Browsing by Author "Aras, F"

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    CAN URINARY BIOMARKERS SUCCEED DIAGNOSTIC VALUE OF RENAL SCINTIGRAPHY IN PATIENTS WITH URETEROPELVIC JUNCTION DISRUPTION?
    Gürer, DE; Yilmaz, Ö; Ertan, P; Eser, E; Taneli, F; Aras, F; Oran, A; Genç, A; Günsar, C; Sencan, A; Gürer, E; Taneli, C
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    Vulvar Cancer with Bilateral Axillary Lymph Node Metastasis
    Hasdemir, PS; Aras, F; Solmaz, U; Guvenal, T
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    The Diagnosis of Yo-Yo Reflux with Dynamic Renal Scintigraphy in a Patient with Incomplete Ureteral Duplication
    Özdogan, Ö; Ates, O; Kart, Y; Aras, F; Olguner, M; Akgür, F; Durak, H
    The diagnosis of yo-yo reflux in patients with incomplete upper collecting system duplications is difficult. We report a case with recurrent urinary tract infections and ultrasonographically detected duplication in the left collecting system in which the presence of yo-yo reflux is demonstrated with dynamic renal scintigraphy.
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    The Correlation of Thallium-201 Uptake and Angiogenesis in Bone and Soft Tissue Tumors
    Degirmenci, B; Bozkurt, H; Ozkal, S; Ozdogan, O; Aras, F; Havitcioglu, H; Kargi, A
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    Effects of 99mTc-MIBI and 99mTc-MDP administration on dual-energy X-ray absorptiometry bone mineral density measurements
    Gumuser, G; Parlak, Y; Topal, G; Aras, F; Ruksen, E
    Objective Nuclear medicine procedures are often performed in close-time proximity to bone densitometry studies. The purpose of this study was to determine the effects of Tc-99m-hexakis-2-methoxyisobutyl isonitrile (MIBI) and Tc-99m-methylene diphosphonate (MDP) on the accuracy of bone mineral density (BMD) measurements performed using dual-energy X-ray density. Methods The effect of a diagnostic dose of Tc-99m-MIBI on BMD estimations in the lumbar spine and the left total hip was assessed in 30 patients (19 female, 11 male; mean age: 55.5 +/- 10.5 years) by using a Lunar DPX-NT scanner. Thirty patients, admitted to the nuclear medicine department for bone scintigraphy (15 female, 15 male; mean age: 56 +/- 15.92 years), were included into the study. Each patient underwent dual-energy X-ray density assessment for which a Lunar DPX-NT scanner was used before and 2 h after intravenous injection of (99m)-Tc-MDP (925MBq) and Tc-99m-MIBI (1110MBq). BMD measurements were calculated from lumbar spine (including L2-4) and left hip (including femoral neck, trochanter, and total hip). For statistical analysis, the Wilcoxon test was used and a P value of less than 0.05 was accepted as statistically significant. Results According to Wilcoxon's statistical test, we found extremely significant changes on the measured BMD, T-score, before and 2 h after the injection of Tc-99m-MIBI for lumbar spine and left hip in 30 patients. We found statistically significant decrement on measured BMD from lumbar spine and trochanter before and 2 h after the injection of Tc-99m-MDP. Although MDP BMD values in femoral neck and total hip were decreased after the injection of Tc-99m, they did not reach a statistically significant value. The comparison of pre-T-score and post-T-score values showed a statistically significant decrease after the injection for only L2-4 lumbar spine (P=0.002), but left hip of pre-T-score and post-T-score values did not reach a statistically significant value. Conclusion In this study, it was determined that measured BMD values are decreased in lumbar spine for all patients. The magnitude of the effect is dependent on the location of the activity. We assume that some radioactivity from (TC)-T-99m is counted by the densitometer's detector, thus resulting in a decrease in the measured BMD. Scintigraphy and bone densitometry should be performed on different days to avoid artifactual reduction in BMD measurements. Nucl Med Commun 30:445-448 (C) 2009 Wolters Kluwer Health | Lippincott Williams & Wilkins.
