Browsing by Author "Üçer, O"
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Item Mediterranean Diet and Overactive BladderBozkurt, YE; Temeltas, G; Müezzinoglu, T; Üçer, OPurpose: The relationship between nutrition and overactive bladder (OAB) has yet to be elucidated. 'therefore, this study investigated the relationship between the Mediterranean diet and OAB. Methods: The 14-item Mediterranean Diet Adherence Screener (MeDAS) and Overactive Bladder-Validated 8-question Screener (OAB-V8), validated in Turkish, were administered to 500 patients over the age of 18 who presented to outpatient clinics other than urology outpatient clinics. Of those patients, 174 with chronic diseases and urinary tract infections (based on urinalysis and a detailed medical history) were excluded. Therefore, 326 patients' data were analyzed. Results: There was a negative correlation between the MeDAS and OAB-V8 scores. High OAB-V8 scores were associated with obesity (body mass index >= 30 kg/m(2)), being single, and a low education level. Conclusions: Dietary patterns represent a broader perspective on food and nutrient consumption and may therefore be more predictive of disease risk. The Mediterranean type should be recommended in the first-line treatment of patients with OAB symptoms. It is easily possible to determine the compliance of patients with this diet by using the 14-item MeDAS.Item Asymptomatic Giant Renal Calculi: Single-Session Percutaneous Nephrolithotomy-ImagesBozkurt, YE; Temeltas, G; Üçer, O; Müezzinoglu, TIn a 55-year-old woman patient with a body mass index of 27 kg/m(2), a giant staghorn kidney stone (10 x 6.4 x 8 cm) was detected in the right kidney on computed tomography, then the patient was treated with a single-session percutaneous nephrolithotomy, and there were no complications afterwards.Item Quantifying subjective assessment of sleep quality, quality of life and depressed mood in children with enuresisÜçer, O; Gümüs, BThe aim of this study was to compare a group of children who has monosymptomatic nocturnal enuresis (MNE) with a healthy control group by assessing their depression scales, quality of life and sleep quality. Hundred and one children with MNE and 38 healthy controls are included in the study, aged between 8 and 16 years old. All participants were performed the Pediatric Quality of Life Inventory (PedsQL 4.0), Depression Scale for Children (CES-DC) and The Pittsburgh Sleep Quality Index (PSQI) tests. The two groups were compared for their demographic factors and for the results of the tests above. There were no significant differences between the two groups according to age, gender and other demographic factors. Quality of life, depression and sleep quality scores implied worse health in the patient group. The PedsQL scores were assessed as 1,659.90 +/- A 296.01 in the patient group and 1,818.42 +/- A 227.92 in the control group (p = 0.001). The CES-DC scores were 11.74 +/- A 6.11 in the patient group and 7.00 +/- A 3.97 in the control group (p < 0.001). And the PSQI scores were 2.58 +/- A 2.48 in the patient group, 1.15 +/- A 1.10 in the control group (p < 0.001). Also in the patient group, there was a positive correlation between participants' ages and the PedsQL (p = 0.010; r = 0.256), the CES-DC (p = 0.000; r = 0.382), the PSQI (p = 0.000; r = 0.403) scores. The success parameters at school were significantly worse in the patient group (p = 0.05). All our findings show us that the children with nocturnal enuresis were affected negatively because of their disease; especially when they grow up the scores get worse health, so we suggest that treatment must be started at suitable age according to guidelines.Item INFLUENCE OF THE ERECTILE DYSFUNCTION ON QUALITY OF LIFE ACCOMPANYING DIABETES MELLITUS: A LONGITUDINAL, CONTROLLED STUDYOkur, M; Gümüs, B; Üçer, O; Karatas, TC; Özmen, E; Büyüksu, CIntroduction: Erectile dysfunction (ED) is one of the most common complications of Diabetes Mellitus (DM) in males and has a negative impact on the quality of life (QoL). The number of studies related with this subject is limited in the literature. QoL was evaluated and compared in diabetic patients with and without ED. Materials and Methods: Patients with ED who applied to our outpatient clinics (Celal Bayar University, Medical Faculty, Department of Urology) were included in the study. We interviewed 82 patients with DM+ED, 85 patients with ED