did not differ between the two periods nor between SES groups in either period. Post-menarcheal height, weight, and BMI increased in the second period compared to the first study and across all SES groups (p < 0.05). The whole group AAM was similar in both periods, only 3 months earlier in the second period than in the first period. However, the AAM in girls with a post-menarcheal BMI indicating being overweight or obese was significantly earlier than that of those with a normal post-menarcheal BMI in both periods (p < 0.05). Conclusions: Despite changing sociodemographic characteristics and an increasing trend in height, weight, and BMI in all socioeconomic groups, no change was observed in mean AAM in an urban region of Western T & uuml;rkiye over 18 years. While the inverse relationship between BMI and postmenarcheal BMI continued in both periods, the decline in AAM became more pronounced over the years in the presence of high postmenarcheal BMI.Item Evaluation of Thyroid Function Tests In Chronic Obstructive Pulmonary DiseaseKaya, E; Coskun, E; Celik, P; Sakar, A; Yorgancioglu, A; Özyurt, BAbnormal thyroid function test (TFT) levels were reported in chronic obstructive pulmonary disease (COPD) patients. We aimed to investigate the relationship between COPD and TFT in our study. Ninety three stable COPD patients and 17 healthy adults as a control group were evaluated. Physical examination, pulmonary function tests, and arterial blood gas analysis were performed in COPD patients. To evaluate the thyroid functions, fT3, fT4, TSH levels were measured. Mean age was 65,8 +/- 9,0 for the COPD group consisting of 9 (% 10) female and 84 (% 90) male, and 44,6 +/- 9,2 for the control group. When COPD and control groups were compared, TSH levels were found to be lower in the COPD group (p= 0.03). There is no relationship between age and TFT levels. In the COPD group, there was a negative correlation between fT4 and PEF (r=-0,21); and a positive correlation between sT4 and pH (r= 0,27). In conclusion, TFT levels are considered to be affected in COPD which is a systemic disorder, thyroid hormone levels decreased in severe COPD, and TFT levels low in all COPD patients, and correlations between TFT and some PFT levels are suggested.Item Low-Level Laser Therapy is More Effective Than Pulse Ultrasound Treatment on Wound Healing: Comperative Experimental StudyTikiz, C; Angin, A; Demireli, P; Taneli, F; Özyurt, B; Tüzün, ÇObjective: To investigate and compare the effects of pulse ultrasound (US) and low-level laser therapy (LLLT) on wound healing. Material and Methods: Thirty-two rats were included in the study and two full-thickness skin wounds were made on dorsum area of the rats bilaterally, with a 17 mm hole-punch. The animals were divided into two groups. Pulsed US (with a power of 0.1 W/cm(2), a frequency of 1 MHz, 5 minutes daily) was applied to to the right sided wounds of Group A (n=16) and Ga-As laser (830 nm wavelength, 0.5 J/cm(2) dosage of 1 MHz frequency for 1 minute duration) was applied to right sided wounds of Group B (n=16). Left sided wound were considered as controls and same procedures were applied without any current (sham). Biochemical and histopathological evaluations were performed in each group on 7(th) and 15(th) days. Results: Inflammatory cells tended to decrease in both treatment groups on the 7(th) day, however, this finding did not reach a statistical significance (p>0.05). Fibroblasts and collagen were found to be significantly increased in the laser group when compared to the other group on the 7(th) day (p<0.05). Angiogenesis was found to be significantly increased only in the laser group when compared to the other group on the 15(th) day (p<0.05). There were no significant differences in tissue nitric oxide values between the groups although the values in the laser group tended to be higher on the 15th day (p=0.058) Conclusion: In this comparative study. LLLT was found to significantly accelerate mainly proliferative phase while pulse US had no effect on wound healing. Our results support the consideration that LLLT may constitute a beneficial treatment modality for wound healing.Item Evaluation of the laboratory parameters in hidradenitis suppurativa: Can we use new inflammatory biomarkers?Çetinarslan, T; Ermertcan, AT; Özyurt, B; Gündüz, KHidradenitis suppurativa (HS) is a chronic, recurrent, and debilitating skin disease. Recent studies showed that inflammatory biomarkers, such as neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), Lymphocyte/HDL ratio (LHR), Neutrophil/HDL ratio (NHR), and Monocyte/HDL ratio (MHR) are an indicator of inflammatory diseases and may be associated with disease severity and disease activity. To investigate NLR, PLR, LHR, NHR, and MHR in HS patients. In addition, to compare erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), complete blood count, leukocyte profile, and biochemical parameters between the control and the patient group. Clinical and biochemical data of patients and healthy subjects were collected from medical records, retrospectively. In total, 166 patients with HS and 124 control subjects were included. We found no significant difference in NLR (P = .207) and PLR (P = .257). LHR (P < .001), NHR (P < .001), and MHR (P < .001) were significantly higher in the patient group. No positive correlation was found