Browsing by Author "Şen S."
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Item Mental health of both child and parents plays a larger role in the health-related quality of life of obese and overweight children(Walter de Gruyter GmbH, 1985) Kızılay D.Ö.; Sapmaz Ş.Y.; Şen S.; Özkan Y.; Özyurt B.C.; Ersoy B.Aims: A decrease in health-related quality of life (HRQOL) measures among obese (OB) and overweight (OW) children has been shown in several studies, but knowledge about the variables affecting HRQOL impairments is missing. The aim of this study was to evaluate the relationship between HRQOL and sociodemographic characteristics, anthropometric measurements, metabolic parameters, mental symptoms and parental attitudes in a sample of OB/OW children. Methods: Eighty-six OB/OW children, aged between 9 and 17 years, participated in the study. We performed sociodemographic questioning, anthropometric examinations and laboratory evaluations of the participants. HRQOL was assessed using the Pediatric Quality-of-Life Inventory (PedsQL), and levels of anxiety and depressive symptoms were measured using the Screen for Child Anxiety-Related Disorders (SCARED) questionnaire and the Children’s Depression Inventory (CDI), respectively. Parental attitudes were assessed with the Parental Attitude Research Instrument (PARI) questionnaire. Results: A statistically significant relationship was found between total scores of CDI and SCARED answered by children and the total and subscale scores of PedsQL. Scores of total quality of life subscale, physical functionality and emotional functionality subscales were significantly lower in children with a family history of mental illness. No relationship was found between PedsQL subscales, anthropometric and metabolic parameters. Conclusions: Emotional problems and parental psychological distress are important factors in models of HRQOL in the OB/OW pediatric population. © 1985 Walter de Gruyter GmbH. All rights reserved.Item Technical and economical applicability study of centrifugal force gravity separator (MGS) to Kef chromite concentration plant(2008) Çiçek T.; Cöcen I.; Engin V.T.; Cengizler H.; Şen S.The results of multigravity separator (MGS) upgrading tests on fine chromite gravity tailings using - 100 and -100 + 150 μm fractions of the initial sample (-1 mm) with 24-7%Cr2O3 grade were presented. The metal screen analysis revealed that 20·66% of the total Cr2O3 content was present in the -106 μm size fraction. Under optimal operational conditions, a concentrate with 43·7%Cr 2O3 content and 65·0% chromite yield for the size fraction of -100 μm and a concentrate with 30·5%Cr2O 3 and 83·3% yield for the size fraction of -100 + 150 μm could be produced. Shaking table test results revealed that the coarse fraction of the tailings could not be enriched any further owing to the high concentration of interlocked particles. However, a saleable concentrate could be obtained by MGS when the coarse tailings were ground down to - 100 μm and used as the feed. The results of the study suggested that multigravity separation of the Kef tailings was technically feasible and economically viable. The payback time of two alternatives suggested for the utilisation of MGS in Kef concentrator was calculated to be <7 months. © 2008 Institute of Materials, Minerals and Mining and The AusIMM.Item Insulin Resistance as Related to Psychiatric Disorders in Obese Children(NLM (Medline), 2018) Özalp Kızılay D.; Yalın Sapmaz Ş.; Şen S.; Özkan Y.; Ersoy B.Objective: The current study aimed to investigate psychiatric consequences of obesity and the relationship between componenets of the metabolic syndrome and psychiatric disorders in children. Our second aim was to elucidate which of the anthropometric parameters or metabolic components were most strongly associated with psychiatric disorders. Methods: The study included 88 obese and overweight children with a body mass index (BMI) greater than 85th percentile. The patients were evaluated for psychiatric disorders by a single child and adolescent psychiatrist. Forty patients diagnosed with psychiatric disorders and 48 patients with normal psychiatric evaluation were