and 65 normal (control) male subjects. All men (study and control groups) were asked to fill the IIEF (International Index of Erectile Function), CES-D (Center of Epidemiological StudiesDepression), BAI (Beck Anxiety Inventory), PIED (Pyschological Impact of Erectile Dysfunction) forms. Sildenafil citrate was administered as a medical treatment. Same forms were asked to be filled again in the 3th, 6th, 9th months of the therapy. Results: We observed that QoL of the patients with DM+ED and ED were affected negatively. ED was worse in the DM group compared to others. Significant improvements were detected in both QoL and ED in 3th and 6th months of the therapy. Conclusion: Our data show that treatment of ED significantly improves QoL in the patients with DM therefore, presence of ED has to be assessed in the patients with DM.Item The effect on the sensitivities of PSA and PSA-age volume score of IPSS and nocturia in predicting positive prostate biopsy findingsÜçer, O; Müezzinoglu, T; Çelen, I; Temeltas, GObjective: The PSA-age volume (PSA-AV) score was calculated by multiplying the age and prostate volume and then dividing the total by the prebiopsy PSA level. The aim of this study was to evaluate the effect on the sensitivities of PSA and PSA-AV score of International Prostate Symptom Score (I-PSS) and nocturia in predicting positive prostate biopsy findings. Subjects and methods: A total of 1302 biopsies data were divided into two groups according to presence/absence of nocturia. Of these biopsies, 452 biopsies data with I-PSS were also divided into three groups according to severity of I-PSS. The sensitivities, specificities, positive and negative predictive values of the PSA-AV and PSA in all the groups were calculated separately. Results: Although the sensitivities of PSA and PSA-AV were similar in the patients with nocturia (94.1% and 95.8%, respectively), the sensitivity of PSA-AV (99.2%) was higher than PSA (91.8%) in the patients without nocturia. The sensitivities of PSA in mild, moderate and severe I-PSS group were found to be 100%, 92.9% and 95%, respectively (the sensitivities of PSA-AV were 100%, 94.4% and 88.2%, respectively). While severity of I-PSS was decreasing, although sensitivity of PSA-AV increased regularly, sensitivity of PSA was variable. Conclusions: All our data shows that if we remove most of the factors which effect PSA such as age, prostate volume, prostatitis and BPH, we may increase the sensitivity of PSA for predicting positive prostate biopsy. Further PSA formulas contain of result of some tests (I-PSS, uroflowmetry or postvoiding residue urine) as well as age and prostate volume should increase the sensitivity and specificity of PSA for detecting prostate cancer. (C) 2016 Pan African Urological Surgeons' Association. Production and hosting by Elsevier B.V.Item Effect of Reduction Mammaplasty on Sexual ActivitySir, E; Üçer, O; Güngör, M; Aksoy, A; Keçeci, Y; Gümüs, BAim This study aimed to evaluate the effects of reduction mammaplasty operation on sexual functions of the patients with macromastia and of their partners. Materials and Methods Thirty-nine patients with macromastia and their partners were assessed for their sexual function before and 6 months after reduction mammaplasty. Sexual function of the women and their partners were evaluated using the Index of Female Sexual Function (IFSF) and the International Index of Erectile Function (IIEF), respectively. Controls (n = 33) were chosen from healthy hospital staff and their partners. Preoperative and postoperative scores were statistically compared with the controls' scores by using Student t test. Also, preoperative and postoperative scores were compared by using paired t test. Results The mean of age and body mass index of the women and their partners in the patient and control group were similar (P = 0.07). Before the operation, the mean of IFSF scores in the patient and control group were 22.75 (3.45) and 27.28 (5.05), respectively (P < 0.001). After the operation, the mean of IFSF scores in the patient group increased significantly to 27.67 (P < 0.001). The postoperative scores of all IFSF subscales except lubrication subscale were higher than the preoperative scores. Although there was no significant difference between preoperative and postoperative IIEF-total scores, postoperative IIEF-erectile function and IIEF-intercourse satisfaction scores were significantly