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    The role and importance of dynamic thyroid scintigraphy in clinical practice
    Aras, F
    Aim: In this study, we aimed to determine the nodule activity in thyroid scintigraphy in patients with thyroid nodules, as well as to determine the contribution of dynamic radionuclide thyroid Scintigraphy (RTS) in distinguishing between benign and malignant nodules. Material and Methods: A total of 48 patients (30 women, 18 men) with hypo- and/or hyperactive thyroid nodules on thyroid scintigraphy larger than 1 cm were included in the study. Dynamic imaging was achieved in the thyroid region of the patients under a gamma camera and with an intravenous injection of 185 M beta q Tc99mpertechnetate. Retention rate (RR) was calculated using these curves and static anterior image counts. RR was found by drawing a total of 75 nodules of 48 patients. Power Doppler ultrasonography (PDUS) was performed on each patient at the same time and central peripheral resistive index (SRI) and peripheral resistive index (PRI) were measured. Nodule vascularization pattern was classified in PDUS. Results: The mean age of the patients was 54.12 +/- 13.41 years. While 40 patients had a fine needle aspiration biopsy (FNAB), 8 patients did not have an FNAB. Of the 64 nodules in 40 patients who underwent FNAB, 20 were identified as non-diagnostic, 38 as benign cytology (BC), and 6 as malignant cytology (MC). In the time activity curve obtained from RTA, it was determined that the probability of malignancy was high in nodules that were hyper-vascular and showed rapid clearance. While the average RR of nodules in BC was 0.41 +/- 0.70, it was calculated as 0.43 +/- 0.23 in MC. The average central RI in nodules in BC was 0.39 +/- 0.12, while in MC it was 0.30 +/- 0.63. The average peripheral RI value was calculated as 0.60 +/- 0.45 in BC and 0.62 +/- 0.29 in MC. Although our number of malignant cytology nodules was quite low, there was a statistically significant positive correlation between the malignant cytology RR value and the malignant cytology peripheral RI value (p = 0.003, r = 0.043). There was a significant positive correlation between the BC central RI value and the BC RR value (p = 0.012, r = 0.054). Discussion: We think that dynamic RTS, which is a method that will increase the sensitivity of classical thyroid scintigraphy, support the necessity of FNAB, and will not bring additional radiation dose or difficulty to the patient, can be used routinely and has diagnostic value in the benign-malignant discrimination of thyroid nodules.
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    Glomerular filtration rate in type 1 diabetic adolescent by using single plasma sample and gamma camera methods
    Aras, F; Bilgin, ES
    Aim: Type-1 diabetes mellitus (DM) has indicated that glomerular hyperfiltration (GFR) is a risk factor for nephropathy. Renal pathological changes develop before features of clinical renal disease including proteinuria and declining GFR are evident. We investigated changes in GFR in children and adolescents with type 1 DM by means of single plasma sample (SPS) and gamma camera Gate's methods using Tc-99m DTPA. Additionally, we determined the specificity, sensitivity, and consistency of the two methods. Material and Methods: Thirty-six patients (mean age: 15.01 +/- 4.03 years) with Type-1 DM (19 males, 17 females) were studied. Impairment of renal function was not detected in any of the patients with routine biochemical tests. Standard Tc-99m DTPA renal images were obtained for 40 minutes and GFR is calculated by Gate's method and values>130/1.73m(2) b.s. were considered hyperfiltration. SPS was obtained at 120 min-post injection and the Cristensen-Groth equation (CG) was used. The patients were divided into two groups according to the duration of diabetes as less than 5 years (Group A) and longer than 5 years (Group B). Results: In Group A, hyperfiltration was detected in 11 of 14 patients with SPS, whereas in 7 of 14 patients with Gate's method. In Group B, hyperfiltration was detected in 17 of 22 patients with SPS, whereas in 13 of 22 patients with Gate's method. Sensitivity of Gate's method was 67.9 % in all patients for diagnosis (Sensitivity: 67.9%, Specificity: 87.5 %, positive predictive value (PPV): 95 %, negative predictive value (NPV): 43.8%). The consistency of these two methods was found as 72.6% (p=0.005). Discussion: Gate's method is useful for clinical practice due to ease of use and high consistency with SPS, especially in the children. SPS remains the first-line method of GFR measurement in suspected diabetic nephropathy patients.
