Browsing by Author "Ascibasi, K"

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    The Relationship Between Schizophrenia and Cavum Septum Pellucidum: A Case Study
    Ascibasi, K; Aydin, O; Kuzu, D; Deveci, A
    Septum pellucidum that forming the medial wall of the lateral ventricles, a thin layer is formed by two laminae. Cavum septum pellucidum (CSP), a space between the two leaflets of the septi pellucidi, is thought to be a neurodevelopmental anomaly associated with schizophrenia. In normal fetal development, the formation of septum pellucidum occurs at the same time with the development of the neighboring limbic system structures such as hippocampus, amygdala, corpus callosum, septal nucleus. Therefore, the anatomical differences that are detected in the septum pellucidum may reflect the embryonal development disorders of the adjacent anatomical structures. Several magnetic resonance imaging studies have reported a higher prevalence of enlarged CSP in patients with schizophrenia than in normal subjects. In the literature of psychiatric disorders, CSP is most associated with schizophrenia. Wide CSP may support the neurodevelopmental etiology of schizophrenia. In this report we present a schizophrenia case. And we tried to discuss the patient's clinical appearance and neurocognitive disability.
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    Attitudes of Resident Physicians Working in a University Hospital Towards Schizophrenia
    Taskin, EO; Ascibasi, K; Cokmus, FP; Özmen, E
    Objective: To evaluate the attitudes of resident physicians working in a university hospital (future specialists) towards schizophrenia. Methods: The data of 170 resident physicians who completed the questionnaires in full were included in the research. The data collection procedure was completed in 6 months by two resident psychiatrists using the sealed envelope method for the questionnaires (an 11-item socio-demographic and an 8-item professional information form and a 32-item attitude towards schizophrenia survey that was prepared by the Psychiatric Research and Training Center). The effect of the sociodemographic and occupational variables on the responses to the questionnaire items was tested using logistic regression analysis. Results: The mean age of the participants was 28.07 +/- 2.40 (min=24-max=42) years. Approximately 98.8% (n=168) described schizophrenia as a 'disorder' and 78.2% (n=133) as a 'psychiatric disorder.' Some 64.1% (n=109) of the participants stated that schizophrenia was a congenital disease, 81.2% (n=138) said it was a curable disease, 85.9% (n=145) though that it could be treated with medication, 60% (n=102) believed that the medications used for treating schizophrenia would cause dependence, and 81.8% (n=139) stated that the medications used would involve serious adverse effects. Nearly 70.6% (n=120) of the participants stated that they could work with someone with schizophrenia and 45.9% (n=78) said that they could marry someone with schizophrenia. The presence of psychiatric diagnoses in a close friend (social acceptance of patients) was found to be an influential variable. Conclusions: The resident physicians had high-level knowledge of schizophrenia as a psychiatric disorder, but their knowledge on the effects and adverse effects of the medication was insufficient or incorrect. The sample's social acceptance of patients was generally good, despite putting social distance in situations requiring more personal intimacy. Based on these results, to treat schizophrenia more successfully, we need to either revise psychiatry curriculum in medical education or provide targeted skill training for non-psychiatric physicians in order to adopt more positive attitudes towards patients with schizophrenia and refer them appropriately to psychiatrists when needed.
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    Evaluation of psychosocial functioning in the acute treatment term of major depressive disorder: A 16-week multi-centered follow-up study
    Altunsoy, N; Dikici, DS; Cökmüs, FP; Özkan, HM; Ascibasi, K; Alçi, D; Kuru, E; Yüzeren, S; Aydemir, O
    Objective: Major depressive disorder is the leading cause of non-fatal burden, and disability in adulthood. Even though depression is well-treated in the acute term,psychosocial functioning does not get back to the premorbid level most of the time. In this present study, it is aimed to evaluate the outcome of the acute term treatment of major depressive disorder in terms of psychosocial functioning. Methods: The study is an open-label, observational, multi-center follow-up study for four months of patients with major depressive disorder according to DSM-5. Patients were evaluated with Montgomery Asberg Depression Rating Scale (MADRS), Sheehan Disability Scale (SDS) and Short Form-36 (SF-36) at the beginning, and at the 2., 4., 8., 12. and 16.weeks. Results: 100 patients were invited to the study and 56 patients completed the study.As a result of the treatment, the mean MADRS and SDS scores decreased significantly. All domains of SF-36 were improved significantly with the treatment. Unfortunately patients suffering from MDD could not reach the normative data,especially on the domains of social functioning, role emotional, pain, and general health perception. Treatment outcomes show that SNRI users presented higher scores on the domains of pain and physical functioning. However SSRI users showed better outcomes on the domains of mental health and vitality. Conclusion: Our research corroborated that even patients gain symptomatic remission in MDD treatment, psychosocial dysfunction persists. It is also concluded that different antidepressant options may act differently on treatment outcomes.
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    Evaluation of Emotional Adverse Effects of Antidepressants A Follow-up Study
    Ascibasi, K; Cökmüs, FP; Dikici, DS; Özkan, HM; Alçi, D; Altunsoy, N; Kuru, E; Yüzeren, S; Aydemir, Ö
    Purpose/Background Emotional adverse effects due to antidepressant use may cause difficulties for the clinician in the treatment of depression. In this prospective study, the emotional adverse effects of antidepressants were evaluated in various aspects. Methods/Procedures Ninety eight patients diagnosed with major depressive disorder were included in the study. At 2nd, 4th, 8th, 12th, and 16th weeks, patients were assessed with Montgomery-Asberg Depression Rating Scale (MADRS), and the antidepressant dose was increased in patients with less than a 50% reduction at each visit compared with the initial MADRS score. The Oxford Questionnaire on the Emotional Side-effects of Antidepressants (OQESA) was used at the 8th-week and 16th-week visits. Findings/Results A significant difference is found in the OQESA score at the 8th-week visit compared with the 16th-week assessment (P < 0.001, t = 5.73). There were significant correlations between MADRS scores and OQESA scores both at the 8th (r = 0.346, P = 0.05) and the 16th (r = 0.490, P < 0.001) weeks. In regression analyses, at eighth-week assessment, MADRS score (B = 1.487, P = 0.002) and selective serotonin reuptake inhibitor use (B = 14.014, P = 0.023) had a significantly predicted OQESA score. Implications/Conclusions In this study, it is found that, as the rate of remitted patients is increased, OQESA scores get decreased, and furthermore, the OQESA score of the remitted group is statistically low when compared with that of the nonremitted group at the 8th- and 16th-week visits. Oxford Questionnaire on the Emotional Side-effects of Antidepressants and MADRS scores are significantly correlated in all assessments. These results suggest that the score obtained from OQESA may be related not only to the emotional adverse effects of antidepressants but also to the residual symptoms of depression.
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    Evaluation of psychosocial and neurocognitive functioning in the acute treatment term of major depressive disorder: preliminary results
    Alci, DK; Cokmus, FP; Altunsoy, N; Ascibasi, K; Ozkan, HM; Dikici, DS; Yuzeren, S; Aydemir, O