Browsing by Author "Akdeniz, F"
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Item Low serum levels of brain-derived neurotrophic factor in patients with schizophrenia do not elevate after antipsychotic treatmentPirildar, S; Gönül, AS; Taneli, F; Akdeniz, FBrain-derived neurotrophic factor (BDNF) has been suggested to be involved in the etiology of schizophrenia. There is a line of evidence that disruption of neurotrophins could play a role in the etiology of schizophrenia, and antipsychotics show their effect by altering levels of neurotrophins. The aim of this study was to evaluate the effect of antipsychotics on serum BDNF levels and their relationship with the symptoms in patients with schizophrenia. Twenty-two schizophrenia patients were enrolled in the study. The control group consisted of 22 age- and sex-matched physically and mentally healthy volunteers (7 male, 15 female). Serum BDNF levels and the positive and negative syndrome scale (PANSS) scores were recorded at baseline and after 6 weeks of treatment. Serum BDNF levels were also recorded in the control group. Schizophrenia patients who failed to meet 30% improvement in PANSS score were excluded from the study. The baseline serum BDNF levels of schizophrenia patients were lower than those of controls (t=4.56; df=21; p<0.001). There was no correlation between serum BDNF levels and PANSS scores inpatients with schizophrenia (p>0.05). Although PANSS (for positive symptoms p<0.001, for negative symptoms p<0.001) and general psychopathology (t=20.9; df=22;p<0.001) scores improved significantly after 6 weeks of antipsychotic treatment; there was no change in BDNF levels in patients' serum (p>0.05). Our results support the view that BDNF would be associated with schizophrenia. However, we could not conclude that treatment with antipsychotics alters serum BDNF levels in patients with schizophrenia. (C) 2004 Elsevier Inc. All rights reserved.Item Kinetics for fast pyrolysis of hazel nut shellDemirbas, A; Akdeniz, F; Erdogan, Y; Pamuk, VIn this article, the potential utilization of hazel nut shell as a combustible residue was studied. To obtain liquid and gaseous products, the hazel nut shell was subjected to pyrolysis and it was converted to 49.3 % (w) gaseous and 20.0 % (w) liquid products at 475 degrees C for 7.5 minutes in a simple pyrolysis device. The kinetic model used in the present study was based on fractional weight loss for each pyrolysis step. The simple fast pyrolysis was compared with TGA technique.Item Neurobiological and neurocognitive features of newly diagnosed, early stage and unmedicated bipolar disorders: a comparative studyOztekin, S; Akdeniz, F; Oran, A; Taneli, F; Tas, C; Aydemir, OItem Valproate-associated reproductive and metabolic abnormalitiesAkdeniz, F; Taneli, F; Noyan, A; Yüncü, Z; Vahip, SObjective: Evidence indicates that valproate (VPA) may have an adverse impact on reproductive endocrine and metabolic functions in women with epilepsy. This study explores whether the association of VPA with reproductive endocrine abnormalities is applicable to women with bipolar disorder (BD) or is unique to women with epilepsy. Methods: Thirty female patients aged 18-40 years with a DSM-IV diagnosis of BD (15 on lithium monotherapy and 15 on VPA monotherapy or VPA in combination with lithium therapy) and 15 with idiopathic generalized epilepsy (IGE) on VIA monotherapy were evaluated for reproductive endocrine functioning and metabolic parameters. Results: The menarche age, mean length of menstrual cycle and mean length of menses were not significantly different between groups. None of the bipolar patients on lithium, three (20%) of the bipolar patients on VIA and seven (47%) of the epileptic patients on VIA reported menstrual disturbances. Hirsutism scores of the epilepsy group were significantly higher than those bipolar women, regardless of treatment. Serum total testosterone levels were significantly higher in patients (both with BD and with IGE) treated with VIA than in those treated with lithium. Serum FSH levels were significantly lower and LH-to-FSH ratio was significantly higher in patients with epilepsy than in patients with BD, regardless of treatment. The weight parameters and lipid values investigated did not differ significantly between the groups. Conclusion: The study supports the conclusion that VPA may be associated with menstrual abnormalities and increased total testosterone levels in both bipolar and