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    Predictive and prognostic values of pretreatment functional imaging-based biomarkers in advanced-stage laryngeal cancer
    Eskiizmir, G; Ovali, GY; Aras, F; Özyurt, BC; Tarhan, S
    Objective: To determine the quantitative values of apparent diffusion coefficient (ADC), standardized uptake values (SUVmax, SUVmean), metabolic tumor volume (MTV), metabolic tumor volume indexes (MTImax, and MTImean) using diffusion weighted-MRI (DW-MRI) and positron emission tomography/computed tomography (PET/CT), and analyze the predictive and prognostic values of these biomarkers in a homogenous group of patients with advanced-stage laryngeal cancer. Methods: Patients with newly diagnosed advanced-stage laryngeal cancer who had both DW-MRI and 18F-FDG PET/CT before treatment, and who had curative cancer treatment (surgery +/- adjuvant therapy or radio +/- chemotherapy) between 2011 and 2015 were included in this study. All patients were followed up clinically and radiologically, if necessary every 3 months for the first 2 years, every 4-6 months for year 3, and then annually thereafter. Results: Thirty-eight patients were retrospectively analyzed. Our analysis demonstrated statistically significant differences when the pretreatment SUV and MTImean value were compared between patients with stages III and IV. Standardized uptake value was also a predictive factor for N-stage. Moreover, a statistically significant difference was determined when patients with and without perinodal involvement (PNI) were compared. Log rank analysis demonstrated that none of functional imaging-based biomarkers had a prognostic role for oncological outcomes. Conclusion: Our results demonstrated that pretreatment SUV and MTImean values were predictive factors for staging, N-stage and PNI. Indeed, functional imaging-based biomarkers are promising, novel, noninvasive techniques that may provide additional information about tumor characteristics, treatment selection and prognosis in the near future.
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    The effects of lornoxicam on brain edema and blood brain barrier following diffuse traumatic brain injury in rats
    Topçu, I; Gümüser, G; Bayram, E; Aras, F; Çetin, I; Temiz, C; Çivi, M
    BACKGROUND In this experiment, the effects of lornoxicam on brain edema and the blood brain barrier (BBB) following diffuse traumatic brain injury (TBI) were studied. METHODS Twenty adult male Wistar albino rats were anesthetized, and experimental closed head trauma was induced by the Marmarou method. After head injury, the rats were randomly divided into two groups: Group I was the control group, to which 2 ml saline was administered intraperitoneally, and Group II was the lornoxicam group, to which 2 ml 1.3 mg kg(-1) lornoxicam was administered intraperitoneally. Twenty-four hours after head trauma, 99 mTc pentetate (DTPA) was injected at a dose of 37 MBq, and posterior planar images of each rat were obtained using an Infinia gamma camera. After imaging of BBB permeability, brain tissues were dissected from the cranium. The brain water content (BWC) of each sample was calculated using the wet-dry method. RESULTS The lesion/background (L/b) ratio of Group I was 3.76 +/- 0.46 and 3.02 +/- 0.66 for early (5th min) and late (60th min) imaging, respectively. In Group II, the L/b ratios were 3.52 +/- 0.96 and 2.63 +/- 0.63 for early and late imaging, respectively (p>0.05). BWC was 79.6 +/- 2.5% and 77.5 +/- 1.1% for Groups I and II, respectively (p<0.05). CONCLUSION In this rat model of TBI, lornoxicam reduced brain edema but did not affect BBB permeability.
