Browsing by Author "Akbay, S"

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    The reliability and validity of the Turkish Version of the Affect Underpinned by Severity and Social Impairment Questionnaire (AUSSI)
    Çetinay, P; Akbay, S; Bilen, C; Gülseren, S; Aydemir, Ö
    Objective: The Affect Underpinned by Severity and Social Impairment Questionnaire (AUSSI) allows clinicians to describe mood symptoms and social impairment and to follow up residual symptoms after treatment in patients with major depressive disorder. The aim of this study was to investigate the reliability and validity of the Turkish version of the AUSSI. Method: The study included 137 (117 female and 20 male) patients between 18 and 65 years of age who were diagnosed as major depressive disorder according to DSM IV diagnosis. Also 32 control subjects (25 female and 7 male) were included. All subjects completed a Sociodemographic Information Form and the Turkish version of the Affect Underpinned by Severity and Social Impairment Questionnaire. The patients were also assessed by Hamilton Depression Rating Scale (HDRS), Hamilton Anxiety Rating Scale (HARS) and Brief Disability Questionnaire (BDQ). For reliability Cronbach's coefficient and split-half reliability analyses were performed. For validity analyses, factor analyses were performed. Pearson correlation coefficient between HDRS, HAIRS, BDQ, and AUSSI were also measured. Results: Concerning the reliability of the scale, Cronbach's alpha coefficient was 0.897, Gutman Split-half coefficient was calculated by split half method as 0.862. Cronbach's alpha coefficient composed of 6 items for the first part was 0.801, and for the second part containing the 5 items was 0.857. In order to determine the construct validity of AUSSI, a principal component factor analysis with Varimax rotations was performed, and two factors (Affect Severity, Social Impairment) were obtained with Eigenvolue greater than 1.0. Also correlations of AUSSI total between BDQ (r=0.61, P<0.001), HDRS (r=0.74, p<0.001) and HAIRS (r=0.69 P<0.001) scores were significant. Conclusion: The Turkish version of the Affect Underpinned by Severity and Social Impairment Questionnaire was found to be reliable and valid in this study.
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    Non-Synchronized Nasal Intermittent Positive Pressure Ventilation (NIPPV) Versus Nasal Continuous Positive Airway Pressure (NCPAP) After Extubation in Preterm Infants with Respiratory Distress Syndrome
    Ilhan, Ö; Özdemir, SA; Akbay, S; Kanar, B; Memur, S; Bor, M; Özer, EA
    Objective: To determine whether non-synchronized nasal intermittent positive pressure ventilation (NIPPV) reduces the rates of extubation failure, compared to nasal continuous positive airway pressure (NCPAP), in preterm infants with respiratory distress syndrome (RDS). Method: This retrospective study included a total of 49 premature infants who were born at <32 gestational weeks with a birth weight of <1.500 g and required intubation due to RDS. The patients were followed up with NIPPV or NCPAP after extubation. The primary outcome was extubotion failure within 48 hrs of extubotion, while the secondary outcome was neonatal morbidities. Results: A total of 23 patients received NCPAP and 26 patients NIPPV following extubation. Demographic characteristics were similar in both NCPAP and NIPPV groups. Extubation failure was observed in five (21.7%) NCPAP, and in nine (34.6%) NIPPV patients, although any statistically significant intergroup difference was not detected (p=0.32). There were no significant intergroup differences as for post-extubation atelectasis, pneumothorax. Neonatal morbidities and mortality rates. However, the incidence of patent ductus arteriosus was statistically significantly higher in the NIPPV group (p<0.05). In none of the patients gastric or intestinal perforations were observed. Conclusion: It was concluded that NIPPV is not superior to NCPAP performed in preterm infants after extubation in reducing the incidence of reintubation and respiratory morbidities, including pneumothorax and post-extubation atelectasis.
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    Efficacy and Safety of Intravenous Colistin in Very Low Birth Weight Preterm Infants
    Ilhan, O; Bor, M; Ozdemir, SA; Akbay, S; Ozer, EA
    BackgroundGiven the severity and high mortality of multidrug-resistant Gram-negative bacilli (MDR-GNB) infections, the use of colistin will increase in patients with MDR-GNB infection.ObjectiveThis study aims to assess the efficacy and safety of intravenous colistin in very low birth weight (VLBW; birth weight <1500g) preterm infants.MethodsWe retrospectively analyzed the medical records of patients who received colistin between June 2016 and December 2017. The patients were assigned to two groups: the VLBW group and the non-VLBW group. Both groups were evaluated for response to treatment and adverse effects.ResultsIn total, 66 infants who received colistin therapy were included; of these, 28 infants were VLBW. All of our patients received standard colistin treatment of 5mg/kg per day in three doses and the median duration of colistin treatment was 14days. No significant differences were observed between the groups with respect to the efficacy of colistin (defined as showing microbiological clearance in control cultures and the absence of mortality during treatment) (89.3 vs 86.8%, p>0.99). Serum magnesium and potassium levels were significantly lower in the VLBW group than in the non-VLBW group during colistin therapy (magnesium, 1.30 vs 1.70mg/dL, p<0.001; potassium, 3.6 vs 4.6mEq/L, p<0.001). Acute kidney injury was observed in four infants in the VLBW group and one in the non-VLBW group, without significant differences (p=0.15).ConclusionsColistin administration appears to be efficacious in VLBW infants; however, renal function tests and serum electrolytes should be monitored more closely in these infants during treatment.
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    Coincidence of Nemaline Myopathy and Agenesis of Corpus Callosum in a Newborn Infant: Case Report
    Akbay, S; Ozer, E; Ilhan, O; Kanar, B; Memur, S; Diniz, G; Cavusoglu, D; Dündar, NO
    The diagnosis of the hypotonia during neonatal period is difficult. In the neonatal period, acute illnesses and systemic diseases such as sepsis, congestive heart failure and inborn errors of metabolism should be considered in the differential diagnosis of the patients. Congenital disorders that affect nervous system can be the reason of hypotonia. Nemaline myopathy (NM) is a rare congenital myopathy, characterized with slowly progressive or nonprogressive muscle weakness and the inclusions known as nemaline rods characterized by rod-shaped structures (nemaline bodies) in muscle biopsy specimens. The disease can be presented with hypotonia, feeding problems, repeated respiratory infections, and arthrogryposis. Also, agenesis of corpus callosum (ACC) can result in an interhemispheric disconnection , neurologic problems such as mental retardation, and seizures. Unfortunately, there is no curative treatment for both of them. Herein, we report an infant who was admitted with generalized muscle weakness at the neonatal period and diagnosed as ACC with NM.