reduced (P < 0.05). Conclusions We found that macromastia adversely affected female sexual function but reduction mammaplasty eliminated this adverse effect. We also found that the partners' erectile function and intercourse satisfaction reduced after the operation. This reduction may be due to psychological effects.Item Evaluation of sexual function in women with labia minora hypertrophy: A preliminary studySir, E; Güngör, M; Üçer, O; Aksoy, AObjective: To compare the sexual functions in women with labia minora hypertrophy and age matched healthy controls. Material and method: 43 patients with labia minora hypertrophy and 30 age-matched healthy controls were enrolled in the present study. The sexual functions of the women were evaluated by using the index of female sexual function (IFSF). Results: Mean ages of the patients and controls were 30.06 +/- 7.11 and 31.34 +/- 4.12 (p = 0.41), respectively. Mean total IFSF scores of the patients and controls were 24.18 +/- 3.24 and 27.53 +/- 4.43 (p < 0.05), respectively. The subscale scores of IFSF-lubrication, orgasm, satisfaction and pain in the patient group were significantly lower than in the control group (respectively, p < 0.001, p < 0.05, p < 0.001 and p < 0.05). There was no statistically significant difference between IFSF-arousal scores of the patient and control groups (p = 0.30). The mean IFSF-desire scores of the patient group was higher than the controls (p < 0.001). Labia minora hypertrophy was significantly associated with female sexual dysfunction (odds ratio [OR] = 14.97, 95% confidence interval [Cl] = [3.66-61.21], p < 0.001). Conclusion: This study suggests that patients with labia minora hypertrophy have poorer lubrication, satisfaction, pain, and orgasm scores on the IFSF scale compared to age-matched healthy controls. (C) 2017 Asociacion Espanola de Andrologia, Medicina Sexual y Reproductiva. Published by Elsevier Espana, S.L.U. All rights reserved.Item Assessment of sexual function in women with macromastia and their partnersÜçer, O; Sir, E; Güngör, M; Keçeci, Y; Aksoy, A; Gümüs, BObjective: To investigate the sexual function in patients with macromastia and their partners. Materials and methods: 48 patients with macromastia and 30 healthy controls and their partners were enrolled in the study. The sexual function of the women and their partners was evaluated by using the Index of Female Sexual Function (IFSF) and International Index of Erectile Function (IIEF), respectively. Results: Mean ages of the patients and controls were respectively, 33.27 +/- 5.24 and 32.06 +/- 3.91 (p > 0.05). Mean IFSF scores of the patients and controls were 23.21 +/- 3.16 and 27.33 +/- 4.94 (p = 0.00), respectively. All of the subscale scores of IFSF in the patient group were significantly lower than in the control group. Mean IIEF scores of the patients' and controls' partners were 60.33 +/- 11.46 and 65.25 +/- 6.18 (p = 0.04), respectively. Conclusion: In this study, Macromastia was shown to affect sexual function of women and their partners adversely. (C) 2014 Asociacion Espanola de Andrologia, Medicina Sexual y Reproductiva. Published by Elsevier Espana, S.L.U. All rights reserved.Item Simultaneous Partial Nephrectomy and Radiofrequency Ablation in a Solitary Kidney PatientAlbaz, AC; Mammadzada, M; Müezzinoglu, T; Üçer, O; Temeltas, GRenal cell carcinomas, which comprise the majority of primary kidney tumors, present diverse challenges in treatment planning. This case report explores the application of simultaneous partial nephrectomy and radiofrequency (RF) ablation in a patient with a solitary kidney, emphasizing the significance of specific interventions. A 52-year-old female patient who underwent radical nephrectomy presented with right flank pain and hematuria. Contrast-enhanced computed tomography revealed exophytic and calyceal system-extending lesions in the right kidney. A multidisciplinary approach involving interventional radiology and nephrology facilitated preoperative preparation. The patient underwent simultaneous partial nephrectomy and RF ablation in a single session, resulting in favorable outcomes. This meta- analysis highlighted radical nephrectomy's association with chronic kidney disease, emphasizing the need for specialized treatment approaches. Ablative treatment was associated with superior perioperative outcomes, whereas partial nephrectomy exhibited higher urological complication