epileptic patients although women with BD did not show clinical features of hyperandrogenism (menstrual abnormalities, hirsutism and truncal obesity) as did frequently as women with epilepsy. (C) 2002 Elsevier Science Inc. All rights reserved.Item Reliability and Validity of the Turkish Version of the Burden Assessment ScaleAydemir, Ö; Dikici, DS; Akdeniz, F; Kalayci, FBackground: In this study, it is aimed to evaluate the reliability and validity of the Turkish version of the Burden Assessment Scale. Methods: The study was carried out on 100 volunteers who were caregivers of in-or outpatients at a university hospital, department of psychiatry. The diagnoses of the patients were schizophrenia (25%), bipolar disorder (22%), major depressive disorder (24%), and anxiety disorder (29%). The mean duration of the illness was 8.2 +/- 8.7 years. For the concurrent validity, the Perceived Family Burden Scale and the Zarit Caregiver Burden Scale were used. In the statistical analyses, internal consistency, item-total score correlation, explorative factor analysis, correlation with other scales were calculated. Results: The Turkish version of the Burden Assessment Scale was prepared after the translation and back-translation of the original scale and after the consensus on the translated form. In the internal consistency analysis, Cronbach alpha coefficient was found to be 0,894 and item-total score correlation coefficients were between 0.297 and 0.742. In the explorative factor analysis, a five-factor solution explaining 67.2% of the total variance was obtained and the conceptual themes of the factors were limitations in daily life, negative emotions, worry for the patient, losses of the caregiver, and disruption in activities. The correlation of the Burden Assessment Scale with the Perceived Family Burden Scale was r=0.485 and with the Zarit Caregiver Burden Scale was r=0.610. Conclusion: It is demonstrated that the Turkish version of the Burden Assessment Scale which is convenient in the milder forms of psychiatric disorders and which is developed for the assessment burden of patients on their caregivers is reliable and valid. (Archives of Neuropsychiatry 2012; 49: 276-280)Item Psychometric properties of the Turkish Versions of Perceived Deficit Questionnaire - Depression and British Columbia Cognitive Complaints InventoryAydemir, Ö; Çökmüs, FP; Akdeniz, F; Sücüllüoglu Dikici, D; Balikçi, KObjective: In major depressive disorder, both during acute episode and in remission neurocognitive symptoms endure, but are underrated. The aim of this study is to demonstrate reliability and validity of the Turkish versions of Perceived Deficit Questionnaire-Depression (PDQ-D) and British Columbia Cognitive Complaints Inventory (BC-CCI) which are useful in the subjective assessment of neurocognitive symptoms in major depressive disorder. Methods: Turkish forms of the instruments are obtained after the translation and back-translation procedure. Thereafter, 50 in-or outpatients diagnosed with major depressive disorder, and 150 healthy volunteers for conducting the factor analyses and 68 healthy age- and education-matched controls for performing the group comparisons were included in the study. Beside the study instruments, Digital Symbol Substitution Test (DSST) used in the objective assessment of neurocognitive symptoms is applied. Results: The mean age of major depressive disorder group (n=50) was 37.5 +/- 11.4 and of healthy control group for the factor analyses was 23.4 +/- 5.5 and of that for the group comparisons was 35.4 +/- 9.9. Cronbach alpha coefficient of BC-CCI was 0.93 and item-total score correlation coefficients were between 0.69-0.85. Cronbach alpha coefficient of PDQ-D was 0.96 and item-total score correlation coefficients were between 0.52-0.91. In the factor analysis of both instruments, one factor solution was obtained. The correlation between BC-CCI and DSST was r=0.40, and for PDQ-D it was r=0.41. Both BC-CCI and PDQ-D significantly differentiated major depressive disorder group from healthy control groups. Conclusion: These results suggest that the Turkish forms of Perceived Deficit Questionnaire-Depression (PDQ-D) and British Columbia Cognitive Complaints Inventory (BC-CCI) are practical in the assessment of neurocognitive symptoms of major depressive disorder and can be used reliably and validly both in studies and in daily practice.Item Reliability and Validity Study of the Turkish Version of