Browsing by Author "Akar Z."

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    The relationship between serum steroid hormon levels and I-PSS, prostatic volume, residual urine: A community based study; [Serum steroid hormon düzeyleri ile I-PSS, prostat aǧirliǧi ve artik i̇drar baǧintisi: Topluma dayali bir çalişma]
    (2007) Temeltaş G.; Müezzinoǧlu T.; Akar Z.; Lekili M.; Büyüksu C.
    Introduction: It is evaluated that endocrinolgical effect is the most reliable factor for development of histological and clinical BPH which is the common disease in older males. Materials and Methods: In our study, we investigated the relationship between BPH incidence and steroid hormone levels by using the criteria of I-PSS, residual urine and prostatic volume in the men over 40 in a rural town. Total and free testosterone, estradiol, dihidroepiandosteron sulfate, sex hormone binding globulin, FSH and LH levels were analyzed. I-PSS and quality of life scores were evaluated. Results: Mean FSH, LH, DREAS, SHBG, E2, tT and fT levels were 11.03±11.06 mIU/ml (0.9-83.7), 9.26±18.7 mIU/ml (0.7-200), 114, 86±68.3 pg/dl (30-417), 55.28±31.4 nmol/L (2-180), 23.03±9.05 pg/mL (20-46.1), 3.9±1.82 ng/dl (0.2-16) and 13.7±4.7 pg/mL (0.6-31.6). Mean I-PSS, QoL, residual urine and prostatic volume were 4.7±5.9 (0-30), 0.7±1.3 (0-6), 21.5±30.7 (0-295) ml and 24.4±11.4 (9-82) gr. respectively. With Pearson correlation system; age, I-PSS, QoL, residual urine and prostatic volume were well correlated with each other (p<0.05). While age increased, FSH and SHBG increased significantly (r=0.2979 and r=0.3642). On the other hand, DHEAS (r=0.4792) and fT (r=0.3306) decreased, while age increased. There was no correlation between E2, LH, tT. SHBG and age. When it is accepted as all the men with their I-PSS over 7 has BPH; fT levels were statistically lower (14/ 12.3, p=0.009) and their SHBG levels were higher than those without BPH (52.5/64.8, p=0.029). Conclusion: If the diagnosis of BPH is determined with the different combination of I-PSS, residual urine and prostatic volume, no significant data was revealed between serum steroid hormone levels and BPH. fT levels were significantly lower in men with high I-PSS than those with low I-PSS.
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    Association between severity of lower urinary tract symptoms, erectile dysfunction and metabolic syndrome
    (2009) Demir O.; Akgul K.; Akar Z.; Cakmak O.; Ozdemir I.; Bolukbasi A.; Can E.; Gumus B.H.
    Introduction. The purpose of this study was to investigate the association between severity of lower urinary tract symptoms LUTS, erectile dysfunction ED and metabolic syndrome. Methods. Our study population included a consecutive series of 190 patients with LUTS International Prostate Symptom Score-IPSS >7 with or without manifestations of the metabolic syndrome. The diagnoses of diabetes mellitus and hypertension were obtained from the patient's medical history. Data on blood pressure, waist measure, body height and weight were collected and body mass index were calculated. Patients were assessed based on the International Index of Erectile Function IIEF for ED and IPSS and IPSS-Quality of Life for LUTS. Blood samples were drawn from fasting patients to determine, fasting blood glucose FBG, triglycerides, HDL-cholesterol and serum total testosterone levels. Results. In severe LUTS patient group, IIEF erectile function domain scores were significantly lower than moderate LUTS patient group p < 0.05. Multiple logistic regression analysis confirmed that presence of ED was the most predictor of severe LUTS. The prevalence of metabolic syndrome was higher in patients with severe LUTS 26vs. 46, p 0.009. The severe form of the LUTS was significantly correlated with waist circumference >102 cm p < 0.05, blood pressure ≥13085 mmHg p < 0.05 and FBG >110 mgdl p < 0.01. Conclusion. Obesity, high plasma level of FBG and hypertension constitute risk factors for the development of severe LUTS. Metabolic syndrome may play a key role in the pathogenesis in both ED and LUTS. Presence of ED is the most predictor of severe LUTS. © 2009 Informa UK Ltd.
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    Effect of side chain substituents on the electron injection abilities of unsymmetrical perylene diimide dyes
    (2011) Dinalp H.; Akar Z.; Zafer C.; Li S.
    Three near-infrared (NIR) absorbing unsymmetrical perylene diimide D-A-D type dyes containing 6-undecanoxy as donor group were utilized in dye-sensitized nanocrystalline TiO2 solar cells. Structure of the acceptor side of the molecules were improved by adding 4-[2-methyl-5-(cyanoacrylic acid)-3-thienyl]-phenyl (V), 3-carboxy-2-pyridil (VI) and 3-carboxy-2-pyrazyl (VII) moieties attached to one of the N-side of the dye. The relationship between the molecular structure of the acceptor sites of the dyes and the photovoltaic performances were discussed. Electrochemical measurements indicated that band gaps of the dyes were energetically favorable for electron injection from the excited state of the dyes to the conduction band of TiO2 nanoparticles. However, three dyes gave lower conversion efficiency on DSSC applications. Strong electron-withdrawing nature of perylene core might not permit to transfer the photo-generated electrons to the carboxyl groups anchoring to TiO2 surface, and then solar-to-electricity conversion efficiencies of the dyes were reduced. © 2011 Elsevier Ltd. All rights reserved.