Browsing by Author "Şahin N."

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    Taxonomic position of 'Pseudomonas oxalaticus' strain Ox1(T) (DSM 110(T)) (Khambata and Bhat, 1953) and its description in the genus Ralstonia as Ralstonia oxalatica comb, nov
    (2000) Şahin N.; Işik K.; Tamer A.Ü.; Goodfellow M.
    'Pseudomonas oxalaticus' strain Ox1(T) (= DSM 1105(T)), which was described as an oxalate-decomposing bacterium, was reinvestigated to clarify its taxonomic position. 16S ribosomal DNA sequence comparisons demonstrated that this species is phylogenetically related to the species of the genus Ralstonia and represents a new species. The result of the DNA-DNA hybridization value was supported in this placement. Strain Ox1(T) is closely related to Ralstonia eutropha with a less than 60% DNA-DNA hybridization value. The new name Ralstonia oxalatica comb. nov. is proposed to strain Ox1(T), on the basis of these results and previously published data for the G + C content of the genomic DNA and the phenotypic characters.
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    Isolation and characterization of a new type of aerobic, oxalic acid utilizing bacteria, and proposal of Oxalicibacterium flavum gen. nov., sp. nov.
    (Elsevier GmbH, 2002) Tamer A.Ü.; Aragno M.; Şahin N.
    A mesophilic, aerobic oxalic acid utilizing yellow-pigmented bacterium has been isolated from litter of oxalate producing plants in the region of Izmir (Turkey). It is motile by means of 1-3 polar flagella. Optimal growth occurred between 25-30 °C at pH 6,9. The G+C content of DNA is 62-64 mol % (Tm). Based on its morphological and biochemical features the organism belongs to the genus Pseudomonas, but differs from all the previously described species. The taxonomic relationships among strains described as or previously tentatively assigned to the genus Pseudomonas were investigated using numerical classification, DNA base composition and DNA-DNA hybridization. 16S rDNA sequences were determined for the strain TA17. On the basis of 16S rDNA sequence comparisons, physiological and biochemical characteristics, it is proposed to classify TA17T in a new genus and species for which the name Oxalicibacterium flavum gen. nov., sp. nov. is proposed. The type strain is TA17T (= NEU98T, = LMG 21571T).
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    Approximate solution of multi-pantograph equation with variable coefficients
    (2008) Sezer M.; yalçinbaş S.; Şahin N.
    This paper deals with the approximate solution of multi-pantograph equation with nonhomogenous term in terms of Taylor polynomials. The technique we have used is based on a Taylor matrix method. In addition, some numerical examples are presented to show the properties of the given method and the results are discussed. © 2007 Elsevier B.V. All rights reserved.
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    Montelukast is effective in preventing of ovarian hyperstimulation syndrome; an experimental study
    (Studio K Krzysztof Molenda, 2015) Eskicioğlu F.; Turan G.A.; Sivrikoz O.N.; Cengiz H.; Akan Z.; Şahin N.; Yilmaz O.; Yeşil H.; Vatansever S.
    Objectives: To determine the efficacy of montelukast in comparison with cabergoline in the prevention of ovarian hyperstimulation syndrome (OHSS) in rats. Material and methods: An experimental OHSS model was formed in 35 female Wistar rats. Rats (22 days old) were randomized into 5 groups, each containing 7 animals. The control group received no therapy; the mild OHSS group was administered pregnant mare serum gonadotropin (PMSG) 10 IU for 4 days, hCG 10 IU on the 5th day; the severe OHSS group received PMSG 10 IU for 4 days, hCG 30 IU on the 5th day. The montelukast group: received montelukast 10 mg/kg/day and the cabergoline group was administered cabergoline 100μg/kg/day via oral gavage for 6 days (days 22-27), in addition to those of severe OHSS. All groups were sacrificed on 28th day. Body weight, ovarian diameter and weight, vascular permeability, vascular endothelial growth factor (VEGF), semiquantitative VEGF receptor-1, and VEGF receptor-2 (VEGFR-2) immunohistochemistry were evaluated. Results: Ovarian diameter and VEGF expression were significantly lower in the montelukast and cabergoline groups than in the severe OHSS group. While montelukast was more effective in limiting vascular permeability in the severe OHSS, cabergoline was superior to montelukast with respect to the limiting effect on increased body weight and VEGFR-2 expression. Conclusions: The VEGF/VEGFR-2 interaction plays an important role in OHSS pathogenesis. Montelukast limits VEGF expression, and cabergoline reduces both VEGF and VEGFR-2 expressions; they are both effective therapies for the prevention of severe OHSS.
