Browsing by Author "Aslan, GG"

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    Therapeutic and protective effects of autologous serum in amikacin-induced ototoxicity
    Arslan, IB; Aslan, GG; Mercan, GC; Vatansever, S; Cukurova, I; Gokalp, S; Aslan, A
    Objective: Possible therapeutic and protective benefits of intratympanic autologous serum application in amikacin-induced ototoxicity were investigated. Methods: Twenty-four guinea pigs were separated equally into two groups: therapeutic (group A) and protective (group B). Transient evoked otoacoustic emissions were recorded before and after autologous serum application. Apoptotic cells were identified in the organ of Corti, spiral limbus and spiral ganglion by the terminal deoxynucleotidyl transferase-mediated dUTP nick-end labelling ('TUNEL') method. Results: Transient evoked otoacoustic emission responses at 1, 1.4 and 2.8 kHz improved without significance after autologous serum application in group A (p > 0.05). A significantly protective effect of autologous serum was determined at 4 kHz in group B (p < 0.05). There were significantly fewer apoptotic cells at the spiral limbus in the therapeutic and protective groups compared to the control group (p < 0.05). Conclusion: Autologous serum may offer protection against ototoxicity-induced hearing loss, but it cannot restore hearing. Immunohistochemically, autologous serum significantly decreases activation of the intrinsic pathway of pro-apoptotic signalling in mesenchymal cells compared to neurons and neurosensory cells.
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    Transmastoid exposure of the labyrinthine segment of the facial nerve: an anatomical study*,**
    Aslan, GG; Aslan, A; Surucu, S
    Introduction: Compression of the labyrinthine segment of the facial nerve by edema has been considered as an important pathology in the majority of the cases of idiopathic facial nerve paralysis. Hence, it is suggested that total decompression of the facial nerve should also include the labyrinthine segment by a middle fossa approach. However, the middle fossa approach requires craniotomy and temporal lobe retraction, which increases the morbidity. The labyrinthine segment of the facial nerve can also be reached through mastoidectomy. How-ever, many ear surgeons are not familiar with this approach due to the lack of anatomical data on this surgical area.Objective: To study the anatomical limitations of decompression of the labyrinthine segment via transmastoid approach.Methods: Complete mastoidectomy was performed in six adult cadavers heads. Dissection was extended in the zygomatic root and posterior bony wall of the external auditory canal to visu-alize the incudomallear joint completely. The bone between tympanic segment, lateral and superior semicircular canal's ampullas and middle fossa dural plate was removed. Fine dis-section was carried out over tympanic segment of the facial nerve in an anterosuperomedial direction the labyrinthine segment was reached.Results: All the mastoids were well pneumatized. Distances between the labyrinthine segment and middle fossa dura, and between the labyrinthine segment and superior semicircular canal, were 2.5 and 4.5 mm on average, respectively. In addition, distances between the middle fossa dura and dome of the lateral semicircular canal, and between the middle fossa dura and tympanic segment were 4.6 mm and 4.3 mm on average, respectively.Conclusion: It is possible to expose the labyrinthine segment of the facial nerve through mas-toidectomy by dissecting the bone in the area between the tympanic segment of the facial nerve, middle fossa dural plate and ampullary ends of the lateral and superior semicircular canals.(c) 2021 Associacao Brasileira de Otorrinolaringologia e Cirurgia Cervico-Facial. Published by Elsevier Editora Ltda. This is an open access article under the CC BY license (http:// creativecommons.org/licenses/by/4.0/).
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    Spectrum of Symptoms in Motion Sickness
    Aslan, GG; Songu, M; Aslan, A
    Objective: To search and report extraordinary symptoms of motion sickness (MS) which have not been classically described. Study Design: Prospective study. Setting: Tertiary referral center + state hospital Patients: Thiry-four MS patients were included in the study. Of these, 32 were female and 2 were male. Intervention(s): No Main Outcome Measures: All patients were asked to fillout a questionaire by face to face conversation for their symptoms. Severity of MS symptoms in general were assessed by visual analog scale. In addition, factors precipitating MS symptoms were also searched. Results: All patients reported to have nausea. In addition to classical knowledge, atypical symptoms decleared by the patients were intolerance to smell, feeling of nausea in the head, intolerance to sound and difficulty in concentrating on conversation. Average VAS score for severity of MS symptoms was found to be 7.3. Relaxing of the symptoms when the eyes were closed was noted as an important feature. Sixteen (47%) reported no symptoms of MS while driving a car. The most important factors leading to the beginning of MS symptoms were curving road, reading, head movements, talking, and the smell of gasoline, respectively. Conclusion: The clinical picture of acute MS may include the symptoms other than the classical symptoms like dizziness, nausea, pallor, cold sweating etc.