rates. Minimally invasive techniques are crucial, especially for solitary kidney cases and small renal tumors. Simultaneous partial nephrectomy and RF ablation are effective for managing exophytic and calyceal system-extending masses in solitary kidneys. The preservation of renal function is of paramount importance, prompting consideration of ablative treatment alongside partial nephrectomy. Despite limited evidence, ablative therapies offer a viable alternative for frail and comorbid patients, ensuring long-term oncological durability and superior preservation of renal function.Item Assessment of Lower Urinary Tract Symptoms and Sexual Function in Women with Metabolic SyndromeBorazan, S; Temeltas, G; Üçer, O; Hekimsoy, Z; Senol, EObjective To assess lower urinary tract symptoms and sexual function in premenopausal women with metabolic syndrome (MetS). Materials and Methods A total of 34 premenopausal patients over 18 years of age with MetS and who were admitted to our endocrinology clinic between September 2013 and April 2014 were included. Control group was consisted of 30 healthy controls chosen from the staff of the hospital. The sexual function, lower urinary tract symptoms and quality of life of the participants were evaluated by using Index of Female Sexual Function (IFSF), Urogenital Distress Inventory (UDI-6), and Incontinence Impact Questionnaire (IIQ-7), respectively. The scores of the patients were statistically compared with those of controls. Results The mean ages of the patient and control groups were 40.50 +/- 5.12 years and 38.17 +/- 2.12 years, respectively (p=0.09). The mean IFSF-total and all of the IFSF sub scales (except pain) in the patient group were significantly lower than those of the control group. The mean UDI-6 score of the patients was significantly higher than the controls (p=0.001). The mean IIQ-7 scores of the patients was higher than controls, however this increase was not statistically significant (p=0.11). Conclusion These findings showed that MetS affected adversely the sexual function of premenopausal women due to the fact that IFSF scores were found to be lower in women with MetS as compared to healthy controls. Moreover, IFSF score under the threshold values in patients showed that patients with MetS had sexual function disorder. These lower urinary tract symptoms in the patients with MetS did not affect the quality of life although the severity of lower urinary tract symptoms of patients with MetS was significantly worse than that in control group.Item The treatment of late-onset hypogonadismÜçer, O; Gümüs, BLate-onset hypogonadism (LOH) in aging men is a clinical and biochemical syndrome caused by an age-related decline in testosterone. Despite published in guidelines and recommendations, uncertainty surrounds the profile of clinical symptoms as well as the biochemical threshold of diagnosis. The only evidence-based treatment of late-onset hypogonadism is testosterone replacement therapy. The actual available evidence of the long-term risks and outcomes of testosterone-replacement therapy remains very limited, and carefully designed placebo-controlled trials of testosterone administration to assess the risks and benefits of such a therapy are required. Until such evidence is available, testosterone treatment should be restricted to elderly men with very low testosterone levels in the presence of clinical symptoms, and the advantages and disadvantages need to be accurately assessed. Careful monitoring of potential side effects is necessary. The purpose of this review is to discuss what is known and what remains unclear with respect to the benefits and risks of testosterone replacement treatment.Item Comparison of audiovisual sexual stimulation test with nocturnal penile tumescence test in the evaluation of erectile dysfunction by using RigiScanIncirci, M; Üçer, O; Karatas, TC; Atesçi, YZ; Gümüs, BObjective: Nocturnal penile tumescence (NPT) test is a time-consuming, cumbersome, and relatively expensive method which is used for the diagnosis of erectile dysfunction (ED). The aims of the study were to clarify the relationship between erotic and nocturnal erections and to evaluate the diagnostic efficacy of the audiovisual sexual stimulation (AVSS) test with and without medication. Materials and methods: A total of 30 patients with ED were examined. Each patient filled in an International Index of Erectile Function-5 (IIEF-5) questionnaire. AVSS and NPT tests were performed using the RigiScan Plus. AVSS test was performed with and without medication (sildenafil citrate 50 mg). Patients were divided into two groups (psychogenic and organic groups) according to NPT and AVSS test results. Results: The mean age of the patients was 46.4 (23-69) years and IIEF-5 score was 10.8 +/- 4.5. Positive AVSS test was found in 18 (85.7%) of the 21 patients with positive NPT test. Negative AVSS test was found in 7 (77, 8%) of the 9 patients with negative NPT test. The specificity of AVSS test was 85.7% and sensitivity was 77.8% for the psychogenic groups. The overall accuracy rate was 83.3%. Conclusion: The NPT test is more expensive, cumbersome, and discomfortable than the AVSS test. Although efficiency of both tests is similar, the AVSS test seems more advantageous. We suggest that the AVSS test without medication should be performed as the first step in the diagnosis of the patients with ED. In patients with negative test result, the AVSS test with medication should be performed as the second step diagnostic method.Item Comparison of Standard Open Wound Care and Vacuum-assisted Closure Therapy in Fournier's GangreneBali, ZU; Akdeniz, CB; Muezzinoglu, T; Üçer, O; Kara, EObjective: Management of Fournier's gangrene (FG) includes large wound debridement, broad-spectrum antibiotic, wound care and re-debridement if necessary. The aim of our study was to compare standard open wound care and vacuum-assisted closure (VAC) therapy in patients with FG. Materials and Methods: Thirty-three patients (29 males and 4 females) who underwent surgery for FG were enrolled in the present study. The data was evaluated retrospectively. The patients were divided into two groups according to wound care after large wound debridement. Standard open wound care with antibiotic pomade was performed twice a day in 14 patients arid VAC therapy was performed every 48-72 hours in 17 patients. The data of the two groups were compared. Results: Twenty-three (69.7%) patients had Diabetes Mellitus and 20 patients (60%) had poor hygiene. The re-debridement rate in patients who received standard open wound care was statistically higher than in those who underwent VAC therapy (p=0.016). There were no statistically significant differences in mortality rate, length of hospital stay and need for reconstruction between the groups. When the data were analyzed, no statistically significant difference was found in FG Severity index score, length of hospital stay and mortality rate. However, the relationship between mortality rate and location of lesion was statistically significant (p=0.03). Four patients died, 3 (75%) due to wide necrotizing fasciitis extending to the abdominal wall. Conclusion: The present study showed that the technique used for wound care did not influence mortality, need for reconstruction and length of hospital stay. The only advantage of VAC therapy was decreased re-debridement rate in patients with FG.Item The Effect of Transurethral Resection and BCG Therapy on Cytokine Levels in Non-Muscle Invasive Bladder CancerÜçer, O; Temeltas, G; Müezzinoglu, T; Ari, Z; Kosova, FObjective: The present study investigated the effect of treatment on interleukin (IL)-1, IL-6, IL-8, and neopterin levels in patients with non-muscle invasive bladder cancer (NMIBC). Materials and Methods: Thirty patients with NMIBC and 30 age-matched controls were included in the study. Preoperative, postoperative first control [at two weeks after second transurethral resection of bladder tumor (TURBT)] and the second control (at the end of intravesical immunotherapy) blood samples were analyzed using ELISA to determine IL-1, IL-6, IL-8, and neopterin levels. The mean cytokine levels of the patients were statistically compared and comparing the patients' and controls' levels. Results: There were no statistically significant differences between the mean IL-1, IL-6, IL-8, and neopterin levels of the patient and control groups before initial TURBT. In the patient group, there were no statistically significant differences in the IL-6 and IL-8 levels after both TURBT and intravesical Bacillus Calmette-Guerin (BCG) therapy. The mean of preoperative IL-1 and neopterin levels significantly decreased after TURBT (p<0.05). However, this reduction does not continue after intravesical BCG instillation. Conclusion: The findings of this study showed that