Browsing by Author "Aksun, S"

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    Allergic Rhinitis and Its Relationship with IL-10, IL-17, TGF-β, IFN-γ, IL 22, and IL-35
    Degirmenci, PB; Aksun, S; Altin, Z; Bilgir, F; Arslan, IB; Colak, H; Ural, B; Kahraman, DS; Diniz, G; Ozdemir, B; Kirmaz, C
    Background. We aimed in our study to research the role of new cytokines such as IL-35, IL-22, and IL-17 that may form a target for novel treatment approaches. Methods. IL-10, IL-17, TGF-beta, IFN-gamma, IL-22, and IL-35 serum levels of allergic rhinitis (AR) patients were measured using ELISA method. Allergic sensitization was demonstrated by the skin prick test. Patients only with olive tree sensitivity were evaluated for seasonal AR (SAR). Patients only with mite sensitivity were included in the study for perennial AR (PAR). AR clinic severity was demonstrated by the nasal symptom scores (NSS). Results. In total, 65 AR patients (patient group), having 31 PAR and 34 SAR patients, and 31 healthy individuals (control group) participated in the study. Cytokine levels between the patient group and the control group were compared; IL-17 (p = 0 038), IL-22 (p = 0 001), and TGF-beta (p = 0 031) were detected as high in the patient group, and IFN-gamma (p < 0 001) was detected as low in the patient group. When correlation analysis was made between age, gender, prick test result, NSS, AR duration, and cytokine levels in the patient group, a negative correlation was detected only between IFN-gamma (p = 0 032/r = -0 266) level and NSS. Conclusions. Accompanied by the literature information, these results made us think that T cell subgroups and cytokines have an important role in AR immunopathogenesis. It is thought that future studies to be conducted relating to this subject will form new targets in treatment.
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    The effect of Paracetamol exposure on hepatic and renal tissues during statin usage
    Aksun, S; Gökcimen, A; Kahyaoglu, F; Demirci, B
    Objective: Statins and Paracetamol have widespread use in clinic and both drugs possess similar side effects; therefore, we investigated if drug-interaction occurs when the combination of these two drugs is used during therapy. Materials and methods: A total of 32 (12-15 months old) grown-up male rats were divided into four groups: Control group, RSV group (10 mg/kg Rosuvastatin/daily), APAP group (50 mg/kg Paracetamol/5 days/weekly), RSV + APAP (10 mg/kg Rosuvastatin/daily + 50 mg/kg Paracetamol/5 days/weekly). At the end of 8 weeks of chronic treatment, the blood and tissue samples were taken under the Ketamine and Xylasine anesthesia (50 mg/kg and 5 mg/kg, respectively). Results: In the liver, sinusoidal dilatations, pyknotic nuclei and hemorrhagic foci are more frequently seen in the group receiving combination therapy; although serum liver functions among groups were not significantly different. Kidney histopathologic alterations in APAP and RSV + APAP groups were found more distinct than in RSV alone group. Inducible nitric oxide synthase activity was highly increased with combination therapy in liver and kidney tissues. Conclusion: RSV-Paracetamol interaction may occur as an important drug interaction histopathologically even before it is manifested biochemically in the clinic.
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    Parental Attitude in Women with Hyperprolactinemia: a Controlled Cross-Sectional Study
    Ulman, C; Aydemir, Ö; Taneli, F; Aksun, S; Öztin, A; Safak, C; Laçin, S
    Objective: Prolactin hormone affects the brain, attitude and mood. Secretion of prolactin may be stimulated by environmental factors. The aim of this study was to demonstrate any possible effect of poor child-parent relationship on hyperprolactinemia. We hypothesize that women with hyperprolactinemia may have been subjected to poor child-parent relationship and neglect. Method: The present study was designed in a maternity hospital and included women with gynecologic complaints referred from the gynaecology outpatient clinic for serum prolactin assessments. An 85-item, self-rated EMBU Scale questionnaire (a scale for perceived parental attitude) was applied. Fifty women were enrolled over a period of 5 months. Results: Women with hyperprolactinemia (prolactin levels above 26 ng/ml) constituted the patient group (Group 1) (n=34) and those with normal serum prolactin levels (below 26 ng/ml) served as the controls (Group 2) (n=16). The mean +/- SD levels of prolactin for group 1 and 2 were 57.25 +/- 38.7 ng/ml and 18.81 +/- 4.4 ng/ml, respectively. Group 1 patients believe that their parents did not show enough emotional warmth and had rejective behavior. Emotional warmth parameters of patients' mothers and fathers were significantly lower (p=0.002 and p=0.01, respectively) than those of the control group. We also found that the patients believed that their mothers and fathers both had rejective behaviors (p=0.008 and p=0.009, respectively). Conclusion: Prolactin secretion is regulated by the dopaminergic system and since dopamine is responsible of pleasure and satisfaction sensations, the negative affection of both mothers and fathers in childhood may play a role in the etiology of chronic low-grade hyperprolactinemia in women.