compared in terms of anthropometric and metabolic parameters. BMI, BMI-standard deviation score and BMI percentile, waist circumference, waist to hip ratio, blood pressure and pubertal stage of all patients were recorded. Fasting serum glucose, insulin, lipid profile and homeostatic model assessments of insulin resistance (HOMA-IR) were measured to evaluate the metabolic parameters. Serum and 24 hour urine cortisol levels were measured. Results: HOMA-IR in the group with psychiatric disorders was found to be significantly higher than in the group without psychiatric disorders (6.59±3.36 vs 5.21±2.67; p=0.035). Other anthropometric measurements and metabolic parameters were not significantly different between the two groups. Conclusion: An understanding of the relationships between obesity related medical comorbidities and psychiatric pathologies is important to encourage patients and their families to make successful healthy lifestyle changes and for weight management in terms of appropriate treatment.Item Associations between serum uric acid concentrations and cardiometabolic risk and renal injury in obese and overweight children(Galenos Yayincilik,, 2019) Kızılay D.Ö.; Şen S.; Ersoy B.Objective: The aim of this study was to assess the association between serum uric acid concentration (SUAC) and the parameters of the metabolic syndrome (MetS) and insulin resistance (IR). The secondary aim was to evaluate whether hyperuricemia is associated with renal injury and cardiovascular risk in obese (OB) and overweight (OW) children. Methods: The subjects of this study consisted of OB/OW children and adolescents (ages: 8-18 years). Sex and age specific serum uric acid (SUA) olarak degistirilecek percentiles were used and a SUA >75th percentile was accepted as hyperuricemia. Anthropometric data, blood pressure (BP) measurements and biochemical parameters, including fasting blood glucose, insulin, total cholesterol, high-density lipoprotein cholesterol (HDL-c), low-density lipoprotein cholesterol, triglycerides (TG), aspartate aminotransferase, alanine aminotransferase, homeostatic model assessments of IR (HOMA-IR) and SUAC were recorded. Oral glucose tolerance tests (OGTT) were performed in all patients. MetS was defined according to the International Diabetes Federation criteria. Total cholesterol/HDL-c ratio >4 and TG/HDL-c ratio >2.2 were used as the atherogenic index (AI) indicating cardiovascular risk. Urinary albumin excretion in a 24-hour and also in a first-morning urine sample were measured. Renal injury was assessed by microalbuminuria according to the National Kidney Foundation criteria. Results: There were 128 participants; 52 (40%) had elevated (SUA >75th percentile) and 76 had (60%) normal SUAC. The mean±SD age was 13.1±2.6 years and 87 (67.4%) were female. The mean±SD weight was 73±18.97 kg and mean±SD height was 155.4±12.11 cm. There was no statistical difference between the groups with and without hyperuricemia in terms of age, sex, puberty stage and degree of obesity. Increased SUAC were significantly associated with higher waist-to-hip ratio (WHR), fasting insulin levels and insulin at 30 and 60 minutes during OGTT, HOMA-IR, lower HDL-c and presence of hypertriglyceridemia as well as with decreased HDL-c, increased AI, presence of IR and MetS. BP and microalbuminuria were not associated with SUAC. SUAC showed significant positive correlations with waist circumference, WHR, post-challenge glucose level at 60 minutes, with fasting insulin, post-challenge insulin levels at 30, 60, 90 and 120 minutes and also with HOMA-IR, total cholesterol/HDL-c ratio, TG/HDL-c ratio and a number of other criteria related to MetS. Also, an inverse correlation with HDL-c was noted. Conclusion: In OB/OW children frequency of MetS, IR and dislipidemia increases with increased SUAC, a finding independent of age, puberty, gender and body mass index. Patients meeting all of the MetS criteria had the highest SUAC. These results demonstrate that the association between UA and metabolic and cardiovascular risk factors can be detected early in childhood. Thus, we recommend monitoring SUAC in OB children and we believe that prevention of