Browsing by Author "Ari Z."
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Item The effect of cigarette smoking during pregnancy on cord blood lipid, lipoprotein and apolipoprotein levels(International Heart Journal Association, 1997) Işcan A.; Yiǧitoǧlu M.R.; Ece A.; Ari Z.; Akyildiz M.We examined the relationship between maternal smoking during pregnancy and serum lipid, lipoprotein and apolipoprotein levels in newborns. Serum concentrations of total cholesterol, triglyceride, high density lipoprotein cholesterol, low density lipoprotein cholesterol, apolipoprotein A-1, apolipoprotein B and lipoprotein (a) were assesed in blood samples from 38 mothers who were smokers and their newborns obtained at delivery and compared to blood sample from 42 nonsmokers and their newborns. As compared with newborns of nonsmoker mothers, newborns of smoker mothers showed a lower mean level of high density lipoprotein cholesterol (21 versus 26 mg/dl, p < 0.01), a higher total cholesterol to high density lipoprotein cholesterol (4.7 versus 3.7, P < 0.01), a higher low density lipoprotein cholesterol to high density lipoprotein cholesterol ratios (3.2 versus 2.3, p < 0.05), a lower mean level of apolipoprotein A-1 (105 versus 129 mg/dl, p < 0.01) and a higher apolipoprotein B to apolipoprotein A-1 ratio (0.44 versus 0.3, p < 0.01). These paremeters were also different between smoker and nonsmoker mothers. There were no significant differences in TC, TG, LDL-C, Apo B and Lp (a) values between the two newborn groups. These data suggest that maternal smoking during pregnancy markedly affects lipid metabolism in the fetus.Item The effect of FAD on erythrocyte glutathione reductase activity in undialyzed uremic patients and healthy subjects(1997) Ari Z.; Uyanik B.S.; Yigitoglu M.R.; Kutlu N.; Pirim I.The erythrocyte glutathione reductase (GSSG-R) activity with and without FAD supplementation (Act. A and Act. B, respectively) was studied in 24 undialyzed uremic patients and 25 healthy subjects. Mean erythrocyte GSSG-R activity from normal subjects was 5.39 ± 1.43 U/g Hb (the active form). After the addition of FAD to the hemolysates, this increased to 7.79 ± 1.07 U/g Hb, an increase of 1.88 ± 0.84 U/g Hb (the inactive from) (p < 0.001). In patients with FAD supplementation, erythrocyte GSSG-R activity increased from 9.26 ± 1.19 U/g Hb to 10.06 ± 1.06 U/g Hb, an increase of 0.80 ± 0.76 U/g Hb (p < 0.01). In addition, there were significant positive correlations between the enzyme activities and plasma urea level, and negative correlations between the enzyme activities and hemoglobin concentrations in patients, but not in the controls. It was concluded that further cross-sectional in vivo studies should be made to determine whether riboflavin administration may or not be useful in preventing renal anemia.Item Increased lipoprotein (a) and its relationships with other parameters of lipoprotein metabolism in chronic renal failure treated by hemodialysis(International Heart Journal Association, 1997) Ramazan Yiǧitoǧlu M.; Fevzi Polat M.; Akçay F.; Ari Z.; Sami Uyanik B.; Özilgili H.M.Background. Studies have shown that patients with chronic renal failure have a high frequency of cardiocascular atheromatous disease. Methods. We examined serum lipoprotein (a) [Lp(a)], very-low density lipoprotein cholesterol (VLDL-C), low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C), apolipoprotein A1 (apo A1) and B (apo B), triglyceride (TG) and total cholesterol (TC) levels as possible risk factors for atherosclerosis in 45 patients with chronic renal failure (CRF) treated by hemodialysis (HD) and in 15 CRF patients who were not on HD. A control group of 20 healthy subjects was also studied. Results. The proportion of smokers and body mass indexes were similar between the groups. In both patient groups, higher TG, TC and Lp(a) and lower apo A1 and HDL-C levels in serum were found than in those of controls. Serum apo B and LDL-C were similar in the patients treated by HD and the controls. Serum VLDL-C and LDL-C were similar in the CRF patients who were not on HD and the controls. The highest ratios of apo B/apo A1 and LDL-C/HDL-C were found in HD patients. The highest ratio of TC/HDL-C was found in the other patient group. We found significant correlations between Lp(a) and other parameters of lipoprotein metabolism in CRF patients, both those who were and those who were not on HD. Conclusions. Our results indicate that CRF patients