Browsing by Author "Acar E.Y."

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    Can urinary gamma glutamyl transferase be used as a bone resorption marker in postmenopausal osteoporosis?; [Üriner gamma glutamil transferaz postmenapozal osteoporozlu olgularda kemik yıkım belirteci olarak kullanılabilir mi?]
    (Turkish Biochemistry Society, 2011) Tikiz C.; Ulman C.; Taneli F.; Acar E.Y.; Gümüşer G.; Horasan G.D.
    Objectives: To evaluate whether γ-glutamyl transferase can be used as a new novel bone resorption marker in postmenopusal osteoporotic subjects. Design and methods: 156 postmenopausal subjects were divided into three groups according to their lumbar spine T-score measured by dual-energy X-ray absorptiometry as normal, (control group, n=56), osteopenic (n=50) and osteoporotic (n=50). Deoxypyridinoline and γ-glutamyl transferase from urine samples and osteocalcin and bone specific alkaline phosphates from blood samples were assessed. Results: Osteocalcin and bone specific alkaline phosphates levels were increased in osteoporotic group (p<0.05). Although there is a tendency to increase in deoxypyridinoline values in osteoporotic group, this difference did not reach to a statistical significance. No significant differences were observed in urinary γ-glutamyl transferase levels between the three groups (p>0.05). No significant correlation was found between urinary γ-glutamyl transferase and deoxypyridinoline, bone specific alkaline phosphates and osteocalcin (p>0.05). Urinary γ-glutamyl transferase levels showed no significant correlation with neither bone mineral density nor T scores in all subjects (r= 0.058 p= 0.625, r=-0.074 p=0.533 respectively). Conclusions: Our primary findings did not support the suggestion that urinary γ-glutamyl transferase could be used as a potential marker for bone resorption in postmenopusal osteoporotic subjects. © 2011 TurkJBiochem.com.