Browsing by Author "Arslan O.A."

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    Congenital midline cervical cleft: A rare embryo pathogenic disorder
    (2002) Genç A.; Taneli C.; Arslan O.A.; Daǧlar Z.; Mir E.
    Congenital midline cervical cleft (CMCC) is a rare disorder of the ventral neck. The cleft consists of an epithelium-covered, longitudinal central depression with a protuberance at the cervical end. The adjacent skin is tethered by scar tissue forming a depression, which ends in a blind sinus at the caudal end. Although a variety of embryological mechanisms are proposed, its etiology is obscure. Up to the present time, fewer than 50 cases have been reported in the English literature. CMCC can be seen in association with several midline anomalies related to the branchial arches, including median cleft of the lower lip and mandible, and hypoplasia or absence of other midline neck structures. We present a 36-day-old boy with CMCC to illustrate its clinical presentation and the result at 24 months postoperatively. © Springer-Verlag 2002.
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    Histopathological evaluation of the urethra after the Snodgrass operation: An experimental study in rabbits
    (2002) Genç A.; Taneli C.; Günşar C.; Türkdoǧan P.; Yilmaz O.; Arslan O.A.; Mir E.
    Objective: To investigate the histopathological outcome of the incised urethral plate after tubularized incised-plate urethroplasty (the Snodgrass procedure to repair hypospadias) in a hypospadiac rabbit model, as it can produce meatal and neourethral strictures, and healing with scarring. Materials and methods: The study comprised 10 male New Zealand White rabbits (2.2-2.4 kg); under general anaesthesia the ventral urethra was completely excised 1 cm from the meatus proximally and a model of hypospadias formed. A full-thickness incision was then made in the distal dorsal urethra and the two sides of the incision marked by Indian ink tattooing. After placing a feeding tube (5 F) as a urethral catheter, both urethral wings were sutured ventrally by a 7/0 polydioxanone running suture, and the penile skin approximated by 5/0 chromic catgut. At 21 days and 3 months after surgery the penises were harvested. assessed histopathologically, and compared with those from control untreated rabbits of the same age and weight. Results: In the study group the incised area of the dorsal urethra was re-epithelialized; the regional tissue and vascularity were normal. Conclusion: In this rabbit model the dorsal urethral incisions healed with no scar tissue: only the ventral suture lines had minimal fibrosis and inflammatory reaction.
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    Urethral meatal dilatation using topical EMLA cream for anaesthesia [3]
    (Blackwell Publishing Ltd., 2003) Genç A.; Tekin I.; Taneli F.; Arslan O.A.; Taneli C.; Mir E.
    [No abstract available]
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    Does high-pressure carbon dioxide insufflation facilitate mucosal dissection in transanal endorectal pull-through? A rabbit model
    (2003) Genç A.; Taneli C.; Türkdoǧan P.; Yilmaz Ö.; Arslan O.A.; Mir E.
    The aim of the present study was to investigate whether high-pressure carbon dioxide insufflation facilitates mucosal dissection in the transanal endorectal pull-through (TEPT) operation performed in Hirschsprung's disease in a rabbit model. In the study, ten New Zealand rabbits were used. In six of the rabbits, CO2 under 50 mmHg pressure was insufflated into the submucosal area through a 25-gauge scalp needle inserted 0.3 cm over the dentate line. Two of the rabbits were taken for histopathological examination. In four rabbits, the TEPT operation was performed and in another four the operation was performed without CO2 insufflation. Histopathological examination in the CO2-insufflated group of rabbits showed that at transversal incisions mucosa was seen to be separated circumferentially from submucosa by high pressure CO2 and at longitudinal incision the separation was seen to be complete along the anal canal. It was noted that mucosal dissection was rapid, non-bloody and without induced mucosal tears or perforation; however, in the non-insufflated group the operation was time-consuming, bloody and more difficult to perform and needed meticulous care. In the present study, it was seen that submucosal high pressure CO2 insufflation in rabbits facilitates mucosal dissection in the TEPT operation and is easy to perform, time-saving and highly economical.
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    Modification of meatal advancement and glanuloplasty for correction of distal hypospadias
    (2004) Taneli C.; Genç A.; Günsar C.; Sencan A.; Arslan O.A.; Daglar Z.; Mir E.
    Objective: The meatal advancement and glanuloplasty (MAGPI) technique is still successfully used for the repair of distal hypospadias. The technique has been modified considerably since it was first described in 1981. The primary drawbacks of the procedure are the complications of meatal regression and meatal stenosis. The aim of this study was to present a modification of MAGPI for correction of distal hypospadias. Material and Methods: Ten cases with distal hypospadias were operated on using our modified MAGPI procedure. The modification involves excision of a pull-out, tag-shaped piece of glanular tissue through the vertical incision in the meatoplasty section of the original operation. By means of this excision, burying of the meatus into the glans was eased without inducing extra mobilization of the glans wings. As less glans tissue was left at the dorsal urethra the urethral meatus could be replaced in the center of the glans and better anatomic reconstruction could be attained. Results: After 1-3 years of follow-up, all the operated cases showed functionally and cosmetically satisfactory results. The cosmetic appearance achieved with our modified technique was better than that obtained with the classical MAGPI procedure. Conclusions: Using our MAGPI modification, the urethra was localized deeper in the glans and an elliptical (slit-like), wide meatus was obtained, the cosmetic appearance of which was more acceptable than that achieved with classical MAGPI.
