Browsing by Author "Ateşçi Y.Z."

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    Testicular sperm retrieval method: Histological effects of location of incision
    (2007) Gümüs B.H.; Ateşçi Y.Z.; Ucer O.; Karatas T.C.; Buyuksu C.; Nese N.; Kandiloglu A.R.
    This research was conducted to evaluate the effects of a transverse vs. longitudinal incision for testicular sperm retrieval. Rats were divided into 4 groups: I: control, II: sham operation, III: longitudinal incision TSRM, IV: transverse incision TSRM. Group II (sham operation) had a dissection of left testis/spermatic cord, then closure of wound. Group III underwent dissection of left testis, then a "longitudinal" incision (15 mm long) of testis, which was fully opened then closed again and sutured with 5-0 Vicryl® sutures. Group IV underwent dissection of the left testis, opening of the testis with a "transverse" incision, then closure with 5-0 Vicryl®. The seminiferous tubule diameter was 0.118-0.224 mm in all groups. Inflammation and abscess formation occurred in one testis each in the sham and longitudinal incision groups, and in two testes in the transverse incision group. There were no differences in histopathology or scoring between the longitudinal and the transverse incision. Copyright © Informa Healthcare.
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    Comparison of audiovisual sexual stimulation test with nocturnal penile tumescence test in the evaluation of erectile dysfunction by using RigiScan; [RigiScan ile erektil disfonksiyonun deǧerlendirilmesinde nokturnal penil tümesans testi ile vizüel seksüel stimülasyon testinin karşılaştırılması]
    (AVES, 2010) Incirci M.; Üçer O.; Karataş T.C.; Ateşçi Y.Z.; Gümüş B.
    Objective: Nocturnal penile tumescence (NPT) test is a time-consuming, cumbersome, and relatively expensive method which is used for the diagnosis of erectile dysfunction (ED). The aims of the study were to clarify the relationship between erotic and nocturnal erections and to evaluate the diagnostic efficacy of the audiovisual sexual stimulation (AVSS) test with and without medication. Materials and methods: A total of 30 patients with ED were examined. Each patient filled in an International Index of Erectile Function-5 (IIEF-5) questionnaire. AVSS and NPT tests were performed using the RigiScan Plus. AVSS test was performed with and without medication (sildenafil citrate 50 mg). Patients were divided into two groups (psychogenic and organic groups) according to NPT and AVSS test results. Results: The mean age of the patients was 46.4 (23-69) years and IIEF-5 score was 10.8±4.5. Positive AVSS test was found in 18 (85.7%) of the 21 patients with positive NPT test. Negative AVSS test was found in 7 (77, 8%) of the 9 patients with negative NPT test. The specificity of AVSS test was 85.7% and sensitivity was 77.8% for the psychogenic groups. The overall accuracy rate was 83.3%. Conclusion: The NPT test is more expensive, cumbersome, and discomfortable than the AVSS test. Although efficiency of both tests is similar, the AVSS test seems more advantageous. We suggest that the AVSS test without medication should be performed as the first step in the diagnosis of the patients with ED. In patients with negative test result, the AVSS test with medication should be performed as the second step diagnostic method.
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    The role of stem/progenitor cells and wnt/β-catenin signaling pathway in the patients with prostate cancer
    (Edizioni Minerva Medica, 2014) Vatansever H.S.; Gumus B.; Aydogdu O.; Sivrikoz O.N.; Türkôz-Uluer E.; Kivanç M.; Ateşçi Y.Z.; Bugdayci H.
    Aim: The aim of this paper was to investigate the possible effect of cancer stem cells (CSCs) and relationship with Wnt/β-catenin signaling pathway progressing of prostate cancer. Methods: Thirty men with a pathological diagnosis of benign prostate hyperplasia (BPH) (group 1, N.=10), prostate cancer with a gleason score of ≤6 (group 2, N.=10), and prostate cancer with a gleason score of >6 (group 3, N.=10) were included in the study. The patients' groups were compared in terms of immunoreactivity strength of prostatic stem/progenitor cell surface markers including CD133 and CD117. We also compared the immunoreactivity of Wnt7a, a part of Wnt signaling pathway which has a potential role in the progression of several cancers including prostate cancer. The immunoreactivity of Frizzled 6 (Fzd 6) which is the receptor of Wnt family was also evaluated in all groups. Results: Immunohistochemical analyses demonstrated that although CD 133 immunoreactivity was positive in all groups, immunoreactivity was significantly stronger in group 3 when compared to other groups. While CD117 immunoreactivity was negative in group 1 and 2, it was positive in group 3. Wnt7a immunoreactivity was weak in all groups and Fzd 6 immunoreactivity was stronger in group 1 and 3 when compared to group 2. Conclusion: Our findings demonstrated that CSCs and Wnt signaling pathway have a potential role in the development and progression of prostate cancer.
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    The effect of bisphosphonates on bone mineral density in metastatic prostate cancer patients who are treated with anti-androgen drugs and radiotherapy
    (S. Karger AG, 2014) Karaköse A.; Yüksel M.B.; Aydoʇdu Ö.; Gümüş B.; Ateşçi Y.Z.; Akan Z.
    Objective: To evaluate the potential effect of bisphosphonates on bone mineral density (BMD) in patients who are treated with anti-androgen drugs and radiotherapy for metastatic prostate cancer.; Materials and Methods: The data of 31 patients with metastatic prostate cancer who were treated with anti-androgen drugs and radiotherapy during a 1-year period were retrospectively reviewed. Patients were divided in 2 groups, in which 17 patients in group 1 were treated with zoledronic acid (4 mg/month, intravenous) and 14 patients in group 2 who did not receive zoledronic acid. BMD was measured before the treatment and at the end of the 1st year by dual energy X-ray absorptiometry. Statistical analyses were performed with the T test.; Results: Mean age of the patients was 71.42 ± 6.7(range 59-85) years. A significant increase was noted for pelvic bone, femoral neck, and lumbar vertebrae t scores when pretreatment and 1st year measurements were compared in group 1 (p < 0.05). In group 2 a significant decrease was noted for pelvic bone and femoral neck t scores at the end of the 1st year (p < 0.05). A significant increase was noted for pelvic bone and femoral neck follow-up in BMD values at the end of the 1st year compared to initial measurements in group 1. A significant decrease was noted for lumbar vertebrae follow-up in BMD values at the end of the 1st year when compared to initial values in group 2.; Conclusion: Zoledronic acid significantly increases BMD and delays unfavorable outcomes for bones in men who are treated with anti-androgen drugs and radiotherapy for metastatic prostate cancer. Copyright © 2013 S. Karger AG, Basel.