between any of these markers and disease severity according to Hurley staging system. However, MCV (Mean corpuscular volume), RDW (Red cell distribution width), and CRP showed a significant positive correlation with disease severity. Among these markers, only MHR was positively correlated with disease duration. Our study shows that CRP still maintains its value for HS patients compared to new inflammation markers. Unlike the studies in other inflammatory diseases, no significant relationship was found with most of these inflammatory parameters. MHR may be more useful in patients with HS as an indicator of inflammation compared to other parameters.Item Lumbar Disc Herniation, the Association Between Quantitative Sensorial Test and Magnetic Resonance Imaging FindingsErbüyün, SC; Ovali, GY; Özyurt, B; Yentür, EAObjective. Quantitative sensorial tests (QST) are used for evaluating specific sensorial nerve function. In this study, QST and magnetic resonance imaging (MRI) findings are compared in lumbar disc herniation patients, and the accuracy of QST data was investigated. Material and Methods. Sixty-four patients between 18 and 70 years of age suffering from radicular pain with positive Lasegue's test were included in this study. Specific criteria included complaints due to L5 discopathy. MRI findings were classified according to the Pfirmann grading system, and QST was applied to the L5 dermatoma of both symptomatic and nonsymptomatic legs of all patients. Vibration detection threshold, heat detection threshold, cold detection threshold, and heat pain detection threshold values were obtained, and MRI findings were classified according to the Pfirmann grading system. Results. When we compared the symptomatic and nonsymptomatic legs of participants, there were significant differences by means of all QST parameters (0 = 0.00). In a comparison of the QST and MRI Pfirmann grading systems, there is also a strong parallel statistical correlation between the Pfirmann grade and QST parameters (P < 0.05). Conclusions. According to the results of our study, QST has an additive effect to MRI for nerve root compression evaluation in the clinical basis, which might enable more sensitive diagnosis and treatment protocol. QST can also be an alternative method for evaluation of nerve root compression in patients who have contraindications for MRI.Item The importance of metric view for photodocumentation of facial reconstructive surgery: a single blinded surveyEskiizmir, G; Özyurt, BPhotodocumentation is an essential part of dermatooncology and reconstructive surgery. The purpose of this study is to suggest an imaging technique named metric view (photograph of the lesion with a surgical ruler) and to assess the accuracy of different views. Frontal, close-up and metric views were taken from the lesions of ten different cases. All the photographs were showed to 30 medical professionals and a prediction about the size of the lesion was requested individually. The relationship between the prediction values for three views and the exact size of the lesions were statistically analysed. The precise prediction of the exact size was only achieved in metric view of one case. In addition, the most approximate prediction values were obtained in metric views. The statistical analysis demonstrated that there was no statistically significant difference between the prediction values for metric view and exact size of the lesions in half of the cases. In contrast, statistically significant differences were detected in almost all of the prediction values for frontal and close-up views. Frontal and close-up views are not adequate to represent the size of the lesions. Metric view may enable a rational solution for a better representation.Item A comparative analysis of the decongestive effect of oxymetazoline and xylometazoline in healthy subjectsEskiizmir, G; Hirçin, Z; Özyurt, B; Ünlü, HBackground Oxymetazoline and xylometazoline are locally effective and direct acting drugs that relieve nasal congestion. The aim of this study was to objectively determine and compare the decongestive effects of oxymetazoline and xylometazoline in healthy subjects. Methods The study population comprised thirty healthy adults. All subjects underwent active anterior rhinomanometry (AARhm) and acoustic rhinometry (AR) tests following the application of oxymetazoline, xylometazoline, or placebo (physiological saline). The change in nasal resistance, nasal airflow, and different cross-sectional areas (CSAs) of the nasal cavity in the subjects were examined for each solution separately. The measurements were obtained over a 1-h period (baseline and 1, 15, 30, and 60 min post-dosing). All results were analyzed using the Kruskal-Wallis test and the Mann-Whitney U test. Results A total of 6,300 measurements of AARhm and AR were obtained. The application of placebo did not cause a statistically significant change in nasal resistance, nasal airflow, and CSAs (CSA1, 2, and 3, respectively) of the nasal cavity. In contrast, statistically significant changes in nasal resistance (inspiration p= 0.000 and p= 0.004; expiration p= 0.000 and p= 0.000), nasal airflow (inspiration p= 0.000 and p= 0.004; expiration p= 0.000 and p= 0.000), and CSAs of the nasal cavity (CSA2 p= 0.000 and p= 0.000, CSA3 p= 0.000 and p= 0.00), with the exception of CSA1 (p= 0.982 and p= 