Browsing by Author "Aguilar D."

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    Rhinitis associated with asthma is distinct from rhinitis alone: The ARIA-MeDALL hypothesis
    (John Wiley and Sons Inc, 2023) Bousquet J.; Melén E.; Haahtela T.; Koppelman G.H.; Togias A.; Valenta R.; Akdis C.A.; Czarlewski W.; Rothenberg M.; Valiulis A.; Wickman M.; Akdis M.; Aguilar D.; Bedbrook A.; Bindslev-Jensen C.; Bosnic-Anticevich S.; Boulet L.P.; Brightling C.E.; Brussino L.; Burte E.; Bustamante M.; Canonica G.W.; Cecchi L.; Celedon J.C.; Chaves Loureiro C.; Costa E.; Cruz A.A.; Erhola M.; Gemicioglu B.; Fokkens W.J.; Garcia-Aymerich J.; Guerra S.; Heinrich J.; Ivancevich J.C.; Keil T.; Klimek L.; Kuna P.; Kupczyk M.; Kvedariene V.; Larenas-Linnemann D.E.; Lemonnier N.; Lodrup Carlsen K.C.; Louis R.; Makela M.; Makris M.; Maurer M.; Momas I.; Morais-Almeida M.; Mullol J.; Naclerio R.N.; Nadeau K.; Nadif R.; Niedoszytko M.; Okamoto Y.; Ollert M.; Papadopoulos N.G.; Passalacqua G.; Patella V.; Pawankar R.; Pham-Thi N.; Pfaar O.; Regateiro F.S.; Ring J.; Rouadi P.W.; Samolinski B.; Sastre J.; Savouré M.; Scichilone N.; Shamji M.H.; Sheikh A.; Siroux V.; Sousa-Pinto B.; Standl M.; Sunyer J.; Taborda-Barata L.; Toppila-Salmi S.; Torres M.J.; Tsiligianni I.; Valovirta E.; Vandenplas O.; Ventura M.T.; Weiss S.; Yorgancioglu A.; Zhang L.; Abdul Latiff A.H.; Aberer W.; Agache I.; Al-Ahmad M.; Alobid I.; Ansotegui I.J.; Arshad S.H.; Asayag E.; Barbara C.; Baharudin A.; Battur L.; Bennoor K.S.; Berghea E.C.; Bergmann K.C.; Bernstein D.; Bewick M.; Blain H.; Bonini M.; Braido F.; Buhl R.; Bumbacea R.S.; Bush A.; Calderon M.; Calvo-Gil M.; Camargos P.; Caraballo L.; Cardona V.; Carr W.; Carreiro-Martins P.; Casale T.; Cepeda Sarabia A.M.; Chandrasekharan R.; Charpin D.; Chen Y.Z.; Cherrez-Ojeda I.; Chivato T.; Chkhartishvili E.; Christoff G.; Chu D.K.; Cingi C.; Correia de Sousa J.; Corrigan C.; Custovic A.; D’Amato G.; Del Giacco S.; De Blay F.; Devillier P.; Didier A.; do Ceu Teixeira M.; Dokic D.; Douagui H.; Doulaptsi M.; Durham S.; Dykewicz M.; Eiwegger T.; El-Sayed Z.A.; Emuzyte R.; Fiocchi A.; Fyhrquist N.; Gomez R.M.; Gotua M.; Guzman M.A.; Hagemann J.; Hamamah S.; Halken S.; Halpin D.M.G.; Hofmann M.; Hossny E.; Hrubiško M.; Irani C.; Ispayeva Z.; Jares E.; Jartti T.; Jassem E.; Julge K.; Just J.; Jutel M.; Kaidashev I.; Kalayci O.; Kalyoncu A.F.; Kardas P.; Kirenga B.; Kraxner H.; Kull I.; Kulus M.; La Grutta S.; Lau S.; Le Tuyet Thi L.; Levin M.; Lipworth B.; Lourenço O.; Mahboub B.; Martinez-Infante E.; Matricardi P.; Miculinic N.; Migueres N.; Mihaltan F.; Mohammad Y.; Moniuszko M.; Montefort S.; Neffen H.; Nekam K.; Nunes E.; Nyembue Tshipukane D.; O’Hehir R.; Ogulur I.; Ohta K.; Okubo K.; Ouedraogo S.; Olze H.; Pali-Schöll I.; Palomares O.; Palosuo K.; Panaitescu C.; Panzner P.; Park H.S.; Pitsios C.; Plavec D.; Popov T.A.; Puggioni F.; Quirce S.; Recto M.; Repka-Ramirez M.S.; Robalo Cordeiro C.; Roche N.; Rodriguez-Gonzalez M.; Romantowski J.; Rosario Filho N.; Rottem M.; Sagara H.; Serpa F.S.; Sayah Z.; Scheire S.; Schmid-Grendelmeier P.; Sisul J.C.; Sole D.; Soto-Martinez M.; Sova M.; Sperl A.; Spranger O.; Stelmach R.; Suppli Ulrik C.; Thomas M.; To T.; Todo-Bom A.; Tomazic P.V.; Urrutia-Pereira M.; Valentin-Rostan M.; Van Ganse E.; van Hage M.; Vasankari T.; Vichyanond P.; Viegi G.; Wallace D.; Wang D.Y.; Williams S.; Worm M.; Yiallouros P.; Yusuf O.; Zaitoun F.; Zernotti M.; Zidarn M.; Zuberbier J.; Fonseca J.A.; Zuberbier T.; Anto J.M.
