Browsing by Author "Akyildiz M."

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    The effect of cigarette smoking during pregnancy on cord blood lipid, lipoprotein and apolipoprotein levels
    (International Heart Journal Association, 1997) Işcan A.; Yiǧitoǧlu M.R.; Ece A.; Ari Z.; Akyildiz M.
    We examined the relationship between maternal smoking during pregnancy and serum lipid, lipoprotein and apolipoprotein levels in newborns. Serum concentrations of total cholesterol, triglyceride, high density lipoprotein cholesterol, low density lipoprotein cholesterol, apolipoprotein A-1, apolipoprotein B and lipoprotein (a) were assesed in blood samples from 38 mothers who were smokers and their newborns obtained at delivery and compared to blood sample from 42 nonsmokers and their newborns. As compared with newborns of nonsmoker mothers, newborns of smoker mothers showed a lower mean level of high density lipoprotein cholesterol (21 versus 26 mg/dl, p < 0.01), a higher total cholesterol to high density lipoprotein cholesterol (4.7 versus 3.7, P < 0.01), a higher low density lipoprotein cholesterol to high density lipoprotein cholesterol ratios (3.2 versus 2.3, p < 0.05), a lower mean level of apolipoprotein A-1 (105 versus 129 mg/dl, p < 0.01) and a higher apolipoprotein B to apolipoprotein A-1 ratio (0.44 versus 0.3, p < 0.01). These paremeters were also different between smoker and nonsmoker mothers. There were no significant differences in TC, TG, LDL-C, Apo B and Lp (a) values between the two newborn groups. These data suggest that maternal smoking during pregnancy markedly affects lipid metabolism in the fetus.
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    Low levels of high density lipoprotein cholesterol in Turkish children: An important risk factor
    (1998) Işcan A.; Yiǧitoǧlu M.R.; Vurgun N.; Uyanik B.S.; Akyildiz M.
    In Turkish adults, the incidence of coronary artery disease (CAD) has been found to be high. However, no detailed lipid, or lipoprotein data of children are available from Turkey. The present study was designed to define the borderline lipid and lipoprotein levels of sera in 397 healthy children (aged 5-14 years; 206 boys and 191 girls). Mean levels of total cholesterol (TC), triglyceride (TG), high- and low-density lipoprotein cholesterol (HDL- C and LDL-C, respectively) were found to be 150, 79, 46.7, and 87.6 mg/dL, respectively, for boys, and 152, 77.5, 46.3 and 90.5 mg/dL, respectively, for girls. Lipids and lipoproteins did not show any significant correlation with age and body mass index (BMI), except for TG in boys in whom TG levels were positively correlated with age and BMI. There were no significant differences in lipid and lipoprotein levels between boys and girls. As in the Turkish adult population, serum HDL-C levels of Turkish children were profoundly low on international comparison. Twenty-three (53%) of 43 children with low HDL- C level (≤ 35 mg/dL) had abnormal ratios of TC/HDL-C (≤ 5) and/or LDL- C/HDL-C (≤ 4.5), whereas only 13 (3.7%) of the remaining 354 children with a HDL-C level less than 35 mg/dL had abnormal ratios of TC/HDL-C (≤ 5) and/or LDL-C/HDL-C (≤ 4.5). The low levels of HDL-C in Turkish children may be associated with the high incidence of CAD in the Turkish adult population.
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    Low levels of high density lipoprotein cholesterol in Turkish children: An important risk factor
    (1998) Işslcan A.K.I.N.; Yiǧitoǧl̈ M.R.; Vurgun N.; Uyanik B.S.; Akyildiz M.