who both were and were not on HD show atherogenic changes in the lipoprotein pattern, and that the increase in Lp(a) during the CRF phase is basically related to the loss of renal function and may also depend on the resultant alterations which are produced in other lipoprotein variables.Item Renal functions of enuretic and nonenuretic children: Hypernatriuria and kaliuresis as causes of nocturnal enuresis(Elsevier B.V., 1997) Vurgun N.; Gumus B.H.; Ece A.; Ari Z.; Tarhan S.; Yeter M.Objective: The aim of this study was to investigate the pathophysiologic cause(s) of primary nocturnal enuresis. Therefore, electrolyte concentrations of urine specimens were evaluated in the morning, and alterations compared between enuretics and nonenuretics. Methods and Patients: First morning urine specimens of 27 enuretics and 21 nonenuretic subjects fed the same diet were collected, and urinary electrolytes were measured. The urinary Ca/Cr ratio, tubular reabsorption of phosphorus (TRP) and fractional sodium (FE Na%) and potassium excretions (FE K%) were determined for patients and controls. Results: There was no significant difference in the Ca/Cr ratio and TRP between patients and controls, but enuretic patients had significantly higher FE Na% and FE K% values than controls (p < 0.001). There were significant positive correlations between FE Na% and (r = 0.81, p < 0.001) FE K% and the frequency of bedwetting, respectively, among enuretic patients (r = 0.54, p < 0.001). Conclusion: Since Na and K excretion of enuretic patients was higher than in nonenuretics, it can be concluded that there may be a benign hereditary and/or postural renal tubular handling disorder of Na and K in enuretic children.Item Beneficial effects of testosterone undecanoate on the lipoprotein profiles in healthy elderly men. A placebo controlled study(International Heart Journal Association, 1997) Uyanik B.S.; Ari Z.; Gümüs B.; Ramazan Yiǧitoǧlu M.; Arslan T.Background and Methods. In order to assess the effects of testosterone undecanoate (TU; 120 mg/d orally for 2 months) on serum lipid, lipoprotein, and apolipoprotein levels in healthy elderly men, the placebo (PL) controlled study was performed on 37 elderly men, aged between 53 and 89 years. In all subjects venous blood samples were taken after an overnight (10 hours) fast and sera were stored -70°C until analysis. Results. In PL group, neither hormonal data nor lipid, lipoprotein, and apolipoprotein levels showed significant changes. After TU supplementation, serum total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and estradiol (E2) levels decreased from 198 ± 30.7 mg/dl to 174 ± 41.9 mg/dl (P < 0.05), from 111 ± 18.14 mg/dl to 87.9 ± 29.4 mg/dl (P < 0.01), and from 86.2 ± 16.9 pmol/l to 70.5 ± 18 pmol/l (P < 0.01), respectively. Statistically significant differences were not observed in the serum triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), and apolipoprotein (apo)A-1 and apo B levels after TU treatment. The mean ratios TC/HDL-C and LDL-C/HDL-C as coronary risk factor criteria decreased significantly in the TU but not in the PL group. No obvious side effect was observed in those who took TU except for reported pyrosis in 2 of 17 elderly men. Conclusions. These data indicate that the increased serum levels of total testosterone (TT) produced by administration of TU, 120 mg/d orally for 2 months lead to supressed levels of TC and LDL-C and E2 but not significantly changed levels of TG, HDL-C, apo A-1 and apo B. Thus, we conclude that TU may be an effective drug for protecting coronary heart disease in healthy elderly men with lowered TT and FT levels. It may also have beneficial effects for sexual function and behavior.Item Serum angiotensin-converting enzyme and plasma atrial natriuretic peptide levels in hyperthyroid and hypothyroid rabbits(1997) Yeǧin E.; Yiǧitoǧlu M.R.; Ari Z.; Çelik I.; Akçay F.; Su̧zek H.Background. It is known that serum angiotensin-converting enzyme (ACE) and plasma atrial natriuretic peptide (p-ANP) levels increase in hyperthyroidism. However, the precise mechanism of the effects of thyroid hormone on ANP release remains to be clarified. No study investigating serum ACE together with p-ANP levels has been performed in experimental hyperthyroid and hypothyroid rabbits. The present study was designed in order to provide additional evidence of increased ANP production and secretion in hyperthyroidism and to investigate the relationships