Browsing by Author "Akalin T."
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Item Trichilemmal cyst with homogeneous blue pigmentation on dermoscopy(2009) Gencoglan G.; Karaarslan I.K.; Akalin T.; Ozdemir F.A 61-year-old woman was referred to our dermoscopy unit for a pigmented lesion that had been present on her left arm for 8 years. The patient did not notice any enlargement or change in colour. On dermoscopy, homogeneous blue pigmentation was seen. The lesion was excised with the pre-operative diagnosis of melanoma, blue naevus and dermatofibroma. Histopathological examination showed a trichilemmal cyst in the mid-dermis. Although homogeneous blue pigmentation on dermoscopy is the hallmark of blue naevus, it may be seen in metastatic melanoma and exceptionally in hemosiderotic and cellular types of dermatofibroma. Trichilemmal cyst should be borne in mind also in the dermoscopic differential diagnosis. © 2009 The Australasian College of Dermatologists.Item Intracerebral metastasis showing restricted diffusion: Correlation with histopathologic findings(2010) Duygulu G.; Ovali G.Y.; Çalli C.; Kitis O.; Yünten N.; Akalin T.; Islekel S.Objective: We aimed to detect the frequency of restricted diffusion in intracerebral metastases and to find whether there is correlation between the primary tumor pathology and diffusion-weighted MR imaging (DWI) findings of these metastases. Material and methods: 87 patients with intracerebral metastases were examined with routine MR imaging and DWI. 11 hemorrhagic metastatic lesions were excluded. The routine MR imaging included three plans before and after contrast enhancement. The DWI was performed with spin-echo EPI sequence with three b values (0, 500 and 1000), and ADC maps were calculated. 76 patients with metastases were grouped according to primary tumor histology and the ratios of restricted diffusion were calculated according to these groups. ADCmin values were measured within the solid components of the tumors and the ratio of metastases with restricted diffusion to that which do not show restricted diffusion were calculated. Fisher's exact and Mann-Whitney U tests were used for the statistical analysis. Results: Restricted diffusion was observed in a total of 15 metastatic lesions (19, 7%). Primary malignancy was lung carcinoma in 10 of these cases (66, 6%) (5 small cell carcinoma, 5 non-small cell carcinoma), and breast carcinoma in three cases (20%). Colon carcinoma and testicular teratocarcinoma were the other two primary tumors in which restricted diffusion in metastasis was detected. There was no statistical significant difference between the primary pathology groups which showed restricted diffusion (p > 0.05). ADCmin values of solid components of the metastasis with restricted diffusion and other metastasis without restricted diffusion also showed no significant statistical difference (0.72 ± 0.16 × 10-3 mm2/s and 0.78 ± 21 × 10-3 mm2/s respectively) (p = 0.325). Conclusion: Detection of restricted diffusion on DWI in intracerebral metastasis is not rare, particularly if the primary tumor is lung or breast cancer. However we found that there is no correlation between the metastasis showing restricted diffusion and primary pathology. Prospective studies with larger groups and more information are necessary regarding the correlation between the primary tumor histopathology and the ADC values of metastasis with restricted diffusion. © 2009 Elsevier Ireland Ltd. All rights reserved.Item Gastrointestinal stromal tumors: A multicenter study of 1160 Turkish cases(2012) Bülbül Doǧusoy G.; Akalin T.; Tunçyürek M.; Kapran Y.; Doran F.; Dursun A.; Ensari A.; Gedikoǧlu G.; Saǧol Ö.; Özoran Y.; Pak I.; Yavuzer D.; Soyuer I.; Yavuz H.; Güneş P.; Sakiz D.; Behzatoǧlu K.; Ekinci N.; Arikök A.T.; Yerci Ö.; Gürbüz Y.; Kayaselçuk F.; Ayhan S.; Turhan N.; Özdamar Ş.Background/aims: The aim of this multicenter study was to determine the histopathological features and immunohistochemical profiles of gastrointestinal stromal tumors diagnosed in Turkish patients. Material and Methods: Twenty-eight participating centers registered their gastrointestinal stromal tumor cases on a nationwide