the IL-1, IL-6, IL-8, and neopterin levels of the patients with NMIBC were similar to the levels of healthy controls. IL-1 and neopterin levels significantly decreased after TURBT. But these reduction did not continue after intravesical BCG instillation. These findings demonstrate that IL-1 and neopterin levels decrease after TURBT due to the reduction in tumor weight or tumor removal.Item Does Late-Onset Hypogonadism Occur by Aging? The Evaluation of IIEF, Ams-Q and Biochemical ParametersÜçer, O; Gümüs, B; Okur, M; Karatas, TC; Büyüksu, CObjective: The aim of this study is to investigate whether biochemical (hormonal) hypogonadism occurs by aging and whether ANIS-Q(Aging Male Symptoms-Questionnaire) and IIEF (International Index of Erectile Function) forms are adequate in order to evaluate its presence in case it occurs. Material and Methods: A total of 182 males who applied to the outpatient clinics of Urology Department and whose ages were between 45-90 years were included in the study. Those who had diabetes mellitus, hypertension, coronary artery disease, dyslipidemia, any psychiatric disorder and any malignancy were excluded. The patients were classified into three groups (Group 1; 45-54, Group 2; 55-64 and Group 3; over 65 years). All participants were asked to complete IIEF and AMS-Q forms and serum levels of total testosterone, free testosterone, LH, DHEA-S, SHBG and prolactin were measured. Results: Total testosterone and prolactin levels did not change with aging. Although free testosterone, bio-available testosterone and DHEA-S levels decreased with age, it was detected that LH and SHBG levels were increased. While IIEF scores decreased with age, however AMS-Q scores did not change. When subgroups of AMS-Q were taken into consideration, sexual scores increased, and a decrease in somatic and psychological scores was detected. There was a strong relationship between IIEF-EF (erectile function) and AMS-Sexual forms, Conclusion: All of the data indicate that secondary hypogonadism occurs by aging and consequent symptoms (especially sexual ones) can be evaluated with IIEF and AMS-Sexual forms.Item Effects of Treatment on Angiogenic (Vascular Endothelial Growth Factor-2 and Matrix Metalloproteinase-2) and Antiangiogenic (Endostatin and Thrombospondin-1) Factors in Non-muscle Invasive Bladder CarcinomaTemeltas, G; Kosova, F; Üçer, O; Müezzinoglu, T; Ari, ZObjective: We aimed to investigate possible effects of treatment on angiogenic [vascular endothelial growth factor-2 (VEGF-2) and matrix metalloproteinase-2 (MMP-2)] and antiangiogenic [ endostatin (ES) and thrombospondin-1 (TSP-1)] factors in non-muscle invasive bladder carcinoma (NMIBC). Materials and Methods: Thirty NMIBC patients and 30 age-matched controls were included in the study. For the above-mentioned markers, peripheral blood samples were drawn at three time points to be studied by enzyme-linked immunosorbent assay: before transurethral resection of bladder tumor (TURBT), at first control (20 days after the operation) and second control (at the end of intravesical immunotherapy). The mean blood levels obtained in the three measurements and those in patients and controls were compared statistically. Results: The mean levels of VEGF-2 and MMP-2 in patients before TURBT were found to be statistically significantly higher than in controls (p=0.04 and p=0.01, respectively), while no significant differences were obtained between the mean ES and TSP-1 levels (p=0.95 and p=0.99, respectively). It was also found that the VEGF-2 and MMP-2 levels were significantly decreased after TURBT (p=0.03 and p=0.01, respectively), but the tendency of these decrease was not found to be statistically significant between the first and second controls. Conclusion: Elevated VEGF-2 and MMP-2 levels in patients with NMIBC were significantly decreased after and probably due to the TURBT, which leads to a conclusion that these angiogenic markers may be used for follow-up of NMIBC.Item What is the Color of Cancer?Tatli, V; Üçer, O; Müezzinoglu, TObjective: To investigate the colors that evokes cancer in the patients with prostate, lung and breast cancer, and in healthy controls. Materials and Methods: A visual card in one of the 9 colors (white, red, orange, yellow, green, blue, purple, navy, black) was shown to totally 210 patients diagnosed with lung cancer (LC), prostate cancer (PC) or breast cancer (BC) and 200 healthy