    In Turkish adults, the incidence of coronary artery disease (CAD) has been found to be high. However, no detailed lipid, or lipoprotein data of children are available from Turkey. The present study was designed to define the borderline lipid and lipoprotein levels of sera in 397 healthy children (aged5–14 years; 206 boys and 191 girls). Mean levels of total cholesterol (TC), triglyceride (TG), high- and low-density lipoprotein cholesterol (HDL-C and LDL-C, respectively) were found to be 150, 79, 46.7, and 87.6 mg/dL, respectively, for boys, and 152, 77.5, 46.3 and 90.5 mg/dL, respectively, for girls. Lipids and lipoproteins did not show any significant correlation with age and body mass index (BMI), except for TG in boys in whom TG levels were positively correlated with age and BMI. There were no significant differences in lipid and lipoprotein levels between boys and girls. As in the Turkish adult population, serum HDL-C levels of Turkish children were profoundly low on international comparison. Twenty-three (53%) of 43 children with low HDL-C level (35 mg/dL) had abnormal ratios of TC/HDL-C (5) and/or LDL-C/HDL-C (4.5), whereas only 13 (3.7%) of the remaining 354 children with a HDL-C level less than 35 mg/dL had abnormal ratios of TC/HDL-C (5) and/or LDL-C/HDL-C (4.5). The low levels of HDL-C in Turkish children may be associated with the high incidence of CAD in the Turkish adult population. © 2017 Wiley. All rights reserved.
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    Experience with mesocaval shunt with autologous jugular vein interposition in patients with Budd-Chiari syndrome
    (2005) Ilkgul Ö.; Kilic M.; Içöz G.; Zeytunlu M.; Demirpolat G.; Akyildiz M.; Tokat Y.; Parildar M.; Memis A.
    Background/Aims: In the present era of interventional radiology and liver transplantation, the role of mesocaval shunt surgery for portal hypertension in Budd-Chiari syndrome is reviewed. Methodology: This study analyzed the management of 35 patients with Budd-Chiari syndrome between June 1994 and June 2004 in our institution. During this 10-year interval, 31 of the 35 patients with Budd-Chiari syndrome underwent shunt procedures and four patients underwent liver transplantation. Mesocaval shunts were preferred in 27 patients and seven of these patients required prior caval stenting. One portocaval shunt was performed in a patient having a thrombosed mesocaval shunt. In all mesocaval shunt procedures the patient's internal jugular vein was used as an interposition graft between the superior mesenteric vein and inferior vena cava. In four patients with thrombosed vena cava a mesoatrial shunt was performed using polytetrafluoroethylene graft while four patients with established cirrhosis underwent orthotopic liver transplantation. Results: In the group of mesocaval shunts, 3 patients were lost in the early postoperative period with a mortality rate of 11%, 2 of them due to thrombosed shunts and one of them due to pneumonia. The median follow-up was 42 months (6-120 months) and one patient experienced shunt thrombosis and died afterwards due to the complications of portal hypertension. In the whole series the patency rate of the mesocaval shunt was 89%. Conclusions: Patients with Budd-Chiari syndrome can be managed by a combination of shunt surgery, interventional radiology and liver transplantation. Our results demonstrate the effectiveness of mesocaval shunt procedure with autologous jugular vein interposition to maintain long-term patency and survival. © H.G.E. Update Medical Publishing S.A.
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    Angiotensin-converting enzyme genotype and acute pancreatitis in Turkey
    (2009) Kasap E.; Akyildiz M.; Tekin F.; Akarca U.
    The renin-angiotensin system (RAS) has been implicated in the pathogenesis of acute and chronic pancreatitis. Angiotensin-converting enzyme (ACE) is the key enzyme which activates RAS. The ACE intron 16 insertion/ deletion (I/D) polymorphism is associated with ACE activity and is considered to be a risk factor for several inflammatory processes. We investigated this polymorphism in 68 patients with acute pancreatitis (AP) and 157 healthy Turkish control subjects. Patients were evaluated with ultrasonography, abdominal tomography and laboratory markers and grouped by status for diabetes mellitus (DM), hypertension (HT), and both these diseases and by etiology. Genotyping of the I/D polymorphism was performed by polymerase chain reaction (PCR). The DD genotype was more prevalent in healthy controls, however, genotype II was significantly more frequent in AP patients (p <0.05). In severe AP patients, the genotype II frequency was significantly higher than in controls (p <0.05). Acute pancreatitis patients with both DM and HT had lower frequencies of genotype DD and of the D allele, and higher frequencies of genotype II and of the I allele than patients with either DM or HT (p <0.05).