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    The prevalence of childhood psychopathology in Turkey: a cross-sectional multicenter nationwide study (EPICPAT-T)
    (Taylor and Francis Ltd, 2019) Ercan E.S.; Polanczyk G.; Akyol Ardıc U.; Yuce D.; Karacetın G.; Tufan A.E.; Tural U.; Aksu H.; Aktepe E.; Rodopman Arman A.; Başgül S.; Bılac O.; Coşkun M.; Celık G.G.; Karakoc Demırkaya S.; Dursun B.O.; Durukan İ.; Fidan T.; Perdahlı Fiş N.; Gençoğlan S.; Gökçen C.; Görker I.; Görmez V.; Gündoğdu Ö.Y.; Gürkan C.K.; Hergüner S.; Tural Hesapçıoğlu S.; Kandemir H.; Kılıç B.G.; Kılınçaslan A.; Mutluer T.; Nasiroğlu S.; Özel Özcan Ö.; Öztürk M.; Öztop D.; Yalın Sapmaz S.; Süren S.; Şahin N.; Yolga Tahıroglu A.; Toros F.; Ünal F.; Vural P.; Perçinel Yazıcı İ.; Yazıcı K.U.; Yıldırım V.; Yulaf Y.; Yüce M.; Yüksel T.; Akdemir D.; Altun H.; Ayık B.; Bilgic A.; Hekim Bozkurt Ö.; Demirbaş Çakır E.; Çeri V.; Üçok Demir N.; Dinç G.; Irmak M.Y.; Karaman D.; Kınık M.F.; Mazlum B.; Memik N.Ç.; Foto Özdemir D.; Sınır H.; Ince Taşdelen B.; Taşkın B.; Uğur Ç.; Uran P.; Uysal T.; Üneri Ö.; Yilmaz S.; Seval Yılmaz S.; Açıkel B.; Aktaş H.; Alaca R.; Alıç B.G.; Almaidan M.; Arı F.P.; Aslan C.; Atabay E.; Ay M.G.; Aydemir H.; Ayrancı G.; Babadagı Z.; Bayar H.; Çon Bayhan P.; Bayram Ö.; Dikmeer Bektaş N.; Berberoğlu K.K.; Bostan R.; Arıcı Canlı M.; Cansız M.A.; Ceylan C.; Coşkun N.; Coşkun S.; Çakan Y.; Demir İ.; Demir N.; Yıldırım Demirdöğen E.; Doğan B.; Dönmez Y.E.; Dönder F.; Efe A.; Eray Ş.; Erbilgin S.; Erden S.; Ersoy E.G.; Eseroğlu T.; Kına Fırat S.; Eynallı Gök E.; Güler G.; Güles Z.; Güneş S.; Güneş A.; Günay G.; Gürbüz Özgür B.; Güven G.; Çelik Göksoy Ş.; Horozcu H.; Irmak A.; Işık Ü.; Kahraman Ö.; Kalaycı B.M.; Karaaslan U.; Karadağ M.; Kılıc H.T.; Kılıçaslan F.; Kınay D.; Kocael Ö.; Bulanık Koç E.; Kadir Mutlu R.; Lushi-Şan Z.; Nalbant K.; Okumus N.; Özbek F.; Akkuş Özdemir F.; Özdemir H.; Özkan S.; Yıldırım Özyurt E.; Polat B.; Polat H.; Sekmen E.; Sertçelik M.; Sevgen F.H.; Sevince O.; Süleyman F.; Shamkhalova Ü.; Eren Şimşek N.; Tanır Y.; Tekden M.; Temtek S.; Topal M.; Topal Z.; Türk T.; Uçar H.N.; Uçar F.; Uygun D.; Uzun N.; Vatansever Z.; Yazgılı N.G.; Miniksar Yıldız D.; Yıldız N.
