Browsing by Author "Aslan S."
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Item Advanced oxidation protein products, ferrous oxidation in xylenol orange, and malondialdehyde levels in thyroid cancer(2007) Kosova F.; Çetin B.; Akinci M.; Aslan S.; Ari Z.; Sepici A.; Altan N.; Çetin A.Aims and Background: The oxidation of protein plays an essential role in the pathogenesis of an important number of degenerative and cancer diseases, which is now widely recognized. The aim is to examine advanced oxidation protein products (AOPPs), lipid peroxidation products malondialdehyde (MDA), and ferrous oxidation in xylenol orange (FOX) in blood samples of papillary thyroid cancer patients compared with healthy controls to determine the oxidation status and the change after thyroidectomy. Methods: Thirty-five female thyroid cancer patients who underwent total thyroidectomy and 39 female control subjects were included into this study. Prethyroidectomy and postthyroidectomy, AOPP, FOX, and MDA levels were studied. Results: Prethyroidectomy AOPP, FOX, and MDA levels were significantly higher compared to control (P < .05). In postthyroidectomy AOPP, FOX, and MDA levels were significantly decreased compared with prethyroidectomy levels (P < .05). However, postthyroidectomy levels on the 20th day were still significantly higher, compared to control subjects (P < .05). Conclusion: In conclusion, all of AOPP, FOX, and MDA levels that are markers of protein oxidation and lipid hyperoxidation may induce thyroid cancer development and begin to decrease after thyroidectomy. © 2007 Society of Surgical Oncology.Item Oxidant/antioxidant balance in patients with thyroid cancer(2008) Akinci M.; Kosova F.; Çetin B.; Sepici A.; Altan N.; Aslan S.; Çetin A.Purpose: To compare the antioxidant enzyme activities of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and the levels of lipid peroxidation product malondialdehyde (MDA) in blood samples of thyroid cancer patients compared to healthy controls. Methods: 43 control subjects (mean age 44±13 years) and 43 patients (43±13 years) presented with multinodular goiter whose fine needle aspiration revealed malignant cytology were included into this study. The SOD, MDA and GSH-Px activities were measured in control subjects, and before/20 days after thyroidectomy in thyroid cancer patients. Results: SOD activities of pre-thyroidectomy, post-thyroidectomy and control groups were not different (p<0.05). Before thyroidectomy GSH-Px activities were lower (p<0.05) and MDA levels were higher (p<0.05) than the control group. In post- thyroidectomy, GSH-Px activity (p<0.05) increased, and MDA levels (p<0.05) decreased compared to prethyroidectomy levels. After thyroidectomy GSH-Px activity was significantly higher than the control group (p<0.05). Although post-thyroidectomy MDA levels significantly decreased, they were still higher than the control group (p<0.05). Conclusion: The superoxide dismutase does not seem to change with thyroid cancer and thyroidectomy but both antioxidant glutathione peroxidase and lipid peroxidation product malondialdehyde do. These preliminary findings may point out oxidant/antioxidant imbalance associated with thyroid cancer.Item Leptin levels in thyroid cancer(Elsevier (Singapore) Pte Ltd, 2009) Akinci M.; Kosova F.; Cetin B.; Aslan S.; Ari Z.; Cetin A.BACKGROUND: Leptin has physiological roles in multiple systems, and has possible effects on several carcinogenesis steps. The aim of this study was to investigate the leptin levels in thyroid papillary carcinoma (TPC) patients. METHODS: Forty-three female TPC patients and 30 healthy female control subjects were recruited for the study. TPC was diagnosed by fine needle aspiration biopsy. TPC patients had a bilateral total thyroidectomy operation and their leptin levels were measured before and 20 days after the operation. RESULTS: Serum leptin levels of TPC patients were higher than in control group subjects (21.15 ± 14.12 ng/mL vs. 9.89 ±0.21 ng/mL, p< 0.05). The leptin levels decreased after total thyroidectomy (13.92 ± 10.55 ng/mL) compared to prethyroidectomy levels (22.94 ± 14.67 ng/mL) in 34 patients who came to the follow-up visit (p< 0.05). However, the decreased post-thyroidectomy levels of leptin were still statistically significantly higher than the control group levels. Multivariate regression analysis showed that the leptin levels in TPC patients were not related to age, menopausal status or pathologic occult status but were directly related to the cancer group. CONCLUSION: Leptin levels were elevated in thyroid cancer, decreased after total thyroidectomy, and might be associated with thyroid papillary carcinogenesis. © 2009 Elsevier. All rights reserved.Item Relationship of sleep quality and quality of life in children with monosymptomatic enuresis(2009) Ertan P.; Yilmaz O.; Caglayan M.; Sogut A.; Aslan S.; Yuksel H.Background: Health-related quality of life (QoL) in children with monosymptomatic nocturnal enuresis might be influenced by impaired quality of sleep. The aim of this study was to evaluate possible deteriorations in QoL and sleep quality and the association between these parameters in children with monosymptomatic nocturnal enuresis. Methods: The study consisted of 44 children with monosymptomatic nocturnal enuresis and 27 healthy controls aged 6-15 years. KINDL QoL and Pittsburgh Sleep Quality Index (PSQI) were applied to all children. Results: Mean total KINDL scores in enuresis and control groups were 65.1 ± 11.0 vs. 67.4 ± 13.7, respectively (P = 0.44). PSQI scores were not significantly different between the groups (P > 0.05l). In the enuresis group, age showed significant negative correlation with self-esteem domain of KINDL (r = -0.39, P = 0.01) and positive correlation with sleep duration sub-score of the PSQI (r = 0.37, P = 0.03). Duration of enuresis showed significantly negative correlation with total KINDL score and self-esteem domain (r = -0.32 and r = -0.39, P = 0.04 and P = 0.01, respectively). There was significant correlation between physical well-being sub-score of KINDL with daytime dysfunction and total scores of PSQI (r = -0.53, P = 0.001 and r = -0.41, P = 0.02, respectively). Daytime dysfunction sub-score of PSQI was significantly correlated with friends sub-score of KINDL (r = -0.33, P = 0.04). Conclusions: As age of the child and duration of enuresis increase, self-esteem domain of QoL worsens. Moreover, there is a significant correlation of physical well-being and friends domains of QoL score and total and daytime dysfunction scores of PSQI. These findings necessitate global evaluation of QoL and sleep quality in children with monosymptomatic nocturnal enuresis to increase efficacy of health care. © 2009 Blackwell Publishing Ltd.Item Vitamin D receptor gene polymorphism in children with urinary tract infection(2012) Aslan S.; Akil I.; Aslan G.; Onay H.; Ozyurt B.C.; Ozkinay F.It is known that small alterations leading to different vitamin D receptor (VDR) alleles affect resistance or susceptibility to infections. In this study, we examined VDR gene polymorphisms in urinary tract infections (UTI), which are common and an important cause of morbidity in children and subsequently of renal scar formation. We evaluated 92 patients diagnosed with UTI and 105 children without prior history of UTI as a control group. The VDR gene polymorphisms BsmI, FokI, ApaI, and TaqI were evaluated in patients and controls. BsmI polymorphism genotype distribution was similar between groups. There was a significant difference between groups for FokI (p=0<001); for the ff genotype, the risk of UTI was significantly increased (p<0.01) ,at 3.94 times higher (odds ratio=3.94; 95% confidence interval 1.71-9.09). ApaI polymorphism was significantly increased in the control group (p<0.01) and evaluated as a protective factor. Comparing the TaqI genotype between groups, there was no statistically significant difference, but in both Tt and tt genotypes, there was minimal increased risk of UTI. The results of this study suggest that VDR gene polymorphisms can be important for susceptibility to UTI and renal scar formation. Association between VDR polymorphisms and UTI is in accordance with the understanding of how vitamin D modulates the immune response against infections. © IPNA 2011.Item Serum copper levels in benign and malignant thyroid diseases(2012) Kosova F.; Cetin B.; Akinci M.; Aslan S.; Seki A.; Pirhan Y.; Ari Z.Objective: To examine the changes in serum copper (Cu) levels in benign and malignant thyroid disease in humans. Background: Thyroid hormones influence the metabolism of trace elements including copper. Methods: 47 papillary thyroid cancer and 43 benign multinodular goitre patients who underwent total thyroidectomy and 37 healthy control subjects were included into this study. All of the patients and controls were females. Serum Cu levels were detected with atomic absorption spectrophotometer. Results: In the papillary thyroid cancer group serum level of Cu was 131.61±33.9 μg/dL before surgery and 120.81±30.4 μg/dL after 20 days from surgery. In the benign group serum Cu level was 84.75±12.1 μg/dL and 68.01±9.4 μg/dL postoperatively. These results were compared to healthy control's value of 105.87±10.68 μg/dL. In the papillary thyroid cancer group pre- and postoperative serum Cu level was significantly higher when compared to control group (p<0.05). Postoperative serum Cu level significantly decreased when compared to pre-operative level(p<0.05), in which, it was still higher than the control(p<0.05). In the benign group pre- and postoperative serum Cu level was significantly lower than in the control group (p<0.05). Postoperative serum Cu level significantly decreased when compared to pre-operative level in the benign group (p<0.05). Conclusion: This is a pioneer study to examine serum Cu level in benign and malignant thyroid patients compared to controls. In our small groups serum Cu levels increased in malignant thyroid patients and decreased in the benign group.Item Some Kannan type fixed point results in rectangular soft metric space and an application of fixed point for thermal science problem(Serbian Society of Heat Transfer Engineers, 2019) Oztunc S.; Mutlu A.; Aslan S.The intention of current study to survey Kannan type mappings for rectangular soft metric space. Some Kannan type results are obtained by using rectangular soft metric and an application for thermal science problem is presented. © 2019 Society of Thermal Engineers of Serbia.Item Jungck type fixed point results for weakly compatible mappings in a rectangular soft metric space(Springer International Publishing, 2019) Öztunç S.; Aslan S.The main objectives of the current study are to explore and to express the proof of some common fixed point theorems by using commuting maps in rectangular soft metric spaces. We obtain some common fixed point results by utilization of rectangular soft metric and scalar-valued parametric functions. © 2019, The Author(s).Item Categorical structures of soft groups(Springer Science and Business Media Deutschland GmbH, 2021) Öztunç S.; Aslan S.; Dutta H.In the current paper, the category of soft groups and soft group homomorphisms is constructed and it is proved that this structure satisfies the category conditions. Also, algebraic properties of some types of soft group morphisms are obtained. Finally, an application is presented as ‘cube’ of soft groups and soft group homomorphisms. © 2020, Springer-Verlag GmbH Germany, part of Springer Nature.Item Evaluation of abdominal computed tomography findings in patients with COVID-19: a multicenter study(Galenos Publishing House, 2023) Onur M.R.; Özbay Y.; İdilman İ.; Karaosmanoğlu A.D.; Ramadan S.U.; Barlık F.; Aydın S.; Odaman H.; Altay C.; Akın I.B.; Dicle O.; Appak Ö.; Gülpınar B.; Erden A.; Kula S.; Çoruh A.G.; Öz D.K.; Kul M.; Uzun Ç.; Karavaş E.; Levent A.; Artaş H.; Eryeşil H.; Solmaz O.; Kaygusuz T.Ö.; Faraşat M.; Kale A.B.; Düzgün F.; Pekindil G.; Apaydın F.D.; Duce M.N.; Balcı Y.; Esen K.; Kahraman A.S.; Karaca L.; Özdemir Z.M.; Kahraman B.; Tosun M.; Nural M.S.; Çamlıdağ İ.; Onar M.A.; Ballı K.; Güler E.; Harman M.; Elmas N.Z.; Öztürk C.; Güngör Ö.; Herek D.; Yağcı A.B.; Erol C.; Şeker M.; İşlek İ.; Can Y.; Aslan S.; Bilgili M.Y.K.; Göncüoğlu A.; Keleş H.; Bekin Sarıkaya P.Z.; Bakır B.; Dağoğlu Kartal M.G.; Durak G.; Oğuzdoğan G.Y.; Alper F.; Yalçın A.; Gürel S.; Alan B.; Gündoğdu E.; Aydın N.; Cansu A.; Kuş C.C.; Tuncer E.O.; Pişkin F.C.; Çolakoğlu Er H.; Değirmenci B.; Özmen M.N.; Kantarcı M.; Karçaaltıncaba M.PURPOSE To evaluate the frequency of abdominal computed tomography (CT) findings in patients with coronavirus disease-2019 (COVID-19) and interrogate the relationship between abdominal CT findings and patient demographic features, clinical findings, and laboratory test results as well as the CT atherosclerosis score in the abdominal aorta. METHODS This study was designed as a multicenter retrospective study. The abdominal CT findings of 1.181 patients with positive abdominal symptoms from 26 tertiary medical centers with a positive polymerase chain-reaction test for severe acute respiratory syndrome coronavirus 2 were reviewed. The frequency of ischemic and non-ischemic CT findings as well as the association between CT findings, clinical features, and abdominal aortic calcific atherosclerosis score (AA-CAS) were recorded. RESULTS Ischemic and non-ischemic abdominal CT findings were detected in 240 (20.3%) and 328 (27.7%) patients, respectively. In 147 patients (12.4%), intra-abdominal malignancy was present. The most frequent ischemic abdominal CT findings were bowel wall thickening (n = 120; 10.2%) and perivascular infiltration (n = 40; 3.4%). As for non-ischemic findings, colitis (n = 91; 7.7%) and small bowel inflammation (n = 73; 6.2%) constituted the most frequent disease processes. The duration of hospital stay was found to be higher in patients with abdominal CT findings than in patients without any positive findings (13.8 ± 13 vs. 10.4 ± 12.8 days, P < 0.001). The frequency of abdominal CT findings was significantly higher in patients who did not survive the infection than in patients who were discharged after recovery (41.7% vs. 27.4%, P < 0.001). Increased AA-CAS was found to be associated with a higher risk of ischemic conditions in abdominal CT examinations. CONCLUSION Abdominal symptoms in patients with COVID-19 are usually associated with positive CT findings. The presence of ischemic findings on CT correlates with poor COVID-19 outcomes. A high AA-CAS is associated with abdominal ischemic findings in patients with COVID-19. © 2023, Galenos Publishing House. All rights reserved.