Browsing by Author "Acar, A"

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    Prognostic Effects of Predominant Histologic Subtypes in Resected Pulmonary Adenocarcinomas
    Yaldiz, D; Kaya, SÖ; Ceylan, KC; Acar, A; Aydogdu, Z; Gürsoy, S; Yaldiz, S
    Background: Predominant histologic subtypes have been reported as predictors of survival of patients with pulmonary adenocarcinoma. Aims: To evaluate the predictive value of histologic classification in resected lung adenocarcinoma using the classification systems proposed by the International Association for the Study of Lung Cancer, American Thoracic Society, European Respiratory Society, and World Health Organization (2015). Study Design: Cross-sectional study. Methods: The histologic classification of a large cohort of 491 patients with resected lung adenocarcinoma (stages I-III) was retrospectively analyzed. The tumors were classified according to their predominant component (lepidic, acinar, papillary, solid, micropapillary, and mucinous), and their predictive values were assessed for clinicopathologic characteristics and overall survival. Results: The patient cohort comprised 158 (32.2%) patients with solid predominant, 150 (30.5%) with acinar predominant, 80 (16.3%) with papillary predominant, 75 (15.3%) with lepidic predominant, 22 (4.5%) with mucinous, and 5 (1.0%) with micropapillary subtype, and 1 (0.2%) with adenocarcinoma in situ. Overall 5-year survival of 491 patients was found to be 51.8%. Patients with lepidic, acinar, and mucinous adenocarcinoma had 70.9%, 59.0%, and 66.6% 5-year survival, respectively, and there was no statistically significant difference between them. Whereas patients with solid, papillary, and micropapillary predominant adenocarcinoma had 41.0%, 40.5%, and 0.0% 5-year survival, respectively. Compared to other histologic subtypes, patients with solid and papillary predominant adenocarcinoma had significantly lower survival than those with lepidic (p<0.001, p=0.002), acinar (p<0.001, p=0.008), and mucinous (p=0.048, p=0.048) subtypes, respectively. The survival difference between patients with solid subtype and those with papillary subtype was not statistically significant (p=0.67). Conclusion: Solid and papillary histologic subtypes are poor prognostic factors in resected invasive lung adenocarcinoma.
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    Papillary predominant histological subtype predicts poor survival in lung adenocarcinoma
    Yaldiz, D; Acar, A; Kaya, SÖ; Aydogdu, Z; Gursoy, S; Yaldiz, S
    Background: This study aims to investigate whether papillary predominant histological subtype can predict poor survival in lung adenocarcinoma. Methods: Between January 2005 and December 2016, a total of 80 patients with papillary predominant subtype lung adenocarcinoma (70 males, 10 females; mean age 60.7 years; range, 42 to 79 years) operated in our clinic were included in the study. These patients were compared with those having lepidic, acinar, and mucinous subtypes. Overall and five- year survival rates were evaluated. Results: Five-year survival was 40.5% in papillary predominant histological subtype, while this rate was 70.9%, 59.0%, and 66.6% in lepidic, acinar, and mucinous subtypes, respectively. Papillary subtype showed significantly poor survival compared to lepidic (p=0.002), acinar (p=0.008), and mucinous subtypes (p=0.048). In Stage 1 disease, it was more evident (papillary, 47.5%, lepidic 86.9% [p=0.001], acinar 69.3% [p=0.040], and mucinous 90.0% [p=0.050]). Conclusion: Our study results suggest that papillary predominant subtype predicts poor survival in lung adenocarcinoma and these cases may be candidates for adjuvant treatment modalities even in the earlier stages of disease.
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    Effects of boron compounds and ozonated olive oil on experimental Microsporum canis infection in rats
    Gezer, AH; Acar, A
    This study aimed to investigate the treatment outcomes of topical application of boric acid, boron-doped gel, and ozonated olive oil in cases of Microsporum canis-induced dermatophytosis. Furthermore, the outcomes were compared to those of terbinafine administration. We included 39 female Wistar albino rats weighing 200-250 g and created an M. canis-infected area on the skin of their backs. The rats were clinically scored on days 0, 7, 14, 21, and 28 and underwent histopathological evaluation. All the treated groups demonstrated significantly lower clinical scores than the control group (P < 0.05). Fewer inflammation cells were observed in the samples of groups treated with 3% boric acid and sodium pentaborate pentahydrate gel than in those of the control group. According to the histopathological evaluation, the groups treated with 3% boric acid and sodium pentaborate pentahydrate gel were statistically different from the control and other treatment groups (P < 0.05). Our results indicated that treatment with 3% boric acid and sodium pentaborate gel was adequate in resolving M. canis-induced infection in rats. Therefore, gels containing 3% boric acid and sodium pentaborate pentahydrate may be alternatives to antifungal agents such as terbinafine by ensuring easy, reliable, inexpensive, and effective treatment modalities.