between ANP, ACE and thyroid hormones. Methods. Male New Zealand white rabbits (2.3-3.4 kg) were used throughout the study. Hyperthyroidism was induced by daily intraperitoneal administration of L-thyroxin (50 μg/100 g). Hypothyroidism was induced by daily intraperitoneal injection of propylthiouracil (2 mg/100 g body weight). Twelve days after the end of treatment, animals were sacrified under anesthesia and blood samples were obtained from the aorta for serum ACE and thyroid hormone and p-ANP determinations. Results. Serum ACE, plasma renin activity (PRA) and p-ANP were higher in hyperthyroid rabbits and lower in hypothyroid rabbits than in euthyroid rabbits. ANP concentration in atria was lower in hyperthyroid rabbits and higher in hypothyroid rabbits than in euthyroid rabbits. p-ANP, PRA and serum ACE levels were positively correlated with serum thyroxin levels. Inverse correlation was found between serum thyroxin and ANP concentration in atria (a-ANP), and between p-ANP and a-ANP. Conclusions. Our results indicate that not only p-ANP but also serum ACE activity was markedly increased in experimental hyperthyroid rabbits. It was thought that there were both direct and indirect effects of thyroxin on the release of ANP.Item Should children with infection be tested for lipid, lipoprotein and apolipoprotein?(1998) IŞĆn A.; YiŞitoŞl̈ R.; OnaǦ A.; Vurgun N.; Ari Z.; Ertan P.; Şengil A.Z.The lipid profile is known to alter in patients with infection, but there has not been a study of the apolipoprotein levels in serum of otherwise healthy children during infection. Lipids, lipoproteins, apolipoproteins A-l and B and lipoprotein (a) were evaluated prospectively in 31 consecutive children, aged4–15 years, who were admitted to the hospital with bacterial pharyngitis. The degree of dyslipidemia associated with bacterial pharyngitis was assessed using each child as his/her own control and by comparison with 79 healthy children who had not had an infection during the past 3 months. Serum total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, apolipoprotein A-l and apolipoprotein B levels were significantly decreased during the symptomatic phase of the disease, whereas the serum triglyceride level was slightly elevated. Serum lipoprotein (a) concentration did not change significantly. In conclusion, it is suggested that serum lipids, lipoproteins and apolipoproteins should not be assessed during infection because of the possible transient changes of these parameters during infection or inflammation. © 2017 Wiley. All rights reserved.Item Hypernatriuria and kaliuresis in enuretic children and the diurnal variation(Elsevier Inc., 1998) Vurgun N.; Yicrossed d Signitocrossed d Signlu M.R.; Ýpcan A.; Ari Z.; Tarhan S.; Balkan C.Purpose: We investigate the underlying pathophysiological cause of primary nocturnal enuresis by comparing electrolyte alterations in urine samples of enuretics during the daytime and nighttime compared with those of nonenuretic subjects. Materials and Methods: Urine output, urine specific gravity and urinary electrolytes in 15 enuretic and 12 nonenuretic children were measured. We collected daytime serum and urine samples of children fed a similar diet between 7 a.m. and 7 p.m., and nighttime between samples 7 p.m. and 7 a.m. Urinary calcium/creatinine ratio, tubular reabsorption of phosphorus and excretions of fractional sodium and potassium were calculated. Results: There was no significant difference between the calcium/creatinine ratio ratios. There was a significant increase in fractional sodium and fractional potassium values in enuretics compared to nonenuretics during the day and at night. Daytime and nighttime fractional sodium and fractional potassium values in enuretics were similar. In contrast to nonenuretics, enuretic patients had no diurnal variation of fractional sodium. There was significant positive correlation between bedwetting status, and fractional sodium and fractional potassium. Conclusions: Since sodium and potassium excretions were higher in enuretic patients than nonenuretic children, and no significant diurnal variation in urinary excretion of these ions there might be a difference in the mechanism of reabsorption of sodium and potassium between enuretic and nonenuretic children.Item Should children with infection be tested for lipid, lipoprotein and apolipoprotein?