Browsing by Author "Akdogan A."

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    Effect of ovarian stimulation with human menopausal gonadotropin and recombinant follicle stimulating hormone on the expression of integrins alpha(3), beta(1) in the rat endometrium during the implantation period
    (Elsevier Ireland Ltd, 2010) Sendag F.; Akdogan A.; Ozbilgin K.; Giray G.; Oztekin K.
    Objective: To investigate the effect of exogenous ovarian stimulation with human menopausal gonadotropin (hMG) and recombinant follicle stimulating hormone (rFSH) on the expression of integrins alpha(3), beta(1) in the rat endometrium during implantation. Study design: Following three successive normal estrous cycles the animals were divided into five groups: Group I (n = 10, control group) received no medication; Group II (n = 10) received 10 units of hMG; Group III (n = 10) received 20 units of hMG; Group IV (n = 10) received 10 units of rFSH; Group V (n = 10) received 20 units of rFSH at midday of middiestrous. The rats were then mated with fertile males. The animals were sacrificed on the day of implantation. The uterine horns were placed in fixative and paraffin blocks of the tissue were cut in 5 μm sections. The tissues were stained with primary antibodies; monoclonal anti-integrin alpha(3) and monoclonal anti-integrin beta(1) using immunohistochemical methods. The staining intensities of alpha(3) and beta(1) integrins were calculated separately for epithelium and stroma in each group. Results: Staining intensities of alpha(3) and beta(1) integrins in both the epithelium and the stroma were significantly lower in the treatment groups than the control group (p < 0.05). Conclusion: Ovarian stimulation by low and high doses of HMG and rFSH may have an effect on endometrial receptivity, possibly via a decrease in expression of integrins in the endometrium during the implantation period. © 2010 Elsevier Ireland Ltd. All rights reserved.
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    EPIdemiology of Surgery-Associated Acute Kidney Injury (EPIS-AKI): Study protocol for a multicentre, observational trial
    (BMJ Publishing Group, 2021) Weiss R.; Saadat-Gilani K.; Kerschke L.; Wempe C.; Meersch M.; Zarbock A.; Makhloufi H.; Cherak A.; Ghanem L.L.; Gouaglia Z.; Guadouri D.N.; Hama F.N.; Kara M.; Saadi O.; Sakhraoui R.; Bourou F.; Cherifi A.; Sadaoui R.G.; Ouyahia A.; Ouahab I.; Bouaoud S.; Abdoun M.; Tidjane A.; Tabeti B.; Boudjenan-Serradj N.; Rivera C.J.P.; Cabrer P.; Corso J.; García J.P.; Idarraga S.; Montoya C.; Figueroa R.; Aldana E.; Torrado M.A.; Peng K.; Ma Z.-M.; Yang Y.-F.; Zhu Y.-J.; Sklienka P.; Frelich M.; Jarkulis V.; Sevcik P.; Vodicka V.; Elbahnasawy M.G.; Elsalhawy S.; Motawea S.; Othman Z.; Sahma M.; Nafea A.M.; Ahmed N.; Attia D.A.; Emara M.M.; Bonna M.M.; Gabr M.A.; Tarbay A.I.; Abdehaleem I.A.; Mohamed E.E.; Eldeeb A.M.; Abbas A.M.; Magdy J.A.; Hamed Z.H.; Osman H.M.E.; Abbas M.S.; Joannes-Boyau O.; Barraud N.; Berthelot C.; Camus T.; Dahmi A.; Defaye M.; Derville S.; El-Boustani Y.; Deloge E.; Jacob H.; Monziols S.; Priem F.; Robin J.