SUAC elevation in early life has a potential protective effect on metabolic impairment and subsequent comorbidities. © 2019 by Turkish Pediatric Endocrinology and Diabetes Society.Item Relationship between Toxoplasma gondii seropositivity and depression in children and adolescents(Elsevier Ireland Ltd, 2019) Yalın Sapmaz Ş.; Şen S.; Özkan Y.; Kandemir H.Identification of the structural causes of depression is important for the treatment process, and toxoplasmosis may be related to psychiatric disorders. The aim of this study was to evaluate the relationship between Toxoplasma gondii (T. gondii) seropositivity and depression in children and adolescents. This case-control study included 37 children and adolescents aged 11–18 years diagnosed with depression who were followed by the Manisa Celal Bayar University Child and Adolescent Mental Health Service and 36 children and adolescents aged 11–18 years with no history of depressive episodes or psychiatric disorder treated by the Pediatric Outpatient Department. The T. gondii serology of these two groups was evaluated and compared. There were no statistically significant age or sex differences between the 37 participants with depression and the 36 healthy controls. Eight patients and two controls were seropositive for T. gondii, a statistically significant difference (p = 0.046). Seropositivity was significantly higher in patients with suicidal ideation (p = 0.005) than in those without suicidal ideation. The seropositivity of seven of the nine participants who attempted suicide was significantly higher (p < 0.001) than that of participants who did not. Thus, T. gondii infection may affect the predisposition for and severity of depression. © 2019Item Education of healthcare personnel working with pediatric patients during covid-19 pandemic within the framework of infection control; [Covid-19 pandemisinde enfeksiyon kontrol çalışmaları çerçevesinde çocuk hastalarla çalışan sağlık personeli eğitimi](AVES, 2020) Oygar P.D.; Büyükçam A.; Bal Z.Ş.; Dalgıç N.; Bozdemir Ş.E.; Karbuz A.; Çetin B.Ş.; Kara Y.; Çetin C.; Hatipoğlu N.; Uygun H.; Aygün F.D.; Törün S.H.; Okur D.Ş.; Çiftdoğan D.Y.; Kara T.T.; Yahşi A.; Özer A.; Demir S.Ö.; Akkoç G.; Turan C.; Salı E.; Şen S.; Erdeniz E.H.; Kara S.S.; Emiroğlu M.; Erat T.; Aktürk H.; Gürlevik S.L.; Sütçü M.; Aydın Z.G.G.; Atikan B.Y.; Yeşil E.; Güner G.; Çelebi E.; Efe K.; İşançlı D.K.; Durmuş H.S.; Tekeli S.; Karaarslan A.; Bülbül L.; Almış H.; Kaba Ö.; Keleş Y.E.; Yazıcıoğlu B.; Oğuz Ş.B.; Ovalı H.F.; Doğan H.H.; Çelebi S.; Çakır D.; Karasulu B.; Alkan G.; Yenidoğan İ.; Gül D.; Küçükalioğlu B.P.; Avcu G.; Kukul M.G.; Bilen M.; Yaşar B.; Üstün T.; Kılıç Ö.; Akın Y.; Cebeci S.O.; Turgut M.; Yanartaş M.S.; Şahin A.; Arslanoğlu S.; Elevli M.; Öz Ş.K.T.; Hatipoğlu H.; Erkum İ.T.; Demirbuğa A.; Özçelik T.; Sarı E.E.; Akkuş G.; Hatipoğlu S.S.; Dinleyici E.Ç.; Hacımustafaoğlu M.; Özkınay F.; Kurugöl Z.; Cengiz A.B.; Somer A.; Tezer H.; Kara A.Objective: In the early stages of any epidemic caused by new emerging pathogens healthcare personnel is subject to a great risk. Pandemic caused by SARS-CoV-2, proved to be no exception. Many healthcare workers died in the early stages of pandemic due to inadequate precautions and insufficient protection. It is essential to protect and maintain the safety of healthcare personnel for the confinement of pandemic as well as continuity of qualified healthcare services which is already under strain. Educating healthcare personnel on appropiate use of personal protective equipment (PPE) is as essential as procuring them. Material and Methods: A survey is conducted on 4927 healthcare personnel working solely with pediatric patients from 32 different centers. Education given on PPE usage were questioned and analyzed depending on age, sex, occupation and region. Results: Among four thousand nine hundred twelve healthcare personnel from 32 different centers 91% (n= 4457) received education on PPE usage. Of those who received education only 36% was given both theoretical and applied education. Although there was no differences among different occupation groups, receiving education depended on regions. Conclusion: It is essential to educate healthcare personnel appropiately nationwidely for the continuity of qualified healthcare services during the pandemic. © 2020, AVES. All rights reserved.Item Should we worry about the eyes of celiac patients?