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    Predictive value of quantitative metabolic tumor volume and metabolic index analysis in lung cancer stereotactic radiotherapy with F-18 FDG PET/CT
    Aras, F; Olmezoglu, A
    OBJECTIVE: The objective of this study was to investigate predictive value of quantitative metabolic tumor volume and metabolic index analysis in lung cancer stereotactic radiotherapy with F-18 FDG PET/CT. PATIENTS AND METHODS: Overall, 94 early-stage non-small cell lung cancer (NSCLC) patients who were administered stereotactic radiotherapy were included in the study. RESULTS: Most of the study patients were male (91.5%). Mean age of the patients was 68.5 +/- 9.0 years. The primary lung tumor was located centrally and peripherally in 25 (26.6%) and 69 (73.4%) of the patients, respectively. The median gross tumor volume (GTV) was 16.2 cc [interquartile range (IQR): 7.1-32.9]. Whereas all patients who had peripheral tumors survived. 17 patients with central tumors (70.8%) died during the study period (p= 0.001). Biologically effective dose (BED10) values were significantly higher in patients who had peripheral tumors compared with patients with central tumors (p= 0.001). Significantly more patients died in patients who had BED values below 100 Gy compared to patients who had BED values over 100 Gy (p= 0.001). The survival distributions for the two groups were significantly different (p < 0.001). Only GTV and Pretreatment SUVmean appeared as significant predictors of mortality. BED10 values showed a significant and strong positive correlation with total radiation dose, whereas it showed a significant strong negative correlation with number of fractions. CONCLUSIONS: The use of repeated 18F-FDG PET to assess survival early during stereotactic radiotherapy is possible in patients with early-stage non-small cell lung cancer. A decrease in GTV and pretreatment SUVmean according to F-18 FDG PET/CT uptake by the primary tumor correlates with survival.
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    Chylous ascites and chylothorax due to membranous nephropathy
    Colak, HB; Alici, T; Tekce, H; Öz, D; Erol, A; Aras, F; Kursat, S
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    Changes of thyroidal Tc-99m MIBI uptake and wash-out in patients with and Graves' disease
    Ruksen, E; Gumuser, G; Hekimsoy, Z; Aras, F; Sayit, E
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    Evaluation of abnormal radiological findings in children aged 2 to 36 months followed by recurrent urinary tract infection: a retrospective study
    Ozen, C; Ertan, P; Aras, F; Gumuser, G; Ozkol, M; Dinc, GH
    Our aim is to determine the rational usage of imaging techniques in order to prevent or minimize permanent renal damage in recurrent urinary tract infections (UTIs). This study was enrolled children aged between 2 and 36 months, following- up with the diagnosis of recurrent UTI. All children had ultrasonography (USG) and dimercaptosuccinic acid scanning, 39 of them had underwent on voiding cystourethrography. There were 133 children (87 girls, 46 boys) with the mean age of 32.82 +/- 38.10 months included into the study. Forty-three kidney units were normal in ultrasonogram of which seven units had reflux whereas among 35 units with hydronephrosis 22 units had reflux. Sensitivity and specificity presence of hydronephrosis in ultrasonogram for prediction of reflux was 75.9% and 73.5%, respectively. There were 19 dilated ureters in ultrasonogram, and among them 14 had reflux. Sensitivity and specificity of presence with ureteral dilatation in ultrasonogram for prediction of reflux was found as 48.3% and 89.8%, respectively. The sensitivity of parenchymal thinning seen in ultrasonogram for the evaluation of renal parenchyma was 15.9%, whereas specificity was 98.2%. Sensitivity and specificity of dimercaptosuccinic acid for prediction of reflux was 51.6% and 72.3%, respectively. The normal ultrasonogram findings cannot rule out neither possibility of reflux presence nor development of renal scarring. Therefore, DMSA scanning has major role both in determination of parenchymal damage and prevention of scarring. Also we get an important result as ureteral dilatation seen in USG, related to presence of reflux.
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    Effect of 99mTc- MDP Administration onDual-Energy X-Ray Absorptiometry Bone Mineral Density Measurements
    Gumuser, G; Parlak, Y; Topal, G; Aras, F; Ruksen, E; Bilgin, ES