Browsing by Author "Şahin G."

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    Retrospective evaluation of cases diagnosed with ulcerative colitis; [Ülseratif Kolit Tanılı Olgularımızın Retrospektif Olarak Deǧerlendirilmesi]
    (Galenos Yayincilik,, 2012) Ünal F.; Şahin G.; Cebe A.; Ayhan S.; Eren F.; Kasirga E.
    Introduction: Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gastrointestinal canal characterised by remissions and exacerbations. This study aimed to make a retrospective evaluation of clinical and laboratory findings of patients being monitored with a diagnosis of IBD. Materials and Methods: Medical records of 18 patients with a diagnosis of IBD and 7 years of follow-up at our pediatric gastroenterology departments were investigated with respect to demographic data, complaints on presentation and accompanying diseases. Unusual findings from physical examination, endoscopic findings, histopathological findings and the applied treatments were examined. Results: The 18 patients (10 female, 8 male) included in this study had a mean age of 13.6±2.9 years and the mean time from onset of symptoms to diagnosis was 6.9±4.5 months. Seventeen patients were diagnosed with ulcerative colitis and 1 patient with intermediate colitis. There was a positive family history of the disease in 2 patients (11%). At the time of diagnosis, the most common complaints on presentation were found to be abdominal pain (100%), bloody diarrhea (94.5%) and tenesmus (44.4%). The most frequent laboratory findings were CRP positivity (89%), increased sedimentation rate (83.3%) and iron-deficient anaemia (77.7%). On colonoscopy, pancolitis involvement (66.6%) was most frequently encountered. Accompanying diseases to IBD were found to be familial Mediterranean fever (FMF) (11%), celiac disease (5.5%) and Heliobacter pylori gastritis (5.5%). One patient (5.5%) who did not respond to medical treatment for pancolitis involvement underwent a colectomy. Discussion: The number of diagnoses of IBD in childhood is gradually increasing. Nonetheless, it can be difficult to define diseases with non-specific symptoms and this may cause a delay in diagnosis. Because of the association of autoimmune diseases with IBD, despite appropriate therapy, diseases with no remission which lead to gastrointestinal inflammation, such as FMF, should be further investigated. © The Journal of Current Pediatrics, published by Galenos Publishing.
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    Diagnostic and therapeutic endoscopic approaches to upper gastrointestinal system bleeding in children; [Çocuklarda üst gastrointestinal sistem kanamalarına tanısal ve tedavi edici endoskopik yaklaşımlar]
    (Galenos Yayincilik,, 2012) Ünal F.; Şahin G.; Ecevit Ç.Ö.; Semizel E.; Cebe A.; Erdoǧan H.; Kasirga E.
    Introduction: Upper gastrointestinal system bleeding in children is always very important problems requiring further investigation. The aim of the study was to investigate retrospectively the etiologies of upper gastrointestinal bleeding, the therapeutic endoscopic approach to the bleeding, and the efficacy of the endoscopy in the treatment of pediatric age group. Materials and Methods: In this study, 139 (F/M: 63/76) cases diagnosed as upper gastrointestinal bleeding and followed up by the Department of Pediatric Gastroenterology were classified into groups according to the age, etiology, the presence of varicose veins, and history of drug ingestion. In addition bleedings caused by peptic ulcer disease were classified according to Forrest classification. Values of p<0.05 were of considered as significant. Results: Upper gastrointestinal bleedings were originated from varicose veins in 15.1% of patients and non-variceal origin in 70.5% of patients. The location of bleeding could not be determined in 14.4% of the patients. The history of drug ingestion was obtained most commonly between 3-9 ages. Sixty patients underwent the procedures of endoscopic band ligation (23.3%), endoscopic sclerotherapy (10%), endoscopic hemoclips application (25%), epinephrine injection (30%), polipectomy (5%), and cauterization (6.7%) according to the etiology. In terms of stopping the bleeding, there was no statistically significant difference between endoscopic hemoclips application and epinephrine injection (p>0.68). Discussion: Endoscopic procedure is very useful in both the determination of etiology of upper gastrointestinal bleeding and the treatment of upper gastrointestinal bleeding in childhood. © The Journal of Current Pediatrics, published by Galenos Publishing.
