Browsing by Author "Arslan, Y"
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Item Prevalence of Prostate Cancer in High Boron-Exposed Population: A Community-Based StudyMüezzinoglu, T; Korkmaz, M; Nese, N; Bakirdere, S; Arslan, Y; Ataman, OY; Lekili, MWe investigated the possible relationship between boron exposure and prostate cancer (PCa) for men living and being employed at boron mines in villages with rich boron minerals. Out of 456 men studied, 159 were from villages with rich boron sources and boron levels in drinking water of > 1 mg L-1 and these men formed the study group, while 63 from villages with rich boron sources and boron levels in drinking water of < 1 mg L-1 were enrolled into control group 1. A further 234 subjects from other villages with no boron mines were considered as control group 2. Prostate specific antigen (PSA) levels could be obtained from a total of 423 men. Urinary boron concentration as an indicator of boron exposure in 63 subjects, prostatic volumes by transrectal ultrasonography in 39 subjects, and prostatic biopsies in 36 subjects were obtained for study and control groups. The daily boron exposure was calculated according to urinary boron levels. Although there was no significant difference among the groups in terms of total PSA levels, the number of subjects with tPSA a parts per thousand yen2.5 and tPSA a parts per thousand yen10.0 ng dL(-1) prostatic volumes in men whose prostates were biopsied (p < 0.012) was significantly lower in the study group as compared with those in the control group 2. These results suggested that high exposure to boron might have an implication within the prostatic cellular processes related to hyperplasia and carcinogenesis, even though we did not find a statistically significant association between PCa and boron exposure.Item Investigation of hematologic findings related to brucellosis in Anatolian regionÇelik, M; Arslan, Y; Topcu, E; Sahinoglu, MS; Altindag, D; Gürbüz, E; Atalay, E; Demircan, SK; Emre, S; Kirik, Y; Atasoy, PY; Özer, D; Ipek, D; Dogan, E; Atli, SB; Kusçu, EG; Alkan, S; Çiçek, Y; Yüksekkaya, E; Aldemir,Ö; Sahin, A; Ürkmez, EY; Al, SÖ; Boran, R; Mizrakçi, SO; Demiray, EKD; Ceylan, MR; Erdogdu, H; Tekin, SObjectives: To investigate the prevalence of hematologic findings and the relationship between hemogram parameters and brucellosis stages in patients. Methods: This multi-center study included patients older than 16 years of age who were followed up with a diagnosis of brucellosis. Patients' results, including white blood cell, hemoglobin, neutrophil, lymphocyte, monocyte, mean platelet volume, platelet and eosinophil counts were analyzed at the initial diagnosis. Results: In this study 51.3% of the patients diagnosed with brucellosis were male. The age median was 45 years for female and 41 years for male. A total of 55.1% of the patients had acute brucellosis, 28.2% had subacute, 7.4% had chronic and 9% had relapse. The most common hematologic findings in brucellosis patients were anemia (25.9%), monocytosis (15.9%), eosinopenia (10.3%), and leukocytosis (7.1%). Pancytopenia occurred in 0.8% of patients and was more prominent in the acute phase. The acute brucellosis group had lower white blood cell, hemoglobin, neutrophil, eosinophil, and platelet counts and mean platelet volume, and higher monocyte counts compared to subacute and chronic subgroups. Conclusion: It was noteworthy that in addition to anemia and monocytosis, eosinopenia was third most prominent laboratory findings in the study. Pancytopenia and thrombocytopenia rates were low.Item Relationship between functional status and fatigue after COVID-19 infection: a multicenter study from TurkiyeCandemir, I; Ergün, P; Kaymaz, D; Sahin, ME; Özmen, I; Yildirim, E; Dilektasli, AG; Yigitliler, B; Odabas, A; Kizilirmak, D; Sari, S; Korkmaz, C; Tasci, C; Arslan, Y; Savci, S; Kahraman, B; Tanriverdi, A; Sevinç, C; Saglam, M; Ince, DI; Yagli, NV; Kütükcü, E; Durmaz, D; Durutürk, N; Ulubay, G; Kiliç, L; Çaglayan, B; Moray, A; Olcay, SS; Özkaya, GBackground/aim: Symptoms of COVID-19 may persist for months. One of the persistent symptoms of COVID-19 is fatigue, which reduces functional status. The relationship between fatigue, functional status, and various other factors has received little attention, which this study aims to address.. Materials and methods: Patients with COVID-19 infection were included in this multicenter cross-sectional study. Age, sex, body mass index (BMI), marital status, smoking status, presence and duration of chronic disease, comorbidity index, regular exercise habits, time since COVID-19 diagnosis, hospitalization status, length of hospital stay, intubation status, home oxygen therapy after discharge, participation in a pulmonary rehabilitation program, presence of dyspnea, presence of cough, presence of sputum, and modified Medical Research Council, Post-COVID Functional Status (PCFS), Fatigue Severity Scale (FSS), and EQ-5D-5L Questionnaire scores were recorded. Results: We enrolled 1095 patients, including 603 (55%) men and 492 (45%) women with a mean age of 50 +/- 14 years. The most common chronic lung disease was COPD (11%) and 266 (29%) patients had nonpulmonary disease. The median time elapsed since COVID-19 diagnosis was 5 months; the hospitalization rate was 47%. The median PCFS grade was 1 (0-4) and the median FSS score was 4.4 (1-7). The PCFS and FSS were positively correlated (r = 0.49, p < 0.01; OR: 1.88, 95% CI: 1.68-2.10). Both functional status and fatigue were associated with quality of life, which was lower in older patients, those with higher BMI, those with systemic disease, those not exercising regularly, and those with more severe COVID-19 infection (defined by dyspnea, pneumonia as indicated by computed tomography, hospitalization, length of stay, ICU admission, intubation, and the need for home oxygen after discharge). Conclusion: Fatigue may cause poorer functional status regardless of the time since COVID-19 diagnosis. In this study, patients with FSS scores of >4.78 showed moderate to severe functional limitations. It is important to address modifiable patient risk factors and reduce the severity of COVID-19 infection.Item The Relationship Between Functional Status and Fatigue After COVID-19 InfectionCandemir, IÇ; Ergun, P; Kaymaz, D; Özmen,; Yildirim, E; Dilektasli, AG; Yigitler, B; Kizilirmak, D; Sari, S; Korkmaz, C; Tasçi, C; Arslan, Y; Savci, S; Kahraman, B; Tanriverdi, A; Sevinç, C; Saglam, M; Ince, DI; Yagli, NV; Kütükçü, E; Durmaz, D; Durutürk, N; Ulubay, G; Kiliç, L; Çaglar, B; Moray, A; Olcay, SS