participants and the question of What is the color of cancer? was asked to them. Disease information of the cancer patients were also recorded. Results: The mean ages of the patient and control groups were 61.54 and 20.49, respectively (p<0.001). While the most preferred color was yellow (24.8%) in the patient group, it was red (39%) in the control group. The patients were divided into three groups according to both type and stage of cancer. While the patients with PC and BC selected yellow color, the patients with LC selected black color. The patients without recurrent and residual diseases preferred yellow, patients with local recurrence preferred red and patients with distant metastasis preferred black colors. Conclusion: While cancer patients selected yellow color which represents positive emotions, the healthy young individuals selected red color which represents negative emotions. However, progressive or aggressive cancer patients selected red and black colors which is associated with negative emotions.Item Evaluating the effect of histopathological parameters of prostate adenocarcinoma on prognosis in radical prostatectomy specimensTercan, E; Erbatu, O; Üçer, O; Metin, S; Nese, NBACKGROUND: Over the past decade, significant updates have been made regarding the classification and grading of prostate adenocarcinoma in radical prostatectomy specimens, following decisions reached in international conferences and through impactful publications. These alterations are closely linked to patient prognosis. OBJECTIVES: Observe the incidence of these changes and their impact on patient prognosis. Additionally, investigate the relationship between histopathological and clinical parameters to assist in multidisciplinary treatment planning. DESIGN: Retrospective cohort study SETTING: Tertiary university hospital METHODS: Hematoxylin and eosin, along with immunohistochemistry stained sections, were reevaluated, and clinical information, including patient demographics, preoperative PSA levels, and patient follow-up were collected from patients who underwent radical prostatectomy at our center. SAMPLE SIZE: 182 patients. MAIN OUTCOME MEASURES: Biochemical recurrence. RESULTS: The study highlighted the negative prognostic effects of factors such as Gleason grade group, lymphovascular invasion, intraductal carcinoma, positive surgical margins, extraprostatic extension, pathological T stage, and seminal vesicle invasion. These factors are important determinants of recurrence-free survival in prostate adenocarcinoma patients. CONCLUSION: This study identified comedonecrosis and intraductal carcinoma as independent negative prognostic factors. A 3-mm cutoff for positive surgical margins was supported, while the current cutoff for extraprostatic extension may require reevaluation. The impact of cribriform pattern and ductal carcinoma appears to be influenced by the grade group. No independent relationship was found between the Gleason score/pattern on positive surgical margins or extraprostatic extension and prognosis. Further, large-scale studies with long-term follow-up are needed.Item Long term follow-up results of ablation treatment for patients with small renal massGümüs, BH; Albaz, AC; Düzgün, F; Üçer, O; Temeltas, G; Müezzinoglu, T; Tarhan, SObjective The aim of this study is to evaluate the outcome of ablation therapy in our clinic for the treatment of patients with a small renal mass Materials and Methods: We retrospectively evaluated the technic and follow-up data of 30 patients with 36 tumours who underwent Radiofrequency Ablation (RFA) and Microwave Ablation (MWA) in our clinic. Demographic data, ablation type, tumour characteristics, peroperative and postoperative complications and treatment success of the patients were evaluated. Results A total of 36 tumours who underwent ablation treatments, 23 were treated with RFA, 13 with MWA. The mean tumour size was 28.9 +/- 6.92 mm in RFA and 29.3 +/- 7.70 mm in MWA. The mean follow-up period was 49.6 +/- 24.7 months in patients with RFA and mean follow-up was 16 +/- 8.05 months in MWA treatments. The overall success in MWA administration was calculated as 76.9%, while the overall success in RFA was 80%. Conclusion Long-term oncologic efficacy of RFA appears to be successful in the treatment of T1a renal carcinomas. Further studies can be conducted to elucidate the influence of MWA on long-term oncological outcomes.