Browsing by Author "Aras F."
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Item Chylous ascites and chylothorax due to membranous nephropathy [2](Dustri-Verlag Dr. Karl Feistle, 2007) Colak H.B.; Alici T.; Tekce H.; Öz D.; Erol A.; Aras F.; Kursat S.[No abstract available]Item Effects of 93m93m and 33m33mTc-MDP administration on dual-energy X-ray absorptiometry bone mineral density measurements(2009) Gumuser G.; Parlak Y.; Topal G.; Aras F.; Ruksen E.; Sayit E.Objective Nuclear medicine procedures are often performed in close-time proximity to bone densitometry studies. The purpose of this study was to determine the effects of 99m99mTc-hexakis-2-methoxyisobutyl isonitrile (MIBI) and 99m99mTc-methylene diphosphonate (MDP) on the accuracy of bone mineral density (BMD) measurements performed using dual-energy X-ray density. Methods The effect of a diagnostic dose of 99m 99mTc-MIBI on BMD estimations in the lumbar spine and the left total hip was assessed in 30 patients (19 female, 11 male; mean age: 55.5 ±±10.5 years) by using a Lunar DPX-NT scanner. Thirty patients, admitted to the nuclear medicine department for bone scintigraphy (15 female, 15 male; mean age: 56 ± 15.92 years), were included into the study. Each patient underwent dual-energy X-ray density assessment for which a Lunar DPX-NT scanner was used before and 2 h after intravenous injection of 99m 99mTc-MDP (925MBq) and 99m99mTc-MIBI (1110MBq). BMD measurements were calculated from lumbar spine (including L2-4) and left hip (including femoral neck, trochanter, and total hip). For statistical analysis, the Wilcoxon test was used and a P value of less than 0.05 was accepted as statistically significant. Results According to Wilcoxon's statistical test, we found extremely significant changes on the measured BMD, T-score, before and 2h after the injection of 99m99mTc-MIBI for lumbar spine and left hip in 30 patients. We found statistically significant decrement on measured BMD from lumbar spine and trochanter before and 2 h after the injection of 99m 99mTc-MDP. Although MDP BMD values in femoral neck and total hip were decreased after the injection of Tc-99m, they did not reach a statistically significant value. The comparison of pre-T-score and post-T-score values showed a statistically significant decrease after the injection for only L2-4 lumbar spine (P= 0.002), but left hip of pre-T-score and post-T-score values did not reach a statistically significant value. © 2009 Wolters Kluwer Health | Lippincott Williams & Wilkins.Item The effects of lornoxicam on brain edema and blood brain barrier following diffuse traumatic brain injury in rats; [Lornoksikamin siçanlarda diffüz travmatik beyin hasarinda beyin ödemi ve kan beyin bariyeri üzerine etkileri](Turkish Association of Trauma and Emergency Surgery, 2013) Topçu I.; Gümüşer G.; Bayram E.; Aras F.; Çetin I.; Temiz C.; Çivi M.BACKGROUND In this experiment, the effects of lornoxicam on brain edema and the blood brain barrier (BBB) following diffuse traumatic brain injury (TBI) were studied. METHODS Twenty adult male Wistar albino rats were anesthetized, and experimental closed head trauma was induced by the Marmarou method. After head injury, the rats were randomly divided into two groups: Group I was the control group, to which 2 ml saline was administered intraperitoneally, and Group II was the lornoxicam group, to which 2 ml 1.3 mg kg-1 lornoxicam was administered intraperitoneally. Twenty-four hours after head trauma, 99 mTc pentetate (DTPA) was injected at a dose of 37 MBq, and posterior planar images of each rat were obtained using an Infinia gamma camera. After imaging of BBB permeability, brain tissues were dissected from the cranium. The brain water content (BWC) of each sample was calculated using the wet-dry method. RESULTS The lesion/background (L/b) ratio of Group I was 3.76±0.46 and 3.02±0.66 for early (5th min) and late (60th min) imaging, respectively. In Group II, the L/b ratios were 3.52±0.96 and 2.63±0.63 for early and late imaging, respectively (p>0.05). BWC was 79.6±2.5% and 77.5±1.1% for Groups I and II, respectively (p<0.05). CONCLUSION In this rat model of TBI, lornoxicam reduced brain edema but did not affect BBB permeability.Item Vulvar Cancer with Bilateral Axillary Lymph Node Metastasis(Taylor and Francis Ltd, 2016) Hasdemir P.S.; Aras F.; Solmaz U.; Guvenal T.