(1998) Işcan A.; Yiǧitoǧlu R.; Onaǧ A.; Vurgun N.; Ari Z.; Ertan P.; Şengil A.Z.The lipid profile is known to alter in patients with infection, but there has not been a study of the apolipoprotein levels in serum of otherwise healthy children during infection. Lipids, lipoproteins, apolipoproteins A-1 and B and lipoprotein (a) were evaluated prospectively in 31 consecutive children, aged 4-15 years, who were admitted to the hospital with bacterial pharyngitis. The degree of dyslipidemia associated with bacterial pharyngitis was assessed using each child as his/her own control and by comparison with 79 healthy children who had not had an infection during the past 3 months. Serum total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, apolipoprotein A-1 and apolipoprotein B levels were significantly decreased during the symptomatic phase of the disease, whereas the serum triglyceride level was slightly elevated. Serum lipoprotein (a) concentration did not change significantly. In conclusion, it is suggested that serum lipids, lipoproteins and apolipoproteins should not be assessed during infection because of the possible transient changes of these parameters during infection or inflammation.Item Relationship between serum lipoprotein (a) levels and retinopathy in patients with type 2 diabetes(American Society of Contemporary Ophthalmology, 2002) Kurt E.; Öztürk F.; Ari Z.; Yigitoglu M.R.; Sari R.A.; Ilker S.S.We studied whether there was an association between development of background or proliferative retinopathy and changes in plasma lipid, lipoprotein, and lipoprotein (a) levels in 112 patients with type 2 diabetes mellitus and in 57 controls. Serum lipoprotein (a) levels were higher in patients with retinopathy than in individuals without retinopathy. Increased serum lipoprotein (a) levels correlated with higher degrees of retinopathy. Thus, lipoprotein (a) may play a role in the development of diabetic retinopathy.Item Serum lipids and apolipoproteins in patients with psoriasis(2002) Uyanik B.S.; Ari Z.; Onur E.; Gündüz K.; Tanülkü S.; Durkan K.Psoriasis is characterized by defects in the normal cycle of epidermal development that lead to epidermal hyperproliferation, altered maturation of skin cells, vascular changes and inflammation. Also, psoriasis has been associated with an abnormal plasma lipid metabolism. Changes in plasma lipid and lipoprotein composition in patients with psoriasis may be the reason for the increased risk of atherosclerosis in these patients. We determined serum concentrations of lipids, lipoproteins and apolipoprotein A1 and B (apo A1 and apo B) in 72 patients with psoriasis and 30 age-matched controls. Serum lipoprotein (a) (Lp(a)), apo A1 and apo B were measured by immunoprecipitation assays, and the lipids and other biochemical parameters by enzymatic methods. Serum Lp(a) and triglyceride (TG) were significantly higher in patients with psoriasis than in healthy control subjects (p<0.01 for both). Apo B was also found to be higher in the patient group, but the difference was not significant. The levels of total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) and apo A1 did not differ significantly from those of the controls. These observations imply that serum Lp(a) and TG concentrations may play a role as risk factors for atherosclerotic disease in patients with psoriasis.Item The acute effect of orlistat on endothelial function in young obese women(2003) Sekuri C.; Tavli T.; Avsar A.; Sozcuer H.; Uyanik B.S.; Ari Z.Recent studies indicate that abdominal fat accumulation is related to impaired endothelial function in young healthy volunteers. The aim of this study was to determine the acute effect of gastrointestinal lipase inhibitor on brachial flow-mediated vasodilatation and hemodynamic parameters in young obese women. The study population was composed of 42 female obese patients (mean age 29 ± 4 years, age range between 18 and 34 years). Flow-mediated endothelial-dependent vasodilatation was assessed in the brachial artery in response to reactive hyperemia using high-resolution ultrasound. Brachial artery diameter (3.46 ± 0.72 mm to 3.82 ± 0.84 mm) and flow-mediated vasodilation (7.6 ± 0.8% to 9.8 ± 1.6%) changed significantly after 12 weeks of therapy (p < 0.001). Brachial artery flow was not changed (124 ± 92 ml/min to 148 ± 14 ml/min, p > 0.05). The results of this study demonstrate that orlistat improved endothelial function, weight, body mass index and systolic and diastolic blood pressure in young women.Item The acute effects of cilazapril