    Aim: The aim of this study was to determine the prevalence of childhood psychopathologies in Turkey. Method: A nation-wide, randomly selected, representative population of 5830 children (6–13 years-old) enrolled as a 2nd,3rd or 4th grade student in 30 cities were evaluated for presence of a psychiatric or mental disorder by a Sociodemographic Form, Kiddie Schedule for Affective Disorders and Schizophrenia for School Age Children-Present and Lifetime Version (K-SADS-PL), and DSM-IV-Based Screening Scale for Disruptive Behavior Disorders in Children and Adolescents scales. Impairment criterion was assessed via a 3 point-Likert scale by the parent and the teacher independently. Results: Overall prevalence of any psychopathology was 37.6% without impairment criterion, and 17.1% with impairment criterion. Attention-deficit hyperactivity disorder was the most frequent diagnosis, followed by anxiety (19.5% and 16.7% without impairment, 12.4% and 5.3% with impairment, respectively). Lower education level and presence of a physical or psychiatric problem of the parents were independent predictors of any psychopathology of the offspring. Conclusion: This is the largest and most comprehensive epidemiological study to determine the prevalence of psychopathologies in children and adolescents in Turkey. Our results partly higher than, and partly comparable to previous national and international studies. It also contributes to the literature by determining the independent predictors of psychopathologies in this age group. © 2019, © 2019 The Nordic Psychiatric Association.
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    The clinical, functional, and radiological features of hand osteoarthritis: TLAR-osteoarthritis multi-center cohort study
    (Turkish League Against Rheumatism (TLAR), 2022) Duruöz M.T.; Gürsoy D.E.; Tuncer T.; Altan L.; Ayhan F.; Bal A.; Bilgilisoy M.; Cerrahoğlu L.; Çapkın E.; Çay H.F.; Çevik R.; Durmaz B.; Dülgeroğlu D.; Gürer G.; Gürsoy S.; Hepgüler S.; Hizmetli S.; Kaçar C.; Kaptanoğlu E.; Kaya T.; Ecesoy H.; Melikoğlu M.A.; Nas K.; Nur H.; Özçakır Ş.; Sarıdoğan M.; Sarıkaya S.; Sezer İ.; Sindel D.; Şahin N.; Şahin Ö.; Şendur Ö.F.; Bozbaş G.T.; Tıkız C.; Uğurlu H.