[No abstract available]Item Evaluation of abnormal radiological findings in children aged 2 to 36 months followed by recurrent urinary tract infection: A retrospective study(Taylor and Francis Ltd, 2017) Ozen C.; Ertan P.; Aras F.; Gumuser G.; Ozkol M.; Dinc G.H.Our aim is to determine the rational usage of imaging techniques in order to prevent or minimize permanent renal damage in recurrent urinary tract infections (UTIs). This study was enrolled children aged between 2 and 36 months, following-up with the diagnosis of recurrent UTI. All children had ultrasonography (USG) and dimercaptosuccinic acid scanning, 39 of them had underwent on voiding cystourethrography. There were 133 children (87 girls, 46 boys) with the mean age of 32.82±38.10 months included into the study. Forty-three kidney units were normal in ultrasonogram of which seven units had reflux whereas among 35 units with hydronephrosis 22 units had reflux. Sensitivity and specificity presence of hydronephrosis in ultrasonogram for prediction of reflux was 75.9% and 73.5%, respectively. There were 19 dilated ureters in ultrasonogram, and among them 14 had reflux. Sensitivity and specificity of presence with ureteral dilatation in ultrasonogram for prediction of reflux was found as 48.3% and 89.8%, respectively. The sensitivity of parenchymal thinning seen in ultrasonogram for the evaluation of renal parenchyma was 15.9%, whereas specificity was 98.2%.Sensitivity and specificity of dimercaptosuccinic acid for prediction of reflux was 51.6% and 72.3%, respectively. The normal ultrasonogram findings cannot rule out neither possibility of reflux presence nor development of renal scarring. Therefore, DMSA scanning has major role both in determination of parenchymal damage and prevention of scarring. Also we get an important result as ureteral dilatation seen in USG, related to presence of reflux. © 2016 The Author(s).Item Is there a relationship between parathyroid hormone and neutrophil lymphocyte ratio or platelet lymphocyte ratio?(Acta Endocrinologica Foundation, 2019) Toraman A.; Aras F.; Hekimsoy Z.; Kursat S.Context. Neutrophil lymphocyte ratio (NLR) and platelet lymphocyte ratio (PLR) are recent prognostic markers associated with inflammation in many diseases such as chronic kidney disease (CKD), malignancies, myocardial infarction. Objective. In this study, we investigated the relationship between NLR-PLR and parathyroid hormone (PTH) and vitamin D in patients with high PTH levels. Design. The patients with high PTH levels in Nephrology and Endocrinolgy Outpatient clinics were evaluated retrospectively. Subjects and methods. The medical records of the patients were examined and clinical data, including demographic details, clinical and laboratory findings, treatment and follow-up data were obtained. NLR and PLR were calculated. Serum creatinine, calcium, phosphorus, magnesium, lipid levels, calcium phosphorus product, PTH and vitamin D values were investigated. The relationship between NLR-PLR and laboratory parameters, GFR (MDRD-GFR), PTH and vitamin D were investigated. Results. 48 male and 253 female patients were enrolled in this study. The mean age was 57.57±13.28. NLR correlated negatively with albumin, hemoglobin, vitamin D, calcium and cholesterol and it positively correlated with creatinine and PTH. Multiple regression analysis showed that main determinants of NLR were PTH, albumin, LDLcholesterol, hemoglobin and gender. Conclusions. In this study NLR and PLR correlated negatively with hemoglobin and cholesterol. Positive correlation between NLR and creatinine could be explained by increased degrees of inflammation associated with more pronounced degrees of renal dysfunction. The impact of PTH on NLR was independent of GFR. In multiple regression model this suggests that PTH could be a pro-inflammatory parameter independent of the degree of renal dysfunction. © 2019, Acta Endocrinologica Foundation. All