Browsing by Author "ALMisned G."
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Item A thorough examination of gadolinium (III)-containing silicate bioactive glasses: synthesis, physical, mechanical, elastic and radiation attenuation properties(Springer Science and Business Media Deutschland GmbH, 2022) Deliormanlı A.M.; Ensoylu M.; Issa S.A.M.; Rammah Y.S.; ALMisned G.; Tekin H.O.Gadolinium (III)-containing (1, 3 and 5 wt.%) silicate-based bioactive glass powders were synthesized by sol–gel method and subsequently die pressed to fabricate disc-shape glass samples. Sintering was performed at 690 °C for 1 h in air atmosphere. Physical, structural, and mechanical properties (compressive strength and Vickers hardness) of the fabricated glass pellets were investigated. Results showed that prepared glass samples were amorphous after sintering and any detrimental effect of Gd2O3 was not observed on the densification. An increase in bulk density and in compressive strength was obtained as the gadolinium (III) concentration was increased. On the other hand, a significant influence of the rare-earth element on the Vickers hardness was not seen. For the sample containing gadolinium (III) at highest concentration, Vickers hardness was measured to be 3.25 ± 0.23 GPa. Our findings indicate that increasing the quantity of Gadolinium (III) significantly affects the gamma-ray attenuation qualities of bioactive glass samples. The addition of Gadolinium (III) improved the attenuation qualities of the bioactive glass samples across a broad energy range. As a result, it can be concluded that Gadolinium (III) and its monotonic effect may be used to modify the basic features of bioactive glass samples. In addition, it can be concluded that this monotonic effect may be employed to optimize the circumstances of use of associated bioactive materials based on their requirements in medical and engineering applications. © 2022, The Author(s), under exclusive licence to Springer-Verlag GmbH, DE part of Springer Nature.Item Two-dimensional molybdenum disulfide/polymer-coated bioactive glass scaffolds for tissue engineering: Fabrication, structural, mechanical, bioactivity, and radiation interaction properties(Elsevier Ltd, 2023) Deliormanli A.M.; Ensoylu M.; ALMisned G.; Tekin H.O.Molybdenum disulfide (MoS2)-based nanostructures are widely used in environmental protection and biomedicine owing to their biological, physical, chemical, electrical, and mechanical properties. In this study, polycaprolactone (PCL)- and polylactide-co-glycolide (PLGA)-coated bioactive glass scaffolds containing MoS2 nanoparticles are prepared, and their usability in bone tissue engineering applications is evaluated. Borate bioactive glass scaffolds are fabricated using the replication method and coated with PCL or PLGA solutions (5 wt%) containing MoS2 (0.1, 0.2, 0.5, 1, and 2 wt%) nanoparticles. The structural and mechanical properties of the scaffolds and their bioactivity in simulated body fluids are investigated comprehensively. The ionization–radiation-shielding properties are investigated using Monte Carlo simulations. The results show that the polymer coating layer and presence of MoS2 nanoparticles in the polymer matrix improves the mechanical properties of the scaffolds. The addition of MoS2 nanoparticles to the structure increases the hydroxyapatite-forming ability of bioactive glass-based composites. Additionally, the prepared composite scaffolds exhibit high radiation-shielding ability owing to the presence of MoS2 nanoparticles embedded in the polymer matrix that shields the glass surface. Bioactive glass composite scaffolds containing MoS2 nanoparticles demonstrate promising potential for bone regeneration and radiation-shielding applications. © 2023 Elsevier Ltd and Techna Group S.r.l.Item Graphene-bioactive glass composites: Structural, Vickers hardness, and gamma-ray attenuation characteristics(Frontiers Media S.A., 2023) Deliormanli A.M.; ALMisned G.; Ene A.; Tekin H.O.Introduction: Graphene-based materials have gained increasing attention for use in radiation attenuation applications. In this study, pristine graphene nanoplatelet-containing (1, 3, 5, and 10 wt%) borate-based bioactive glass composites were prepared. Methods: Structural properties, Vickers microhardness, and gamma-ray radiation shielding properties of the fabricated composites were examined in detail. Results and Discussion: Results revealed that the inclusion of the graphene in the glass matrix led to a decrease in the bulk density of the glass-based composites from 2.41 to 2.31 g/cm3. Similarly, a decrease in Vickers hardness was obtained as the graphene concentration was increased due to a convoluted effect of the non-uniform distribution of graphene nanoplatelets in the bioactive glass matrix and the higher residual