-J.; Legros V.; Floch T.; Muccio S.; Geneve C.; Legouge M.L.; Mauny S.T.; Mfam W.; Pascot L.; Aveline C.; Chartier M.; Duteurtre B.; Gautier J.F.; Cousin A.L.; Vautier P.; Nadaud J.; Begel N.; Chekirine C.-A.; Derlon V.; Grein E.; Lehair M.-A.; Magazzeni L.; Magazzeni P.; Potter C.; Roth C.; Voivret F.; Rimmelé T.; Cerro V.; Suria S.; Elmawieh J.; Stoclin A.; Cirenei C.; Andrieu G.; Couloumy S.; Falcone J.; Fajardy M.; Gagneuil A.; Girardet E.; Mazereeuw A.; Ponsonnard S.; Egreteau P.-Y.; Bertel M.; Bocher S.; Carn V.; Guen L.L.; Loup G.L.; Lefevre M.; Ichai C.; Diop A.; Jean-Michel V.; Devlieger S.; Duthoit J.; El Kadiri M.; Léger M.; Cassisa V.; Lasocki S.; Masson C.; Rineau E.; Verrier P.; Coquerel A.; Montravers P.; Atchade E.; Rochon C.-E.; Delerue C.; Quentin V.; Latry V.; Queixalos N.; Cottenceau V.; Braun T.; Bouzoubaa S.; Christ B.; Geiger A.; Gomille J.; Kieffer V.; Mangeant S.; Prochilo C.; Schmitt C.; Skwirba S.; Grand H.; Boury F.; Mayeur N.; Pasquie M.; Garçon P.; Bruckert V.; Arnould V.; Bonciu M.; Chapelle T.; Facchino L.; Fagot-Gandet F.; Iachim A.; Mannu E.; Perus O.; Plattier R.; Rozier R.; Pradel G.; Boudinaud M.; Hausermann M.-H.; Nguyen M.H.; Ramorasata A.; Barreau A.; Boivin A.-H.; Ravry C.; Mottard N.; Beuvelot J.; Bossion F.P.; Desebbe O.; Dörr C.; von Groote T.C.; Küllmar M.; Massoth C.; Ziemann S.; Grüßer L.; Kowark A.; Wittig P.; Brandenburger T.; Dimski T.; Döhmen N.; Huthmann L.; Kaierle D.; Pelletier C.; Schleß M.; Hohn A.; Cleophas S.; Haunhorst S.; Jansen M.; Schmitt A.; Soisch J.; Sturm K.; Rosenberger P.; Bendig A.; Flohr L.; Häberle H.; Hofmann P.; Kuhle J.; Leser N.M.; Pfister K.; Prohaska S.; Sennholz F.; Stetz L.; Weber K.; Stehr S.; Klaus S.; Sadlo M.; Boschin M.; Sengelhoff C.; Göbel U.M.; Haaker J.G.; Göttker C.-K.; Gründel M.; Heringlake M.; Baumgärtel R.; Berggren A.; Gülzow M.; Muras L.; Paarmann H.; Thal S.; Bentley A.; El-Masri D.; Sebastiani A.; Arnaoutoglou E.; Ntalouka M.; Stratigopoulou P.; Analytis A.; Mavrommatis E.; Tzimas P.; Karakosta A.; Pantazi D.; Dimakopoulou A.; Dimitropoulou K.; Ioannidis O.; Jalaawiy H.; Anwar A.; Hashim H.T.; Aldawoody H.I.R.; Cortegiani A.; Catalisano G.; Ingoglia G.; Ippolito M.; De Rosa S.; Cattin L.; Bianchin A.; Barone M.; Paternoster G.; Cutuli S.L.; Russo A.; Sollazzi L.; Cascarano L.; Antonelli M.; Aceto P.; Romanò B.; Spadaro S.; Tripodi V.F.; Rossi M.; Scappatura R.; Vadalà M.C.; Fiume D.; Strano M.T.; Oddo G.; Santorsola C.; Hussain B.A.; Alnaser A.R.; Ghassan A.H.; Hasanein K.; Theab M.; Shin S.; Jung S.; Lee K.; Jung S.M.; Baek J.; Elhadi M.K.; Aldressi W.W.O.; Abuzeid I.; Albaraesi M.; Aldressi S.; Khalel W.; Abdulwahed E.; Abujrad A.A.A.; Almaghrabi