Browsing by Author "İşisağ A."

Now showing 1 - 4 of 4
  • No Thumbnail Available
    Item
    Sinonasal-type haemangiopericytoma: A case report; [Sinonazal tip hemanjioperisitom: Bir olgu sunumu]
    (Federation of Turkish Pathology Societies, 2015) Uğur Duman F.; Ayhan S.; İşisağ A.; Eskiizmir G.; Tarhan S.
    Sinonasal-type hemangiopericytomas, which comprise less than 0.5% of all sinonasal neoplasms, arise unilaterally in the nasal cavity as polypoid masses with a mean diameter of about 3 cm. A 34-year-old female patient was admitted due to nasal obstruction and epistaxis. A polypoid mass covered with intact mucosa that originated both from the right inferior concha and lateral nasal wall was detected by nasal endoscopy. The tumor, extending from the oropharynx to the nasopharynx, was measured as 3,5×3×2 cm. Although exhibiting characteristic histopathological features and typical clinical symptoms, this case with unexpected immunohistochemical findings can provide a viewpoint on the nature of this kind of tumors. © 2015, Federation of Turkish Pathology Societies. All rights reserved.
  • No Thumbnail Available
    Item
    Small-cell glioblastoma in the craniovertebral junction mimics meningioma; [Kraniovertebral bileşkede menenjiomu taklit eden küçük hücreli glioblastom]
    (Turkiye Klinikleri, 2018) Mete M.; Ovali G.; İşisağ A.
    Glioblastome multiforme (GBM) is the most common primary central nervous system tumor and can mimic various pathologies, such as meningioma, arteriovenous malformation, metastatic disease, lymphoma, and infection. Here, we report a case of GBM in a female patient with radiological features suggestive of a more common benign lesion such as meningioma in craniovertebral junction. The lesion was completely excised and the histopathological study was consistent with small-cell GBM. © 2018 by Türkiye Klinikleri.
  • No Thumbnail Available
    Item
    The Prognostic Impact of Tumor Microenvironment and Checkpoint Blockade-Associated Molecules (PD-1, PD-L1, CD163 and CD14) in Nodal Diffuse Large B-cell Lymphoma, NOS
    (Springer, 2024) Atmış Ö.; Neşe N.; Aydoğdu İ.; Alaca İ.; Mavili H.S.; İşisağ A.
    It is aimed to determine expression of programmed cell death-1 (PD-1), programmed cell death ligand-1 (PD-L1), CD163 and CD14 in diffuse large B-cell lymphomas (DLBCL), and whether these markers may predict prognosis in DLBCL cases. A total of 52 nodal DLBCL, NOS cases with no known extranodal involvement at the time of diagnosis were evaluated. PD-1, PD-L1, CD163, and CD14 were studied by immunohistochemistry. The relationships between the results and clinical and laboratory prognostic markers were investigated. It was observed that patients with PD-1 expression < 5 positive cells/HPF had worse overall survival. No significant relationship was found between survival and PD-L1, CD163 and CD14 expressions. In addition, cases that are > 60 years of age, that have Eastern Cooperative Oncology Group (ECOG) performance score ≥ 2, stage IV disease, high International Prognostic Index score score (≥ 3), elevation of LDH, low albumin level, low hemoglobin level, low peripheral blood lymphocyte count, high peripheral blood neutrophil/lymphocyte ratio, high peripheral blood platelet/lymphocyte ratio were found to have worse overall survival. It was concluded that in patients with low number of PD-1 positive tumor-infiltrating lymphocytes have low survival rates and therefore PD-1 expression may be useful in indicating prognosis. © The Author(s), under exclusive licence to Indian Society of Hematology and Blood Transfusion 2023.
  • No Thumbnail Available
    Item
    Anaplastic Ependymoma and Atypical Refractory Longitudinal Expansive Transverse Myelitis Due to Immune Reaction After COVID-19-A Case Discussion That Raises Many Unknown Questions About Covid-19; [ COVID-19 Sonrası İmmün Reaksiyona Bağlı Atipik Refrakter Longitudinal Ekspansif Transvers Miyelit ve Anaplastik Ependimom - COVID-19 Hakkında Birçok Bilinmeyen Soruyu Gündeme Getiren Bir Vaka Tartışması]
    (Turkish Neuropsychiatric Society, 2024) İnalkaç Gemici Y.; Çelik F.; Göz Z.Z.; İşisağ A.; Yilmaz Ovali G.; Zileli M.; Barutçuoğlu M.; Mavioğlu H.
    Inflammatory neurologic manifestations, both infectious and non-infectious, have been reported secondary to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2/COVID-19). However, the relationship of spinal tumor and COVID-19 longitudinally extensive transverse myelitis (LETM) coexistence has never been reported in our knowledge. The clinical presentation and response to treatment of a 24-year-old female patient diagnosed with COVID-19 LETM and anaplastic ependymoma are described in this case report. The Patient’s cerebrospinal fluid COVID-19 antibody level was higher than serum and she was resistant to immunosuppressive treatment. The interaction between COVID-19 and spinal tumor was discussed in the light of the literature. It is thought that COVID-19 infection could trigger tumor growth in this patient. Also, this is the first case of anaplastic ependymoma and COVID-19 myelitis coexistence in the literature. © 2023 by Turkish Association of Neuropsychiatry.