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    Primary polydipsia case presenting with severe malnutrition; [Aǧır beslenme bozukluǧu ile başvuran birincil polidipsi olgusu]
    (Kare Publishing, 2013) Şahin G.E.; Zorlu P.; Çaylan N.D.; Uçar Ş.; Açoǧlu E.A.; Şahin G.
    Primary polydipsia is a clinical status with excessive fluid consumption without any physiological need. A seventeen-month-old male infant with severe malnutrition and developmental retardation was found to have polyuria and polydipsia in the follow-up. The urine density was found to be 1001, Na was found to be 124 mEq/L and the serum and urine osmolarity was found to be low. The patient was diagnosed with primary polydipsia and was treated by gradually water restriction. This case is presented to emphasize that primary polydipsia changes nutritional habits which may lead to malnutrition and developmental retardation.
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    Correlations among enthesitis, clinical, radiographic and quality of life parameters in patients with ankylosing spondylitis
    (Informa Healthcare, 2014) Rezvani A.; Bodur H.; Ataman Ş.; Kaya T.; Buǧdayci D.S.; Demir S.E.; Koçyiǧit H.; Altan L.; Uǧurlu H.; Kirnap M.; Gür A.; Kozanoǧlu E.; Akinci A.; Tekeoǧlu I.; Şahin G.; Bal A.; Sivrioǧlu K.; Yazgan P.; Aydin G.; Hepgüler S.; Ölmez N.; Şendur Ö.F.; Yener M.; Altay Z.; Ayhan F.; Durmuş O.; Duruöz M.T.; Günendi Z.; Nacir B.; Öken Ö.; Toktaş H.; Delialioǧlu S.Ü.; Evcik D.; Sertpoyraz F.M.
    Objectives. To investigate the relationship between enthesitis and disease activity, functional status, fatigue, joint mobility, radiological damage, laboratory parameter and quality of life in patients with ankylosing spondylitis (AS). Methods. A total of 421 patients with AS (323 male and 98 female) who were included in the Turkish League Against Rheumatism Registry were enrolled in the study. The Bath AS Disease Activity Index (BASDAI), fatigue, the Bath AS Functional Index (BASFI), the Bath AS Metrology Index (BASMI), the Maastricht AS Enthesitis Score (MASES), AS quality of life (ASQoL), the Bath AS Radiology Index (BASRI) and erythrocyte sedimentation rate (ESR) were evaluated. Results. Enthesitis was detected in 27.3% of patients. There were positive correlations between MASES and BASDAI, BASFI and fatigue (p < 0.05). MASES was not correlated with BASRI, BASMI, ASQoL and ESR. The mean MASES score was 1.1 ± 2.4. The most frequent regions of enthesopathies were right iliac crest, spinous process of L5 and proximal to the insertion of left achilles tendon, respectively. Conclusions. Enthesitis was found to be associated with higher disease activity, higher fatigue, worse functional status and lower disease duration. As enthesitis was correlated with BASDAI, we conclude that enthesitis can reflect the disease activity in patients with AS. © 2014 Japan College of Rheumatology.
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    The frequency of lysosomal acid lipase deficiency in children with unexplained liver disease
    (Lippincott Williams and Wilkins, 2019) Kuloglu Z.; Kansu A.; Selbuz S.; Kalayci A.G.; Şahin G.; Kirsaclioglu C.T.; Demirören K.; Dalgiç B.; Kasirga E.; Önal Z.; Işlek A.
