Browsing by Author "Arslan S."

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    The role of virulent Helicobacter pylori strains in the etiopathogenesis of coronary artery disease; [Virulan Helicobacter pylori suslarinin koroner arter hastaligi etyopatogenezindeki rolu]
    (1999) Yuceyar H.; Saruc M.; Arslan S.; Goksel G.; Ozbakkaloglu B.; Uyanik B.S.; Yigitoglu R.; Sengil A.Z.
    Epidemiological studies have shown a positive correlation between coronary artery disease (CAD) and gastric Helicobacter pylori (H. pylori) infection. The possible mechanism by which H. pylori could increase the risk of CAD is chronic inflammation. More virulent H. pylori strains bearing the cytotoxin associated gene-A (CagA) can induce much more inflammation than CagA negative strains. The aim of our study was to assess the role of virulent H. pylori strains and inflammatory response in the pathogenesis of CAD. We studied 30 patients with CAD, age and sex being matched with 30 controls of similar social class. We determined the presence of H. pylori infection by rapid urease test, histology and serology (anti-H. pylori IgG). CagA status, serum tumor necrosis factor-alpha (TNF-α), gastrin and fibrinogen levels were also studied. The presence of H. pylori infection was statistically equal in CAD group (93.3%) and controls (86.6%)(p = 0.705). Serum CagA titers were 28.13 ± 9.21 U and 18.32 ± 5.8 U in the CAD and control group respectively. Serum TNF-α levels were 15.21 ± 4.30 pg/ml in the CAD group and 5.36 ± 2.41 pg/ml in the control group. Serum CagA and TNF-α levels showed a significant difference between the two groups (p = 0.000). Patients with CAD had a higher prevalence of CagA-positive strains than controls (67.8% versus 42.3%; p = 0.021). The serum gastrin level was higher in CAD but there was no significant difference between two groups (p = 0.379). Fibrinogen levels of the CAD group were significantly higher than those of the control (370 ± 51 mg/ml and 247 ± 43 mg/ml, p = 0.001). Further more, numbers of occluded vessels in CAD patients were positively correlated with both cagA positivity and TNF-α levels. In conclusion, CagA bearing strains of H. pylori may increase the risk of CAD by inducing chronic inflammation and increasing the expression of cytokines and procoagulant substance.
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    Investigation of hand hygiene knowledge level of physiotherapy and rehabilitation students
    (A. CARBONE Editore, 2018) Ilgin D.; Karaali H.K.; Ozcan O.; Arslan S.; Arslan T.; Gunduz T.; Limoncu M.E.
    Introduction: Increasing health care students' awareness about the hand hygiene (HH) during the pre-graduation period becomes an important requirement for providing both patient's safety and the healthcare student's safety by preventing healthcare associated infections (HCAIs). Although it has been emphasized that rehabilitation clinics are important places to be taken into consideration in the transmission of HCAIs, the number of studies about the students from department of physiotherapy and rehabilitation (DPR) are limited. Thus, our research was done to examine the HH knowledge level of students of DPR. Materials and methods: This cross-sectional study was done by 191 volunteers from a total of 209 first and second-year students. We recorded the sociodemographic characteristics. Based on the suggestions commented in the Center for Disease Control and Prevention Guideline for HH in Health Care Settings, HH knowledge levels were assessed using face to face interview technique. Results: The average correct answer rate to the questions about the HH knowledge level was 69.49%. The level of knowledge about the importance of HH was good, but the correct response rates for terminology and alcohol-based handrub were less than 50%. Conclusions: Since DPR students form an important ring in the therapy chain, so in the development of educational programs for the students of DPR, it is very important to improve their knowledge level especially about terminology and alcohol-based handrub techniques. © 2018 A. CARBONE Editore.