0.994), were obtained after the application of oxymetazoline and xylometazoline. A comparison of oxymetazoline and xylometazoline based on nasal resistance, nasal airflow, and CSAs of the nasal cavity demonstrated no statistically significant difference, except for CSA3. Conclusion Oxymetazoline and xylometazoline are fast-acting and potent topical decongestants that have similar decongestive effects.Item Prevalence of Asthma and Allergic Symptoms in ManisaSakar, A; Yorgancioglu, A; Dinç, G; Yüksel, H; Çelik, P; Dagyildizi, L; Coskun, E; Kaya, E; Özyurt, B; Özcan, CThe aim of this study was to determine the prevalence of asthma and allergic symptoms in Manisa city centre (Turkey), to evaluate the data obtained and to review the prevalences reported from different parts of our country. Data were collected from 610 home visits and complete interviews were conducted with 1336 adults over the age of 18. The questionnaire was consisted of sociodemographic questions and European Community Respiratory Health Survey (ECRHS) questionnaire. The prevalences of current asthma, cumulative asthma, asthma-like symptoms were found as 1.2, 1.0, and 25.0% respectively in 20-44 years age group and allergic rhinitis, allergic dermatitis, family atopy were found as 14.5, 10.9, and 15.2% respectively in the overall group. Wheezing with breathlessness, wheezing in the absence of upper respiratory tract infection, waking up with shortness of breath and waking up with cough were detected in 9.1, 6.9, 6, and 16.1% of the study population respectively. Gender, age, active or passive smoking, familial history of atopy and in-house conditions are the factors that effect the prevalence of asthma and allergic symptoms. In this study, the prevalence of asthma in Manisa was found to be consistent with the low prevalence rates reported from different parts of our country.Item Reliability and validity of the Turkish version of the WHO-5, in adults and older adults for its use in primary care settingsEser, E; Çevik, C; Baydur, H; Günes, S; Esgin, TA; Öztekin, ÇS; Eker, E; Gümüssoy, U; Eser, GB; Özyurt, BBackground: This study aims to determine the psychometric properties of the World Health Organization Well-Being Index (WHO-5) Turkish version in Turkish adults and older adults. Methods: This is a multicenter cultural adaptation study carried out with 1752 participants. Internal consistency (by Cronbach's alpha); Construct validity (by known groups and confirmatory factor analysis-CFI) and discriminant validity are evaluated stratified by adults and older adults. Cohen's Effect Size is used in known groups and discriminant validity analyses. Results: Distribution properties of the WHO-5 Turkish version are in acceptable limits. Alpha values are 0.81 for adults and 0.86 for older adults. The variances of the 58.5% of the adults sample and 63.9% of the older adults sample are explained in Exploratory FA. Model fits (CFI) are satisfactory ( > 0.95) in both samples; but RMSEA is poor in the older adults sample (0.166) whereas it is acceptable (0.073) in the adults sample. Known groups validity and discriminant analyses are satisfactory in both adults and older adults. Conclusion: The WHO-5 Turkish version has a good measurement capacity, internal consistency and good model fits in both samples. The error values in the older adults group suggest that the results when testing older adults should be interpreted with caution.Item The radiological evaluation of anatomical variations of frontal recess in normal population and cases with frontal rhinosinusitisKüçükgünay, B; Eskiizmir, G; Ünlü, HH; Aslan, A; Bayindir, P; Ovali, GY; Özyurt, BObjective: In this study, we aimed to evaluate the anatomical variations around frontal recess and the influence of variations on frontal rhinosinusitis (FR) in healthy individuals and in cases with frontal rhinosinusitis (FR). Methods: A total of 61 cases that applied to our outpatient center were grouped according to: cases with ear complaints (Group I, control group), cases with sinonasal symptoms but FR findings (Group II), and cases with both sinonasal and FR findings (Group III). All cases underwent paranasal computerized tomography (CT) with parasagittal reconstruction. All scans were assessed for the presence of fronto-ethmoidal cells, anatomical variations, osteomeatal complex diseases and sinus opacifications. Results: In all sides of study, the rate of fronto-ethmoidal cell was 20.9%. When cases with sinonasal signs (Groups II and III) and control group (Group I) were compared, intersinus septum (p=0.01) and agger nasi cells (p=0.001) were statistically significant. In sides with frontal recess disease (+) and/or frontal sinus opacification (+), Kuhn type III (p=0.03) fronto-ethmoidal cells and bulla frontalis (p=0.02) were significantly increased, and Kuhn type IV fronto-ethmoidal cell (both sides) was present only in cases with frontal recess disease (+) and/or frontal sinus opacification (+). When the role of fronto-ethmoidal cells on frontal recess disease and/or frontal sinus opacification were assessed, Kuhn Type III cell was 4.55 times (% 95 GS: 0.560-12.196) more effective. Conclusion: Kuhn type III and IV fronto-ethmoidal cells and bulla frontalis may have a role in FR. The radiological evaluation of anatomical variations around frontal recess with parasagittal sections was useful.