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  1. Home
  2. Browse by Author

Browsing by Author "Arslan Ö."

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    Serum level of insulin-like growth factor-1 and insulin-like growth factor binding protein-3 in acute coronary syndromes and relationship with prognosis; [Akut Koroner Sendromlarda ̇ Insl̈in Benzeri Büyüme Faktörü-I ve ̇ Insülin Benzeri Büyüme Faktörü Baǧlayici Protein-3 Düzeyleri ve Prognozla ̇ Ilişkisi]
    (2004) Şekuri C.; Arslan Ö.; Ütük O.; Bayturan Ö.; Onur E.; Tezcan U.K.; Tavli T.
    Objective: The aim of the present study was to examine the levels of insulin-like growth factor (IGF-I) and binding protein-3 (IGFBP-3) in acute coronary syndrome (ACS) and their relationship with prognosis. Methods: Thirty patients with ACS (22 male, 8 female) were included in our study. Patient's population included 20 patients with ST elevation myocardial infarction (STEMI) and 10 with non-ST-elevation ACS. Death, re-infarction, revascularization and malignant arrhythmia were monitored during 3 months. Study group was compared with 20 healthy subjects (Controls). Blood samples were collected in the first 24 hours and at the end of third month. Serum IGF-I and IGFBP-3 levels were determined by radioimmunoassay method. Results: We found decreased level of IGF-I only in the STEMI group (105±84 ng/ml vs. 715±150 ng/ml, p<0.0001). There were no significant differences in IGFBP-3 levels between two groups. Serum IGF-I levels were significantly increased after 3rd month in the STEMI group (356±72 ng/ml vs. 105±84 ng/ml, p=0.025). There was no relationship between IGF-I, IGFBP-3 levels and cardiovascular events occurred during 90 days of follow-up. Conclusion: These data allows to suggest that significantly decreased level of IGF-I in STEMI group of ACSs can be used as a marker of myocardial necrosis. There was no relationship between IGF-I level and cardiovascular events occurred in 90 days, so this parameter can not be used as a negative prognostic factor.
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    The effect of tunicamycin on embryonic and newborn murine spleen tissues; [Tunikamisinin embriyonik ve yenidoǧan fare dalak dokularına etkisi]
    (KAFKAS UNIVERSITY, 2009) Balcan E.; Arslan Ö.; Gümüş A.; Şahin M.
    Tunicamycin is an antibiotic that widely used in cell biology for its ability to inhibit N-linked glycosylation of asparagine residues on proteins and to induce endoplasmic reticulum stress. In the present study, the effects of tunicamycin on murine splenic tissues at 17th embryonic day and 1st and 3rd postnatal days were evaluated with three structural and physiological parameters: 1) alterations in glycosaminoglycan molecules, 2) apoptosis and 3) alterations in laminin molecules. It was shown that splenic microenvironments of control groups contain carboxylated glycosaminoglycans, but their content slightly decreased in all tunicamycin treated groups by alcian blue-periodic acid-Schiff method. On the other hand, there was an increase in the interstitial space among the cells of tunicamycin treated groups. In addition, it was shown by immunoblotting analyses that expression levels of laminin molecules were decreased by tunicamycin tratment in developing spleen tissues. In order to determine apoptotic effects of tunicamycin, TUNEL assay was performed and it was found that the number of apoptotic cells in developing spleen was strongly increased with tunicamycin treatments. These results suggest that, during the spleen development, the alterations of glycosaminoglycan contents in the extracellular matrix and the glycosylation status of extracellular glycoproteins (e.g. laminins) that mediate cell-extracellular matrix interactions are very important factors that seal the fate of cell physiology and morphogenesis.
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    The effect of anti-tumor necrosis factor (TNF)-alpha therapy with etanercept on endothelial functions in patients with rheumatoid arthritis; [Romatoid artrit'li hastalarda etanercept ile yapilan anti-tümör nekroz faktör (TNF)-alfa tedavisinin endotel fonksiyonlari üzerine etkisi]
    (2010) Tikiz H.; Arslan Ö.; Pirildar T.; Tikiz C.; Bayindir P.
    Objective: To investigate the effects of tumor necrosis factor (TNF)-〈 antagonism with etanercept (ENC) on endothelial functions in patients with active rheumatoid arthritis (RA). Methods: A total of 21 patients with RA were enrolled in this prospective study. Eleven of them (8 women, 3 men mean age 47.0±10.1 years) with high disease activity despite the conventional treatment were assigned to Group 1 and were given ENC treatment twice a week (25 mg SC injection) for 12 weeks. Ten patients with RA (8 women, 2 men mean age 55.0±6.4 years) under conventional methotrexate and prednisone therapy were assigned as Control group (Group 2). Endothelium-dependent and -independent vasodilator responses of the brachial artery were assessed by high-resolution ultrasound. Erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) were also measured at baseline and at the post treatment period. Mann-Whitney U and Wilcoxon tests were used to compare the data and correlation analysis was performed using Pearson correlation test. Results: Endothelium-dependent vasodilatation improved from 5.2±0.8% to 7.9±1.3% (p=0.04) in ENC group, while no significant change was observed in the control group (from 6.6±1.1% to 7.0±1.8% p=0.67). No significant changes were found in endothelium-independent vasodilatation and baseline brachial artery diameters in both groups. A significant reduction in ESR and CRP were observed in patients receiving ENC (from 16.2±6.8 to 9.2± 5.1 mm/h, p=0.003 and from 14.68±3.4 to 9.25± 3.7 mg/L, p=0.003, respectively). Conclusion: Treatment with ENC for 12 weeks significantly improved endothelial function in patients with active RA compared to those under conventional therapy. The findings of the present study support the hypothesis that the use of TNF-〈 blockers in patients with active RA may reduce the high incidence of cardiovascular complications. (Anadolu Kardiyol Derg 2010; 10: 98-103) © Copyright 2010 by AVES Yayincilik Ltd.
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    Effect of tunicamycin on glycosaminoglycans and laminins in embryonic and postnatal thymic tissues
    (Science Printers and Publishers Inc., 2015) Balcan E.; Arslan Ö.
    OBJECTIVE: To compare histological and molecular alterations in the embryonic and neonatal thymi following exposure to tunicamycin. STUDY DESIGN: Mouse embryos at gestational days 17 (n=7) and 18 (n=7) and newborn animals at postnatal days 1 (n=5) and 3 (n=5) were divided into two groups: control and tunicamycin-treated. Combined Alcian blue and Periodic acid-Schiffsequences immunohistochemistry and immunoblotting were performed to determine glycosaminoglycan (GAG) accumulation and laminin expression in control and tunicamycin-treated embryonic and postnatal thymi. The apoptotic effect of tunicamycin was evaluated by TUNEL assay. RESULTS: In the control group acidic GAGs first appeared in medullary cells at postnatal day 3, whereas treatment with tunicamycin promoted the accumulation of acidic GAGs in all treated groups as of embryonic day 17. However, tunicamycin slightly decreased the laminin expression, and the number of apoptotic cells was considerably increased after tunicamycin treatment. CONCLUSION: Results suggest that carboxylated and acidic GAGs are two presumptive candidates to establish the thymic microenvironment during the late fetal development and postnatal periods of mice and that tunicamycin would be implicated in this establishment by increasing the acidic GAG accumulation and by reducing the laminin expression and the thymic stromal cell population. © Science Printers and Publishers, Inc.

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