rights reserved.Item Molecular subtypes of invasive breast cancer: Correlation between PET/computed tomography and MRI findings(Lippincott Williams and Wilkins, 2020) Akin M.; Orguc S.; Aras F.; Kandiloglu A.R.Objective The aim of the study was to investigate the diagnostic value of fluorodeoxyglucose-18 (FDG)-PET/computed tomography (CT) and MRI parameters in determining the molecular subtypes of invasive breast cancer. Methods Data from 55 primary invasive breast cancer masses in 51 female patients who underwent pre-treatment PET/CT and MRI scans, and histopathological diagnosis at the authors' center were retrospectively reviewed. The relationship between FDG-PET/CT and MRI parameters, including maximum and mean standard uptake values (SUVmax and SUVmean, respectively), mean metabolic index (MImean) and metabolic tumor volume (MTV) values obtained from FDG-PET, and shape, margin, internal contrast-enhancement characteristics, kinetic curve types, functional tumor volume (FTV), apparent diffusion coefficient (ADC) values obtained from MRI was evaluated. Subsequently, differences among molecular subtypes (i.e. luminal A, luminal B, c-erbB-2 positive, and triple-negative) in terms of PET/CT and MRI parameters were evaluated. Results The luminal B subtype of invasive breast cancer had higher SUVmax and SUVmean (P = 0.002 and P = 0.017, respectively) values than the luminal A subtype. In addition, the triple-negative subtype had a higher SUVmax (P = 0.028) than the luminal A subtype. There was a statistically significant positive correlation between pathological tumor volume (PTV) and SUVmean (P = 0.019, r = 0.720). SUVmax and ADC were negatively correlated (P = 0.001; r =-0.384). A very strong positive correlation was detected between MTV and FTV (P = 0.000; r = 0.857), and between MTV and PTV (P = 0.006, r = 0.796), and between FTV and PTV (P = 0.006, r = 0.921). Conclusion Results of the present study suggest that SUVmax was superior to MRI findings in predicting molecular subtypes and that MRI was superior to PET/CT in predicting PTV. © 2020 Lippincott Williams and Wilkins. All rights reserved.Item Predictive value of quantitative metabolic tumor volume and metabolic index analysis in lung cancer stereotactic radiotherapy with F-18 FDG PET/CT(Verduci Editore s.r.l, 2022) Aras F.; Olmezoglu A.OBJECTIVE: The objective of this study was to investigate predictive value of quantitative metabolic tumor volume and metabolic index analysis in lung cancer stereotactic radiotherapy with F-18 FDG PET/CT. PATIENTS AND METHODS: Overall, 94 early-stage non-small cell lung cancer (NSCLC) patients who were administered stereotactic radiotherapy were included in the study. RESULTS: Most of the study patients were male (91.5%). Mean age of the patients was 68.5 ± 9.0 years. The primary lung tumor was located centrally and peripherally in 25 (26.6%) and 69 (73.4%) of the patients, respectively. The median gross tumor volume (GTV) was 16.2 cc [interquartile range (IQR): 7.1-32.9]. Whereas all patients who had peripheral tumors survived, 17 patients with central tumors (70.8%) died during the study period (p = 0.001). Biologically effective dose (BED10) values were significantly higher in patients who had peripheral tumors compared with patients with central tumors (p = 0.001). Significantly more patients died in patients who had BED values below 100 Gy compared to patients who had BED values over 100 Gy (p = 0.001). The survival distributions for the two groups were significantly different (p < 0.001). Only GTV and Pretreatment SUVmean appeared as significant predictors of mortality. BED10 values showed a significant and strong positive correlation with total radiation dose, whereas it showed a significant strong negative correlation with number of fractions. CONCLUSIONS: The use of repeated 18F-FDG PET to assess survival early during stereotactic radiotherapy is possible in patients with early-stage non-small cell lung cancer. A decrease in GTV and pretreatment SUVmean according to F-18 FDG PET/CT uptake by the primary tumor correlates with survival. © 2022 Verduci Editore s.r.l. All rights reserved.