    Objectives: This study aims to evaluate the clinical, functional, and radiological features of hand osteoarthritis (OA) and to examine their relationships in different geographic samples of the Turkish population. Patients and methods: Between April 2017 and January 2019, a total of 520 patients (49 males, 471 females; mean age: 63.6±9.8 years) with hand OA were included in the study from 26 centers across Türkiye by the Turkish League Against Rheumatism (TLAR). The demographic characteristics, grip strengths with Jamar dynamometer, duration of hand pain (month), the severity of hand pain (Visual Analog Scale [VAS]), and morning stiffness were evaluated. The functional disability was evaluated with Duruöz Hand Index (DHI). The Kellgren-Lawrence (KL) OA scoring system was used to assess the radiological stage of hand OA. Results: The DHI had significant correlations with VAS-pain (r=0.367, p<0.001), duration of pain (r=0.143, p=0.001) and bilateral handgrip strengths (r=-0.228, p=0.001; r=-0.303, p<0.001). Although DHI scores were similar between the groups in terms of the presence of hand deformity (p=0.125) or Heberden's nodes (p=0.640), the mean DHI scores were significantly higher in patients with Bouchard's nodes (p=0.015). The total number of nodes had no significant correlations with the VAS-pain and DHI score (p>0.05). The differences between the groups of radiological hand OA grades in terms of age (p=0.007), VAS-pain (p<0.001), duration of pain (p<0.001), and DHI (p<0.001) were significant. There were no significant differences between radiological hand OA grades according to the duration of the stiffness, grip strength, and BMI (p>0.05 for all). Conclusion: In our population, the patients with hand OA had pain, functional disability, and weak grip strength. The functional impairment was significantly correlated with the severity of the pain, and the functional status was worse in high radiological hand OA grades. © 2022 Turkish League Against Rheumatism. All rights reserved.
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    Effect of Impairment on the Prevalence and Comorbidities of Attention Deficit Hyperactivity Disorder in a National Survey: Nation-Wide Prevalence and Comorbidities of ADHD
    (SAGE Publications Inc., 2022) Ercan E.S.; Unsel-Bolat G.; Tufan A.E.; Karakoc Demirkaya S.; Bilac O.; Celik G.; Kılıç B.G.; Akyol Ardic U.; Yalin Sapmaz S.; Aksu H.; Yolga Tahiroglu A.; Karacetin G.; Tural U.; Aktepe E.; Rodopman Arman A.; Başgül S.; Coşkun M.; Dursun O.B.; Durukan İ.; Perdahli Fiş N.; Gençoğlan S.; Gökçen C.; Sarı Gokten E.; Görker I.; Görmez V.; Yıldız Gündoğdu Ö.; Hesapçioğlu S.T.; Kandemir H.; Mutluer T.; Nasiroğlu S.; Özcan Ö.; Şahin N.; Toros F.; Perçinel Yazici İ.; Yazici K.U.; Yulaf Y.; Yüksel T.; Bilgic A.; Altun H.; Akdemir D.; Mazlum B.; Çakın Memik N.; Foto Özdemir D.; Üneri Ö.; Ünal F.
    Objective: This study aimed to determine the prevalence and comorbidities of attention-deficit hyperactivity disorder (ADHD) by evaluating a large-scale nation-wide sample of children. Method: The inclusion criterion was being enrolled as a 2nd, 3rd, or 4th-grade student. A semi-structured diagnostic interview (K-SADS-PL), DSM-IV-Based Screening Scale for Disruptive Behavior Disorders, and assessment of impairment (by both parents and teachers) were applied to 5,842 participants. Results: The prevalence of ADHD was 19.5% without impairment and 12.4% with impairment. Both ADHD with and without impairment groups had similar psychiatric comorbidity rates except for oppositional defiant disorder (ODD) and conduct disorder (CD) diagnoses. Impairment in the ADHD group resulted in significantly higher ODD and CD diagnoses. Conclusion: Even when impairment is not described, other psychiatric disorders accompany the diagnosis of ADHD and may cause impairment in the future. Impairment in the diagnosis of ADHD significantly increases the likelihood of ODD and CD. © ©The Author(s) 2021.
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    Correlation of clinical signs and magnetic resonance imaging findings in patients with lumbar spondylosis
    (Turkish League Against Rheumatism (TLAR), 2023) Altan L.; Metin Ökmen B.; Tuncer T.; Sindel D.; Çay H.F.; Hepgüler S.; Sarıkaya S.; Ayhan F.; Bal A.; Bilgilisoy M.; Çapkın E.; Cerrahoğlu L.; Çevik R.; Dülgeroğlu D.; Durmaz B.; Duruöz T.; Gürer G.; Gürsoy S.; Hizmetli S.; Kaçar C.; Kaptanoğlu E.; Ecesoy H.; Melikoğlu M.; Nas K.; Nur H.; Özçakır Ş.; Şahin N.; Şahin Ö.; Sarıdoğan M.; Şendur Ö.F.; Sezer İ.; Bozbaş G.T.; Tıkız C.; Uğurlu H.
