Browsing by Author "Akbay S."

Now showing 1 - 2 of 2
  • No Thumbnail Available
    Item
    Validity and reliability of the affect underpinned by severity and social impairment questionnaire turkish form; [Duygulanim şddet ve sosyal bozulma ölçeǧi türkçe formu'nun geçerlik ve güvenirliǧi]
    (2008) Çetinay P.; Akbay S.; Bilen C.; Gülseren Ş.; Aydemir Ö.
    Objective: The aim of this study was to investigate the validity and reliability of the Affect Underpinned by Severity and Social Impairment Questionnaire (AUSSI) Turkish Form. Method: The study included 137 (117 female and 20 male) patients between 18 and 65 years of age who were diagnosed as major depressive disorder according to DSM IV diagnosis. Also 32 control subjects (25 female and 7 male) were included. All subjects completed Sociodemographic Information Form and Affect Underpinned by Severity and Social Impairment Questionnaire. The patients were also assessed by Hamilton Depression Rating Scale (HDRS), Hamilton Anxiety Rating Scale (HARS) and Brief Disability Questionnaire (BDQ). For reliability Cronbach's coefficient and split-half reliability analyses were performed. For Validity Analyses, Factor Analyses was performed. Pearson correlation coefficient that between HDRS, HARS, BDQ and AUSSI were also measured. Results: Concerning the reliability of the scale, Cronbach's alpha coefficient was 0.897, Gutman Split-half coefficient was calculated by split half method as 0.862. Cronbach's alpha coefficient composed of 6 items for the first part was 0.801, and for the second part containing the 5 items was 0.857. In order to determine the construct validity of AUSSI, factor analysis was performed using varimax rotation method, and two factors (Affect Severity, Social Impairment) were obtained with Eigenvalue greater than 1.0. Also correlations of AUSSI total between BDQ (r=0.61, p<0.001), HDRS (r=0.74, p<0.001) and HARS (r=0.69 p<0.001) scores were significant. Conclusion: The Turkish version of the Affect Underpinned by Severity and Social Impairment Questionnaire was found to be valid and reliable in this study. AUSSI, allows on a scale to describe mood symptoms and social impairment and to follow up residual symptoms after treatment in patients with major depressive disorder.
  • No Thumbnail Available
    Item
    Efficacy and Safety of Intravenous Colistin in Very Low Birth Weight Preterm Infants
    (Adis, 2018) Ilhan O.; Bor M.; Ozdemir S.A.; Akbay S.; Ozer E.A.
    Background: Given the severity and high mortality of multidrug-resistant Gram-negative bacilli (MDR-GNB) infections, the use of colistin will increase in patients with MDR-GNB infection. Objective: This study aims to assess the efficacy and safety of intravenous colistin in very low birth weight (VLBW; birth weight < 1500 g) preterm infants. Methods: We retrospectively analyzed the medical records of patients who received colistin between June 2016 and December 2017. The patients were assigned to two groups: the VLBW group and the non-VLBW group. Both groups were evaluated for response to treatment and adverse effects. Results: In total, 66 infants who received colistin therapy were included; of these, 28 infants were VLBW. All of our patients received standard colistin treatment of 5 mg/kg per day in three doses and the median duration of colistin treatment was 14 days. No significant differences were observed between the groups with respect to the efficacy of colistin (defined as showing microbiological clearance in control cultures and the absence of mortality during treatment) (89.3 vs 86.8%, p > 0.99). Serum magnesium and potassium levels were significantly lower in the VLBW group than in the non-VLBW group during colistin therapy (magnesium, 1.30 vs 1.70 mg/dL, p < 0.001; potassium, 3.6 vs 4.6 mEq/L, p < 0.001). Acute kidney injury was observed in four infants in the VLBW group and one in the non-VLBW group, without significant differences (p = 0.15). Conclusions: Colistin administration appears to be efficacious in VLBW infants; however, renal function tests and serum electrolytes should be monitored more closely in these infants during treatment. © 2018, Springer Nature Switzerland AG.