Browsing by Author "Ayça, S"
Now showing 1 - 8 of 8
Results Per Page
Sort Options
Item Information is Power: An Interventional Study on Parents of Children with Febrile SeizuresKizilay, DÖ; Kirdök, AA; Ertan, P; Ayça, S; Demet, MM; Polat, MAim: Febrile seizures (FS) cause great fear and panic in the families. The majority of parents think that they may lose their child during a seizure, and feel anxious about the possibility of seizures recurring in the future. We believe that educating the families with high levels of anxiety due to FS may help to reduce the level of anxiety. In this study, we aimed to determine the needs of parents regarding FS, and the effect of education on FS on the approach and anxiety of the parents. Materials and Methods: In our study, we interviewed the parents of 113 children who suffered from FS. We conducted a survey aiming at detailed detection of knowledge, attitudes, thoughts and concerns of the families about FS, and their approaches to fever and FS. We also performed Hospital Anxiety and Depression Scale and State-Trait Anxiety Inventory to determine the levels of anxiety and depression of the parents. Results: In this study, we found that parents were misinformed and had misbeliefs suggesting that FS damage the brain and cause epilepsy, that they are life-threatening and electroencephalography, magnetic resonance imaging and computed tomography scans of the brain are required. We also determined a significant lack of information about interventions during a seizure and thus, a high level of anxiety. Conclusion: We concluded that parents provided with sufficient information and given psychosocial support have their anxiety levels significantly reduced, making them better in first aid practices and reducing their requests for unnecessary preventive interventions.Item Levels of Melatonin in Continuous Spikes and Waves During SleepAyça, S; Aksoy, HU; Tastan, I; Polat, MLevels of melatonin have been reported before in children with epilepsy, but such has not been reported to date in those with continuous spikes and waves during sleep. The aim of the present study was to assess serum melatonin levels and melatonin circadian rhythm in patients with continuous spikes and waves during sleep and epilepsy. Serum melatonin was measured in 39 children stratified into 3 groups. Group 1 included 15 patients with continuous spikes and waves during sleep, group 2 included 12 epilepsy patients, and group 3 included 12 controls, respectively. Blood samples were taken from all participants at 1:00 am and 9:00 am and melatonin levels were measured using a quantitative enzyme-linked immunosorbent assay test. The 9:00 am melatonin levels of group 1 were significantly decreased and pair groups were compared. The P-a value (representing a comparison between groups 1 and 2) was .002, the P-b value (representing a comparison between groups 1 and 3) was .001, and the P-c value (representing a comparison between groups 2 and 3) was .86. These findings suggest that the 9:00 am melatonin levels were significantly decreased in the comparison of groups 2 and 3. Further detailed research is necessary to determine the factors leading to the rapid decline of morning melatonin levels of children with continuous spikes and waves during sleep.Item A Novel Frameshift Mutation in Two Siblings with Merosin-deficient Congenital Muscular DystrophyAyça, S; Çelebi, HBG; Çam, S; Polat, MWe present two siblings with elevated serum creatine kinase concentrations, developmental delay, muscle weakness, and contractures of the lower limbs. Cranial magnetic resonance imaging revealed diffuse white matter hyperintensity in both siblings. In the older sister, muscle biopsy was performed; immunohistochemical studies showed a dystrophic pattern and merosin deficiency. With the diagnosis of merosin-deficient congenital muscular dystrophy (MDC1A), LAMA2 gene mutation analysis revealed an NM_000426.3:c.163_163delA; (p.N55Mfs*16) homozygous frameshift mutation in the siblings. This mutation leads to a premature stop codon and has not been reported previously in the literature.Item Acute Ophthalmoplegia; Same Disease, Different Variants: Anti GQ1b Antibody SyndromeAyça, S; Ergani, AC; Polat, MPatients with Miller Fisher syndrome (MFS) are characterized by acute ophthalmoplegia (AO) and aretlexia. MFS is an immune mediated process, triggered by an infection and includes incomplete forms, such as ophthalmoplegia, ataxia and a central nervous system subtype known as Bickerstaff brainstem encephalitis (BBE). We present two cases admitted to our hospital