    Asthma, rhinitis, and atopic dermatitis (AD) are interrelated clinical phenotypes that partly overlap in the human interactome. The concept of “one-airway-one-disease,” coined over 20 years ago, is a simplistic approach of the links between upper- and lower-airway allergic diseases. With new data, it is time to reassess the concept. This article reviews (i) the clinical observations that led to Allergic Rhinitis and its Impact on Asthma (ARIA), (ii) new insights into polysensitization and multimorbidity, (iii) advances in mHealth for novel phenotype definitions, (iv) confirmation in canonical epidemiologic studies, (v) genomic findings, (vi) treatment approaches, and (vii) novel concepts on the onset of rhinitis and multimorbidity. One recent concept, bringing together upper- and lower-airway allergic diseases with skin, gut, and neuropsychiatric multimorbidities, is the “Epithelial Barrier Hypothesis.” This review determined that the “one-airway-one-disease” concept does not always hold true and that several phenotypes of disease can be defined. These phenotypes include an extreme “allergic” (asthma) phenotype combining asthma, rhinitis, and conjunctivitis. Rhinitis alone and rhinitis and asthma multimorbidity represent two distinct diseases with the following differences: (i) genomic and transcriptomic background (Toll-Like Receptors and IL-17 for rhinitis alone as a local disease; IL-33 and IL-5 for allergic and non-allergic multimorbidity as a systemic disease), (ii) allergen sensitization patterns (mono- or pauci-sensitization versus polysensitization), (iii) severity of symptoms, and (iv) treatment response. In conclusion, rhinitis alone (local disease) and rhinitis with asthma multimorbidity (systemic disease) should be considered as two distinct diseases, possibly modulated by the microbiome, and may be a model for understanding the epidemics of chronic and autoimmune diseases. © 2023 The Authors. Allergy published by European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd.
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    Leadership development training for orthopaedic trauma surgeons: an international survey
    (Wolters Kluwer Health, 2024) MacKechnie M.C.; Miclau E.; MacKechnie M.A.; Miclau T.; Abalo A.G.; Adem E.G.; Aguilar D.; Ahmed S.O.M.; Akue A.H.-M.; Alhadhoud M.; Al-Saadan W.A.; AlSaifi M.; Anicet L.F.; Apivatthakakul T.; Areu M.M.M.; Babhulkar S.; Babikir E.; Barquet A.; Bataga T.; Begue T.; Brink O.; Burda R.; Buteera A.M.; Chesser T.J.S.; Chokotho L.; Cimerman M.; De Ridder V.A.; Dieme C.B.; Dogjani A.; Dragon K.; Ebrahimpour A.; Ekure J.; Escalante Elguezabal I.A.; Enghelmayer R.A.; Farouk O.; Garnavos C.; Garuz M.; Gebhard F.; Gelink A.; Gerich T.G.; Glinkowski M.W.; Grecu D.-C.; Gudushauri P.; Guerado E.; Haonga B.T.; Hattar Y.; Herrera A.C.; Hussein K.; Isiklar Z.U.; Jagdeo R.; Kagda F.H.Y.; Kojima K.E.; Lamichhane A.; Laubscher M.; Leandre N.L.; Leung J.P.; Makelov B.; Michail K.; Miller A.N.; Mkochi V.L.; Mukalamusi D.M.; Muñoz-Vives J.M.; Munthali J.; Narayan R.C.; Nau T.; Navarre P.; Neyra H.T.; Ngissah R.K.S.; Noda T.; Oberli H.; Okcu G.; Orujov E.; Padilla L.; Pesantez R.; Radko K.; Salce I.; Schemitsch E.H.; Schmidt U.; Schuetz M.A.; Sciuto D.; Segovia J.; Selmani E.; Siniki F.; Sitnik A.; Smirnov A.; Taha W.S.; Talevski D.; Terjajevs I.; Ullman M.; Venerand B.; Weill Y.A.; Woolley P.M.; Younes E.M.
    Purpose:This study examined the leadership development themes that global orthopaedic surgeons in differently resourced countries perceive as essential components and evaluated barriers to attending leadership development programs.Methods:This multinational, 45-question survey engaged orthopaedic surgeons (one expert per country). The questionnaire collected participants' demographics, perception of effective leadership traits, and valuation of various leadership themes based on importance and interest.Results:The survey was completed by 110 orthopaedic surgeons worldwide. Respondents most commonly reported holding a leadership position (87%) in hospital settings (62%), clinical settings (47%), and national orthopaedic societies (46%). The greatest proportion of participants reported having never attended a leadership course (42%). Participants regarded "high performing team-building," "professional ethics," and "organizational structure and ability to lead" as the most important leadership themes. No significant (P ≤ 0.05) differences were identified among perceived importance or interest in leadership themes between income levels; however, statistically significant differences were identified in the questionnaire; respondents in low- and middle-income countries (LICs/LMICs) demonstrated a stronger interest in attending a leadership course than those in high-income countries (HICs) (98% vs. 79%, P = 0.013), and fewer surgeons in LICs/LMICs had taken personality assessment tests than those in HICs (22% vs. 49%, P = 0.019). The most common barriers to attending leadership courses were lack of opportunities and invitations (57%), difficulty missing work (22%), and cost of course attendance (22%).Conclusions:These findings can better inform the development of effective curricula and provide a framework for a successful model for the future. © 2024 Wolters Kluwer Health. All rights reserved.