on pulmonary function tests and arterial blood gas changes in patients with pulmonary hypertension(2003) Tavli T.; Sekuri C.; Goktalay T.; Uyanik B.S.; Ari Z.The aim of the present study was to evaluate pulmonary function tests and arterial oxygen transport in patients with pulmonary hypertension due to congestive heart failure before and after cilazapril treatment. Thirty patients (16 men and 14 women, mean age, 65 ± 18 years) with congestive heart failure and 30 healthy volunteers (20 men and 10 women, mean age 59 ± 12 years, p > 0.05) were included in the study. All patients underwent evaluation of pulmonary function by spirometry and arterial blood gas analysis. Arterial oxygen saturation and arterial oxygen transport changed significantly after treatment (81 ± 7 to 87 ± 8 and 317 ± 74 to 392 ± 8, respectively). Forced expiration volume in 1 second, vital capacity and total lung capacity were increased after cilazapril treatment (2.55 ± 0.7 to 2.61 ± 0.8, 3.2 ± 0.9 to 3.3 ± 1.0 and 3.6 ± 0.9 to 4.1 ± 1.1, respectively, p < 0.05). In conclusion, short-term cilazapril administration improved pulmonary function and arterial oxygen transport because it increased cardiac output, produced pulmonary vasodilatation, improved the pulmonary hemodynamics and removed interstitial fluid.Item Serum testosterone, growth hormone, and insulin-like growth factor-1 levels, mental reaction time, and maximal aerobic exercise in sedentary and long-term physically trained elderly males(2004) Ari Z.; Kutlu N.; Uyanik B.S.; Taneli F.; Buyukyazi G.; Tavli T.The aim of the study was to investigate the effect of regular exercise on maximum oxygen uptake capacity (VO2max), reaction time (RT), testosterone (T), growth hormone (GH), insulin-like growth factor-I (IGF-1) in athletes compared to sedentary controls. VO2max RT, T, GH, and IGF-I levels were 31.2 ± 6.2 ml/min/kg, 106.7 ± 23.2 s, 8.3 ± 1. 3 ng/mL 1.6 ± 0.7 ng/mL, 106.5 ± 27.0 ng/mL in master athlete group and 18.8 ± 5.1 ml/min/kg, 148.3 ± 39.3 s, 5.4 ± 1.7 ng/mL, 0.8 ± 0.3 ng/mL, 90.2 ± 23.8 ng/mL in sedentary control group, respectively. The differences between regularly exercising males and the control group of sedentary males were found to be statistically significant. The results showed that long-term exercise decreased RT and increased VO 2max, T, and GH in elderly males; elevated serum T and GH levels may be advantageous for brain functions.Item Serum nitric oxide metabolite levels and the effect of antipsychotic therapy in schizophrenia(2004) Taneli F.; Pirildar S.; Akdeniz F.; Uyanik B.S.; Ari Z.Recently it was proposed that nitric oxide metabolites (NO) may have a role in the pathophysiology of schizophrenia and major depressive disorders. The present study was performed to assess changes in serum nitric oxide metabolite levels in schizophrenic patients compared with healthy controls. Our secondary aim was to further evaluate the impact of psychopharmacologic treatment on circulating NO levels not assessed previously. Serum NO levels of patients with schizophrenia (n = 20) before and after 6 weeks of treatment were compared with those of healthy controls (n = 20). Severity of schizophrenia and response to treatment were assessed with positive and negative symptoms of schizophrenia. NO levels were estimated by Griess method in serum samples. In patients with schizophrenia, pre-treatment serum NO levels were higher than those of control subjects (39.15 ± 18.24 vs. 25.40 ± 5.83 μmol/L, p = 0.036) and also of post-treatment values (34.41 ± 16.35 vs. 25.40 ± 5.83 μmol/L, p = 0.049), respectively. However, no significant difference was found between serum NO levels in pre- and post-treatment values. Our findings of increased serum NO levels in schizophrenic patients confirmed the role of NO in the pathophysiology of schizophrenia. However, we found that antipsychotic drugs do not reveal significant effects on serum levels of NO in schizophrenia in a 6-week treatment regimen. Further studies with longer therapy periods may suggest some new clues for novel treatment strategies employing antioxidants and NOS inhibitors in schizophrenia. © 2004 IMSS. Published by Elsevier Inc.Item The long-term effect of mesh bioprosthesis in inguinal hernia repair on testicular nitric oxide metabolism and apoptosis in rat testis(2005) Taneli F.; Aydede H.; Vatansever S.; Ulman C.; Ari Z.; Uyanik B.S.Polypropylene mesh is the most widely used material in inguinal hernia repair. Although