Bipolar Prodrome Symptom ScaleAydemir, O; Öztekin, S; Akdeniz, FObjective: In this study, it is aimed to evaluate the reliability and validity of the Turkish version of Bipolar Prodrome Symptom Scale. Method: The study was carried out with subjects who participated the study on the epidemiology of bipolar disorder among the students in the 1st grade of Celal Bayar University. The sample consisted of 30 volunteers diagnosed as bipolar disorder and 122 healthy controls. For concurrent validity, Hypomania Checklist-32-Revised was used. In the statistical analysis, internal consistency coefficient, item-total score correlation coefficients, exploratory factor analysis, correlation with concurrent scale and ROC curve were calculated. Results: Translation into Turkish and back-translation into English of were performed and thus the semantic harmony of the scale was obtained. In the internal consistency, Cronbach alpha coefficient was between 0,969-0,979 and item-total score correlations were between 0,767-0,929 and 0,725-0,890. In factor analysis, for the severity subscale a one-factor solution representing 78,9% of the variance and for the frequency subscale one-factor solution representing 71,7% of the solution are obtained. Correlation of Bipolar Prodrome Symptom Scale with Hypomania Checklist-32-Revised was r=0,513 and 0,530. In the ROC analysis, area under the curve was 0,977 and 0,999. The scale discriminates well between the bipolar group and healthy control group. Conclusion: Bipolar Prodrome Symptom Scale developed for screening hypomania is reported to be reliable and valid in Turkish.Item Prevalence and risk factors of bipolar disorder in university students in TurkeyOmer, A; Akdeniz, F; Oztekin, SItem Pituitary gland volumes in major depressive disorder patientsEker, OD; Ovali, GY; Eker, MC; Kitis, O; Ozan, E; Akdeniz, F; Vahip, S; Gonul, ASItem Nation-wide analysis of the impact of Covid-19 pandemic on daily urology practice in TurkeyBozkurt, O; Sen, V; Irer, B; Sagnak, L; Onal, B; Tanidir, Y; Karabay, E; Kaya, C; Ceyhan, E; Baser, A; Duran, MB; Suer, E; Celen, I; Selvi, I; Ucer, O; Karakoc, S; Sarikaya, E; Ozden, E; Deger, D; Egriboyun, S; Ongun, S; Gurboga, O; Asutay, MK; Kazaz, IO; Yilmaz, IO; Kisa, E; Demirkiran, ED; Horsanali, O; Akarken, I; Kizer, O; Eren, H; Ucar, M; Cebeci, OO; Kizilay, F; Comez, K; Mercimek, MN; Ozkent, MS; Izol, V; Gudeloglu, A; Ozturk, B; Akbaba, KT; Polat, S; Gucuk, A; Ziyan, A; Selcuk, B; Akdeniz, F; Turgut, H; Sabuncu, K; Kaygisiz, O; Ersahin, V; Kahraman, HI; Guzelsoy, M; Demir, OObjective To present a nation-wide analysis of the workload of urology departments in Turkey week-by-week during Covid-19 pandemic. Methodology The centres participating in the study were divided into three groups as tertiary referral centres, state hospitals and private practice hospitals. The number of outpatients, inpatients, daily interventions and urological surgeries were recorded prospectively between 9-March-2020 and 31-May-2020. All these variables were recorded for the same time interval of 2019 as well. The weekly change of the workload of urology during pandemic period was evaluated, also the workload of urology and the distributions of certain urological surgeries were compared between the pandemic period and the same time interval of the year 2019. Results A total of 51 centres participated in the study. The number of outpatients, inpatients, urological surgeries and daily interventions were found to be dramatically decreased by the 3rd week of pandemics in state hospitals and tertiary referral centres; however, the daily urological practice were similar in private practice hospitals throughout the pandemic period. When the workload of urology in pandemic period and the same time interval of the year 2019 were compared, a huge decrease was observed in all variables during pandemic period. However, temporary measures like ureteral stenting, nephrostomy placement and percutaneous cystostomy have been found to increase during Covid-19 pandemic compared with normal life. Conclusions Covid-19 pandemic significantly affected the routine daily urological practice likewise other subspecialties and priority was given to emergent and non-deferrable surgeries by urologists in concordance with published clinical guidelines.Item Treatment of manic patients during hospitalisation - a retrospective chart review in 2004-2008: what has