A.; Alteleeb M.; Alshareea E.A.A.; Biala M.I.; Deeknah A.; Gheddim D.A.; Ghmagh R.; Ikhrays N.S.A.A.; Sinan M.; Soula E.; Bahroun S.G.; Derwish K.; Mohamed A.M.; Younes E.S.; Al Islam Benjouira R.; Aliwa M.; Altashani N.A.; Alteb M.O.; Msherghi A.; Alagelli F.; Albarouni S.; Albishti A.; Aljamal S.; Alsori M.; Ekhuja T.; Elzwai S.; Ghula M.; Mustafa T.; Tuwaib A.; Zriba H.; Agilla H.M.; Rafanomezantsoa T.A.; Podesta A.M.C.; Bonnici D.M.; Pirotta T.; López G.A.G.; Mijovska M.M.; Davitkovska T.; Gavrilovska A.; Lukikj S.; Vesova M.; Zafirova D.; Amro S.; Hajjaj B.N.F.; Alkhazendar M.; Barakat Y.; Elejla S.A.; Elhissi A.; Khader A.; Salem A.; de Freitas Regufe R.; de Oliveira Eloy A.F.; Perdigão L.M.N.C.; Grigoriev E.; Ivkin A.; Kornelyuk R.; Yaroustovsky M.; Abramyan M.; Komardina E.; Lesteva N.; Aybazova M.; Kumykova E.; Lesina S.; Rybakov G.; Shestov A.; Barmou A.A.A.; Ahmed B.L.A.; Eliyas A.M.; Emadeldin Y.; Kaserer A.; Castellucci C.; Rössler J.; Akbas S.; Petrun A.M.; Gregorcic I.; Sok V.; Cicak R.; Bárcena E.; Guisado A.; Wi I.; Melchor J.R.; Becerra-Bolaños Á.; Cabrera-Doreste S.; Domínguez-Arbelo A.; Delgado-Alonso M.C.; Muiño-Palomar V.; Rodríguez-Pérez A.; Estévez J.M.; Munoz M.B.C.; Matas J.M.; Palao S.P.; Quirós M.D.M.; Teslev A.C.; Argilaga M.; Campos M.; Bainac A.; Batalla A.; Alvarez M.G.; Giné M.; Herránz G.; Hinojal I.; Ejea M.L.; de la Rosa Ruiz N.; Abasolo M.G.; Acuna C.R.H.; Zaranton I.I.; Mendigurenmurua A.; Sanz M.J.M.; de la Fuente E.O.; Vaquero M.P.P.; Iglesias A.S.; Mieres A.U.; Urrestizala A.U.; Ferreira L.; Lobato F.; Sevilla M.A.; Erazo A.; Miró P.; Sabaté S.; Vernetta D.; Perez A.A.; Pagola M.A.; Paulis B.C.; del Val Peciña E.; Odriozola A.G.; Aizpurua A.L.; Piquer O.P.; Garcia P.P.; Rezola P.O.; Lopez A.O.; de la Calle Gil I.; Casado R.N.; Adamove P.; Domenge R.B.; Blasco F.M.B.; Villamizar A.A.R.; Llaneras M.A.P.; García-Sánchez J.I.; Téllez L.F.; Zamorano S.G.; Herreros N.G.; Esteve A.R.; Rodríguez P.M.; Trigo I.G.; Alcaraz A.; Jiménez A.L.; Rubio I.; García N.; Callejas R.; Toha A.M.C.; Claros E.; Cobeta P.; Crespo P.; Dorado T.; Elías E.; Felices J.; Gil D.; Gómez M.; Mané N.; Martín M.; Martínez A.; Pereira L.; Samaranch A.B.N.; Serrano A.; Tiscar C.; VillaHoz J.; Menéndez P.G.; Cardona E.; Conesa A.; Estepa V.; Galán P.; Espí L.L.; Aldeán Y.L.; Manrique S.; Ariza V.M.; Villa L.V.; Suliman E.S.M.A.; Hamid H.; Ibrahim A.M.; Saeed M.M.; Mukadder O.S.; Altun D.; Canbolat N.; Dinçer M.B.; Seyhan T.Ö.; Yildirim S.A.; Iyigün M.; Yapici D.; Özdemir L.; Sagun A.; Boztug N.; Cetintas Y.; Dinc B.; Gündüz E.; Ünlügenç H.; Tunay D.L.; Karakaya D.; Dost B.; Komurcu O.; Akcil E.F.; Dilmen Ö.K.; Tunali Y.; Ok G.; Alsina E.T.; Hakli Ö.; Polat C.; Turgut N.; Kizilcik N.; Köner Ö.; Sen Ö.; Aydin N.; Basaran B.; Bingul E.S.; Gürkan Y.; Darcin K.; Ugur S.; Saracoglu K.T.; Demir A.; Aysegül Ö.; Balci E.; Girgin B.; Guler A.; Karadeniz Ü.; Özaslan N.; Hülya Y.