(SAGE Publications Ltd, 2020) Doğan G.; Şen S.; Çavdar E.; Mayalı H.; Cengiz Özyurt B.; Kurt E.; Kasırga E.Purpose: In this article, we evaluate subfoveal choroidal thickness in celiac patients with respect to adherence to the gluten-free diet and nonadherence to the gluten-free diet, comparing with age and sex matched healthy controls using spectral-domain optical coherence tomography. Materials and Methods: A case-control study among 42 celiac patients and 42 healthy participants was conducted in the Department of Pediatric Gastroenterology. Celiac patients of our policlinics compliant with spectral-domain optical coherence tomography examination enrolled in the study. Celiac patients had been asked verbally about their adherence to gluten-free diet, were evaluated according to negative or positive EmA and anti-TG2 for defining adherence, and were divided into two groups (adherence to gluten-free diet and nonadherence to gluten-free diet). Results: Subfoveal choroidal thickness was thinner in EmA (+) or anti-TG2 (+) eyes than EmA(−) or anti-TG2 (−) eyes in celiac patients, but it was not statistically significant. The mean subfoveal choroidal thickness values in eyes with celiac disease, whose diagnosis time was longer than 60 months, were thinner than shorter group. Longer duration of gluten-free diet was associated with adherence difficulty and thinner choroidal thickness (r = −0.15, p = 0.34). Adherence to gluten-free diet was 88.2% for children below the age of 60 months and 57.1% for children older than 60 months. Conclusion: In conclusion, in addition to other extraintestinal manifestations of celiac disease, diagnosis time longer than 60 months in pediatric celiac patients, nonadherence to the gluten-free diet, and antibody positivity should be focused on during ophthalmologic examination and choroid measurement. © The Author(s) 2019.Item Women’s experiences after abnormal Pap smear results: a qualitative study(Taylor and Francis Ltd, 2020) Er Güneri S.; Şen S.Background: Abnormal Pap smear result means there have been cell changes on the cervix but are not cancer. Women with abnormal test result may be affected from this situation. What do women with abnormal Pap smear results experience from a biopsychosocial perspective? Objective: This study aimed to explore the experiences of women with abnormal Pap smear results according to the biopsychosocial model. Methods: This phenomenological study’s data were collected in interviews with 12 women who had abnormal Pap smear test results. Data collection tool consists of two parts that are an “Women’s Information Form (WIF)” identifying women and semi-structured “Interview Form”. Interviews were done face-to-face by using in-depth interviews technique. Semi-structured interview was recorded in audio recording device. Thematic approach was used to assess the data. Results: The average age of the women was 42.5 ± 3.64, their age at first sexual intercourse was 23.0 ± 2.8 years and all of them were legally married. Five main themes were determined, which were grouped under the Biopsychosocial Model Domains. The Biological Domain themes were Perception of Health and Disease, and Cervical Cancer Risk Factors; the Psychological Domain themes were Positive Feelings and Negative Feelings; the Social Domain theme was Continuing Social Life. Conclusions: It was concluded that the cultural beliefs, perceptions, emotions and practices of women with abnormal Pap smear results should be considered in the diagnostic and treatment processes. These characteristics of women’s experience are also important to consider when developing strategies to address barriers to effective cervical screening, diagnosis and treatment. © 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group.Item Is Monitoring of Cytomegalovirus Disease Required in Nontransplant Pediatric Acute Lymphoblastic Leukemia?(Lippincott Williams and Wilkins, 2021) Şen S.; Özdemir H.H.; Karadaş N.; Bal Z.