changed?Yazici, O; Aydemir, O; Guloksuz, S; Akdeniz, F; Yenilmez, C; Akkaya, C; Cetinay, P; Ozpoyraz, N; Bozkurt, A; Oguzhanoglu, NKItem THE DEMOGRAPHY AND PARTNER'S RELATIONSHIP OF PREMATURE EJACULATION IN TURKEY: MULTICENTER STUDYCan, E; Demir, O; Gumus, B; Degirmenci, T; Bolukbasi, A; Basar, M; Akbal, C; Guner, GK; Alici, B; Inci, K; Aridogan, A; Erol, H; Akdeniz, F; Zeren, F; Esen, AAItem THE APPLICABILITY OF A PREMATURE EJACULATION PROFILE QUESTIONNAIRE FORMS IN OUR COUNTRYCan, E; Demir, O; Gumus, B; Degirmenci, T; Bolukbasi, A; Basar, M; Akbal, C; Ozgur, GK; Alici, B; Inci, K; Aridogan, A; Erol, H; Akdeniz, F; Zeren, F; Esen, AAItem Reliability and validity of Turkish version of biological rhythms interview of assessment in neuropsychiatryAydemir, O; Akkaya, C; Altinbas, K; Kora, K; Dikici, DS; Akdeniz, F; Kalayci, F; Oral, ET; Vahip, SItem Reliability and validity of Turkish version of Biological Rhythms Interview of Assessment in NeuropsychiatryAydemir, Ö; Akkaya, C; Altinbas, K; Kora, K; Sücüllüoglu, DS; Akdeniz, F; Kalayci, F; Oral, ET; Vahip, SObjective: In this study, it is aimed to perform the validity and reliability of the Turkish version of Biological Rhythms Interview of Assessment in Neuropsychiatry. Methods: The study was performed with 79 bipolar type-I disorder, 26 bipolar type-II disorder and 42 major depressive disorder patients attending to mood disorder clinics of three university hospitals and one state training hospital as well as 116 university students consisting healthy control subjects. The mean duration of the illness was 15.1 years for the bipolar groups and 9,3 years for the depressive group. For concurrent validity, Pittsburgh Sleep Quality Index was used. In the statistical analyzes, internal consistency coefficient, item-total score correlations, exploratory and confirmatory factor analyzes, correlation with the other scale and ROC curve were calculated. Results: The forward and back translation of the Biological Rhythms Interview of Assessment in Neuropsychiatry was performed, and linguistic equivalence was obtained with the scale prepared. In internal consistency, the Cronbach's alpha coefficient was found to be 0.899 and item-total correlation coefficients were between 0.239 and 0.747. In the exploratory factor analysis, a total of three factors representing 56.5% of the total variance were obtained and the themes of the factors were daily activities, sleep and eating habits and interpersonal relations. In the confirmatory factor analysis, confirmatory fit index was 0.932 and root mean square of approximation was 0.065. The correlation between Biological Rhythms Interview of Assessment in Neuropsychiatry and Pittsburgh Sleep Quality Index was found to be r=0.238. In the sensitivity and specificity analysis, the area under the ROC curve was 0.876. The scale discriminated mood disorder groups from the healthy control group. Conclusion: It is shown that the Turkish version of Biological Rhythms Interview of Assessment in Neuropsychiatry which is used in the assessment of circadian rhythm and functionality is reliable and valid.Item Reliability and validity of Turkish form of the personality inventory for DSM-5 adult versionCökmüs, FP; Yüzeren, S; Aydin, O; Aydin, PÜ; Öztekin, S; Akdeniz, F; Dikici, DS; Çöldür, EÖ; Balikçi, K; Köroglu, E; Aydemir, ÖItem Reliability and Validity Study of the Turkish Version of Hypomania Checklist-32-RevisedVahip, S; Aydemir, Ö; Akkaya, C; Altinbas, K; Kora, K; Dikici, D; Akdeniz, F; Kalayci, F; Oral, T; Vahip, I; Alkan, M; Angst, JObjective: In this study, it is aimed to evaluate the reliability and validity of the Turkish version of Hypomania Checklist-32-Revised. Method: The study was carried out with 80 patients diagnosed with bipolar I disorder, 26 patients diagnosed with bipolar II disorder and 42 patients diagnosed with major depressive disorder attending the out- and in-patient psychiatry departments of three university hospitals and one training hospital, and 116 healthy volunteers consisting of university students. Mean duration of illness was 15,1 years for the bipolar disorder group, and 9,3 years for the major depressive disorder group. For concurrent validity, Mood Disorder Questionnaire was used. In the statistical analysis, internal consistency coefficient, item-total score correlation coefficients, exploratory factor analysis, correlation with concurrent scale and ROC curve were calculated. Results: Translation into Turkish and back-translation into English of Hypomania