Browsing by Author "Alpdogan, S"

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    Effect of Subcutaneous Immunotherapy on The Natural Course of Allergic Diseases in Pediatric Patients: A Real-Life Cohort
    Yilmaz, O; Yasar, A; Simsek, Y; Alpdogan, S; Kunay, B; Yuksel, H
    Aim: Specific allergen immunotherapy (SIT) is the only disease-modifying therapy for allergic diseases. We aimed to examine the effect of subcutaneous specific allergen immunotherapy (SCIT) applications on the prognosis of asthma and allergic rhinitis in pediatric cases in real-life settings. Methods: The study was designed as a retrospective cohort study. Patients with asthma and/or allergic rhinitis aged between 5 and 18 years old were enrolled between 2010 and 2015. The groups who received SCIT and who did not receive were compared in terms of disease severity parameters in follow-up recorded in their files. Results: A total of 298 cases, among which 140 received subcutaneous specific allergen immunotherapy. The frequency of asthma, allergic rhinitis, and co-morbidity was similar between the two groups. In the first year of the follow-up, asthma symptoms severity was not significant between the two groups; however, both asthma and allergic rhinitis symptoms were significantly lower in the SCIT patients at the end of the third year of follow-up. While the follow-up rate for three years or more was 62% in the group that received subcutaneous specific allergen immunotherapy, it was 38% in the group that did not receive. Conclusion: These results showed that SIT is an effective treatment modality in real-life settings with low side effects in pediatric patients with uncontrolled asthma and allergic rhinitis despite medical treatment.
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    Assessment of Clinical and Laboratory Predictors for Chronic Childhood Immune Thrombocytopenia
    Alpdogan, S; Gülen, H
    Aim: To determine the risk factors associated with chronic childhood immune thrombocytopenia (ITP). Materials and Methods: We retrospectively analyzed the medical records of 123 children with ITP who were admitted to our Department of Pediatric Hematology between May, 2006 and May, 2019. We evaluated their demographic, clinical, and laboratory characteristics, and assessed the risk factors associated with chronic ITP in childhood. Results: Of the 123 children with ITP, 60.2% were male, with an average age of 6.4 +/- 4.0 years. At follow-up, 93 (75.6%) of the patients were diagnosed as acute ITP, whereas 30 (24.4%) progressed to chronic ITP with a platelet count of lower than 100x109/L at the end of the 12-month follow-up period. Older age at admission [Odds ratio (OR): 1.4, 95% confidence interval (CI): 1.2-1.6, p<0.001], female gender (OR: 4.1, 95% CI: 1.5-10.3, p=0.003), and insidious onset of the symptoms (OR: 5.0, 95% CI: 1.1-22.6, p=0.03) were determined to be risk factors for chronic ITP. Conclusion: Our study indicates that older age, female gender and insidious onset of the disease at admission may predict chronic ITP in childhood.