Browsing by Author "Acar H."
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Item Evaluation of the association between null genotypes of glutathione-S-transferases and Behcet's disease(2006) Uzunoǧlu S.; Acar H.; Okudan N.; Gökbel H.; Mevlitoǧlu I.; Sari F.Glutathione S-transferases (GST) play an important role in oxidative stress related syndromes. An imbalance of the oxidant and antioxidant systems is important in the pathogenesis of Behcet's disease (BD). The objective of this study was to evaluate the association of null genotypes of GST-M1 and GST-T1 with BD since some preliminary molecular genetic data were recently published. Ninety-four Turkish BD patients (42 male, 52 female, 37.1 ± 10.4 years) and 140 healthy volunteers (70 male, 70 female, 36.8 ± 11.7 years) matched for age and gender with the patients as the control group were included in the study. Distributions of GST-M1 and GST-T1 genotypes were determined by multiplexed PCR using three sets of primers for GST-M1, GST-T1, and β-globulin genes. There was no association between BD and the frequencies of GST-M1 and GST-T1 null genotypes when compared to controls by separate analysis. However, by cross and pooled combination analysis there was a significant association between the frequencies of pooled GSTs with one or both null genotypes in BD and controls. This is the first evidence that the association between the frequencies of GST-M1 and GST-T1 null genotypes and BD might be dependent on the interaction of multiple null allele polymorphisms rather than a single null allele of GST-M1 and GST-T1. © Springer-Verlag 2005.Item Withdrawal users' perceptions of and experience with contraceptive methods in Manisa, Turkey(2006) Yanikkerem E.; Acar H.; Elem E.Objective: to gain an understanding of the knowledge, perceptions and experiences of using contraceptive methods among Turkish withdrawal users. Design: population-based, cross-sectional and descriptive study using a questionnaire conducted face to face. Setting: women who live in the Number 6 primary health unit area in Manisa, Turkey. Participants: 276 women who used the 'withdrawal' method for contraception. Measurements and findings: almost all women were aware of modern contraceptive methods. The condom, intrauterine contraceptive device (IUCD) and oral contraceptives were the most known methods. The most common reasons for using 'withdrawal' were that this method was reliable, husbands preferred it, it was healthier, easier to use or more convenient than other methods. Conclusion and implications for practice: it is important for midwives and nurses to recognise the effects of cultural beliefs on women's contraceptive use. Educational programmes should be individualised to meet the specific needs of women and their partners. © 2005 Elsevier Ltd. All rights reserved.Item Lack of association between leptin levels and leptin gene polymorphism in obese women(Informa Healthcare, 2014) Okudan N.; Gökbel H.; Acar H.; Uzunoʇlu S.; Belviranli M.The aim of the present study was to evaluate the relationship between oligopolymorphism in the 25th codon of leptin gene and obesity. Eighty-seven obese women and 75 healthy women were constituted obese and control groups. Body fat percent, fat mass and lean body mass were determined by bioimpedance meter and leptin levels were determined. The presence of 25th codon oligopolymorphism in the leptin gene was done by PCR-RFLP technique. Mean leptin levels were 38.5±22.0ng/ml, and 147.9±44.8ng/ml in the control and obese groups, respectively. The correlations of serum leptin level to body fat percentage and fat mass in the control group were significant. The correlations in the obese group were not significant. This data implies that the difference of leptin levels between control and obese groups are more likely to be associated with alterations in the leptin gene other than 25th codon or alterations in the leptin receptor gene. © 2014 Informa UK Ltd. All rights reserved.