Ş.; Göktepe Ş.Ö.; Ece D.; Balkan C.; Aydinok Y.; Karapinar D.Y.Introduction: Cytomegalovirus (CMV) infections in developing countries are experienced at an early age. This study was performed to investigate the frequency of reactivation and risk factors of infection acquired at an early age of nontransplant acute lymphoblastic leukemia (ALL) patients receiving immunosuppressive therapy with weekly monitoring of CMV levels in Turkey. Materials and Methods: This was a retrospective, single-center study of 172 pediatric patients (102 boys and 70 girls) with ALL. All patients were monitored routinely for CMV-DNA at the initial presentation of leukemia and twice a week during chemotherapy. The CMV immunoglobulin (Ig)M/IgG titers were measured at admission. Results: CMV seropositivity at baseline was 90,11%. The overall prevalence of CMV infection (viremia) was 70.34%, 116 of whom were seropositive for CMV IgG and 5 of whom were negative for CMV at the time of ALL diagnosis. Reactivation was more common than de novo CMV infections (P=0.000). CMV seropositivity at the beginning of the leukemia diagnosis was found to be an independent predictor for developing CMV infection (P=0.001). A total of 60 CMV infection episodes were treated with antivirals. Four of these included organ involvement. The duration of CMV-DNA viremia episodes was longer in patients with CMV-DNA ≥1000 copies/mL (n=45) than in those with lower CMV-DNA levels (P=0.002). Infection was shown not to be associated with chemotherapy phase. Conclusion: This study suggests the importance of monitoring for CMV infections in developing countries because of frequent reactivations in seropositive ALL patients. It should be kept in mind that low CMV-DNA levels may also lead to organ involvement. © 2021 Lippincott Williams and Wilkins. All rights reserved.Item SARS-CoV-2 seropositivity among pediatric health care personnel after the first peak of the pandemic: nationwide surveillance in Turkey(Elsevier B.V., 2021) Oygar P.D.; Büyükçam A.; Bal Z.Ş.; Dalgıç N.; Bozdemir Ş.E.; Karbuz A.; Çetin B.Ş.; Kara Y.; Çetin C.; Hatipoğlu N.; Uygun H.; Aygün F.D.; Törün S.H.; Okur D.Ş.; Çiftdoğan D.Y.; Kara T.T.; Yahşi A.; Özer A.; Demir S.Ö.; Akkoç G.; Turan C.; Salı E.; Şen S.; Erdeniz E.H.; Kara S.S.; Emiroğlu M.; Erat T.; Aktürk H.; Gürlevik S.L.; Sütçü M.; Aydın Z.G.G.; Atikan B.Y.; Yeşil E.; Güner G.; Çelebi E.; Efe K.; İşançlı D.K.; Durmuş H.S.; Tekeli S.; Karaaslan A.; Bülbül L.; Almış H.; Kaba Ö.; Keleş Y.E.; Yazıcıoğlu B.; Oğuz Ş.B.; Ovalı H.F.; Doğan H.H.; Çelebi S.; Çakır D.; Karasulu B.; Alkan G.; Yenidoğan İ.; Gül D.; Küçükalioğlu B.P.; Avcu G.; Kukul M.G.; Bilen M.; Yaşar B.; Üstün T.; Kılıç Ö.; Akın Y.; Cebeci S.O.; Bucak I.H.; Yanartaş M.S.; Şahin A.; Arslanoğlu S.; Elevli M.; Çoban R.; Öz Ş.K.T.; Hatipoğlu H.; Erkum İ.T.; Turgut M.; Demirbuğa A.; Özçelik T.; Çiftçi D.; Sarı E.E.; Akkuş G.; Hatipoğlu S.S.; Dinleyici E.Ç.; Hacımustafaoğlu M.; Özkınay F.; Kurugöl Z.; Cengiz A.B.; Somer A.; Tezer H.; Kara A.Background: Understanding SARS-CoV-2 seroprevalence among health care personnel is important to explore risk factors for transmission, develop elimination strategies and form a view on the necessity and frequency of surveillance in the future. Methods: We enrolled 4927 health care personnel working in pediatric units at 32 hospitals from 7 different regions of Turkey in a study to determine SARS Co-V-2 seroprevalence after the first peak of the COVID-19 pandemic. A point of care serologic lateral flow rapid test kit for immunoglobulin (Ig)M/IgG was used. Seroprevalence and its association with demographic characteristics and possible risk factors were analyzed. Results: SARS-CoV-2 seropositivity prevalence in health care personnel tested was 6.1%. Seropositivity was more common among those who did not universally wear protective masks (10.6% vs 6.1%). Having a COVID-19-positive co-worker increased the likelihood of infection. The least and the most experienced personnel were more likely to be infected. Most of the seropositive health care personnel (68.0%) did not suspect that they had previously had COVID-19. Conclusions: Health surveillance for health