porosity. Vickers hardness of the bare and the 10 wt% graphene-containing bioactive glass discs were measured to be 5.03 ± 0.28 GPa and 1.87 ± 0.56 GPa, respectively. On the other hand, the incorporation of graphene starting from 3 wt% decreased the crack propagation after indentation which may be attributed to an increase in fracture toughness. In the study, fundamental gamma ray absorption properties of graphene-containing bioactive glasses were examined in the 0.015–15 MeV incident photon energy range. For this purpose, the Py-MLBUF code was employed to determine gamma ray absorption parameters. Results showed that linear attenuation coefficients of the glass-based composites decreased due to a decrease in the density of the samples. On the other hand, as graphene was incorporated into the bioactive glass structure, exposure buildup factor and energy absorption buildup factor values increased. The growing graphene ratio in the glass structure contributed negatively to the photon’s tendency to interact with the material. Copyright © 2023 Deliormanli, ALMisned, Ene and Tekin.Item Nanoarchitectonics and properties of sol-gel-derived bioactive glasses containing maghemite@ZnO core-shell nanoparticles(Springer Science and Business Media Deutschland GmbH, 2024) Deliormanlı A.M.; ALMisned G.; Tekin H.O.This study comprehensively examined the structural, magnetic, hemocompatibility, and bioactivity properties of magnetic bioactive glass particles embedded with zinc oxide-coated superparamagnetic maghemite (γ-Fe2O3@ZnO) nanoparticles. Bioactive glass particles with varying concentrations of maghemite (2, 5, 10, and 20 wt%) were synthesized using the sol-gel method. The particles ranged in size from 6.83 μm to 14.5 μm, with size decreasing as maghemite content increased. The saturation magnetization values were 1.31 emu/g and 2.74 emu/g for the lowest and highest maghemite concentrations, respectively, indicating superparamagnetic behavior. Hydroxyapatite formation on the glass surfaces diminished with increased maghemite content, but hemocompatibility tests showed no significant hemolytic activity at a concentration of 0.5 mg/ml. The inclusion of γ-Fe2O3@ZnO nanoparticles significantly enhanced the gamma radiation attenuation properties of the bioactive glasses, particularly at higher maghemite concentrations. In conclusion, γ-Fe2O3@ZnO-enriched bioactive glasses exhibit promising potential for biomedical applications, offering a balance between magnetic functionality, bioactivity, and radiation shielding. Future research will focus on optimizing nanoparticle concentrations and surface modifications to enhance their multifunctionality. © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2024.Item Synthesis and characterization of Nb5+ and Sm3+-doped 13–93 bioactive glass particles with improved photon transmission properties for advanced biomedical and dental applications(Elsevier Ltd, 2024) Deliormanlı A.M.; ALMisned G.; Tekin H.O.Bioactive glasses are renowned for their applications in dentistry, serving as restorative materials, dental adhesives, intracanal medicaments, and agents for enamel remineralization. Niobium pentoxide (Nb2O5) is employed in dental adhesive resins and orthodontic adhesives, offering radio-pacifying properties essential for dental materials. Samarium oxide (Sm2O3) emerges as a potential additive in aesthetic restorative dental ceramics and resins, enhancing the natural fluorescence of teeth. In this study Nb2O5 and Sm2O3-doped (1, 3, and 5 wt%) 13–93 bioactive glass particles were synthesized via the sol-gel method, tailored for dental implementations. We conducted a comprehensive analysis of the physical, structural, and optical properties of the resultant glass powders. Additionally, their in vitro bioactivity and ionizing radiation shielding characteristics were rigorously evaluated. The results indicate that Sm3+ ions preserve the amorphous nature of the silicate glasses, while Nb5+ incorporation leads to the crystallization of the T-Nb2O5 phase. Bioactivity assays across three physiological fluids—simulated body fluid, α-minimum essential medium, and phosphate-buffered saline, demonstrated the ability of doped glasses to facilitate hydroxyapatite layer formation, with the most pronounced bioactivity observed in phosphate-buffered saline immersed samples. Furthermore, radiation shielding simulations reveal that the addition of Nb2O5 and Sm2O3 enhances the ionizing radiation attenuation capabilities of the glasses, a property that holds significant promise for protecting against radiation in dental radiology. It can be concluded that the dual functionality of Nb5+ and Sm3+-doped bioactive glasses, which may revolutionize restorative dental practices and offer improved protection in radiological applications. © 2024 Elsevier Ltd and Techna Group S.r.l.