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    The maturity of intestinal neomucosa: Integrin expression and ultrastructural aspects
    (2004) Günşar C.; Vatansever H.S.; Arslan O.A.; Şencan A.; Müftüoǧlu S.; Özbilgin K.; Kaymaz F.; Mir E.
    Background/purpose The maturity of neomucosa growing on a serosal surface for the treatment of short bowel syndrome still is questionable. The aim of this study was to evaluate the intestinal neomucosa to assess its histologic maturity. Methods A 6-cm-long isolated ileal segment (IS) was prepared in 8 Wistar albino-type rats. The IS was divided from the antimesenteric side, and 2 intestinal tubes were established, which shared a common wall and a common pedicle. After ileal biopsy sampling for the control group (CG), the IS was fashioned into a mucous fistula. Eight weeks later, all the rats were killed, and the ISs were investigated for neomucosal growth. Sections were prepared with periodic acid shift (PAS) and H & E staining for light microscopy. They also were evaluated by transmission electron microscopy. The microscopic morphology of the 2 groups was evaluated. Immunohistochemical staining was performed to show the expression of the tissue β1, α3 and α2β1 integrin subunits of both the neomucosa (NS) and control group (CG) segments. Results Sections of the NS showed a well-arranged columnar epithelial cell layer with goblet cells that were generally located superficially and with a complete basement membrane. Under the electron microscope, the sections from the NS group showed an epithelial cell layer with proper microvilli of the same height, although they were shorter than those of the CG, and tight intercellular junctions between the epithelial cells. Significant differences between the NS and CG groups were found in the measurements of villus width at base, microvillus surface, and microvillus height. The lamina propria consisted of rich collagen fibers and active fibroblasts in the NS group. In the immunohistochemical staining, although β1 integrine showed a dense distribution (+++) in the lamina propria, particularly localizing at the depth of the tunica mucosa layer, α3 integrin was observed to have a less dense immunoreactivity (++) in both groups. The expression of α2β1 integrin showed slight and dispersed (+) staining. Conclusions The NS showed histologic maturity and ultimate structural similarity with the native small bowel mucosa, which provides strong indirect evidence for the proper functioning of the neomucosa. © 2004 Elsevier Inc. All rights reserved.
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    Effect of adhesion barrier (Interceed TC7) on two-stage orchidopexy operation
    (2004) Genc A.; Taneli F.; Yilmaz O.; Turkdogan P.; Arslan O.A.; Sencan A.; Taneli C.
    Objective: In two-stage orchidopexy, adhesions formed after the first stage usually cause difficulty during the second operation and may even lead to injury to the testis itself or to the spermatic cord. We investigated whether the use of adhesion-preventing barriers in the abdominal or pelvic region during surgery could lessen adhesions formed during two-stage orchidopexy and thus ease dissection. Material and Methods: The study subjects comprised 21 male, albino, 30-day-old Wistar rats that were divided into three equal groups. In Group 1, the right testes were enveloped in adhesion barriers after dissection and sutured to the inguinal canal. In Group 2, the right testes were sutured to the inguinal canal without the barriers. In Group 3 (sham-operated group), all testes were dissected but no suturing was performed. Rats were sacrificed after 21 days and the ipsilateral testes were harvested. Results: Dissection of barrier-enveloped testes was relatively easy; however, no significant (p < 0.535) difference was seen in adhesion scores between Groups 1 and 2. Total tissue collagen was estimated by means of the hydroxyproline content. Tissue hydroxyproline levels were 16.04 ± 8.58, 13.20 ± 6.34 and 14.71 ± 5.51 μg/mg wet tissue in Groups 1-3, respectively and these differences were not significant. The histopathologic evaluation revealed significant differences only in the thickness of the tunica albuginea in Groups 1 and 2 (110.0 ± 30.0 vs 77.1 ± 21.3 μm, respectively; p < 0.038). Conclusion: The adhesion scores and the biochemical and histopathological examinations showed that an adhesion barrier is not beneficial in two-stage orchidopexy.
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    CHARGE association: Case report; [CHARGE birlikteliǧi: Olgu sunumu]
    (2005) Yilmaz Ö.; Arslan O.A.; Genç A.; Kücükoǧlu T.; Günşar C.; Şencan A.; Mir E.; Taneli C.
    CHARGE association is a combination of a number of related birth defects and acronyme of the first letter of each defect. A 5-year-old male admitted to our hospital with complaint of passing urine through a stenotic hypospadic meatus. Physical examination showed that his weight was 10-20th percentiles and his height was 10-20th percentiles. He had a left sided bad ear. Ophthalmologic examination revealed microphthalmia, iris coloboma, choroid coloboma and lens coloboma of both eyes. External genital examination revealed a coronal hypospadias and a ventral chordee. His mental development was found 3.5 years in social, 4 years in motor skills. An urethroplasty was performed by the Snodgrass technique. Four of the 7 components of the CHARGE association were present in present case.