Browsing by Author "Alkin, T"
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Item Evaluation of serum MicroRNA expression profiles in patients with panic disorderÇökmüs, FP; Özmen, E; Alkin, T; Batir, MB; Çam, FSBACKGROUND: Studies on the role of microRNAs (miRNA) in anxiety disorders are limited. We aimed to determine the availability of miRNAs as biomarkers in serum and to demonstrate the changes of miRNAs expression in patients with panic disorder (PD). METHODS: Thirty-five patients with PD and 35 healthy controls (HC) were evaluated with Structured Clinical Interview for DSM Disorders-I (SCID-I) and Panic Disorder Severity Scale (PDSS). In each group miRNA expression analysis was performed in venous blood by the Real-time Polymerase Chain Reaction (RT-PCR) method for genetic evaluation. RESULTS: Compared with the HC group, eight miRNA expression levels were found different in the PD group. Five of them were upregulated and three of them were downregulated. There was no correlation between the levels of miRNA expression with PDSS total score and PDSS sub-items. However, miR-1297 and miR-4465 expression levels were significantly different between the two groups. LIMITATIONS: There are some limitations in this research. Firstly the number of samples is small. Another limitation of our study is that the presence of medical illness and continuous drug use were not excluded when PD and HC groups were selected. CONCLUSIONS: Our research is the first miRNA expression study in patients with PD which excluded psychotropic use and additional psychiatric disorders. In the PD group, miR-1297 and miR-4465 expression was upregulated than compared to the HC group. miR-1297 and miR-4465 regulate the GABAA gene regions that affect GABA(A) receptor subtypes that thought to play a role in the aetiology of PD.Item Tetranectin and Cortisol as Markers of the Relationship Between Perinatal Maternal Depression-Anxiety Symptoms and Recurrent Wheezing in the First Year of LifeYilmaz, O; Polat, AC; Cingoz, FO; Ay, P; Alkin, T; Taneli, F; Yasar, A; Hasdemir, S; Simsek, Y; Yuksel, HItem Maternal psychiatric status and infant wheezing: The role of maternal hormones and cord blood cytokinesYilmaz, O; Yasar, A; Polat, AC; Ay, P; Alkin, T; Taneli, F; Cingoz, FO; Hasdemir, PS; Simsek, Y; Yuksel, HRationale Maternal psychosocial stress might be associated with development of allergic diseases in the offspring. Objectives To evaluate the association of maternal depression and anxiety with ever wheezing and recurrent wheezing among infants and to assess the role of maternal hypothalamo-pituatary-adrenal axis changes and fetal immune response in this association. Methods This study encompasses two designs; cohort design was developed to evaluate the association of prenatal depression with development of wheezing in infants while nested case-control design was used to assess the role of maternal cortisol and tetranectin and cord blood interleukin 13 and interferon gamma. Results We enrolled 697 pregnant women. Elementary school graduate mother (odds ratio [OR] = 1.5, p = .06), maternal smoking during pregnancy (OR = 3.4, p = .001), familial history of asthma (OR = 2.7, p < .001) increased the risk of ever wheezing. Elementary school graduate mother (OR = 2.6, p = .002), maternal smoking during pregnancy (OR = 4.8, p < .001) and familial history of asthma (OR = 1.7, p = .01) increased the risk of recurrent wheezing. Maternal previous psychiatric disease, or Edinburgh Postnatal Depression Scale or Spielberger State-Trait Anxiety Inventory scores were not associated with wheezing. Maternal tetranectin levels were significantly higher among never wheezers compared to the ever wheezers (264.3 +/- 274.8 vs. 201.6 +/- 299.7, p = .04). Conclusions In conclusion, the major risk factors for ever wheezing and recurrent wheezing were maternal smoking, level of education and family history of asthma. However, maternal depression and anxiety were not determined as risk factors for wheezing. Maternal tetranectin carries potential as a biomarker for wheezing in the infant.Item Cord blood Interleukin-13 and IFN-Gamma levels As Biomarkers of Ever-Wheezing in the First Year of LifeYilmaz, Ö; Yasar, A; Ay, P; Polat, AC; Cingöz, FO; Alkin, T; Taneli, F; Hasdemir, S; Basbay, YS; Yüksel, HItem Undergraduate Psychiatric Training in TurkeyBasterzi, ADC; Tükel, R; Ulusahin, A; Coskun, B; Alkin, T; Demet, MM; Konuk, N; Tasdelen, BObjective: The current trend in medical education is to abandon the experience-based traditional model and embrace the competency-based education model (CBE). The basic principle behind CBE is standardization. The first step in standardization is to determine what students must know, what they must accomplish, and what attitude they should display, and the establishment of educational goals. One of the goals of the Psychiatric Association of Turkey, Psychiatric Training Section is to standardize psychiatric training in Turkish medical schools. This study aimed to determine the current state of undergraduate psychiatric training in Turkish medical schools. Method: Questionnaires were sent to the psychiatry department chairs 01 41 medical schools. Data were analyzed using descriptive statistical methods. Results: Of the 41 department chairs that were sent the questionnaire, 29 (70%) completed and returned them, of which 16 (66.7%) reported that they had already defined goals and educational objectives for their undergraduate psychiatric training programs. The Core Education Program, prepared by the Turkish Medicine and Health Education Council, was predominately used at 9 (37.5%) medical schools. Pre-clinical and clinical training schedules varied between medical schools. In all, 3 of the medical schools did not offer internships in psychiatry. The majority of chairs emphasized the importance of mood disorders (49.9%) and anxiety disorders (40%), suggesting that these disorders should be treated by general practitioners. Computer technology was commonly used for lecturing; however, utilization of interactive and skill-based teaching methods was limited. The most commonly used evaluation methods were written examination (87.5%) during preclinical training and oral examination (91.6%) during clinical training. Conclusion: The most important finding of this study was the lack of a standardized curriculum for psychiatrictraining in Turkey. Standardization of psychiatric training in Turkish medical schools must be developedItem Three years' follow up: relationship of maternal depression and anxiety with ever-wheezingYilmaz, O; Yasar, A; Ocalan, M; Ay, P; Alkin, T; Hasdemir, S; Yuksel, HItem Evaluation of serum microRNA expression profile in panic disorder patientsÇökmüs, FP; Özmen, E; Alkin, T; Batir, MB; Çam, FS