Browsing by Author "Akin F."

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    Disease burden and associated factors in caregivers of patients with obsessive-compulsive disorder
    (Kare Publishing, 2020) Suculluoglu-Dikici D.; Cokmus F.P.; Akin F.; Eser E.; Demet M.M.
    Objective: Obsessive-compulsive disorder (OCD) is one of the leading causes of disability and poor quality of life, with impairment in many areas. It can also adversely affect family members and friends that the person lives with, and this results in a burden. We aimed to evaluate the disease burden in caregivers of patients with OCD and the factors that negatively affect caregiver burden. Method: The study population consisted of 94 patients with OCD and their caregivers. The Yale-Brown Obsessive-Compulsive Scale (YBOCS), the Hamilton Depression Rating Scale, and the World Health Organization Quality of Life Questionnaire Brief Form were filled out by the patients, and the Burden Assessment Scale (BAS) by the caregivers. Results: Longer duration of treatment, higher YBOCS obsession and compulsion scores of the patients, and lower environmental quality of life dimension scores of the patients were found to increase the BAS scores of the caregivers. Additionally, these variables were found to be significant predictors for disease burden (BAS score) (p<0.05). Conclusion: Our study revealed that many variables affect burden, even in caregivers who have no extra burden (who has no disease to cause a burden). Caregivers of patients with OCD should be included in the behavioral and pharmacologic treatment process for the benefit of both the OCD treatment management and the protection of family health. © 2020 Yerkure Tanitim ve Yayincilik Hizmetleri A.S.. All rights reserved.
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    Investigation of Genetic Changes in Three Families with Bipolar Disease
    (S. Karger AG, 2024) Çolak-Geniş E.; Özdemir Erdoǧan M.; Çam F.S.; Aydemir Ö.; Akin F.; Gerik-Celebi H.B.; Solak M.
    Introduction: Bipolar disorder (BD) is a serious psychiatric disorder characterized by mood swings (depressive and manic phases) that can strongly affect the quality of life of patients and their families. The lifetime prevalence of BD in the general population is 1%. The pathogenesis of BD is unknown; however, comprehensive epidemiological studies have shown that both genetic and environmental factors play a role. Within the scope of the current project, we aim to determine the genetic change responsible for the emergence of the disease and to make a genotype-phenotype correlation. Methods: In this study, we evaluated single nucleotide gene variants in three families (n = 6 patients) with bipolar disorder using whole-exome sequencing. Results: Seven genes (TMTC1, DGKH, STARD9, ITIH1, MARCKS, CSMD1, and ADRA2B) were identified as possibly associated with BPD. In addition, two novel variants were presented in the TMTC1 (c.1214T>G) and STARD9 (c.8288C>G) genes. Conclusion: Prospective studies in larger patient groups are required to determine the role of these genes in the etiology of the disease and their potential in diagnosis and treatment. To the best of our knowledge, this is the first methodically comprehensive study conducted in our country and cancontribute to the identification of genes that may be associated with BD and the etiopathogenesis of the disease. © 2024 S. Karger AG, Basel.
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    Retinal abnormalities and their relationship with social cognition in patients with schizophrenia and their healthy siblings
    (Kare Publishing, 2024) Akin F.; Danaci A.E.; Kayikcioglu R.O.; Tasci M.Y.
    Objective: This study aimed to investigate retinal abnormalities and their relationship with social cognitive function, and to assess whether retinal changes could be observed in the healthy siblings of patients with schizophrenia in a similar manner, suggesting their potential as an endophenotype. Method: The study included 28 patients with schizophrenia, 28 of their siblings, and 28 healthy control subjects. Social cognition tests were administered, and measurements of the retinal nerve fiber layers (RNFL), ganglion cell layer plus inner plexiform layer (GCL+IPL), and cup volumes were obtained using optical coherence tomography (OCT). Results: Analyses revealed no differences between the groups in RNFL thickness. The cup volume was significantly larger in both eyes of the patient group compared to the control group. The mean thickness of the GCL+IPL in the left eye was significantly lower in the patient group compared to the healthy control group, with a similar difference also observed between the siblings of patients and the control group. A statistically significant difference was found among all groups in the total scores of social cognition tests. A weak correlation was identified between retinal layer thicknesses and social cognition test scores in both the patient and sibling groups. Conclusion: These findings suggest that GCL+IPL thickness can be a useful endophenotype for the early diagnosis of schizophrenia. While retinal changes do not predict cognitive symptoms in patients with schizophrenia, they may play an important role in identifying high-risk groups. © 2024 Kare Publishing. All rights reserved.