Checklist-32-Revised were performed and thus the semantic harmony of the scale was obtained. In the internal consistency, Cronbach alpha coefficient was 0,914 and item-total score correlations were between 0,235-0.743. Solely the coefficient of item #23 was found as 0,110. In factor analysis, six factors were obtained but a two-factor solution representing 44,5% of the total variance was accepted and first factor represents overactivity and being expansive, second factor represents impulsivity and risky behaviors. Correlation of Hypomania Checklist-32-R with Mood Disorder Questionnaire was r=0,379. In the ROC analysis, the cut off point of the scale was calculated as 14 with a sensitivity of 71,0 and specificity of 69,8. The scale discriminates well between the bipolar group, and depressive and control groups. Conclusion: Hypomania Checklist-32-Revised developed for screening hypomania is reported to be reliable and valid in Turkish after cutting out item #23.Item The effect of treatment on serum brain-derived neurotrophic factor levels in depressed patientsGonul, AS; Akdeniz, F; Taneli, F; Donat, O; Eker, C; Vahip, SItem Serum nitric oxide metabolite levels and the effect of antipsychotic therapy in schizophreniaTaneli, F; Pirildar, S; Akdeniz, F; Uyanik, BS; Ari, ZBackground. Recently it was proposed that nitric oxide metabolites (NO) may have a role in the pathophysiology of schizophrenia and major depressive disorders. The present study was performed to assess changes in serum nitric oxide metabolite levels in schizophrenic patients compared with healthy, controls. Our secondary aim was to further evaluate the impact of psychopharmacologic treatment on circulating NO levels not assessed previously. Methods. Serum NO levels of patients with schizophrenia (n = 20) before and after 6 weeks of treatment were compared with those of healthy controls (n = 20). Severity of schizophrenia and response to treatment were assessed with positive and negative symptoms of schizophrenia. NO levels were estimated by Griess method in serum samples. Results. In patients with schizophrenia, pre-treatment serum NO levels were higher than those of control subjects (39.15 +/- 18.24 vs. 25.40. +/- 5.83 mumol/L, p = 0.036) and also of post-treatment values (34.41 +/- 16.35 vs. 25.40 +/- 5.83 mumol/L, p = 0.049), respectively. However, no significant difference was found between serum NO levels in pre- and post-treatment values. Conclusions. Our findings of increased serum NO levels in schizophrenic patients confirmed the role of NO in the pathophysiology of schizophrenia. However, we found that antipsychotic drugs do not reveal significant effects on serum levels of NO in schizophrenia in a 6-week treatment regimen. Further studies with longer therapy periods may suggest some new clues for novel treatment strategies employing antioxidants and NOS inhibitors in schizophrenia. (C) 2004 IMSS. Published by Elsevier Inc.Item Effect of treatment on serum brain-derived neurotrophic factor levels in depressed patientsGonul, AS; Akdeniz, F; Taneli, F; Donat, O; Eker, Ç; Vahip, SResearchers have reported that serum brain-derived neurotrophic factor (sBDNF) of drug-free depressed patients are lower than those of healthy controls and proposed that low sBDNF levels might reflect failure of neuronal plasticity in depression. In this study, we compared sBDNF levels of depressed patients (n = 28) before and after 8 weeks of antidepressant treatment, with those of healthy controls (n = 18) to test the hypothesis that initially low sBDNF levels of drug-free depressed patients will increase parallel with their clinical response to antidepressant treatment. The severity of depression and response to treatment were assessed with Hamilton Rating Scale for Depression (HAM-D). sBDNF was assayed with the sandwich ELISA method. Baseline sBDNF levels of patients (mean, 20.8 ng/ml; [S.D., 6.7]) were significantly lower than those of controls (mean, 26.8 ng/ml; [S.D., 9.3]; p = 0.015), and were negatively correlated with HAM-D scores (r = -0.49, p = 0.007). After 8 weeks of treatment, sBDNF levels of patients had increased significantly (mean, 33.3 ng/ml; [S.D., 9.9]; p < 0.001) and no longer differed from those of controls. These results support the hypothesis that BDNF might play a critical role in the pathophysiology of major depressive disorder and successful antidepressant treatment increases the attenuated BDNF levels in depressed patients.