care personnel involving routine point-of-care nucleic acid testing and monitoring personal protective equipment adherence are suggested as important strategies to protect health care personnel from COVID-19 and reduce nosocomial SARS-CoV-2 transmission. © 2021 The Author(s)Item Cervicofacial Actinomycosis in Children(Springer International Publishing, 2021) Şen S.; Arısoy E.S.; Starke J.R.Actinomycosis is a slowly progressive, chronic, suppurative, granulomatous disease. The etiologic agents are Actinomyces spp. and cervicofacial, thoracic, and abdominal actinomycosis are the primary clinical forms of the disease worldwide [1]. The cervicofacial illness is the most common form (50–70%); however, actinomycosis of oral and pelvic regions, the central nervous system (CNS), and metastatic foci to other sites are also reported [2]. © The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2022.Item Consideration whether hepatitis b exists in children whose mothers suffer from chronic hepatitis b and these mothers in gestational age; [Kronik Hepatit B Enfeksiyonu Olan Annelerin Gebeliklerinde ve Çocuklarında Hepatit B Enfeksiyonun Değerlendirilmesi](Galenos Publishing House, 2021) Yıldız İ.E.; Tosun S.; Şen S.; Altunal L.N.; Uğurlu K.; Bahşi A.Objectives: Perinatal and intrauterine transmission of the hepatitis B virus (HBV) represents a major factor, leading to the development of chronic infection. This study aimed to explore the status of mothers and their children for hepatitis B (HB) infection during pregnancy and childhood, and whether active and passive immunoprophylaxis was administered to infants shortly after birth. Materials and Methods: We performed multicenter, retrospective research on voluntary hepatitis B surface antigen (HBsAg)-positive mothers admitted to infectious diseases polyclinics was performed. Mothers and their children were queried by a questionnaire about their HB infection status. Data from the electronic data recording system was scanned retrospectively. Results: Three hundred-one mothers and 616 children were included in the study. HBsAg was examined in 354 (57.4%) of pregnancies. Of 91 children with HBsAg positivity, 83 were not applied active and passive immunoprophylaxis after birth. Eight 276 babies received both immune prophylaxes after birth were then detected as HBsAg positive. On HBV examination, 148 children were found to encounter the HBV. HBsAg positivity rate was significantly higher in children born before 1997. Conclusion: The remarkable decrease in HBsAg positivity of children reveals the efficacy of national vaccination. By informing both healthcare workers and society, awareness about examining pregnants for HBsAg during pregnancy should be increased. © 2020 by Viral Hepatitis Society / Viral Hepatitis Journal published by Galenos Publishing House.Item Urinary NGAL is a Potential Biomarker for Early Renal Injury in Insulin Resistant Obese Non-diabetic Children(Galenos Publishing House, 2021) Şen S.; Kızılay D.Ö.; Taneli F.; Özen Ç.; Ertan P.; Özunan İ.; Yıldız R.; Ersoy B.Objective: Neutrophil gelatinase-associated lipocalin (NGAL) is one of the new biomarkers for detecting acute renal injury. There are studies showing the relationship between NGAL and renal injury in obese children. The aim of this study was to investigate whether urinary levels of NGAL, kidney injury molecule-1, and serum cystatin C are increased in insulin resistance (IR) patients before the development of diabetes. Methods: Cross-sectional, case-controlled study that included non-diabetic obese children and adolescent patients with IR and a non-diabetic obese control group with no IR, who attended a tertiary center pediatric endocrinology outpatient clinic between 2016-2018. Those with diabetes mellitus and/or known renal disease were excluded. NGAL and creatinine (Cr) levels were evaluated in the morning spot urine from all participants. Serum renal function was evaluated. Results: Thirty-six control and 63 IR patients were included in the study, of whom 68 (68.7%) were girls. The mean age of all participants was 13.12±2.64 years and no statistically significant difference was found between the two