polypropylene mesh is known as an inert material, it is experimentally proven that mesh generates a chronic inflammatory tissue reaction. The aim of the present study was to investigate the long-term effects of polypropylene mesh material used in inguinal hernia operations on testicular function, testicular nitric oxide (NO) metabolism and germ cell-specific apoptosis in rats. The study comprised 40 male rats that were randomly allocated into two groups. In group 1, the left spermatic cord was elevated and a 0.5 × 1 cm polypropylene mesh was placed behind the left inguinal spermatic cord and group 2 consisted of the sham-operated controls. Blood samples were taken at 6 months preoperatively and postoperatively after to assess luteinizing hormone (LH) and follicle stimulating hormone (FSH) levels for hormonal evaluation. Testicular NO was evaluated by the Griess method, apoptosis by a TUNEL method and inducible nitric oxide synthase (iNOS) and endothelial NOS (eNOS) expressions by immunohistochemical staining. Mild (+) eNOS expression was observed in all specimens. Mild (+) iNOS expression was only detected in ipsilateral testis of the mesh-implanted study group. Apoptotic cells were not detected in any samples. We are of the opinion that long-term polypropylene mesh implantation has no effect on testicular hormonal function and only a limited effect on nitric oxide levels and this effect is not sufficient to cause apoptosis in testis that could lead to infertility. It seems that mesh implantation is a reliable method in inguinal hernia repair; however, further work is required by more sensitive methods to fully elucidate the potential testicular damage. Copyright © 2004 John Wiley & Sons, Ltd.Item Increased serum leptin concentrations in patients with chronic stable angina pectoris and ST-elevated myocardial infarction(2006) Taneli F.; Yegane S.; Ulman C.; Tikiz H.; Bilge A.R.; Ari Z.; Uyanik B.S.Leptin is an adipocytokine that is produced mainly by adipose tissue; it is also identified in atherosclerotic lesions in human coronary atherosclerosis. However, the relation of serum leptin concentrations to ischemic heart disease (IHD) is still obscure. The aims of the present study were to investigate serum leptin concentrations in patients with ST-elevated myocardial infarction (STEMI) and with chronic stable angina pectoris (CSAP) and to evaluate the possible correlations of leptin to other atherosclerotic risk factors; including serum high sensitive C-reactive protein (Hs-CRP), serum homocysteine, and fibrinogen concentrations. For this purpose, 35 patients with CSAP, 40 with acute STEMI, and 30 control subjects with normal findings from coronary angiography were taken into the study prospectively. Serum leptin concentrations were significantly higher in patients with CSAP and STEMI compared to the control group (7.74 ± 1.34 vs 6.37 ± 1.85 ng/mL, p = 0.021 and 8.22 ± 3.13 vs 6.37 ± 1.85 ng/mL, p = 0.023, respectively). In addition, serum homocysteine concentrations were significantly increased in patients with CSAP (15.23 ± 5.96 vs 11.40 ± 2.11 μmol/L, p = 0.025) and patients with STEMI (15.90 ±5.02 vs 11.40 ±2.11 μmol/L, p = 0.012) compared to the control group. Serum fibrinogen concentrations were significantly increased only in the CSAP group as compared to controls (4.15 ± 1.39 vs 3.45 ± 1.19 g/L, p = 0.025). No significant correlation was found between leptin levels and selected risk factors. In conclusion, serum leptin concentrations were significantly higher in both the CSAP and STEMI groups. However, owing to the lack of correlation between the leptin levels and selected classical coronary risk factors, it may be considered that leptin can be evaluated as one of the independent risk factors for IHD. Further randomized and controlled studies will be required to determine the pathophysiological meaning of the increased leptin levels and the central role between adipocyte function and atherosclerosis. ©2006 Westminster Publications, Inc.Item Advanced oxidation protein products, ferrous oxidation in xylenol orange, and malondialdehyde levels in thyroid cancer(2007) Kosova F.; Çetin B.; Akinci M.; Aslan S.; Ari Z.; Sepici A.; Altan N.; Çetin A.Aims and Background: The oxidation of protein plays an essential role in the pathogenesis of an important number of degenerative and cancer diseases, which is now widely recognized. The aim is to examine advanced oxidation protein products (AOPPs), lipid