Ö.; Ozcan N.; Postaci A.; Sahap M.; Salman N.; Sagir Ö.; Atik B.; Bicakcioglu M.; Demir H.F.; Fatih U.; Kocaoglu N.; Toprak H.I.; Aslan D.D.; Colak Y.Z.; Ozcan M.S.; Yilmaz M.; Karaca U.; Sahin S.H.; Karka Ö.E.; Senoglu G.D.; Karadag S.E.; Alkis N.; Baytas V.; Akdogan A.; Besir A.; Erturk E.; Kutanis D.; Saylan S.; Tugcugil E.; Ayvat P.; Günaydin B.; Büyükgebiz B.M.; Boran O.F.; Calisir F.; Orak Y.; Balkan B.K.; Büyükcoban S.; Gökel E.; Günenc S.F.; Özbilgin S.; Göre S.; Akesen S.; Cansabuncu S.; Momot N.; Panchenko A.; Pittet J.-F.; Rutledge K.
    Introduction More than 300 million surgical procedures are performed each year. Acute kidney injury (AKI) is a common complication after major surgery and is associated with adverse short-term and long-term outcomes. However, there is a large variation in the incidence of reported AKI rates. The establishment of an accurate epidemiology of surgery-associated AKI is important for healthcare policy, quality initiatives, clinical trials, as well as for improving guidelines. The objective of the Epidemiology of Surgery-associated Acute Kidney Injury (EPIS-AKI) trial is to prospectively evaluate the epidemiology of AKI after major surgery using the latest Kidney Disease: Improving Global Outcomes (KDIGO) consensus definition of AKI. Methods and analysis EPIS-AKI is an international prospective, observational, multicentre cohort study including 10 000 patients undergoing major surgery who are subsequently admitted to the ICU or a similar high dependency unit. The primary endpoint is the incidence of AKI within 72 hours after surgery according to the KDIGO criteria. Secondary endpoints include use of renal replacement therapy (RRT), mortality during ICU and hospital stay, length of ICU and hospital stay and major adverse kidney events (combined endpoint consisting of persistent renal dysfunction, RRT and mortality) at day 90. Further, we will evaluate preoperative and intraoperative risk factors affecting the incidence of postoperative AKI. In an add-on analysis, we will assess urinary biomarkers for early detection of AKI. Ethics and dissemination EPIS-AKI has been approved by the leading Ethics Committee of the Medical Council North Rhine-Westphalia, of the Westphalian Wilhelms-University Münster and the corresponding Ethics Committee at each participating site. Results will be disseminated widely and published in peer-reviewed journals, presented at conferences and used to design further AKI-related trials. Trial registration number NCT04165369. ©
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    Acute kidney disease beyond day 7 after major surgery: a secondary analysis of the EPIS-AKI trial