groups in terms of age or gender distribution. Median (range) spot urinary NGAL (u-NGAL) values in the IR group were significantly higher at 26.35 (7.01-108.7) ng/mL than in the control group at 19.5 (3.45-88.14) ng/mL (p=0.018). NGAL/Cr ratio was also significantly higher in the IR group compared to the control group (p=0.018). Conclusion: Obese pediatric patients with IR were shown to have elevated levels of u-NGAL, a marker of renal injury. u-NGAL examination may show early renal injury before development of diabetes. © 2021 by Turkish Pediatric Endocrinology and Diabetes Society.Item Evaluation of attitudes and knowledge of influenza diagnosis, treatment and vaccination among pediatric residents; [Pediatri asistanlarının çocuklarda influenza tanı, tedavi ve bağışıklaması hakkındaki bilgi düzeyleri, algı, tutum ve davranışları](AVES, 2021) Garipçin P.; Keleş Y.E.; Karadağ-öncel E.; Kıymet E.; Böncüoğlu E.; Özlü C.O.; Asrak H.K.; Özenen G.G.; Ümit Z.; Kara S.S.; Şen S.; Kara-Aksay A.; Bal Z.Ş.; Devrim İ.; Belet N.; Çiftdoğan D.Y.Objective: Influenza virus is common in children, especially in winter, causing hospitalization, admission to the intensive care unit, or even death. There are few studies on the attitudes or knowledge of influenza diagnosis, treatment, and vaccination among pediatricians. This study was planned to determine pediatric residents’ attitudes and behaviors about recognizing the influenza virus, making treatment decisions, pro-phylaxis, and immunization. Material and Methods: This descriptive cross-sectional study was per-formed from 31 July-1 December 2019 among pediatric residents work-ing in six different hospitals in the Aegean Region by an online survey. Twenty-seven questions were asked regarding articipant’s demographic characteristics, recognition of the influenza symptoms, treatment, pro-phylaxis, and immunization. Results: Two hundred and four (58.5%) of 349 pediatric residents were included in the study, who answered the questionnaire. Among the par-ticipants, 72.5% were females, and their mean age was 27.9 ± 2.1 years, and 59.3% worked as a pediatric residents for less than two years. When the symptoms of influenza were evaluated, the most known symptoms were fever (94.1%), myalgia (81.9%), tiredness (77.0%), headache (70.1%), and cough (68.6%). When oseltamivir treatment indications were ques-tioned, most pediatric residents (82.2%) answered the questions. It was observed that 21.1% of the pediatric residents had the flu vaccine in the current season. According to the state of having chronic diseases, the rate of vaccination in participants was not statistically significant (p= 0.136). Conclusion: In this study, it was determined that pediatric residents’ knowledge about influenza awareness, treatment, and immunization was insufficient. It may be beneficial to train pediatric residents about the influenza virus and vaccine before each influenza season. © Telif Hakkı 2021.Item Autochthonous transmission of Leishmania donovani and Leishmania major with all the components of infection cycle at Europe's doorstep(Elsevier B.V., 2022) Özbilgin A.; Tunalı V.; Akar Ş.Ş.; Yıldırım A.; Şen S.; Çavuş I.; Zorbozan O.; Gündüz C.; Turgay N.; İnanır I.Objectives: Leishmaniasis is a vector-borne disease and dogs may act as urban reservoirs. Turkey and most of the Mediterranean basin countries are endemic for leishmaniasis. In this study, it is aimed to report the autochthonous leishmaniasis cases, with all the components of the infection cycle (reservoir, vector, and the host) in a region close to Europe. Methods: Nine human and four canine autochthonous leishmaniasis cases were included in the study. Direct microscopy, culture methods, serological, and molecular tests were applied to the samples obtained from the cases. Results: VL and CL patients consisted of 2 L.infantum, 1 L. donovani, 2 L. tropica, and 2 L. tropica,1 L. major,1 L. infantum infected patients respectively. CanL cases were infected with L. infantum, L. donovani, L. tropica, and L. major. Conclusions: All the cases were autochthonous cases located in Manisa province. As Greece and all the Mediterranean basin countries in Europe share