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    Comparison of tympanometric volume measurement with temporal bone CT findings in the assessment of mastoid bone pneumatization in chronic otitis media patients
    Aslan, GG; Aghayarov, OY; Pekçevik, Y; Arslan, IB; Çukurova, I; Aslan, A
    OBJECTIVE: Since mastoid bone aeration is a pressure buffer for the middle ear, it can be accepted as a prognostic factor for tympanoplasty. Temporal bone computed tomography (TBCT) is a primary method for estimating mastoid aeration. However, due to the risk of radiation and its high cost, there is a need for a more straightforward, faster, and more reliable method in non-complicated chronic otitis media cases (COM). Tympanometric volume measurement might be used for this purpose. This study investigated tympanometric volume measurement's reliability in showing mastoid bone aeration by comparing tympanometric volume measurement with TBCT aeration grading. PATIENTS AND METHODS: Preoperative tympanometric volume measurements were performed in patients who underwent audiological examination and temporal computerized tomography (CT) with the diagnosis of COM and sequela of COM without discharge for the last three months and were indicated for surgery. CT was classified into six grades: grade 0: there is no aeration, sclerotic mastoid; grade 1: pneumatization only in the mastoid antrum; grade 2: <25% pneumatization; grade 3: 25-50% pneumatization; grade 4: >50 pneumatization, grade 5: full pneumatization. Averages of tympanometric volume values were determined according to CT degrees. RESULTS: 48 left and 52 right ears (n: 100) of 81 patients, 24 females and 57 males, were included in the study. The mean age was 37.69 +/- 13.38. Mastoid pneumatization grades of patients were 32 grade 0, 23 grade 1, 16 grade 2, 14 grade 3, 11 grade 4, and 4 grade 5, respectively. Each grade's mean tympanometric volume (mL) was grade 0: 1.1594, grade 1: 1.6991, grade 2: 2.2250, grade 3: 3.0471, grade 4: 4.0327, and grade 5: 2.9775. CONCLUSIONS: There is a statistically significant relationship between tympanometrically measured ear volume and mastoid degrees of pneumatization on temporal bone tomography. As the degree of mastoid aeration increases, the tympanometric volume also increases. According to the results of this study, tympanometric air volume can be used reliably in the preoperative evaluation of mastoid bone aeration in cases of simple COM without ear drainage.
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    Effect of thermal energy produced by drilling on the facial nerve: histopathologic evaluation in guinea pigs
    Aslan, A; Vatansever, HS; Aslan, GG; Eskiizmir, G; Giray, G
    The effect of thermal energy due to drilling around the facial nerve canal on the facial nerve was histopathologically evaluated in four guinea pigs. The bony canal of the facial nerve was drilled using a 3-mm diamond burr for one minute. The temperature changes on the facial nerve canal were noted before and after dissection. The temporal bones of the animals were histopathologically examined under light microscopy using haematoxylin & eosin (H&E) and solochrome cyanine staining for myelin, and immunohistochemical staining for neuronal nitric; oxide synthase (nNOS). Compared to the control group, it was observed with H&E staining that there was oedema among the axonal fibres and with solochrome cyanine staining that the thickness of the myelin fibres was decreased, and that the severity and extent of nNOS activity was decreased in the axonal fibres. It was concluded that a temperature increase on the facial canal may potentially lead to inflammation of the nerve, and may also cause deterioration of nerve conduction to some extent.
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    Considerations of isolated destruction of the short process of the incus in a case of cholesteatoma
    Aslan, A; Aslan, GG
    Cholesteatoma occurs frequently with the destruction of the ossicles. The most commonly eroded ossicle has been reported to be the incus. Many studies report destruction of the long process and body of the incus. However, isolated erosion of the short process of the incus is an unusual finding. We present such a case with a slight conductive hearing loss that remained unchanged at 2 1/2 years postoperatively. The short process of the incus may contribute to hearing up to 10-15 dB. It is also possible that it plays a role in epitympanic aeration by supplying an attachment surface to the incudal folds.
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    Turkish nurses' perceptions of spirituality and spiritual care
    Ozbasaran, F; Ergul, S; Temel, AB; Aslan, GG; Coban, A
    Aim. To explore Turkish nurses' perceptions of spirituality and spiritual care and to investigate the relationship between their perceptions and their demographic/independent variables. Background. Nurses' perception of spirituality can directly affect how they behave, deal with their patients and communicate with them in regard to the provision of spiritual care. Design. Survey. Methods. This study employed a convenience sample of 348 staff nurses from the public hospitals in the west of Turkey. The data were collected with two tools; a 'sociodemographic data form' and the 'Spirituality and Spiritual Care Rating Scale' (SSCRS). The response rate was 92% (n = 319). Results. The mean age of the nurses was 31.70 (SD 6.34) years and 22.9% of them had a Bachelor's degree. Among the nurses, 54.98% had >= 11 years of clinical experience. The mean score for the SSCRS was 3.21 (SD 0.63) which indicated that nurses' perceptions concerning spirituality and spiritual care were 'uncertain' or 'less clearly' defined. Significant differences were found between nurses' perceptions of spirituality and spiritual care and their ages (p < 0.05), marital status (p < 0.05) and education levels (p < 0 01). Conclusion. The research findings suggest that Turkish nurses' perceptions were indecisive and inconclusive. Nurses' educational level, belief in the evil eye and department of employment appeared to have a positive impact on their perception of spirituality and spiritual care. Relevance to clinical practice. These findings will enable nurses to consider the importance of spirituality and spiritual care. Grasping these concepts will enable nurses to become more sensitive in their daily practices of spiritual care.