Browsing by Author "Ates, H"

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    Leveraging augmented reality and gamification for enhanced self-regulation in science education
    Ates, H; Polat, M
    This study investigates the efficacy of integrating augmented reality (AR)-based gamification with self-regulated learning (SRL) strategies to enhance middle school students' academic performance, engagement, satisfaction, and self-efficacy in science education. Employing immersive AR technologies alongside gamification elements, this approach is designed to cultivate an engaging and learner-centered environment that promotes essential SRL competencies including goal-setting, self-monitoring, and reflective thinking. Utilizing an experimental research design, the study engaged 60 middle school students who were allocated into two groups: one experiencing self-regulated AR-based gamification and the other experiencing traditional AR-based gamification without self-regulation components. The findings reveal that students in the self-regulated AR-based gamification group demonstrated significantly enhanced levels of academic achievement, engagement, self-efficacy, and overall satisfaction compared to their peers in the traditional group. These outcomes suggest that the strategic integration of AR-based gamification with SRL strategies not only fosters significant improvements in educational performance but also enriches the learning experience, thereby providing critical insights for the development of innovative educational technologies that support comprehensive understanding and foster student autonomy in science education.
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    Exploring adoption of humanoid robots in education: UTAUT-2 and TOE models for science teachers
    Ates, H; Polat, M
    This study examines the factors influencing science teachers' intentions to adopt humanoid robots in educational settings. It employs the Unified Theory of Acceptance and Use of Technology 2 (UTAUT-2) and the Technology-Organization-Environment (TOE) framework as guiding theoretical models. By integrating UTAUT-2, which emphasizes individual factors, and TOE, which addresses organizational and environmental influences, the study constructs a comprehensive model that explores both personal and contextual drivers of adoption. Utilizing structural equation modeling on a sample of 1,150 pre-service and in-service science teachers, the study reveals that the integrated model demonstrates superior predictive power compared to each framework individually. Results highlight the moderating role of professional experience in the adoption process, with significant differences identified between pre-service and in-service teachers. The findings reveal significant differences between pre-service and in-service teachers, illustrating the moderating role of professional experience in the adoption process. This study provides a deeper understanding of how motivational, organizational, and environmental factors interact to influence adoption intentions. These insights provide practical guidance for developing targeted training programs, promoting institutional readiness through well-crafted policy initiatives, and implementing pilot projects to support schools in the effective integration of humanoid robots into educational curricula. These findings provide actionable insights for educational policymakers and practitioners aiming to enhance teaching quality and student engagement through innovative technologies.
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    Corneal Hysteresis, Corneal Resistance Factor, and Intraocular Pressure Measurement in Patients with Scleroderma Using the Reichert Ocular Response Analyzer
    Emre, S; Kayikçioglu, Ö; Ates, H; Çinar, E; Inceoglu, N; Yargucu, F; Pirildar, T; Oksel, F
    Purpose: The Reichert ocular response analyzer (ORA) measures corneal biomechanical properties in vivo by monitoring and analyzing the corneal behavior when its structure is submitted to a force induced by an air jet. This study was designed to examine corneal biomechanical properties and intraocular pressure in patients with systemic sclerosis (SSc) and to compare with control eyes. Patients and Methods: ORA measurements were performed on the right eyes of 29 patients with SSc (group 1) and 29 healthy people who served as the control group (group 2). Corneal hysteresis, conical resistance factor (CRF), and intraocular pressure [Goldmann correlated (IOPg) and conical compensated] were recorded with ORA. Results: Mean age of patients with SSc and control groups were 51.7 +/- 11.1 and 50.3 +/- 10.8 years, respectively. Mean (+/- SD) of the corneal hysteresis and CRF readings were 9.8 +/- 1.7 versus 9.5 +/- 1.2 mm Hg (P>0.05) and 10.0 +/- 1.5 versus 9.2 +/- 1.4 mm Hg (P<0.05), in groups 1 and 2, respectively. Mean (+/- SD) of the IOPg and intraocular pressure corneal-compensated recordings were 15.9 +/- 2.5 versus 14.1 +/- 2.4 mm Hg (P<0.05) and 16.9 +/- 3.2 versus 15.6 +/- 2.9 mm Hg (P>0.05), in groups 1 and 2, respectively. Statistical analysis revealed significant differences for CRF and IOPg between the study groups. Conclusions: The mean CRF and IOPg values of patients with SSc were higher when compared with normal controls. According to the results of our study, one can conclude that corneal biomechanical properties would be changed in patients with SSc and this can be determined by CRF.
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    Cytotoxic effects of boron compounds in P53 (+/+) and P53 (-/-) HCT-116 colon carcinoma cells lines
    Serdar, BS; Özen, G; Günay, IC; Korkmaz, M; Ates, H; Koçturk, AS
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    Borax Pentahydrate and Disodium Pentaborate Decahydrate Are Candidates as Anti-leukemic Drug Components by Inducing Apoptosis and Changing Bax/Bcl-2 Ratio in HL-60 Cell Line
    Erkmen, T; Serdar, BS; Ates, H; Korkmaz, M; Koçtürk, S
    Acute myeloid leukemia (AML) is the most common form of acute leukemia and has the lowest 5-year survival rates. Current treatment strategies do not meet the expectations also. Therefore, there is a need to improve therapeutic approaches still. Boron, which is a natural trace element in human diet, is gaining attention with its important roles in cellular processes for the development of new anti-cancer drug candidates. For instance, bortezomib, a dipeptidyl boronic acid, has encouraging results in the treatment of multiple myeloma and mantle cell lymphoma. However, severe toxic effects and resistance development are the limitations to its application for AML treatment. Hence, the development of alternative boron-derived anti-AML agents is unmet need. Therefore, we aimed to evaluate anti-leukemic effect of two promising boron compounds, borax pentahydrate (BP) and disodium pentaborate decahydrate (DPD), and comparison of each other in terms of the capacity to trigger apoptosis on acute promyelocytic leukemia cells (HL-60). Cell viability was assessed by MTT assay. Apoptotic effects of the boron compounds on HL-60 cells were evaluated by annexin V/propidium iodide dyes and caspase 3/7 activity assay by flow cytometry. In addition, Bax/Bcl-2 and cleaved PARP levels were detected by western blotting. Although BP showed greater apoptosis-inducing capacity, we observed that both DPD (6 mM) and BP (24 mM) treatment showed anti-leukemic effect by triggering apoptotic pathway through increasing Bax/Bcl-2 ratio for the first time. Our study suggests that BP and DPD are the promising candidates for anti-AML drug development research, which may be confirmed by further wide-spectrum studies.