    (Springer Science and Business Media Deutschland GmbH, 2024) Meersch M.; Weiss R.; Strauß C.; Albert F.; Booke H.; Forni L.; Pittet J.; Kellum J.A.; Rosner M.; Mehta R.; Bellomo R.; Rosenberger P.; Zarbock A.; Makhloufi H.; Sakhraoui R.; Ouyahia A.; Rais M.; Kouicem A.T.; Derwish K.; Abdoun M.; Ouahab I.; Bouaoud S.; Tidjane A.; Pérez Rivera C.J.; García J.P.; Peng K.; Ji F.-H.; Ma Z.-M.; Elbahnasawy M.G.; Elsalhawy S.; Nafea A.M.; Osman N.A.; Emara M.M.; Bonna M.M.; Abdehaleem I.A.; Abbas A.M.; Abbas M.S.; Esmaeil H.M.; Joannes-Boyau O.; Legros V.; Floch T.; Muccio S.; Menage-Innocenti L.; Brochet B.; Leclercq-Rouget M.; Geneve C.; Mocarquer B.V.; Aveline C.; Vautier P.; Nadaud J.; Rimmelé T.; Cerro V.; Suria S.; Elmawieh J.; El-Jawiche R.; Cirenei C.; Lebuffe G.; Ponsonnard S.; Egreteau P.-Y.; Ichai C.; Jean-Michel V.; Léger M.; Lasocki S.; Masson C.; Rineau E.; Cassisa V.; Verrier P.; Atchade E.; Rochon C.-E.; Quentin V.; Queixalos N.; Braun T.; Grand H.; Mayeur N.; Pasquie M.; Garçon P.; Bruckert V.; Pradel G.; Ramorasata A.; Ravry C.; Mottard N.; von Groote T.; Dörr C.; Küllmar M.; Massoth C.; Motekallemi A.; Saadat-Gilani K.; Kerschke L.; Storck M.; Varghese J.; Wempe C.; Grüßer L.; Kowark A.; Brandenburger T.; Hohn A.; Häberle H.; Hofmann P.; Kuhle J.; Calov S.; Bernard A.M.; Mirakaj V.; Weber K.; Pfister K.; Stetz L.; Müller S.D.; Klaus S.; Sadlo M.; Sengelhoff C.; Stenger C.-K.; Göbel U.; Heringlake M.; Arnaoutoglou E.; Stratigopoulou P.; Danai P.; Dimakopoulou A.; Menis A.-A.; Ioannidis O.; Jalaawiy H.; Anwar A.; Hashim H.T.; Rasheed Aldawoody H.I.; Cortegiani A.; Ippolito M.; Marino C.; Presti G.; Fricano D.C.; De Rosa S.; Bianchin A.; Paternoster G.; Fasciano U.; Cutuli S.L.; Savino S.; Enrico B.; Marco P.; Alberto V.C.; Tripodi V.F.; Fiume D.; Iuorio A.; Santorsola C.; Abu-Hussein B.; Hasanein K.; Shin S.; Baek J.; Kim S.; Elhadi M.; Aldressi W.; Abuzeid I.A.; Albaraesi M.N.; Moftah M.A.; Aldressi S.; Khalel W.; Abdulwahed E.; Ali Alshareea E.A.; Abujrad Reem Ghmagh A.A.A.; Biala M.I.; Benjouira R.A.I.; Aliwa M.; Msherghi A.; Tuwaib A.; Mustafa T.; Zriba H.; Agilla H.M.; Sadek Ben Hamida B.T.; Mohamed Otman R.H.; Mijovska M.M.; Podesta A.M.C.; Gasca López G.A.; Amro S.; de Freitas Regufe R.; Grigoryev E.; Ivkin A.; Balakhnin D.; Shukevich D.; Yaroustovsky M.; Barmou A.; Kaserer A.; Castellucci C.; Akbas S.; Petrun A.M.; Gregorcic I.; Sok V.; Links A.; Barreto E.B.; Melchor J.R.; Becerra-Bolaños Á.; Rodríguez-Pérez A.; Estévez J.M.; Matas J.M.; Palao S.P.; Álvarez M.G.; Albadalejo A.B.; González A.B.; Caro A.M.G.; Blanco I.H.; Fernandez D.T.; Perez G.H.; Ejea M.L.; de la Rosa Ruiz N.; Abasolo M.G.; Ferreira L.; Lobato F.; Sevilla M.A.; Erazo A.; Paulis B.C.; de la Calle Gil I.; Adamove P.; Blasco F.M.B.; García-Sánchez J.I.; Zamorano S.G.; Herreros N.G.; Callejas R.; Gómez M.E.; Candela-Toha A.M.; Claros-Llamas E.; Cobeta-Orduña P.; Crespo-Aliseda P.; Dorado-Díaz T.; Gómez-Rojo M.; Mané-Ruiz M.N.; González M.C.M.; Martínez-Pérez A.; Tiscar C.; Menéndez P.G.; Calvo V.E.; Espí L.L.; Aldeán Y.S.L.; Ariza V.M.; Vila L.V.; García-Miguel F.J.; Suliman E.S.M.; Ibrahim A.M.; Fadlalmola H.A.; Swed S.; Wu V.