on the same day. The first case was presented as AO, with elevated levels of anti GQ1b. The second case was presented as AO, oropharyngeal palsy and sensory motor polyneuropathy with borderline levels of anti GQ1b, diagnosed as BBE. There are atypical forms of MFS with different clinical symptoms and elevated levels of antibodies called Anti GQ1b Antibody syndrome. The cases of the two patients diagnosed as MFS variants' AO and BBE.Item Evaluation of GFAP, S100B, and UCHL-1 Levels in Children With Refractory EpilepsyAksoy, HU; Yilmaz, C; Orak, SA; Ayça, S; Polat, MIntroduction A number of biomarkers are used to evaluate the duration of the epileptic seizure and the interictal period following neuronal injury. Invasive diagnostic methods are increasingly being replaced by peripheral or minimally invasive biomarkers that give results faster and are more secure.Purpose We aimed to evaluate serum glial fibrillary acidic protein (GFAP), S100B, and ubiquitin C-terminal hydrolase (UCHL-1) levels in children with epilepsy.Methods Our study included 3 groups: a nonrefractory epilepsy group, a refractory epilepsy group, and a control group. The GFAP, S100B, and UCHL-1 levels in serum samples collected 2-24 hours after the last seizure were analyzed using enzyme-linked immunosorbent assays.Results A total of 69 children participated in the study, with 35 participants in the refractory epilepsy group, 18 in the nonrefractory epilepsy group, and 16 in the control group. The GFAP values in the refractory (25.4 ng/mL) and nonrefractory (26.1 ng/mL) epilepsy groups were found to be statistically significantly higher than those in the control group (17.9 ng/mL; P = .001). The S100B values were found to be significantly higher in the refractory epilepsy group (34.13 pg/mL) than in both the control group and the nonrefractory epilepsy group (28.05 pg/mL; P = .028). No significant differences were observed in the UCHL-1 levels between the 3 groups.Conclusions We conclude that the observed differences may be due to the increased expression of S100B and GFAP caused by increased and repetitive neuronal damage in refractory epilepsies compared with nonrefractory epilepsies.Item Efficacy of Lacosamide Therapy in Focal Onset Refractory Epilepsy of Childhood: A Single Center ExperienceAksoy, HU; Yilmaz, C; Ayça, S; Atasever, AK; Polat, M; Öztürk, SObjective: Treatment of childhood refractory epilepsy is a challenge for clinicians. Lacosamide is a new generation antiepileptic drug which is being used for focal onset seizures of adults and children. Efficacy and safety of the drug for adults have been demonstrated in various studies. The aim of this retrospective cross-sectional study is to evaluate the efficacy and safety of lacosamide in childhood refractory focal seizures in our clinic. Methods: We examined the medical records of 14 patients treated with lacosamide in our clinic between January 2016 and January 2020 in terms of demographic, etiological, neuroimaging findings, responses to treatment, adverse effects and drug-drug interactions. We evaluated the patients as responders to treatment whose seizure frequency decreased >=%50 after 6 months of lacosamide treatment. Results: in 12 patiens (%85.7) seizure frequency decreased >=%50 (rho<0.001) while 5 of them (%35.7) was seizure free. Despite to the long term treatment one patient did not response to lacosamide treatment, and 1 patient's treatment stopped due to aggravation of seizure after initiation of lacosamide treatment. Clinical adverse effects were observed in 3 (%21.4) patients. Cardiac adverse effects or drug-drug interactions were not observed in any patient. Conclusion: As a result of our study, we think that lacosamide is an effective and reliable treatment option for refractory focal seizures of childhood similar to the results of the studies cited in the literature. We also think that further investigations are needed to evaluate its efficacy in focal and different type of seizures of childhood.Item A multicenter retrospective study in Turkish children with myotonic dystrophy type 1Tuncer, GO; Sanri, A; Bayir, GK; Erol, I; Ardiçli, D; Öztürk, M; Tekin, HG; Kutluk, G; Hergüner, Ö; Tekgül, H; Toker, RT; Per, H; Çavusoglu, D; Yildiz, EP; Kömür, M; Türkdogan, D; Özgör, B; Ayça, SItem Phenotypic variability and novel variants in TBC1D24-associated epilepsy: Insights from a multicentre studyKarakayali, B; Türkdogan, D; Ayaz, A; Geckinli, BB; Ayça, S; Özcan, S; Uzunhan, TA; Ayvaz, A; Uyanik, B; Cansu, A; Özkan, P; Basarir, G; Dündar, NO; Gençpinar, P; Kara, B; Polat, H; Akbeyaz, H