Browsing by Author "Arga, M"

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    Food-induced anaphylaxis in early childhood and factors associated with its severity
    Aydogan, M; Topal, E; Yakici, N; Acar, HC; Demirkale, ZH; Arga, M; Uysal, P; Aydemir, S; Simsek, IE; Tamay, Z; Cekic, S; Cavkaytar, O; Kaplan, F; Kiykim, A; Cogurlu, MT; Süleyman, A; Yücel, E; Akkelle, E; Hancioglu, G; Yasar, A; Tuncel, T; Nacaroglu, HT; Aydogmus, C; Güler, N; Cokugras, H; Sapan, N; Yüksel, H; Sancak, R; Erdogan, MS; Ozdemir, O; Ozdemir, C; Orhan, F
    Background: Several factors that increase the risk of severe food-induced anaphylaxis have been identified. Objective: We aimed to determine the demographic, etiologic, and clinical features of food-induced anaphylaxis in early childhood and also any other factors associated with severe anaphylaxis. Methods: We carried out a medical chart review of anaphylaxis cases from 16 pediatric allergy and immunology centers in Turkey. Results: The data of 227 patients with 266 food-induced anaphylaxis episodes were included in the study. The median (inter quartile range) age of the first anaphylaxis episode was 9 months (6-18 months); 160 of these patients were boys (70.5%). The anaphylaxis episodes were mild in 75 cases (28.2%), moderate in 154 cases (57.9%), and severe in 37 cases (13.9%). The most frequent food allergens involved were cow's milk (47.4%), nuts (16.7%), and hen's egg (15.8%). Epinephrine was administered in only 98 (36.8%) of these anaphylaxis episodes. A logistic regression analysis revealed two statistically significant factors that were independently associated with severe anaphylaxis: the presence of angioedema and hoarseness during the anaphylactic episode. Urticaria was observed less frequently in patients who developed hypotension. In addition, confusion and syncope were associated with 25.9- and 44.6-fold increases, respectively, in the risk of concomitant hypotension. Conclusion: Cow's milk, nuts, and hen's egg caused the majority of mild and moderate-to-severe anaphylaxis episodes. The presence of angioedema and hoarseness in any patient who presents with a history of food-induced anaphylaxis should alert clinicians that the reaction may be severe. In addition, the presence of confusion, syncope, or stridor probably indicates concomitant hypotension.
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    Anaphylaxis: Turkish National Guideline 2018
    Orhan, F; Civelek, E; Sahiner, ÜM; Arga, M; Can, D; Çalikaner, AZ; Çetinkaya, F; Ercan Sariçoban, H; Erkoçoglu, M; Gelincik, A; Güner, SN; Igde, M; Kartal, Ö; Kiliç, M; Kocabas, CN; Musabak, UH; Topal, E; Toyran, M; Tamay, ZÜ; Yilmaz, Ö
    Anaphylaxis is an acute and potentially fatal systemic reaction that sould be recognized and managed by all helthcare professionals. This is the first national guideline of Turkish National Society of Allergy and Clinical Immunology on diagnosis and management of anaphylaxis. The guideline is prepared by Anaphylaxis Interest Group with the incorporation of 20 allergy/immunology specialists and the epidemiology, etiology, pathophysiology, symptoms and signs, diagnosis/differentials, and acute and long-term management of anaphylaxis are reviewed in detail.