-C.; Orhan-Sungur M.; Altun D.; Canbolat N.; Dinçer M.B.; Yildirim S.A.; Iyigun M.; Yapıcı D.; Özdemir L.; Sagün A.; Boztug N.; Gündüz E.; Lafli-Tunay D.; Karakaya D.; Dost B.; Komurcu O.; Dilmen O.K.; Akcil E.F.; Tunali Y.; Ok G.; Tok-Alsina E.; Polat C.; Kızılcık N.; Şen Ö.; Darçın K.; Uğur S.; Gürkan Y.; Saracoglu K.T.; Yıldız-Koyuncu Ö.; Demir Z.A.; Postacı N.A.; Özgök A.; Karadeniz Ü.; Özay H.Y.; Balcı E.; Salman N.; Girgin B.; Sagir O.; Demir H.F.; Ugun F.; Toprak H.İ.; Özcan M.S.; Alkaya-Solmaz F.; Yilmaz M.; Karaca U.; Şahin S.H.; Erkoç S.K.; Alkış N.; Baytaş V.; Erturk E.; Saylan S.; Akdogan A.; Yeşil B.B.; Boran O.F.; Orak Y.; Çalişir F.; Büyükçoban S.; Kuvaki B.; Cansabuncu S.; Akesen S.; Gören S.; Yeniocak T.; Orman O.; Karka Ö.E.; Sahin T.; Momot N.; Panchenko A.; Rutledge K.
    Purpose: Acute kidney disease (AKD) is a significant health care burden worldwide. However, little is known about this complication after major surgery. Methods: We conducted an international prospective, observational, multi-center study among patients undergoing major surgery. The primary study endpoint was the incidence of AKD (defined as new onset of estimated glomerular filtration rate (eCFR) < 60 ml/min/1.73 m2 present on day 7 or later) among survivors. Secondary endpoints included the relationship between early postoperative acute kidney injury (AKI) (within 72 h after major surgery) and subsequent AKD, the identification of risk factors for AKD, and the rate of chronic kidney disease (CKD) progression in patients with pre-existing CKD. Results: We studied 9510 patients without pre-existing CKD. Of these, 940 (9.9%) developed AKD after 7 days of whom 34.1% experiencing an episode of early postoperative-AKI. Rates of AKD after 7 days significantly increased with the severity (19.1% Kidney Disease Improving Global Outcomes [KDIGO] 1, 24.5% KDIGO2, 34.3% KDIGO3; P < 0.001) and duration (15.5% transient vs 38.3% persistent AKI; P < 0.001) of early postoperative-AKI. Independent risk factors for AKD included early postoperative-AKI, exposure to perioperative nephrotoxic agents, and postoperative pneumonia. Early postoperative-AKI carried an independent odds ratio for AKD of 2.64 (95% confidence interval [CI] 2.21–3.15). Of 663 patients with pre-existing CKD, 42 (6.3%) had worsening CKD at day 90. In patients with CKD and an episode of early AKI, CKD progression occurred in 11.6%. Conclusion: One in ten major surgery patients developed AKD beyond 7 days after surgery, in most cases without an episode of early postoperative-AKI. However, early postoperative-AKI severity and duration were associated with an increased rate of AKD and early postoperative-AKI was strongly associated with AKD independent of all other potential risk factors. © The Author(s) 2024.