peroxidation products malondialdehyde (MDA), and ferrous oxidation in xylenol orange (FOX) in blood samples of papillary thyroid cancer patients compared with healthy controls to determine the oxidation status and the change after thyroidectomy. Methods: Thirty-five female thyroid cancer patients who underwent total thyroidectomy and 39 female control subjects were included into this study. Prethyroidectomy and postthyroidectomy, AOPP, FOX, and MDA levels were studied. Results: Prethyroidectomy AOPP, FOX, and MDA levels were significantly higher compared to control (P < .05). In postthyroidectomy AOPP, FOX, and MDA levels were significantly decreased compared with prethyroidectomy levels (P < .05). However, postthyroidectomy levels on the 20th day were still significantly higher, compared to control subjects (P < .05). Conclusion: In conclusion, all of AOPP, FOX, and MDA levels that are markers of protein oxidation and lipid hyperoxidation may induce thyroid cancer development and begin to decrease after thyroidectomy. © 2007 Society of Surgical Oncology.Item Leptin levels in thyroid cancer(Elsevier (Singapore) Pte Ltd, 2009) Akinci M.; Kosova F.; Cetin B.; Aslan S.; Ari Z.; Cetin A.BACKGROUND: Leptin has physiological roles in multiple systems, and has possible effects on several carcinogenesis steps. The aim of this study was to investigate the leptin levels in thyroid papillary carcinoma (TPC) patients. METHODS: Forty-three female TPC patients and 30 healthy female control subjects were recruited for the study. TPC was diagnosed by fine needle aspiration biopsy. TPC patients had a bilateral total thyroidectomy operation and their leptin levels were measured before and 20 days after the operation. RESULTS: Serum leptin levels of TPC patients were higher than in control group subjects (21.15 ± 14.12 ng/mL vs. 9.89 ±0.21 ng/mL, p< 0.05). The leptin levels decreased after total thyroidectomy (13.92 ± 10.55 ng/mL) compared to prethyroidectomy levels (22.94 ± 14.67 ng/mL) in 34 patients who came to the follow-up visit (p< 0.05). However, the decreased post-thyroidectomy levels of leptin were still statistically significantly higher than the control group levels. Multivariate regression analysis showed that the leptin levels in TPC patients were not related to age, menopausal status or pathologic occult status but were directly related to the cancer group. CONCLUSION: Leptin levels were elevated in thyroid cancer, decreased after total thyroidectomy, and might be associated with thyroid papillary carcinogenesis. © 2009 Elsevier. All rights reserved.Item Do walking programs affect C-reactive protein, osteoprotegerin and soluble receptor activator of nuclear factor-kappaβ ligand?(2009) Esen H.; Büyükyazi G.; Ulman C.; Taneli F.; Ari Z.; Gözlükaya F.; Tikiz H.Aim: To examine the effects of 10-week walking programs on maximal oxygen consumption, body composition, serum lipids, highly-sensitive C-reactive protein, osteoprotegerin and soluble receptor activator of nuclear factor-kappaβ ligand. Method: Twenty-seven middle-aged men (40-60years) walked for ten weeks, five days per week, 40-52min per day at either moderate or high intensity (∼5.95±0.26km/h and ∼7.64±0.36km/h; 50-55% and 70-75% maximum heart rate reserve, respectively). Non-walking, sedentary men served as controls (n=13). Estimated maximal oxygen consumption, body composition, lipid profile, highly-sensitive C-reactive protein, osteoprotegerin and soluble receptor activator of nuclear factor-kappaβ ligand were determined before and after the study. Results: After 10 weeks, estimated maximal oxygen consumption improved in both exercise groups (p<.05), favoring high-intensity group (p<.05). Body weight, percent body fat, and body mass index reduced significantly in both exercise groups (p<.05). Walking programs did not cause any significant changes in blood lipids, highly-sensitive Creactive protein, and osteoprotegerin levels; however, soluble receptor activator of nuclear factor-kappaβ ligand levels were found to decrease in high-intensity group (p<.05) and the change observed in both exercise groups was different from the change in control group (p<.05). Conclusion: For protective effects against cardiac risk factors and arterial calcification, high-intensity walking programs are advisable due to the greater improvements in soluble receptor activator of nuclear factor-kappaβ ligand and estimated maximal oxygen consumption. © TurkJBiochem.com.