    Objectives: The purpose of the study was to contribute further to this debated topic by investigating the correlation of magnetic resonance imaging (MRI) findings with the clinical picture in lumbar spondylosis patients. Patients and methods: This multicenter retrospective study (as part of the epidemiological project of the TLAR-OASG [Turkish League Against Rheumatism-Osteoarthritis Study Group]) included 514 patients (101 males, 413 females; mean age: 63.6±10.8 years; range, 40 to 85 years) who were diagnosed as lumbar spondylosis by clinical examination and direct X-ray between December 2016 and June 2018. Demographic characteristics of patients, Visual Analog Scale for pain, presence of radiating pain, Roland-Morris disability questionnaire, straight leg raise test, deep tendon reflexes, neurogenic intermittent claudication symptoms, any decrease of muscle strength, and abnormality of sensation were recorded. Lumbar MRI findings of the patients were recorded as positive or negative in terms of disc herniation, intervertebral disc degeneration, root compression, osteophytes, spinal stenosis. Statistical analysis was done to assess the correlation between the clinical symptoms, physical examination, and MRI findings. Results: Correlation analysis of the MRI results and the clinical findings showed a significant correlation between straight leg raise test and root compression (p<0.001, r=0.328) and a significant correlation between neurogenic intermittent claudication and spinal stenosis (p<0.001, r=0.376). Roland-Morris disability questionnaire had a significant correlation with all MRI findings (p<0.05, r<0.200). Conclusion: The results of this study corroborate the notion that diligent patient history and physical examination are more valuable than MRI findings, even though a higher incidence of abnormal MRI findings have been obtained in patients with disability and dermatomal radiating pain. © 2023, Turkish League Against Rheumatism (TLAR). All rights reserved.
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    Influence of Boron Doping on the Dielectric Characteristics of Eu3+-Doped β-SrTa2O6 and Eu3+-Doped BaTa2O6 Tungsten Bronze-Type Ceramics
    (Springer, 2024) İlhan M.; Katı M.İ.; Şahin N.; Esmer K.
    The effect of boron doping on dielectric properties was examined using β-SrTa2O6:xEu3+ (x = 1.5 mol%, 3 mol%, 5 mol%, 10 mol%), β-SrTa2O6:xEu3+, yB3+ (x = 1.5 mol%, 3 mol%, 5 mol%, 10 mol%, y = 10 mol%) and BaTa2O6:xEu3+, yB3+ (x = 10 mol%, y = 0 mol%, 5 mol%, 15 mol%, 30 mol%, 50 mol%, 70 mol%, 100 mol%) tungsten bronze ceramics produced by the solid-state reaction method. X-ray diffraction (XRD ) results of all the β-SrTa2O6 and BaTa2O6 samples showed that they retained a single-phase structure. In scanning electron microscopy (SEM) examinations, the presence of boron promoted grain growth and agglomeration in the β-SrTa2O6 grains, while the increased boron concentration led to grain elongation in addition to grain growth in the BaTa2O6 grains. The dielectric results for the β-SrTa2O6:xEu3+ and β-SrTa2O6:xEu3+, yB3+ series showed that increased Eu3+ caused a decrease in the dielectric constant (ε′) and dielectric loss (tan δ), whereas the increasing B3+ presence for the BaTa2O6:xEu3+, yB3+ series led to an increase in the dielectric constant and a decrease in dielectric loss. The increase in tetragonality for BaTa2O6:xEu3+, yB3+ ceramics was correlated with a higher ferroelectric Curie temperature. © The Minerals, Metals & Materials Society 2024.