Browsing by Author "Alper, H"

Now showing 1 - 4 of 4
  • No Thumbnail Available
    Item
  • No Thumbnail Available
    Item
    Clinical correlation of epithelial barrier dysfunction related to neutrophilic inflammation in cystic fibrosis
    Kanik, ET; Yilmaz, O; Ozdogru, E; Alper, H; Ulman, C; Kanik, A; Simsek, Y; Yuksel, H
  • No Thumbnail Available
    Item
    Relevance between clinical status and exhaled molecules related to neutrophilic inflammation in pediatric cystic fibrosis
    Kanik, ET; Yilmaz, O; Ozdogru, E; Alper, H; Ulman, C; Kanik, A; Simsek, Y; Yuksel, H
    Introduction:Cystic fibrosis (CF) is characterized with chronic inflammation with neutrophil and related cytokines in airway secretions. We aimed to measure the levels of neutrophil related inflammatory markers as nitric oxide, IL-8, IL-17, leukotriene B4 and neutrophil elastase as well as e-cadherin in exhaled breath condensate (EBC), and to determine their relation with clinical findings.Methods:We consecutively enrolled cystic fibrosis patients into our clinics between the age of six and eighteen years who could cooperate for exhaled breath condensate to this case-control study (n = 30). The age and sex matched control group (n = 26) was enrolled. Spirometry was performed during the stable period and EBC samples were obtained for measurement of the markers.Results:The mean age of the subjects enrolled was 12.1(4.2) years and 40% were positive forP.Aeruginosain sputum. Subjects who hadP.Aeruginosain sputum cultures had significantly lower FEV1, FVC and FEF 25/75 values compared to the ones withoutP.Aeruginosa(p = 0.002, p = 0.002 and p = 0.005 respectively). EBC neutrophil elastase levels were significantly higher in the CF patients compared to non-CF controls (3.11 4.71 versus 0.90 2.68, p = 0.04). Nitric oxide, IL-17, IL-8, e-cadherin, neutrophil elastase or leukotriene B4 levels in EBC of CF patients were not related toP.Aeruginosas infection, FEV1 levels or hospital admission in the last year.Conclusion:In our study, neutrophil elastase levels in EBC are higher in CF patients compared to non-CF controls. This is independent of acute infection and is evidence to the persistence of neutrophilic lung injury. However, EBC NO, IL-8, IL-17, e-cadherin, neutrophil elastase and leukotriene B4 levels as inflammatory markers, are not correlated with disease progression or clinical findings.
  • No Thumbnail Available
    Item
    Isolated Optic Nerve Relapse in Acute Lymphoblastic Leukemia: Two Case Reports
    Yildirim, AT; Oymak, Y; Yaman, Y; Saatçi, O; Malatyali, R; Kamer, S; Alper, H; Vergin, C
    Notwithstanding extensive chemotherapy, intrathecal methotrexate treatments and prophylactic central nervous system radiotherapy, extramedullary relapses can still be seen in leukemia patients. Isolated optic nerve relapses, one of its symptoms being a sudden vision loss that occurs prior to a bone marrow relapse, are rarely seen in acute lymphoblastic leukemia patients. Sudden vision loss can be cured by an early diagnosis and rapid treatment. In this study, we investigate two male patients (10 and 12 years old) with optic nerve relapses, sudden vision loss complaints and pre-T acute lymphoblastic leukemia in the light of the literature.