Browsing by Author "Şirin B.H."

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    Ischaemic preconditioning reduces spinal cord injury in transient ischaemia
    (Acta Cardiologica, 2002) Şirin B.H.; Ortaç R.; Cerrahoǧlu M.; Saribülbül O.; Baltalarli A.; Çelebisoy N.; Işkesen I.; Rendeci O.
    Objective - Paraplegia remains a devastating complication after thoracic and thoracoabdominal aortic surgery for coarctations, dissections or aneurysms. Since the advent of ischaemic preconditioning of the myocardium, attention has been directed to the nervous system. This study was designed to evaluate the acute protective effect of ischaemic preconditioning on the spinal cord. Medhods and results - Thirty-six New Zealand white rabbits were randomly assigned to one of three groups. The preconditioning group had 5 minutes of aortic occlusion, 25 minutes reperfusion and 20 minutes of ischaemia, whereas the controls had only 20 minutes of ischaemia. The sham group was anaesthetized and subjected to laparotomy without aortic occlusion. Physiological parameters and somatosensory evoked potentials were monitored during the experiment. Neurological outcome was clinically evaluated up to 48 hour after ischaemia and motor function was scored. Then the animals were sacrificed. Their spinal cord, abdominal aorta and its branches were removed and processed for histopathological examination. Histhopathological changes of the gray matter in the lumbosacral segments were scored from 0 to 6 according to a semi-quantitative scala. The changes in amplitudes of evoked potentials during ischaemia and recovery periods were similar in preconditioning and control groups. The average motor function score was significantly higher in the preconditioning group than the control group at 24 and 48 hours after the ischaemic event (p < 0.05). Histological observations were consistent with the neurological findings. The histopathological scores in the control group and the preconditioning group were 3.2 (1.4-5.2) and 2.4 (0.8-4.4), respectively (p < 0.05). Conclusions - The results suggest that ischaemic preconditioning reduces the spinal cord injury and improves neurological outcome in transient ischaemia in rabbits. This protective mechanism is rapidly invoked within only 25 minutes interval between the preconditioning stimulus and the ischaemic insult.
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    Early ischaemic preconditioning reduces spinal cord injury in transient ischaemia (multiple letters)
    (2003) Toumpoulis I.K.; Şirin B.H.
    [No abstract available]
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    The effect of cardiopulmonary bypass on the expression of inducible nitric oxide synthase, endothelial nitric oxide synthase, and vascular endothelial growth factor in the internal mammary artery
    (2006) Toprak V.; Şirin B.H.; Tok D.; Özbilgin K.; Saribülbül O.
    Objective: Endothelial function of a vessel may be impaired by local or systemic inflammation initiated by cardiopulmonary bypass (CPB) during coronary artery bypass graft (CABG) surgery. The present study was designed to investigate the early effects of CPB on nitric oxide production and vascular endothelial growth factor (VEGF) expression in internal mammary artery (IMA). Design: Prospective study. Setting: University hospital. Participants: Twenty patients who were scheduled for elective CABG with CPB. Interventions: IMA sections were studied immunohistochemically from these patients. The samples were taken from the distal end of the IMA before the institution of CPB and just before the construction of the IMA-left anterior descending artery anastomosis. Measurement and Main Results: After CPB, VEGF and endothelial nitric oxide synthase immunoreactivity increased significantly when compared with baseline values in the endothelium (p = 0.0156, p = 0.0313) and adventitia (p = 0.0313, p = 0.0001), respectively. No significant change was observed in inducible nitric oxide synthase immunoreactivity. Conclusions: The increase in eNOS expression may have been induced by the inflammation caused by CPB. © 2006 Elsevier Inc. All rights reserved.
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    The effect of levosimendan in patients undergoing to coronary bypass operation with low ejection fraction; [Koroner baypas geçi̇ren düşük ejeksi̇yon fraksi̇yonlu hastalarda levosi̇mendanin etki̇leṙi]
    (2009) Kurdal A.T.; Öztürk T.; Badak O.T.; Eserdaǧ M.; Işkesin I.; Cerrahoǧlu M.; Şirin B.H.
    In this study we determined the effects of levosimendan on hemodynamic parameters during weaning from cardiopulmonary bypass and in the early postoperative period in patients with low ejection fraction. Charts of 39 patients with an ejection fraction of ≤30% who underwent elective coronary artery bypass surgery were reviewed. Nineteen (Group L) had received a loading dose of levosimendan (6 μg·kg-1) within 10 minutes after removal of the cross clamp, followed by an infusion (0.1 mcg·kg-1·min-1). Control patients (n=20, Group C) did not receive levosimendan. Hemodynamic parameters during the early postoperative period were compared. Cardiac index was significantly higher than baseline in both groups at one and six hours after removal of the cross clamp (p<0.05). Cardiac index was significantly greater, and systemic vascular resistance index and Pulmonar vascular resistance index were significantly lower, in Group L at both one and six hours (p<0.001). In conclusion, the use of levosimendan was associated with more favourable hemodynamic effects in patients with low ejection fraction during weaning from cardiopulmonary bypass and in the early postoperative period after Coronary Artery Bypass Grefting surgery.
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    A rare cardiac tumor in childhood: Right atrial myxoma; [Çocuk yaş grubunda nadir bir kardiyak tümör: Saǧ atriyal miksoma]
    (2011) Kurdal A.T.; Eserdaǧ M.; Işkesen I.; Şirin B.H.
    Myxoma is a rare tumor in childhood and unlike left atrial localization is quite rare in right atrium. A 14-year-old male child presented with complains of exertional dys-pnea and tachycardia. Transthoracic echocardiography revealed a huge myxoma in the right atrium, closing the inferior vena cava orifice and causing tricuspid stenosis. Cardiopulmonary bypass was started only with superior vena cava cannulation. Inferior vena cava cannulation was performed after cardiac arrest due to the embolic risk. The total resection was performed by right atriotomy.