    Objectives:Evidence suggests that lysosomal acid lipase deficiency (LAL-D) is often underdiagnosed because symptoms may be nonspecific. We aimed to investigate the prevalence of LAL-D in children with unexplained liver disease and to identify demographic and clinical features with a prospective, multicenter, cross-sectional study.Methods:Patients (aged 3 months-18 years) who had unexplained transaminase elevation, unexplained hepatomegaly or hepatosplenomegaly, obesity-unrelated liver steatosis, biopsy-proven cryptogenic fibrosis and cirrhosis, or liver transplantation for cryptogenic cirrhosis were enrolled. A Web-based electronic data collection system was used. LAL activity (nmol/punch/h) was measured using the dried blood spot method and classified as LAL-D (<0.02), intermediate (0.02-0.37) or normal (> 0.37). A second dried blood spot sample was obtained from patients with intermediate LAL activity for confirmation of the result.Results:A total of 810 children (median age 5.6 years) from 795 families were enrolled. The reasons for enrollment were unexplained transaminase elevation (62%), unexplained organomegaly (45%), obesity-unrelated liver steatosis (26%), cryptogenic fibrosis and cirrhosis (6%), and liver transplantation for cryptogenic cirrhosis (<1%). LAL activity was normal in 634 (78%) and intermediate in 174 (21%) patients. LAL-D was identified in 2 siblings aged 15 and 6 years born to unrelated parents. Dyslipidemia, liver steatosis, and mild increase in aminotransferases were common features in these patients. Moreover, the 15-year-old patient showed growth failure and microvesicular steatosis, portal inflammation, and bridging fibrosis in the liver biopsy. Based on 795 families, 2 siblings in the same family were identified as LAL-D cases, making the prevalence of LAL-D in this study population, 0.1% (0.125%-0.606%). In the repeated measurement (76/174), LAL activity remained at the intermediate level in 38 patients.Conclusions:Overall, the frequency of LAL-D patients in this study (0.1%) suggests that LAL-D seems to be rare even in the selected high-risk population. © 2019 Lippincott Williams and Wilkins. All rights reserved.
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    Cross-sectional study: Long term follow-up care for pediatric cancer survivors in a developing country, turkey: Current status, challenges, and future perspectives
    (Turkiye Klinikleri, 2020) İncesoy Özdemir S.; Taçyildiz N.; Varan A.; Kebudi R.; Zülfikar B.; Celkan T.; Şahin G.; Çorapçioğlu F.; Keskin Yildirim Z.; Pinarli F.G.; Olgun N.; Sari N.; Dağdemir A.; Özyörük D.; Eren T.; Çakir F.B.; Adakli Aksoy B.; Bozkurt C.; Güler E.; Özgüven A.A.; Erbey F.; Berber M.; Dinçaslan H.; Ünal E.; Kantar M.
    Aim: The main purpose of this study is to determine the current status of long-term follow-up (LTFU) for childhood cancer survivors and the challenges of LTFU for pediatric cancer survivors at pediatric oncology institutions in Turkey. Material and methods: A questionnaire was e-mailed to the directors of 33 pediatric oncology centers (POCs) registered in the Turkish Pediatric Oncology Group (TPOG). Of these 33 active TPOG institutions, 21 participated in the study and returned their completed questionnaires. Results: Only 1 of the 21 participating centers had a separate LTFU clinic. The remaining centers provided LTFU care for childhood cancer survivors at the pediatric oncology outpatient clinic. Of these centers, 17 (80.9%) reported difficulty in transition from the pediatric clinic to the adult clinic, 14 (66.6%) reported insufficient care providers, and 12 (57.1%) reported insufficient time and transportation problems. As neglected late effects, 16 (76.1%) centers reported psychosocial and getty job problems and 11 (52.3%) reported sexual and cognitive problems. None of the centers had their own LTFU guidelines for their daily LTFU practice. Conclusion: This study was the first to gain an overview of the needs of POCs and the gaps in survivorship services in Turkey. The results from this study will help to develop a national health care system and national guidelines for pediatric cancer survivors. © TÜBİTAK.