competent vectors, it is concluded that the detection of all 4 species of Leishmania parasites in such proximity to Europe poses an important public health threat for Europe. This study reports all four species of Leishmania spp., including L. major and L.donovani in close proximity to continental Europe. © 2022 Elsevier B.V.Item The adaptation states of women with urinary incontinence according to the Roy Adaptation Model: A qualitative study(John Wiley and Sons Inc, 2022) Er Güneri S.; Şen S.Aims: This study aimed to explore experiences of women with urinary incontinence (UI) according to the Roy Adaptation Model (RAM). Methods: A phenomenological design was used in this study, and its conceptual framework was formed by the RAM. The sample was composed of 12 women with UI. Face-to-face in-depth interviews were conducted according to data collection tools. Semi-structured interviews were recorded in audio-recording device. Thematic approach was used to assess the data. Results: The average age of the women was 52.77 ± 7.32 years, seven women had menopause, eight had vaginal birth. According to the thematic approach, four main themes emerged: physiological mode, self-esteem mode, role function mode, and interdependence mode and they had difficulties in this regard. Conclusions: The results show that women cannot adapt to the problem of incontinence according to the dimensions of RAM. These factors are important to consider when developing strategies to address UI, diagnosis, and treatment. © 2022 Wiley Periodicals LLC.Item Clinical, Demographic, and Radiological Characteristics of Patients Demonstrating Antibodies Against Myelin Oligodendrocyte Glycoprotein(Galenos Publishing House, 2024) Koç S.; Şen S.; Terzi Y.; Kızılay F.; Demir S.; Aksoy D.B.; Kurtuluş F.; Bilge N.; Idilman E.; Uzunköprü C.; Güngör S.; Çilingir V.; Ethemoğlu Ö.; Boz C.; Gümüş H.; Kılıç A.K.; Kısabay A.; Bir L.S.; Turan Ö.F.; Soysal A.; Köseoğlu M.; Uzuner G.T.; Bayındır H.; Kabay S.C.; Çam M.; Yayla V.; Tan H.; Özcan A.; Taşkapıoğlu Ö.; Korkmaz M.; Tamam Y.; İnanç Y.; Efendi H.; Kotan D.; Yetkin M.F.; Bilgiç A.B.; Saçmacı H.; Demirci S.; Çelik Y.; Poyraz T.; Terzi M.Background: Optic neuritis, myelitis, and neuromyelitis optica spectrum disorder (NMOSD) have been associated with antibodies against myelin oligodendrocyte glycoprotein-immunoglobulin G (anti-MOG-IgG). Furthermore, patients with radiological and demographic features atypical for multiple sclerosis (MS) with optic neuritis and myelitis also demonstrate antibodies against aquaporin-4 and anti-MOG-IgG. However, data on the diagnosis, treatment, follow-up, and prognosis in patients with anti-MOG-IgG are limited. Aims: To evaluate the clinical, radiological, and demographic characteristics of patients with anti-MOG-IgG. Study Design: Multicenter, retrospective, observational study. Methods: Patients with blood samples demonstrating anti-MOG-IgG that had been evaluated at the Neuroimmunology laboratory at Ondokuz Mayıs University’s Faculty of Medicine were included in the study. Results: Of the 104 patients with anti-MOG-IgG, 56.7% were women and 43.3% were men. Approximately 2.4% of the patients were diagnosed with MS, 15.8% with acute disseminated encephalomyelitis (ADEM), 39.4% with NMOSD, 31.3% with isolated optic neuritis, and 11.1% with isolated myelitis. Approximately 53.1% of patients with spinal involvement at clinical onset demonstrated a clinical course of NMOSD. Thereafter, 8.8% of these patients demonstrated a clinical course similar to MS and ADEM, and 28.1% demonstrated a clinical course of isolated myelitis. The response to acute attack treatment was lower and the disability was higher in patients aged > 40 years than patients aged < 40 years at clinical onset. Oligoclonal band was detected in 15.5% of the patients. Conclusion: For patients with NMOSD and without anti-NMO antibodies, the diagnosis is supported by the presence of anti-MOG-IgG. Furthermore, advanced age at clinical onset, Expanded Disability Status Scale (EDSS) score at clinical onset, spinal cord involvement, and number of attacks may be negative prognostic factors in patients with anti-MOG-IgG. © Author(s).