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    Cholangitis of pancreatitis? Does the angiotensin-converting enzyme genotype favor either?
    (2009) Kasap E.; Akyildiz M.; Akarca U.
    Acute cholangitis and pancreatitis are serious complications of gallstones, with considerable morbidity and mortality. Angiotensin-converting enzyme (ACE) is an exopeptidase that is important in regulating blood pressure, metabolizing bradykinin and in maintaining an inflammatory response. To determine whether the ACE genotype determines occurrence of cholangitis or pancreatitis we examined ACE I/D genotypes in 31 patients who had cholangitis, 44 patients with biliary pancreatitis and 157 healthy individuals. The patients had been hospitalized at the Department and Intensive Care Faculty of Medicine, Ege University, Izmir, Turkey. The patients were recalled 4 years later and their prognosis was evaluated. The ACE II genotype was found at a higher frequency in the cholangitis and biliary pancreatitis patients when compared with the healthy subjects (p <0.05). There was no significant difference between cholangitis and biliary pancreatitis cases regarding the genotype and allele distribution (p >0.05). Recurrence of infection occurred more frequently in the patients with the DD genotype, although it was not significant according to the first assessment (p >0.05). The ACE gene polymorphism did not seem to favor development of either cholangitis or pancreatitis.
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    Academic procrastination behaviour of pre-service teachers' of Celal Bayar University
    (2011) Pala A.; Akyildiz M.; Baǧci C.
    Procrastination is extremely prevalent behaviour, mainly in school settings. It is described as"knowing that one is supposed to and perhaps even wanting to complete an academic task but failing to perform the activity within the expected or desired time frame." Procrastination also appears to be a troubling phenomenon. People most strongly characterize it as being bad, harmful, and foolish (Briody, 1980), and over 95% of procrastinators wish to reduce it (O'Brien, 2002). The aim of this study is to investigate the impact of variables such as gender, department, grade level, and income on students' academic procrastinations. Participants were the 366 students attending Faculty of Education and Faculty of Science and Letters of Celal Bayar University in Manisa, Turkey. The results of the study show that procrastination means are different for gender groups. Male students are more likely to procrastinate their academically works. Means are also different according to department. English Literature and Letters students are more procrastinators than Biology and Turkish Literature students. There are no differences according to grade level or socio-economical degree. © 2011 Published by Elsevier Ltd.
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    The comparrision of the avarage of students' succes in exams for transition to secondary education (SBS) and the placement exam for student success (ÖBSS); [Seviye belirleme sinavlari (SBS) ve ögrenci başarilarini belirleme sinavlarinin (ÖBBS) başari ortalamalarinin karşilaştirilmasi]
    (2013) Yalçin M.; Özsan C.; Kenç M.F.; Akyildiz M.; Ekiz N.
    The kinds of evaluation in education differ depending on the input, progress and output of the curriculum. The large-scale evaluation exams implemented in our country serve, in general, different aims as grading, electing, placing, holding accountable, observing and indicating status. In this paper, the datas of average exam success of the same students gained from the Placement Exams for transition to secondary education (SBS) implemented in the years 2008-2009-2010 by the Ministry of National Education and the Placement Exam for Student Success (ÖBSS) implemented by the abolished Research and Improvement Presidency (EARGED) of the Ministry of National Education are compared. The field successes in the datas of SBS and ÖBBS in the 2008-2009- 2010 are evaluated based on class and year and the trend is provided to be observed. As a result of the study, it is seen that there is a similarity between the SBS and ÖBBS in terms of ordering the student's academic success. This result shows that these two exams can be used interchangebly. Therefore, the opinion that removing the SBS, which is competition based and requires long-term exam preparation besides creating stress and pressure on the students, would be beneficial has gained strength. With the observation-aimed evaluations which can be done instead of SBS, it will be possible to have similar results and also do research to improve the process determining the underwhelming points of teaching efforts.