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    The relationship between violence against women and gender attitudes in men, Bolu province Kibriscik example
    Özpinar, S; Acar, A
    Purpose The study has two purposes: ascertaining the determinants and the frequency of violence against women in men and determining the relation between men's violence against women and gender attitudes. Design and Methods The study is of cross-sectional type. Three questionnaires were used to collect the research data: sociodemographic information form, violence against women questionnaire, and the Gender Equality Scale. Findings The first important finding of the study is that the rate of domestic violence against women is high. The second important finding is that men who have resorted to violence against women have more unequal gender attitudes. Practice Implications The research reveals the significance related to the participation of men in gender equality policies and provides guiding data for healthcare professionals.
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    The effect of thoracic trauma scoring system in thoracic trauma patients with rib fracture
    Sarmis, NB; Kuzucuoglu, M; Taylan, KI; Yekdes, AC; Ünal, M; Sirzai, S; Sakariya, BC; Acar, A
    ObjectiveRib fractures are common in thoracic trauma patients. There are various factors, including flail chest, pulmonary contusion, and accompanying conditions, affecting morbidity and mortality. The study aimed to identify high-risk patients for morbidity and mortality with a scoring system that the authors created.MethodsCases over the age of 18 admitted due to trauma and diagnosed with rib fractures between 1 January 2019 and 1 March 2023, were included. Trauma scores were determined by applying the new trauma scoring system. Trauma scores and other variables regarding morbidity and mortality were evaluated.ResultsA total of 1023 cases were included in the study. The total trauma scores were higher in bilateral and multiple fractures. In those without respiratory failure, the total score was statistically significantly lower than in the groups with respiratory failure. The total score was significantly higher in those who needed surgery, those who were hospitalized, and those who needed intensive care compared to the non-surgical groups. However, there was no correlation between intensive care unit stay and total score. Trauma mechanism, presence of additional extrathoracic pathology, and thoracic trauma-age score were independent predictors of survival.ConclusionThe present study demonstrated that the number of rib fractures and the presence of pulmonary contusion did not have an effect on mortality and morbidity. The presence of extrathoracic pathology and age significantly affect survival.
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    Effects of Different Treatment Modalities on Lung Injury in Experimental Pulmonary Contusion Model
    Kuzucuoglu, M; Balta, C; Altun, E; Yekdes, AC; Acar, A
    Introduction: The study experimentally evaluated the efficacies of different agents in treating pulmonary contusion. Methods: In our study, 42 Wistar albino rats were divided into six groups of seven animals each. A model of lung contusion with blunt chest trauma was performed in five groups, except for the control group. One group with pulmonary contusion was considered an untreated group, and saline was administered. For other groups, prednisolone, tranexamic acid, N-acetylcysteine, and vitamin E were applied to determine their efficacy in treatment. The rats were sacrificed 24 h after trauma, and their injured lungs were collected for histopathological examination and blood samples for blood gas analysis. Histopathologically, bronchial damage, alveolar hemorrhage, emphysema, and leukocyte infiltration were assessed using the scoring system. Results: In our study, statistically significant differences were detected between the rat groups in terms of intraalveolar hemorrhage, leukocyte infiltration, and bronchial damage. In post hoc analysis, intraalveolar hemorrhage was significantly higher in the untreated group compared to the control group (P = 0.012). A near-significant difference was observed between the untreated group and the N-acetylcysteine group (P = 0.061). Regarding leukocyte infiltration, the tranexamic acid group showed significantly higher values compared to both the prednisolone and control groups (P = 0.007; P = 0.016, respectively). For bronchial damage, the levels observed in the vitamin E and tranexamic acid groups were significantly higher than those in the control group (P = 0.08 and P = 0.037, respectively). Conclusions: Many agents are used to treat pulmonary contusion, but no gold standard treatment exists. Prednisolone and N-acetylcysteine play significant roles in treatment. These two drugs contributed to the regression of the findings in pulmonary contusion treatment. 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.