database. The diagnosis of gastrointestinal stromal tumor relied upon hematoxylin & eosin features and the results of antibody panel including CD117, CD34, desmin, smooth muscle actin, S-100 protein, and Ki67. The database consisted of parameters including age, gender, location, and all other histopathological and immunohistochemical findings. Statistical analysis was performed using Pearson, Kruskal-Wallis, Mann-Whitney U, and Spearman tests. Results: From all of the gastrointestinal stromal tumors in the database, 1160 cases with a male to female ratio of 1.22 and a mean age of 56.75 years were included in the study. The most common location was the stomach (45.0%), followed by the small intestine, omentum-peritoneum, large intestine, and esophagus (32.0%, 12.6%, 9.3%, 1.1%, respectively). The risk groups were distributed as: 6.1% very low, 21.7% low, 19.3% intermediate, and 53% high-risk cases. Many histopathologic findings were correlated with risk groups. CD117 was positive in 95.3% of gastrointestinal stromal tumors, whereas CD34 was positive in 74.9%, smooth muscle actin in 45.9%, desmin in 9.2%, and S-100 in 19.1.%. Though no significant relation was found between CD117 expression and tumor location, CD34, smooth muscle actin and Ki67 expressions significantly varied in different locations (p=0.001) and risk groups. Conclusions: The results of this multicenter study demonstrated that features other than tumor size and mitosis and immune markers other than CD117 and Ki67 included in the antibody panel seem to be useful as predictive risk factors.Item A retrospective multicenter evaluation of cutaneous melanomas in Turkey(Asian Pacific Organization for Cancer Prevention, 2014) Gamsizkan M.; Yilmaz I.; Buyukbabani N.; Demirkesen C.; Demiriz M.; Cetin E.D.; Ince U.; Akalin T.; Demirkan N.C.; Lebe B.; Erdem O.; Gokoz O.; Sakiz D.; Demireli P.T.; Astarci H.M.; Adim S.B.; Zemheri I.E.; Acikalin A.; Yaman B.; Aydin O.; Bassorgun C.I.Background: We defined melanoma distribution in a large series of Turkish patients and evaluated the prognostic parameters of melanomas. Materials and Methods: A total of 1574 patients' data was retrospectively collected at 18 centers in Turkey. Demographic characteristics were questioned and noted. Prognostic parametres were evaluated based on sentinel lymph node involvement. Results: Mean age was 56.7 (4-99) years. While 844 (53.6%) cases were male, 730 (46.4%) cases were female. One thousand four hundred forty-seven (92%) cases were invasive melanoma and 127 (8%) cases were in-situ melanoma. The most common histopathological form was the superficial spreading melanoma (SSM) which was found in 549 patients (37.9%). It was followed by nodular melanoma in 379 (26.2%), acral lentiginous melanoma (ALM) in 191 (13.2%) and lentigo maligna melanoma in 132 (9.1%), respectively. On univariate analysis, lymphovascular invasion (p < 0.001), tumor thickness (p < 0.001), histopathological subtype (p < 0.001), Clark level (p = 0.001), ulceration (p < 0.001), ≥ 6/mm2 mitosis (p = 0.005), satellite formation (p = 0.001) and gender (p = 0.03) were found to be associated with sentinel lymph node positivity. Regression was associated with sentinel lymph node negativity (p = 0.017). According to multivariate analysis, lymphovascular invasion and tumor thickness were significant independent predictive factors of SLN positivity. Patient age, tumor localization, precursor lesions, lymphocytic infiltration and neurotropism were not related with sentinel lymph node involvement. Conclusions: In this retrospective analysis, it was found that the prevalence of SSM is at a lower rate while the prevalence of ALM is at a higher rate when compared to western countries. According to Breslow index; most of the melanoma lesions' thickness were greater than 2 mm, corresponding Clark IV. Vascular invasion and tumor thickness are the most important factors for sentinel lymph node involvement.Item Sclerosing extramedullary hematopoietic tumor mimicking intra-abdominal sarcoma(Seoul National University, 2015) Karaarslan S.; Nese N.; Oncel G.; Ozsan N.; Akalin T.; Kaplan H.; Buyukkececi F.; Hekimgil M.[No abstract available]