Browsing by Author "Ak, G"

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    Effect of Asbestos Exposure on the Frequency of EGFR Mutations and ALK/ROS1 Rearrangements in Patients With Lung Adenocarcinoma A Multicentric Study
    Yilmaz, S; Demirci, NY; Metintas, S; Zamani, A; Karadag, M; Guçlu, OA; Kabalak, PA; Yilmaz, U; Ak, G; Kizilgoz, D; Ozturk, A; Yilmaz, U; Batum, O; Kavas, M; Serifoglu, I; Unsal, M; Komurcuoglu, BE; Cengiz, TI; Ulubay, G; Ozdemirel, TS; Ozyurek, BA; Kavurgaci, S; Alizoroglu, D; Celik, P; Erdogan, Y; In, E; Aksoy, A; Altin, S; Gunluoglu, G; Metintas, M
    Objective: The aim of this study is to investigate the effect of asbestos exposure on cancer-driver mutations. Methods: Between January 2014 and September 2018, epidermal growth factor receptor (EGFR), anaplastic lymphoma receptor tyrosine kinase (ALK), and c-ros oncogene 1 receptor tyrosine kinase gene (ROS1) alterations, demographic characteristics, asbestos exposure, and asbestos-related radiological findings of 1904 patients with lung adenocarcinoma were recorded. Results: The frequencies of EGFR mutations, ALK, and ROS1 rearrangements were 14.5%, 3.7%, and 0.9%, respectively. The rates of EGFR mutations and ALK rearrangements were more frequent in asbestos exposed non-smokers (48.7% and 9%, respectively). EGFR mutation rate was correlated to female gender and not-smoking, ALK rearrangement rate was correlated to younger age, not-smoking, and a history of asbestos exposure. Conclusions: The higher rate of ALK rearrangements in asbestos-exposed lung adenocarcinoma cases shows that asbestos exposure may most likely cause genetic alterations that drive pulmonary adenocarcinogenesis.
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    Frequency of Mutations and Related Factors in Lung Adenocarcinoma Cases in Turkey
    Yilmaz, S; Karadag, M; Demirci, N; Kizilgöz, D; Kabalak, PA; Metintas, M; Ak, G; Yilmaz, U; Komurcuoglu, B; Guclu, O; Ozturk, A; Ozdemirel, T; Cengiz, TI; Ozyurek, B; Erdogan, Y; Altin, S; Celik, P; Gunluoglu, G; Ulubay, G; Zamani, A; Kavas, M; Tatar, D; Metintas, S